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Background. Pollinosis (hay fever) is a widespread disease in Russia. Often the cause of pollinosis is allergens of weeds, among which ragweed (Ambrosia artemisiifolia, Ambrosia trifida) and wormwood predominate. The purpose of the study was to evaluate the spectrum of sensitization to different types of ragweed in Samara, as well as the effectiveness of allergen immunotherapy, depending on the patient’s IgE profile. Materials and methods. Sensitisation to weeds was evaluated retrospectively based on the results of skin prick-tests. The determination of allergocomponents (Amb a 1 and Аmb.trifida) was carried out using the ImmunoCAP ISAC diagnostic test system (Sweden). Patients with confirmed sensitization to ragweed tridividual and lack of IgE to Amb a 1 were treated with allergen immunotherapy with ragweed allergoid preseason. Results. More than half of the patients suffering from pollinosis in Samara are sensitized to ragweed. In case of negative CP with the allergen Ambrosia artemisiifolia, positive IgE-AT to ambrosia are detected in 79.5 % of cases. Against the background of allergen immunotherapy during the ragweed flowering season, most patients noted an improvement in their condition. At the same time, there were no excellent results of allergen immunotherapy. Conclusions. A comprehensive examination for different types of ragweed, a study of IgE-AT to Ambrosia trifida for the diagnosis of ragweed pollinosis is necessary. When conducting allergen immunotherapy with the ragweed allergen, the patient’s IgE profile and the effect of different types of ragweed on the results of immunotherapy should be taken into account.