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Summary: Background: A temporal relationship between hidradenitis suppurativa (HS) and obesity has not been established. Objectives: To compare baseline body mass index (BMI) and change in BMI for patients with HS and controls before and after diagnosis. Methods: We performed a retrospective case–control analysis of 1284 patients with HS and controls matched for age, sex, race and calendar year between 1 January 1999 and 9 September 2019. BMI 7 years prior to first HS diagnosis, and rate of BMI change, were compared for patients with HS and controls using linear mixed effects models. Results: Baseline BMI was higher among patients with HS than controls [mean difference 3·03 kg m−2, 95% confidence interval (CI) 2·44–3·62; P < 0·001)]. This difference was larger for women [mean difference 3·37 kg m−2 (95% CI 2·73–4·01)] than men [mean difference 1·27 kg m−2 (95% CI − 0·20–2·73; interaction P = 0·01)], and for patients with HS diagnosed before age 40 years [mean difference 4·10 kg m−2 (95% CI 3·15–5·06)] than those diagnosed after age 40 years [mean difference 2·38 kg m−2 (95% CI 1·63–3·12; interaction P < 0·001)]. Prior to diagnosis, average annual increase in BMI among patients with HS was slightly higher than controls. There was no statistically significant change in annual BMI among patients with HS following diagnosis. Conclusions: Baseline BMI and, to a lesser extent, rate of BMI change appear to be risk factors for developing HS. The influence of BMI may play a larger role among female patients and younger patients. What is already known about this topic? The association between hidradenitis suppurativa (HS) and obesity is well established.However, whether obesity influences the development of HS or is a consequence of having HS is unknown. What does this study add? We have observed that obesity and, to a lesser extent, rate of change in body mass index appear to be risk factors for developing HS. Linked Comment: L.A.V. Orenstein. Br J Dermatol 2021; 185:6–7. [ABSTRACT FROM AUTHOR]

A Thomson Web of Science search for the topic "leaf age" AND potassium AND tropic* identified just one similar study, which reported a similar strong decline in foliar K with leaf age ([16]). This scientific commentary refers to 'Changes in leaf functional traits with leaf age: When do leaves decrease their photosynthetic capacity in Amazonian forests? Google Scholar Crossref Search ADS WorldCat 6 Kitajima K, Mulkey SS, Wright SJ (1997 a) Decline of photosynthetic capacity with leaf age in relation to leaf longevities for five tropical canopy tree species. The LDO model integrates seasonality in the timing of leaf production and abscission, total leaf area present and the contribution of expanding, mature and old leaves to successfully explain seasonality in gross ecosystem production. [Extracted from the article]

Leaf dark respiration (R) and its temperature sensitivity are essential for efforts to model carbon fluxes in tropical forests under current and future temperature regimes, but insufficient data exist to generalize patterns of R in species-rich tropical forests. Here, we tested the hypothesis that R and its temperature sensitivity (expressed as Q10, the proportional increase in R with a 10 °C rise in temperature) vary in relation to leaf functional traits, and among plant functional types (PFTs). We conducted in situ measurements of R of 461 leaves of 26 species of tree and liana in the upper canopy of a tropical forest in Panama. A construction crane allowed repeated non-destructive access to measure leaves kept in the dark since the previous night and equilibrated to the ambient temperature of 23–31 °C in the morning. R at 25 °C (R25) varied among species (mean 1.11 μmol m−2 s−1; range 0.72–1.79 μmol m−2 s−1) but did not differ significantly among PFTs. R25 correlated positively with photosynthetic capacity, leaf mass per unit area, concentrations of nitrogen and phosphorus, and negatively with leaf lifespan. Q10 estimated for each species was on average higher than the 2.0 often assumed in coupled climate–vegetation models (mean 2.19; range 1.24–3.66). Early-successional tree species had higher Q10 values than other functional types, but interspecific variation in Q10 values was not correlated with other leaf traits. Similarity in respiration characteristics across PFTs, and relatively strong correlations of R with other leaf functional traits offer potential for trait-based vegetation modeling in species-rich tropical forests. [ABSTRACT FROM PUBLISHER]

