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2. Synthesis and antiviral activity of adamantyl-containing phosphonous and phosphinic acids

Author

Alexander N. Reznikov, O. V. Savinova, Yu. N. Klimochkin, N. L. Bogdanova, E. I. Boreko, and S. V. Orlova

Subjects
Hypophosphorous acid, viruses, Adamantane, Phosphonous Acids, Sodium hypophosphite, Influenza a, General Chemistry, medicine.disease_cause, Virus, chemistry.chemical_compound, Herpes simplex virus, chemistry, Phosphinic Acids, medicine, Organic chemistry
Abstract

The method of adamantly-containing phosphonous and phosphinic acids preparation, based on radical addition of hypophosphorous acid and sodium hypophosphite to unsaturated derivatives of adamantane, has been developed. Unsymmetrical phosphinic acids have been prepared by reacting bistrimetylsilyl esters of phosphonous acids with halides. The obtained phosphinic acids exhibit antiviral activity against herpes simplex virus, influenza A (H5N1), respiratory syncytial virus, and adenovirus.

Published
2014
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