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1. Synthesis and biological activity of the metabolites of syn-3-ethyl-7-methyl-3,7-diazabicyclo[3.3.1]non-9-yl 4-chlorobenzoate hydrochloride.

Author

Yamawaki I, Bukovac SW, and Sunami A

Subjects
Animals, Chlorobenzenes, Guinea Pigs, Heart drug effects, Heart Ventricles cytology, Heart Ventricles drug effects, Myocardium metabolism, Sodium Channels drug effects, Sodium Channels physiology, Anti-Arrhythmia Agents chemical synthesis, Anti-Arrhythmia Agents pharmacology, Bridged Bicyclo Compounds metabolism, Bridged Bicyclo Compounds, Heterocyclic
Abstract

Five metabolites of syn-3-ethyl-7-methyl-3,7-diazabicyclo[3.3.1]non-9-yl 4-chlorobenzoate hydrochloride (YUTAC) (1) were prepared and examined for Na+ current blocking activity in guinea pig ventricular myocytes. These metabolites showed lower inhibitory activities than the parent compound or were inactive.

Published
1994
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