Search

Your search keyword '"Filimonova M."' showing total 8 results
Start Over Author "Filimonova M." Publisher pleiades publishing
8 results on '"Filimonova M."'

8. Binary Proton Therapy of Ehrlich Carcinoma Using Targeted Gold Nanoparticles.

Author

Filimonova MV, Kolmanovich DD, Tikhonowski GV, Petrunya DS, Kotelnikova PA, Shitova AA, Soldatova OV, Filimonov AS, Rybachuk VA, Kosachenko AO, Nikolaev KA, Demyashkin GA, Popov AA, Savinov MS, Popov AL, Zelepukin IV, Lipengolts AA, Shpakova KE, Kabashin AV, Koryakin SN, Deyev SM, and Zavestovskaya IN

Subjects
Animals, Mice, Cell Line, Tumor, Polyethylene Glycols chemistry, Gold chemistry, Gold pharmacology, Metal Nanoparticles chemistry, Metal Nanoparticles therapeutic use, Proton Therapy methods, Carcinoma, Ehrlich Tumor radiotherapy, Carcinoma, Ehrlich Tumor drug therapy, Carcinoma, Ehrlich Tumor pathology
Abstract

Proton therapy can treat tumors located in radiation-sensitive tissues. This article demonstrates the possibility of enhancing the proton therapy with targeted gold nanoparticles that selectively recognize tumor cells. Au-PEG nanoparticles at concentrations above 25 mg/L and 4 Gy proton dose caused complete death of EMT6/P cells in vitro. Binary proton therapy using targeted Au-PEG-FA nanoparticles caused an 80% tumor growth inhibition effect in vivo. The use of targeted gold nanoparticles is promising for enhancing the proton irradiation effect on tumor cells and requires further research to increase the therapeutic index of the approach., (© 2024. Pleiades Publishing, Ltd.)

Published
2024
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results