Search

The complexity of Neolithic population movements and their interpretation through material culture have been the subject of archaeological research for decades. One of the dominant narratives proposes that groups from the Starčevo-Ko¨ro¨ s-Criş complex spread from the central towards the northern Balkans in the Early Neolithic and eventually brought the Neolithic lifestyle into present-day Hungary. Broad geographical migrations were considered to shape the continuous expansion of Neolithic groups and individuals. However, recent archaeological research, aDNA, and isotope analyses challenged the synchronous appearance of specific material culture distributions and human movement dynamics through emphasizing communication networks and socio-cultural transformation processes. This paper seeks to retrace the complexity of Neolithic mobility patterns across Hungary by means of strontium and oxygen stable isotope analyses, which were performed on a total of 718 human dental enamel samples from 55 Neolithic sites spanning the period from the Starčevo to the Balaton-Lasinja culture in Transdanubia and from the Ko¨ro¨s to the Tiszapolga ´ r cultural groups on the Great Hungarian Plain (Alfo¨ ld). This study presents the largest strontium and oxygen isotope sample size for the Neolithic Carpathian Basin and discusses human mobility patterns on various geographical scales and throughout archaeological cultures, chronological periods, and sex and gender categories in a multiproxy analysis. Based on our results, we discuss the main stages of the Neolithisation processes and particularly trace individual movement behaviour such as exogamy patterns within extensive social networks. Furthermore, this paper presents an innovative differentiation between mobility patterns on small, micro-regional, and supra-regional scales, which provides new insights into the complex organisation of Neolithic communities. The complexity of Neolithic population movements and their interpretation through material culture have been the subject of archaeological research for decades. One of the dominant narratives proposes that groups from the Starčevo-Ko¨ro¨ s-Criş complex spread from the central towards the northern Balkans in the Early Neolithic and eventually brought the Neolithic lifestyle into present-day Hungary. Broad geographical migrations were considered to shape the continuous expansion of Neolithic groups and individuals. However, recent archaeological research, aDNA, and isotope analyses challenged the synchronous appearance of specific material culture distributions and human movement dynamics through emphasizing communication networks and socio-cultural transformation processes. This paper seeks to retrace the complexity of Neolithic mobility patterns across Hungary by means of strontium and oxygen stable isotope analyses, which were performed on a total of 718 human dental enamel samples from 55 Neolithic sites spanning the period from the Starčevo to the Balaton-Lasinja culture in Transdanubia and from the Ko¨ro¨s to the Tiszapolga ´ r cultural groups on the Great Hungarian Plain (Alfo¨ ld). This study presents the largest strontium and oxygen isotope sample size for the Neolithic Carpathian Basin and discusses human mobility patterns on various geographical scales and throughout archaeological cultures, chronological periods, and sex and gender categories in a multiproxy analysis. Based on our results, we discuss the main stages of the Neolithisation processes and particularly trace individual movement behaviour such as exogamy patterns within extensive social networks. Furthermore, this paper presents an innovative differentiation between mobility patterns on small, micro-regional, and supra-regional scales, which provides new insights into the complex organisation of Neolithic communities.

Removal models were proposed over 80 years ago as a tool to estimate unknown population size. More recently, they are used as an effective tool for management actions for the control of non desirable species, or for the evaluation of translocation management actions. Although the models have evolved over time, in essence, the protocol for data collection has remained similar: at each sampling occasion attempts are made to capture and remove individuals from the study area. Within this paper we review the literature of removal modelling and highlight the methodological developments for the analysis of removal data, in order to provide a unified resource for ecologists wishing to implement these approaches. Models for removal data have developed to better accommodate important features of the data and we discuss the shift in the required assumptions for the implementation of the models. The relative simplicity of this type of data and associated models mean that the method remains attractive and we discuss the potential future role of this technique.

Communications, navigation, and other related systems need to have a well-defined antenna radiation pattern. In onboard vessel systems, the radiation pattern can be much different than the one obtained for an isolated antenna (because of the vessel’s structure and other nearby radiating systems interference). Finding out the onboard antenna’s radiation pattern is a well-known problem for any shipbuilder/owner. The conventional method consists of measuring radiation patterns from a fixed antenna on the coast while the ship is navigating in circles. Recent electronic systems in the market now allow for an alternative method: keeping the ship static while an unmanned aerial vehicle (UAV) circles it, measuring the antenna’s transmitted power. This research paper examines the airspace volume and optimal flight path of an off-the-shelf UAV system for measuring the onboard antenna’s radiation pattern in the presence of physical constraints such as the vessel’s dimensions, safety zone, distance to base, Fresnel’s and multipath distances, and considering the loss due to polarization decoupling between the antenna under test and UAV’s antenna.

