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Start Over Author "Q W, Huang" Publisher pleiades publishing ltd
2 results on '"Q W, Huang"'

1. Crystal structure and antitumor activities of a dinuclear cobalt(II) complex based on meso-1,2,3,4-tetra(1H-benzo[d]imidazol-2-yl)butane

Author

Wen-Yi Su, Sheng-Gui Liu, S. X. Wang, Q. W. Huang, G. B. Li, and Y.-M. He

Subjects
Benzimidazole, biology, 010405 organic chemistry, Stereochemistry, chemistry.chemical_element, Butane, Crystal structure, 010402 general chemistry, biology.organism_classification, 01 natural sciences, Medicinal chemistry, Chloride, 0104 chemical sciences, Inorganic Chemistry, chemistry.chemical_compound, chemistry, Materials Chemistry, medicine, Tetra, Physical and Theoretical Chemistry, Single crystal, Cobalt, medicine.drug, Monoclinic crystal system
Abstract

The [Co2(tbb)Cl4]∙4DMF complex, where tbb is meso-1,2,3,4-tetra(1H-benzo[d]imidazol-2-yl)butane, is synthesized and characterized by single crystal X-ray diffraction. For the complex: C44H54Co2Cl4N12O4, Mr = 1074.65, monoclinic crystal system, space group P21/n, a = 9.2350(13) A, b = 11.3566(15) A, c = 23.879(3) A, β = 90.547(2)°, V = 2504.3(6) A3, Z = 2, Dc = 1.425 g/cm3, λ = 0.71073 A, μ(MoKα) = = 0.929 mm–1, F(000) = 1112, S = 1.047, R = 0.0765, and wR = 0.2110 for 13668 observed reflections with I > 2σ(I). It is a neutral dinuclear complex. One meso-1,2,3,4-tetra(1H-benzo[d]imidazol-2-yl)butane coordinates two cobalt(II) ions. Each cobalt(II) ion is formed by two tbb nitrogen atoms and two chloride ions. The antiproliferative activities of the complex are screened by MTT assay against Eca109 cancer cells. The complex exhibits inhibition on the growth of Eca109 cancer cells with IC50 of 22.1±6.7 μM after 48 h treatment. The cobalt complex has potential application in treatment of Eca109 cancer. CCDC 1015791.

Published
2016

2. Crystal structure and antitumor activities of the dichloride 2,6-bis(1-phenylbenzimidazol-2-yl)pyridine copper(II) complex

Author

Wen-Yi Su, Sheng-Gui Liu, S. X. Wang, D. M. Liang, G. B. Li, S. Q. Mao, and Q. W. Huang

Subjects
Benzimidazole, Stereochemistry, chemistry.chemical_element, Crystal structure, Triclinic crystal system, Chloride, Copper, Inorganic Chemistry, chemistry.chemical_compound, Crystallography, Trigonal bipyramidal molecular geometry, chemistry, Pyridine, Materials Chemistry, medicine, Physical and Theoretical Chemistry, Single crystal, medicine.drug
Abstract

A new complex Cu(bpbp)Cl2·DMF·H2O is synthesized by treatment of CuCl2 with 2,6-bis(1-phenylbenzimidazol-2-yl)pyidine in DMF. Its structure is characterized by elemental, IR, UV, and single crystal X-ray structure analyses. For the complex: crystal system, triclinic, space group \(P\bar 1\), a = 1.0537(1) nm, b = 1.1735(1) nm, c = 1.3749(2) nm, α = 112.275(2)°, β = 91.531(2)°, γ = 97.700(2)°, V = 1.553(4) nm3, Z = 2. In a distorted trigonal bipyramidal geometry the Cu(II) ion is coordinated by three nitrogen atoms from 2,6-bis(1-phenylbenzimidazol-2-yl)pyridine and two chloride ions. The antiproliferative activities of the complex are screened by MTT assay against HepG2, Huh7, Eca109, and Eca9706 cancer cells. The complex exhibits specific inhibition on Eca9706 cancer cells with the IC50 value of 28 μM after 48 h treatment. CCDC: 968927.

Published
2015

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