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1. Chemical constituents of Prangos tschiniganica; structure elucidation and absolute configuration of coumarin and furanocoumarin derivatives with anti-HIV activity.

Author

Shikishima Y, Takaishi Y, Honda G, Ito M, Takfda Y, Kodzhimatov OK, Ashurmetov O, and Lee KH

Subjects
Acetylation, Anti-HIV Agents pharmacology, Coumarins pharmacology, Furocoumarins pharmacology, HIV-1 drug effects, Magnetic Resonance Spectroscopy, Molecular Conformation, Spectrometry, Mass, Fast Atom Bombardment, Uzbekistan, Zidovudine pharmacology, Anti-HIV Agents chemistry, Apiaceae chemistry, Coumarins chemistry, Furocoumarins chemistry, Plants, Medicinal chemistry
Abstract

The methanol extract of the dried aerial parts of Prangos tschimganica gave three new coumarin derivatives and 30 known coumarin derivatives. Their structures were established on the basis of chemical and spectroscopic evidence. Absolute configuration of the isolated compounds were determined by using a modified Mosher's method. Some of the isolated compounds showed anti-HIV activity.

Published
2001
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