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Bacillus mojavensis is an endophytic bacterium which has been reported to have fungicidal effect against some phytopathogens. Bioactive secondary metabolites produced by B. mojavensis could have promising applications in agricultural, food industry and clinical fields. The current research has been conducted to: i) evaluate the antagonistic effect of B. mojavensis isolate against some phytopathogens; ii) characterize chemically the principal bioactive substances produced by the studied isolate of B. mojavensis using Gas Chromatography-Mass Spectroscopy (GC-MS); iii) evaluate its ability to produce a biofilm using ELISA technique. Results showed that the studied isolate has an antagonistic activity against the majority of tested microorganisms. Results showed also that the studied isolated produced a biofilm in Supplemented Luria-Bertani Casamino acid (SLB) and Minimal Mineral (MM) medium. The substantial attached growth in SLB was significantly higher than MM media. GC-MS analysis revealed the presence of 9 compounds accounting 87.8% of the total extract, where oxygenated monoterpenes are the main constituents. [ABSTRACT FROM AUTHOR]

Regulatory T-cells (Tregs) constitute a small subset of cells that are actively involved in maintaining self-tolerance, in immune homeostasis and in antitumor immunity. They are thought to play a significant role in the progression of cancer and are generally increased in patient with chronic lymphocytic leukemia (CLL). Their number correlates with more aggressive disease status and is predictive of the time to treatment, as well. Moreover, it is now clear that dysregulation in Tregs cell frequency and/or function may result in a plethora of autoimmune diseases, including multiple sclerosis, type 1 diabetes mellitus, myasthenia gravis, systemic lupus erythematosus, autoimmune lymphoproliferative disorders, rheumatoid arthritis, and psoriasis. Efforts are made aiming to develop approaches to deplete Tregs or inhibit their function in cancer and autoimmune disorders, as well. [ABSTRACT FROM AUTHOR]