1. [A new Russian gestagen with anticancer activity].
- Author
-
Sergeev PV, Fedotcheva TA, Rzheznikov VM, Grinenko GS, Semeĭkin AV, Vetchinkina VB, Atroshkin KA, and Shimanovskiĭ NL
- Subjects
- 17-alpha-Hydroxyprogesterone therapeutic use, Animals, Cell Proliferation drug effects, Humans, Neoplasms pathology, Treatment Outcome, 17-alpha-Hydroxyprogesterone analogs & derivatives, Drug Evaluation, Neoplasms drug therapy
- Abstract
The authors present results obtained in a complex study of 17alpha-acetoxy-3beta-butanoyloxy-6-methyl-pregna-4,6-dien-20-on (ABMP). ABMP was shown to differ from existing analogues by high gestagen activity and prolonged action. The substance does not possess androgenic or mineralocorticoid activity, is not toxic when used in high doses, and possesses significant cytostatic and chemiosensitizing activity. These properties of ABMP demonstrate that the substance should be studied in clinical setting as a gestagen with anticancer and chemiosensitizing activity for further application to therapy of hyperplastic processes in the female genital system and tumors that are sensitive to female sex hormones.
- Published
- 2007