[EN] Emergency Care Networks (ECNs) were created as a response to the increased demand for emergency services and the ever-increasing waiting times experienced by patients in emergency rooms. In this sense, ECNs are called to provide a rapid diagnosis and early intervention so that poor patient outcomes, patient dissatisfaction, and cost overruns can be avoided. Nevertheless, ECNs, as nodal systems, are often inefficient due to the lack of coordination between emergency departments (EDs) and the presence of non-value added activities within each ED. This situation is even more complex in the public healthcare sector of low-income countries where emergency care is provided under constraint resources and limited innovation. Notwithstanding the tremendous efforts made by healthcare clusters and government agencies to tackle this problem, most of ECNs do not yet provide nimble and efficient care to patients. Additionally, little progress has been evidenced regarding the creation of methodological approaches that assist policymakers in solving this problem. In an attempt to address these shortcomings, this paper presents a three-phase methodology based on Discrete-event simulation, payment collateral models, and lean six sigma to support the design of in-time and economically sustainable ECNs. The proposed approach is validated in a public ECN consisting of 2 hospitals and 8 POCs (Point of Care). The results of this study evidenced that the average waiting time in an ECN can be substantially diminished by optimizing the cooperation flows between EDs., The authors would like to express his gratitude to Giselle Polifroni Avendaño for supporting this research.

One of the key challenges in real-time systems is the analysis of the memory hierarchy. Many Worst-Case Execution Time (WCET) analysis methods supporting an instruction cache are based on iterative or convergence algorithms, which are rather slow. Our goal in this paper is to reduce the WCET analysis time on systems with a simple lockable instruction cache, focusing on the Lock-MS method. First, we propose an algorithm to obtain a structure-based representation of the Control Flow Graph (CFG). It organizes the whole WCET problem as nested subproblems, which takes advantage of common branch-and-bound algorithms of Integer Linear Programming (ILP) solvers. Second, we add support for multiple locking points per task, each one with specific cache contents, instead of a given locked content for the whole task execution. Locking points are set heuristically before outer loops. Such simple heuristics adds no complexity, and reduces the WCET by taking profit of the temporal reuse found in loops. Since loops can be processed as isolated regions, the optimal contents to lock into cache for each region can be obtained, and the WCET analysis time is further reduced. With these two improvements, our WCET analysis is around 10 times faster than other approaches. Also, our results show that the WCET is reduced, and the hit ratio achieved for the lockable instruction cache is similar to that of a real execution with an LRU instruction cache. Finally, we analyze the WCET sensitivity to compiler optimization, showing for each benchmark the right choices and pointing out that O0 is always the worst option.

Publisher's version (útgefin grein), Traditional search tasks have taught us much about vision and attention. Recently, several groups have begun to use multiple-target search to explore more complex and temporally extended “foraging” behaviour. Many of these new foraging tasks, however, maintain the simplified 2D displays and response demands associated with traditional, single-target visual search. In this respect, they may fail to capture important aspects of real-world search or foraging behaviour. In the current paper, we present a serious game for mobile platforms, developed in Unity3D, in which human participants play the role of an animal foraging for food in a simulated 3D environment. Game settings can be adjusted, so that, for example, custom target and distractor items can be uploaded, and task parameters, such as the number of target categories or target/distractor ratio are all easy to modify. We are also making the Unity3D project available, so that further modifications can also be made. We demonstrate how the app can be used to address specific research questions by conducting two human foraging experiments. Our results indicate that in this 3D environment, a standard feature/conjunction manipulation does not lead to a reduction in foraging runs, as it is known to do in simple, 2D foraging tasks., The authors received no specific funding for this work.

