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Humans use time-varying pitch patterns to convey information in music and speech. Recognition of musical melodies and lexical tones relies on relative pitch (RP), the ability to identify intervals between two pitches. RP processing in music is usually more fine-grained than that in tonal languages. In Western music, there are twelve pitch categories within an octave, whereas there are only three level (non-glide) lexical tones in Taiwanese (or Taiwanese Hokkien, a tonal language). The present study aimed at comparing the neural substrates underlying RP processing of musical melodic intervals with that of level lexical tones in Taiwanese. Functional magnetic resonance imaging data from fourteen participants with good RP were analyzed. The results showed that imagining the sounds of visually presented musical intervals was associated with enhanced activity in the central subregion of the right dorsal premotor cortex (dPMC), right posterior parietal cortex (PPC), and right dorsal precuneus compared to auditory imagery of visually presented Taiwanese bi-character words with level lexical tones. During the sound-congruence-judgement task (auditory imagery of musical intervals or bi-character words, and subsequently judging if the imagined sounds were melodically congruent with heard sounds), the contrast of the musical minus linguistic conditions yielded activity in the bilateral dPMC-PPC network and dorsal precuneus, with the dPMC activated in the rostral subregion. The central dPMC and PPC may mediate the attention-based maintenance of pitch intervals, whereas the dorsal precuneus may support attention control and the spatial/sensorimotor processing of the fine-grained pitch structures of music. When judging the congruence between the imagined and heard musical intervals, the bilateral rostral dPMC may play a role in attention control, working memory, evaluation of motor activities, and monitoring mechanisms. Based on the findings of this study and recent studies of amusia, we suggest that higher order cognitive operations are critical to the more fine-grained pitch processing of musical melodies compared to lexical tones., (Copyright © 2018 Elsevier Ltd. All rights reserved.)

Functional magnetic resonance imaging (fMRI) was used to examine the developmental changes in a group of normally developing children (aged 8-12) and adolescents (aged 13-16) during semantic processing. We manipulated association strength (i.e. a global reading unit) and semantic radical (i.e. a local reading unit) to explore the interaction of lexical and sublexical semantic information in making semantic judgments. In the semantic judgment task, two types of stimuli were used: visually-similar (i.e. shared a semantic radical) versus visually-dissimilar (i.e. did not share a semantic radical) character pairs. Participants were asked to indicate if two Chinese characters, arranged according to association strength, were related in meaning. The results showed greater developmental increases in activation in left angular gyrus (BA 39) in the visually-similar compared to the visually-dissimilar pairs for the strong association. There were also greater age-related increases in angular gyrus for the strong compared to weak association in the visually-similar pairs. Both of these results suggest that shared semantics at the sublexical level facilitates the integration of overlapping features at the lexical level in older children. In addition, there was a larger developmental increase in left posterior middle temporal gyrus (BA 21) for the weak compared to strong association in the visually-dissimilar pairs, suggesting conflicting sublexical information placed greater demands on access to lexical representations in the older children. All together, these results suggest that older children are more sensitive to sublexical information when processing lexical representations., (Copyright © 2015 Elsevier Ltd. All rights reserved.)

The crystal structure of TM-1, a P-I class snake-venom metalloproteinase (SVMP) from the Trimeresurus mucrosquamatus venom, was determined at 1.8-Å resolution. The structure exhibits the typical feature of SVMPs and is stabilized by three disulfide linkages. The active site shows a deep S1' substrate-binding pocket limited by the non-conserved Pro174 at the bottom. Further comparisons with other SVMPs suggest that the deep S1' site of TM-1 correlates with its high inhibition sensitivity to the endogenous tripeptide inhibitors. Proteolytic specificity analysis revealed that TM-1 prefers substrates having a moderate-size and hydrophobic residue at the P1' position, consistent with our structural observation., (Copyright © 2013 Elsevier Ltd. All rights reserved.)

The Chinese classifier system classifies nouns and builds a relation between classifiers and their corresponding nouns. This functional magnetic resonance imaging (fMRI) study examined brain activation of Chinese classifiers during reading comprehension. Thirty-four participants read and performed semantic congruency judgments on congruent, inside-classifier (IC) violated, and outside-classifier (OC) violated sentences. The IC and OC violations were created by changing the correct classifier to an inappropriate classifier and a non-classifier, respectively. The comparison of the IC violation vs. the congruent condition produced greater activation in the mid-ventral region (BA 45) of the left inferior frontal gyrus (IFG), suggesting an increased demand on semantic processing. Contrasting different subtypes of IC violation produced greater activation in the right IFG (BAs 45 and 47), indicating that processing mass/count classifiers involves distinct brain activations. The OC violation produced greater activation in the left IFG (BAs 45 and 44), suggesting both semantic and syntactic processing. These results indicate that different parts of the IFG contribute to syntactic and semantic processing of classifier phrases in reading Chinese for comprehension., (Copyright © 2012 Elsevier Ltd. All rights reserved.)

Neural changes related to learning of the meaning of Chinese characters in English speakers were examined using functional magnetic resonance imaging (fMRI). We examined item specific learning effects for trained characters, but also the generalization of semantic knowledge to novel transfer characters that shared a semantic radical (part of a character that gives a clue to word meaning, e.g. water for lake) with trained characters. Behavioral results show that acquired semantic knowledge improves performance for both trained and transfer characters. Neuroimaging results show that the left fusiform gyrus plays a central role in the visual processing of orthographic information in characters. The left superior parietal cortex seems to play a crucial role in learning the visual-spatial aspects of the characters because it shows learning related decreases for trained characters, is correlated with behavioral improvement from early to late in learning for the trained characters, and is correlated with better long-term retention for the transfer characters. The inferior frontal gyrus seems to be associated with the efficiency of retrieving and manipulating semantic representations because there are learning related decreases for trained characters and this decrease is correlated with greater behavioral improvement from early to late in learning.