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Peripheral vascular disease (PVD) is a chronic disease and is also an atherosclerotic process. It causes occlusion and stenosis of the lower extremity arteries. Inflammation plays a role in pathogenesis and complications of atherosclerosis. It is known that elevated levels of high sensitivity C-reactive protein (hs-CRP) is related with systemic inflammation. hs-CRP is an acute phase reactant and is stimulated by cytokines. It is known that the elevated levels of hs-CRP are correlated with myocardial infarction (MI), stroke and PVD. Interleukin-6 (IL6) is one of the proinflammatory cytokines which plays an important role in the pathogenesis of coronary artery disease. A polymorphic variant of IL-6 has also a role in inflammation. It has been shown that IL-6 gene polymorphism is related to atherosclerosis of carotid, coronary and peripheral arteries. Adiponectin is an adipocytokine released from adipose tissue. Adiponectin has protective effects on cardiovascular system through its antiinflammatory properties. It has been suggested that decreased of adiponectin levels is an early cardiovascular risk factor. In the light of these knowledges, we aimed to research the relationship among genetic variant of IL-6 -174 G/C and serum levels of IL-6, hs-CRP and, adiponectin in patients with PAD. The study consisted of 106 patients with PVD. The control group consisted of 65 healthy adults matched for age and gender with patients. Blood samples were collected in vacuum tubes containing disodium EDTA. Genomic DNA was isolated from these samples by using salting -out method. DNA was amplified using designed primers with polymerase chain reaction (PCR) for IL-6 174 G/C genotyping. For the statistical analyses Pearsons's Chi-Squared (?2), Kruskal-Wallis tests were used where appropriate. The levels of IL-6 and hs-CRP were significantly higher in patients with PVD compared to those of the controls (p<0.001). However, adiponectin levels were found significantly lower in patients with PVD than healthy controls (p<0.001). They were seen that the distributions of IL-6 -174 G/C genotype were not statistically significant between groups (p>0.05). The high levels of IL-6 and hs-CRP were statistically significant among carriers of each three genotypes of IL-6 -174 G/C and in patient with PVD compared to controls. Moreover, it was also found the relation between the decreased levels of adiponectin and IL-6 -174 genotypes between the same groups (p<0.001) . In conclusion, we may suggest that there was an important relationship among genotype distributions of IL-6 -174 variants and hs-CRP, IL-6 and, adiponectin levels in patients with PVD and healthy control groups although there were not statistically significancy in the distrubition of IL-6 -174 G/C genotype between groups [ABSTRACT FROM AUTHOR]