1. Polymorphisms of the gamma-glutamyl hydrolase gene and risk of relapse to acute lymphoblastic leukemia in Mexico.
- Author
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Organista-Nava J, Gómez-Gómez Y, Saavedra-Herrera MV, Rivera-Ramírez AB, Terán-Porcayo MA, Alarcón-Romero Ldel C, Illades-Aguiar B, and Leyva-Vázquez MA
- Subjects
- Adolescent, Antimetabolites, Antineoplastic adverse effects, Antimetabolites, Antineoplastic therapeutic use, Case-Control Studies, Child, Child, Preschool, Female, Gene Frequency, Genotype, Humans, Infant, Male, Methotrexate adverse effects, Methotrexate therapeutic use, Mexico, Precursor Cell Lymphoblastic Leukemia-Lymphoma drug therapy, Precursor Cell Lymphoblastic Leukemia-Lymphoma pathology, Recurrence, Risk, Treatment Outcome, Polymorphism, Single Nucleotide physiology, Precursor Cell Lymphoblastic Leukemia-Lymphoma genetics, gamma-Glutamyl Hydrolase genetics
- Abstract
This study evaluated the association of -401C/T and +452C/T polymorphisms of gamma-glutamyl hydrolase and the risk of relapse to acute lymphoblastic leukemia. Genotyping was performed in 70 children with acute lymphoblastic leukemia and 140 healthy children. An association between the -401C/T polymorphism and the risk of relapse was found (p=0.028), patients with the -401T/T genotype have 10.83 (95% CI 1.30-90.14) more chance of a relapse of leukemia. No association was found between the +452C/T polymorphism and the risk of relapse. Therefore, our investigation suggests that the -401C/T polymorphism in the gamma-glutamyl hydrolase may be a factor involved in the generation of relapse to disease in patients with ALL., (Copyright 2009 Elsevier Ltd. All rights reserved.)
- Published
- 2010
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