1. Infantile mixed phenotype acute leukemia (bilineal and biphenotypic) with t(10;11)(p12;q23);MLL-MLLT10.
- Author
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Lou Z, Zhang CC, Tirado CA, Slone T, Zheng J, Zaremba CM, Oliver D, and Chen W
- Subjects
- Flow Cytometry, Gene Rearrangement, Humans, Immunophenotyping, Infant, Karyotyping, Leukemia, Biphenotypic, Acute pathology, Leukemia, Biphenotypic, Acute therapy, Leukemia, Monocytic, Acute pathology, Leukemia, Monocytic, Acute therapy, Male, Neoplasm, Residual genetics, Neoplasm, Residual pathology, Neoplasm, Residual therapy, Phenotype, Precursor Cell Lymphoblastic Leukemia-Lymphoma pathology, Precursor Cell Lymphoblastic Leukemia-Lymphoma therapy, Prognosis, Remission Induction, Chromosomes, Human, Pair 10 genetics, Chromosomes, Human, Pair 11 genetics, Leukemia, Biphenotypic, Acute genetics, Leukemia, Monocytic, Acute genetics, Myeloid-Lymphoid Leukemia Protein genetics, Oncogene Proteins, Fusion genetics, Precursor Cell Lymphoblastic Leukemia-Lymphoma genetics, Translocation, Genetic genetics
- Abstract
We report a case of a 6-month-old boy with a mixed phenotype acute leukemia (MPAL), bilineal and biphenotypic immunophenotype (B-lymphoid lineage and combined B-lymphoid and monocytic lineage) with t(10;11)(p12;q23);MLL-MLLT10. He was treated with acute myeloid leukemia protocol and in complete remission at 7-month follow-up. To the best of our knowledge, this is the first reported MLL-MLLT10 rearranged case presenting as MPAL in an infant. From a clinical practice standpoint, this case illustrates the importance of detection of MLL rearrangement due to its prognostic implication and the effectiveness of flow cytometry immunophenotyping in diagnosing MPAL and monitoring minimal residual disease., (Copyright (c) 2010 Elsevier Ltd. All rights reserved.)
- Published
- 2010
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