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Your search keyword '"Pneumonia, Aspiration metabolism"' showing total 3 results
Start Over Descriptor "Pneumonia, Aspiration metabolism" Publisher polish physiological society
3 results on '"Pneumonia, Aspiration metabolism"'

1. Aminophylline treatment in meconium-induced acute lung injury in a rabbit model.

Author

Mokra D, Mokry J, Tatarkova Z, Redfors B, Petraskova M, and Calkovska A

Subjects
Aminophylline administration & dosage, Animals, Anti-Inflammatory Agents administration & dosage, Bronchial Provocation Tests, Bronchoconstriction drug effects, Bronchoconstrictor Agents administration & dosage, Bronchodilator Agents administration & dosage, Central Venous Pressure drug effects, Disease Models, Animal, Histamine administration & dosage, Humans, Infant, Newborn, Injections, Intravenous, Lipid Peroxidation drug effects, Lung metabolism, Lung physiopathology, Meconium Aspiration Syndrome metabolism, Meconium Aspiration Syndrome physiopathology, Neutrophil Infiltration drug effects, Oxidative Stress drug effects, Pneumonia, Aspiration metabolism, Pneumonia, Aspiration physiopathology, Protein Carbonylation drug effects, Pulmonary Circulation drug effects, Pulmonary Edema prevention & control, Pulmonary Gas Exchange drug effects, Pulmonary Ventilation drug effects, Rabbits, Aminophylline pharmacology, Anti-Inflammatory Agents pharmacology, Bronchodilator Agents pharmacology, Lung drug effects, Meconium Aspiration Syndrome prevention & control, Pneumonia, Aspiration prevention & control
Abstract

Administration of methylxanthines may diminish meconium-induced acute lung injury. Meconium-instilled rabbits intravenously received aminophylline (2.0 mg/kg) at two doses 0.5 h and 2.5 h after meconium instillation or were left without treatment, and were oxygen-ventilated for additional 5 h. At the end of experiment, lungs and trachea were excised. Within 5 h after the first dose of treatment, aminophylline significantly improved gas exchange and decreased right-to-left pulmonary shunts, central venous pressure, and ventilatory pressures. Moreover, aminophylline reduced meconium-induced lung edema formation, airway hyperreactivity to histamine, count of neutrophils in bronchoalveolar lavage fluid associated with higher total white blood cells and neutrophils in the blood, and diminished oxidative modifications of proteins and lipids in lung tissue compared with the non-treated meconium-instilled group. In a rabbit model of the meconium aspiration syndrome, aminophylline treatment enhanced pulmonary functions and alleviated oxidative injury and changes in airway reactivity related to lung inflammation.

Published
2007

2. Intratracheally administered corticosteroids improve lung function in meconium-instilled rabbits.

Author

Mokra D, Mokry J, Drgova A, Petraskova M, Bulikova J, and Calkovska A

Subjects
Animals, Bronchial Provocation Tests, Bronchoconstriction drug effects, Bronchoconstrictor Agents administration & dosage, Central Venous Pressure drug effects, Disease Models, Animal, Histamine administration & dosage, Humans, Infant, Newborn, Intubation, Intratracheal, Lipid Peroxidation drug effects, Lung metabolism, Lung physiopathology, Meconium Aspiration Syndrome metabolism, Meconium Aspiration Syndrome physiopathology, Neutrophil Infiltration drug effects, Oxidative Stress drug effects, Pneumonia, Aspiration metabolism, Pneumonia, Aspiration physiopathology, Protein Carbonylation drug effects, Pulmonary Circulation drug effects, Pulmonary Edema physiopathology, Pulmonary Edema prevention & control, Pulmonary Gas Exchange drug effects, Pulmonary Ventilation drug effects, Rabbits, Adrenal Cortex Hormones administration & dosage, Budesonide administration & dosage, Lung drug effects, Meconium Aspiration Syndrome drug therapy, Pneumonia, Aspiration prevention & control, Respiratory System Agents administration & dosage
Abstract

Local administration of corticosteroids may diminish acute lung injury associated with meconium aspiration. Budesonide was given intratracheally in 2 doses of 0.25 mg/kg each by means of inpulsion effect of high-frequency jet ventilation 0.5 and 2.5 hours after meconium instillation to oxygen-ventilated adult rabbits. Within 5 hours after the first dose, budesonide significantly improved gas exchange and decreased right-to-left pulmonary shunts, central venous pressure, and ventilatory pressures. In addition, budesonide reduced the meconium-induced lung edema formation, airway hyperreactivity to histamine, count of neutrophils in bronchoalveolar lavage fluid associated with higher total white blood cell and neutrophil counts in the blood, and diminished oxidative modifications of proteins and lipids in lung tissue compared to non-treated meconium-instilled group. The intratracheally administered corticosteroid budesonide effectively improved pulmonary functions and alleviated changes associated with inflammation in meconium-instilled rabbits.

Published
2007

3. Single-dose versus two-dose dexamethasone effects on lung inflammation and airway reactivity in meconium-instilled rabbits.

Author

Mokra D, Mokry J, Drgova A, Bulikova J, Petraskova M, and Calkovska A

Subjects
Animals, Bronchial Provocation Tests, Bronchoconstrictor Agents administration & dosage, Disease Models, Animal, Dose-Response Relationship, Drug, Histamine administration & dosage, Humans, Infant, Newborn, Injections, Intravenous, Lipid Peroxidation drug effects, Lung metabolism, Lung physiopathology, Meconium Aspiration Syndrome metabolism, Meconium Aspiration Syndrome physiopathology, Neutrophil Infiltration drug effects, Oxidative Stress drug effects, Pneumonia, Aspiration metabolism, Pneumonia, Aspiration physiopathology, Protein Carbonylation drug effects, Pulmonary Edema prevention & control, Rabbits, Time Factors, Tracheal Diseases metabolism, Tracheal Diseases physiopathology, Anti-Inflammatory Agents administration & dosage, Bronchoconstriction drug effects, Dexamethasone administration & dosage, Lung drug effects, Meconium Aspiration Syndrome drug therapy, Pneumonia, Aspiration prevention & control, Respiratory System Agents administration & dosage, Tracheal Diseases prevention & control
Abstract

Two doses of the corticosteroid dexamethasone may alleviate meconium-induced acute lung injury more effectively than a single dose. Meconium-instilled rabbits intravenously received dexamethasone (0.5 mg/kg) at one dose 0.5 hours after meconium instillation or at two doses 0.5 hours and 2.5 hours after meconium instillation or were left without treatment, and were oxygen-ventilated for additional 5 hours. At the end of experiment, lungs and trachea were excised. Two doses of dexamethasone effectively diminished meconium-induced lung edema, tracheal hyperreactivity to histamine, neutrophil count in bronchoalveolar lavage fluid, and decreased oxidative modifications of proteins and lipids in lung homogenate compared with the non-treated group. Single-dose dexamethasone also reduced lung edema, lung neutrophils, and tracheal hyperreactivity to histamine, but these effects were weaker than those after two-dose dexamethasone. We conclude that two-dose dexamethasone is superior to single-dose dexamethasone in prevention lung injury in meconium-instilled rabbits.

Published
2007

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