1. Cytotoxic cardenolides from the leaves of Calotropis gigantea.
- Author
-
Seeka C and Sutthivaiyakit S
- Subjects
- Cardenolides chemistry, Cardenolides isolation & purification, Cell Line, Tumor, Cell Survival drug effects, Drug Screening Assays, Antitumor, Female, Humans, Inhibitory Concentration 50, KB Cells, Magnetic Resonance Spectroscopy, Molecular Structure, Plant Extracts chemistry, Antineoplastic Agents chemistry, Calotropis chemistry, Cardenolides pharmacology, Plant Extracts pharmacology, Plant Leaves chemistry
- Abstract
Two 15beta-hydroxycardenolides (1,2) and a 16alpha-hydroxycalactinic acid methyl ester (3) along with eleven known compounds including 16alpha-hydroxycalotropagenin, coroglaucigenin, 16alpha-hydroxycalotropin, calactinic acid, calotoxin, 6'-O-(E-4-hydroxycinnamoyl)desglucouzarin, 12beta-hydroxycoroglaucigenin, frugoside, calotropagenin, 9,12,13-trihydroxyoctadeca-10(E),15(Z)-dienoic acid and R-(-)-mevalonolactone were isolated from the polar fraction of the CH(2)Cl(2) extract, and n-BuOH extract of the leaves of this plant. The isolated compounds were evaluated for their inhibitory activities against a panel of cell lines.
- Published
- 2010
- Full Text
- View/download PDF