Heterostyly is a genetic polymorphism in which plant populations are composed of two or more morphs that differ in stigma and anther heights. The polymorphism promotes intermorph pollen transfer, thus outcrossing. Heterostyly has been reported in 28 angiosperm families and is frequently lost in heterostylous lineages. To assess ecological factors related to shifts from heterostyly to monomorphy, we examined the reproductive ecology of heterostylous tropical shrubs of Psychotria. Among 21 species at Barro Colorado Island and the nearby Parque Nacional Soberania, Panama, 14 species were heterostylous while seven were monomorphic. A molecular phylogeny and the existence elsewhere of heterostylous populations indicated that the breakdown of heterostyly had occurred independently. Heterostylous and monomorphic species were visited by the same bee species, although visit frequencies were lower in monomorphic species. Monomorphic species had significantly lower population density and greater fruit set than did heterostylous species. Autonomous autogamy made a large contribution to fruit set in monomorphic species and was only rarely observed in heterostylous species. The results indicate monomorphic and heterostylous species produce more seeds through selfing and outcrossing, respectively. The limitation of outcrossing as a result of low population density may be related to the breakdown of heterostyly and the evolution of selfing. © 2008 The Linnean Society of London, Biological Journal of the Linnean Society, 2008, 93, 125–134. [ABSTRACT FROM AUTHOR]

Dear Editor, Within the U.K., Wales has some of the highest rates of skin cancer annually, and skin cancer diagnosis rates have increased 63% in 10 years.[1] The charity Skin Care Cymru (SCCym) provides a voice for skin health in Wales. This novel campaign promoted the importance of sun protection to reduce skin cancer rates in Wales and, by extension, the U.K. Using the extensive support and coverage of #DontBeALobster, SCCym will further expand and develop the campaign to measure its effect on skin cancer knowledge and sun-protection behaviour. While more evidence is needed to show that mass media campaigns are as effective as multicomponent campaigns in increasing sun-safe behaviour,[2] social media can improve knowledge and attitudes toward skin cancer.[3]. [Extracted from the article]

We have evaluated the effect of brief intervention by an alcohol health worker on alcohol consumption by 202 alcohol misusing patients. For 71 patients where questionnaires were successfully completed, 46 (65%) reported drinking less alcohol at 6 months as opposed to six (8.5%) who reported drinking more. The overall reduction was statistically significant (P<0.001), with a mean reduction of 43%. [ABSTRACT FROM PUBLISHER]

The intraepithelial lymphocytes of the jejunal mucosa from patients with giardiasis and from control patients were counted in coded serial sections. Patients with giardiasis and normal intestinal absorption and control patients who had lived and travelled in tropical areas had similar counts, which were higher than those reported for controls from temperate areas. Where giardiasis was accompanied by malabsorption of one substance the mean count was significantly higher than that of controls (P < 0.02). In those patients with giardiasis and malabsorption of two or three substances the mean count was significantly higher than that of controls (P < 0.02) and that of patients with giardiasis and normal absorption (P < 0.05). After treatment, intraepithelial lymphocyte counts declined consistently in patients with malabsorption. An association between raised intraepithelial lymphocyte counts and malabsorption is indicated. The possible significance of this finding is discussed. [ABSTRACT FROM AUTHOR]

A study of the prevalence of tinea capitis at a residential school for physically handicapped children in Harare, Zimbabwe is reported. In the 7-12 year old age group the prevalence of mycologically proven fungus infection was 39%. It is suggested that this can be explained by their hygiene. Two species of dermatophyte were isolated: Trichophyton violaceum from 88% and Microsporum audouimi from 38% of cases which were positive following culture. Twenty-six per cent of these cases were mixed infections. There was a slightly higher rate of infection amongst boys. The effectiveness of the clinical and mycological examination was assessed. Affect5ed children were treated with a 6-weed course of either Whitefield's ointment or miconazole cream. Results are presented to show that neither treatment is fully effective. [ABSTRACT FROM AUTHOR]

The article presents a report on woolly hair naevi with systematized linear epidermal naevus. Woolly hair naevus is a rare abnormality of scalp hair which is frequently found in association with a linear epidermal naevus. In this article, a case where woolly hair naevi has been discussed which is associated with a systemized linear epidermal naevus, a previously undescribed combination. Under the light microscope, no morphological difference between the woolly hair and normal hair is evident. Scanning electron micrographs of normal and abnormal hair are identical.

A single blind comparison of 0.1%, dithranol in a 17% urea cream base (Psoradrate®) with a coal tar and salicyclic acid pomade in the treatment of scalp psoriasis is described. Both treatments were equally effective, though Psoradrate caused significantly more side-effects. We concluded that Psoradrate is effective in the treatment of scalp psoriasis. [ABSTRACT FROM AUTHOR]

Basal cell epithelioma with eccrine differentiation is a turnout that has previously been characterized as a rare turnout in which the histological and histochemical differentiation towards eccrine epithelium has been taken to indicate a more aggressive clinical course. We present a further ease of this tumour with studies of its pattern of keratin expression using a battery of antikeratin monoclonal antibodies and conclude that the presence of simple epithelial markers within the turnout confirm the differentiation towards eccrine epithelium. [ABSTRACT FROM AUTHOR]

Presents a letter to the editor about strategies for improving the risk-benefit ratio of cyclosporin.