Constructed wetlands are sustainable technologies for the treatment of wastewater. These biological systems have been widely studied throughout the world for more than 30 years; however, most studies have focused on the effects of design and engineering on pollutant removal from wastewater. Undoubtedly, agro-technical aspects have been given too little consideration by research. This paper reports the main results of a set of experiments carried out on two pilot horizontal subsurface flow systems in Sicily (Italy). Festuca, Lolium and Pennisetum spp. in combination and three emergent macrophytes-Arundo donax L., Cyperus alternifolius L. and Typha latifolia L.-alone, were assessed. The aim of the study was to demonstrate that, under predetermined hydraulic and design conditions, the choice of plant species and the management of the vegetation can significantly affect the pollutant removal performance of constructed wetlands. In addition, wastewater (after treatment) can also be used for agricultural purposes leading to increased sustainability in agricultural systems. Arundo and Typha-planted units performed better than Cyperus-planted units in terms of chemical, physical and microbiological contaminant removal. All the species adapted extremely well to wetland conditions. Polyculture systems were found to be more efficient than monocultures in the removal of dissolved organic compounds. The reuse of treated wastewater for the irrigation of open fields and horticultural crops led to significant savings in the use of freshwater and fertilizers. The results of physical-energy characterization of A. donax above-ground plant residues and pellets highlighted the fact that a constructed wetland could also be a potential source of bioenergy.

Purpose The aim of this paper is to show how a specialized planning and guidance application called Fraxinus, can be built on top of the CustusX platform (www.custusx.org), which is an open source image-guided intervention software platform. Fraxinus has been customized to meet the clinical needs in navigated bronchoscopy. Methods The application requirements for Fraxinus were defined in close collaboration between research scientists, software developers and clinicians (pulmonologists), and built on top of CustusX. Its superbuild system downloads specific versions of the required libraries and builds them for the application in question, including the selected plugins. New functionality is easily added through the plugin framework. The build process enables the creation of specialized applications, adding additional documentation and custom configurations. The toolkit’s libraries offer building blocks for image-guided applications. An iterative development process was applied, where the clinicians would test and provide feedback during the entire process. Results Fraxinus has been developed and is released as an open source planning and guidance application built on top of CustusX. It is highly specialized for bronchoscopy. The proposed workflow is adapted to the different steps in this procedure. The user interface of CustusX has been modified to enhance information, quality assurance and user friendliness with the intention to increase the overall yield for the patient. As the workflow of the procedure is relatively constant, some actions are predicted and automatically performed by the application, according to the requirements from the clinicians. Conclusions The CustusX platform facilitates development of new and specialized applications. The toolkit supports the process and makes important extension and injection points available for customization. © 2019 Lervik Bakeng et al. This is an open access article distributed under the terms of the Creative Commons Attribution License

ObjectivesThe Norwegian randomized controlled trial Early Food for Future Health provided parental anticipatory guidance on early protective feeding practices from child age 6 to 12 months through an eHealth intervention. Previously published outcomes at child age 12 months indicated that the eHealth intervention increased daily vegetable/fruit intake and promoted more beneficial mealtime routines. The objective of the current paper is to evaluate the effects of the intervention at child age 24 months, one year after cessation.MethodsParents of infants aged 3-5 months were recruited via social media and child health clinics during spring 2016. At child age 5.5 months, 715 mothers were randomized to either control (n = 358) or intervention (n = 360) arm. Primary study-outcomes were child eating behaviors, dietary intake, mealtime routines and maternal feeding practices and feeding styles. Secondary outcome was child anthropometry.ResultsIn total 295 mothers (41%) completed the follow-up questionnaire at child age 24 months. Regarding fruit intake, 54.3% in the intervention group had a high score compared with 48.3% of the control group (p = 0.29). For intake of vegetables, 54.5% in the intervention group had a high score compared with 50.7% in the control group (p = 0.49). A total of 65.7% of the children in the intervention group were eating breakfast together with family ≥ 4 times per week, compared with 57.3% of the children in the control group (p = 0.12). There was no difference between the groups for child anthropometric outcomes at child age 24 months.ConclusionsAt child age 24 months, we found no evidence of sustained intervention-effects. Although dietary patterns and mealtime routines at child age 24 months were reasonably consistent and in the same directions as at child age 12 months, the between-group differences were not significant. The large loss to follow-up may have limited power and validity and makes it difficult to draw overall conclusions. Future research is needed to improve knowledge of how short-time effects could be retained over longer term, taking into account that larger samples are necessary when planning longer-term follow-up studies.Trial registrationISRCTN, ISRCTN13601567.

Data Availability: Relevant data are contained within the paper and its Supporting Information files. All unique sequence tags obtained following virus infections are available for download via the Dryad Digital Repository (http://dx.doi.org/10.5061/dryad.3c7m4)., MicroRNAs (miRNAs) are a class of small non-coding RNAs involved in post-transcriptional gene regulation. Some viruses encode their own miRNAs and these are increasingly being recognized as important modulators of viral and host gene expression. Cyprinid herpesvirus 3 (CyHV-3) is a highly pathogenic agent that causes acute mass mortalities in carp (Cyprinus carpio carpio) and koi (Cyprinus carpio koi) worldwide. Here, bioinformatic analyses of the CyHV-3 genome suggested the presence of non-conserved precursor miRNA (pre-miRNA) genes. Deep sequencing of small RNA fractions prepared from in vitro CyHV-3 infections led to the identification of potential miRNAs and miRNA–offset RNAs (moRNAs) derived from some bioinformatically predicted pre-miRNAs. DNA microarray hybridization analysis, Northern blotting and stem-loop RT-qPCR were then used to definitively confirm that CyHV-3 expresses two pre-miRNAs during infection in vitro. The evidence also suggested the presence of an additional four high-probability and two putative viral pre-miRNAs. MiRNAs from the two confirmed pre-miRNAs were also detected in gill tissue from CyHV-3-infected carp. We also present evidence that one confirmed miRNA can regulate the expression of a putative CyHV-3-encoded dUTPase. Candidate homologues of some CyHV-3 pre-miRNAs were identified in CyHV-1 and CyHV-2. This is the first report of miRNA and moRNA genes encoded by members of the Alloherpesviridae family, a group distantly related to the Herpesviridae family. The discovery of these novel CyHV-3 genes may help further our understanding of the biology of this economically important virus and their encoded miRNAs may have potential as biomarkers for the diagnosis of latent CyHV-3., Funding: This work was supported by the Marine Institute Research Fellowship programme (https://www.marine.ie; OHD), Defra https://www.gov.uk/government/organisati​ons/department-for-environment-food-rura​l-affairs; research contracts FC1193 and FC1202; KW), the Programme for Research in Third Level Institutions (PRTLI) (http://www.hea.ie/en/prtli,official; RH, DW) Cycle 5 [The Bioanalysis and Therapeutics (BioAT) programme at DCU]. The PRTLI is co-funded through the European Regional Development Fund (ERDF), part of the European Union Structural Funds Programme 2007–2013 (http://eustructuralfunds.gov.ie). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

In high-income nations mainstream television news remains an important source of information about both general health issues and low- and middle-income countries (LMICs). However, research on news coverage of health in LMICs is scarce. The present paper examines the general features of Australian television coverage of LMIC health issues, testing the hypotheses that this coverage conforms to the general patterns of foreign news reporting in high-income countries and, in particular, that LMIC health coverage will largely reflect Australian interests. We analysed relevant items from May 2005 – December 2009 from the largest health-related television dataset of its kind, classifying each story on the basis of the region(s) it covered, principal content relating to health in LMICs and the presence of an Australian reference point. LMICs that are culturally proximate and politically significant to Australia had higher levels of reportage than more distant and unengaged nations. Items concerning communicable diseases, injury and aspects of child health generally consonant with ‘disease, disaster and despair’ news frames predominated, with relatively little emphasis given to chronic diseases which are increasingly prevalent in many LMICs. Forty-two percent of LMIC stories had explicit Australian content, such as imported medical expertise or health risk to Australians in LMICs. Media consumers’ perceptions of disease burdens in LMICs and of these nations’ capacity to identify and manage their own health priorities may be distorted by the major news emphasis on exotic disease, disaster and despair stories. Such perceptions may inhibit the development of appropriate policy emphases in high-income countries. In this context, non-government organisations concerned with international development may find it more difficult to strike a balance between crises and enduring issues in their health programming and fundraising efforts. This work was supported by a Capacity Building Grant from the National Health and Medical Research Council (http://www.nhmrc.gov.au) to the Australian Health News Research Collaboration (2009–2013) [571376].