Strong gravitational lenses can be used to detect low-mass subhaloes, based on deviations in image fluxes and positions from what can be achieved with a smooth mass distribution. So far, this method has been limited by the small number of (radio-loud, microlensing-free) systems which can be analysed for the presence of substructure. Using the gravitational lens B1422+231, we demonstrate that adaptive optics integral field spectroscopy can also be used to detect dark substructures. We analyse data obtained with OH Suppressing Infra-Red Imaging Spectrograph on the Keck i Telescope, using a Bayesian method that accounts for uncertainties relating to the point spread function and image positions in the separate exposures. The narrow-line [O iii] fluxes measured for the lensed images are consistent with those measured in the radio, and show a significant deviation from what would be expected in a smooth mass distribution, consistent with the presence of a perturbing low-mass halo. Detailed lens modelling shows that image fluxes and positions are fitted significantly better when the lens is modelled as a system containing a single perturbing subhalo in addition to the main halo, rather than by the main halo on its own, indicating the significant detection of substructure. The inferred mass of the subhalo depends on the subhalo mass density profile: the 68 per cent confidence intervals for the perturber mass within 600 pc are 8.2$^{+0.6}_{-0.8}$, 8.2$^{+0.6}_{-1}$ and 7.6 ± 0.3 log10[Msub/M⊙], respectively, for a singular isothermal sphere, a pseudo-Jaffe and a Navarro–Frenk–White mass profile. This method can extend the study of flux ratio anomalies to virtually all quadruply imaged quasars, and therefore offers great potential to improve the determination of the subhalo mass function in the near future. [ABSTRACT FROM AUTHOR]

Background and Aims Leaf life span is widely recognized as a key life history trait associated with herbivory resistance, but rigorous comparative data are rare for seedlings. The goal of this study was to examine how light environment affects leaf life span, and how ontogenetic development during the first year may influence leaf fracture toughness, lamina density and stem density that are relevant for herbivory resistance, leaf life span and seedling survival. Methods Data from three experiments encompassing 104 neotropical woody species were combined. Leaf life span, lamina and vein fracture toughness, leaf and stem tissue density and seedling survival were quantified for the first-year seedlings at standardized ontogenetic stages in shade houses and common gardens established in gaps and shaded understorey in a moist tropical forest in Panama. Mortality of naturally recruited seedlings till 1 year later was quantified in 800 1-m2 plots from 1994 to 2011. Key Results Median leaf life span ranged widely among species, always greater in shade (ranging from 151 to >1790 d in the understorey and shade houses) than in gaps (115–867 d), but with strong correlation between gaps and shade. Leaf and stem tissue density increased with seedling age, whereas leaf fracture toughness showed only a weak increase. All these traits were positively correlated with leaf life span. Leaf life span and stem density were negatively correlated with seedling mortality in shade, while gap mortality showed no correlation with these traits. Conclusions The wide spectrum of leaf life span and associated functional traits reflects variation in shade tolerance of first-year seedlings among coexisting trees, shrubs and lianas in this neotropical forest. High leaf tissue density is important in enhancing leaf toughness, a known physical defence, and leaf life span. Both seedling leaf life span and stem density should be considered as key functional traits that contribute to seedling survival in tropical forest understoreys. [ABSTRACT FROM AUTHOR]

Background: Osteoporosis (OP) is a major and increasing health problem worldwide, especially in European countries, where the modern, sedentary lifestyle from an early age leads to brittle bones later in life. Patients affected by OP tend to move less and have a lower quality of life (QoL). This study aims to evaluate how OP affects individual markers for QoL in postmenopausal women and assess the influence of exercise on these markers. Methods: The EQ-5D questionnaire was administered to evaluate Mobility, Self-care, Usual Activities, Pain/Discomfort and Anxiety/Depression in a sample of Italian women with osteoporotic vertebral fractures, aged 60-75. Markers linked to QoL were compared for these women with those of an average female Italian population (AFIP) of similar age. Concurrently, a 6-month exercise trial was conducted, in which the OP patients were divided into two groups: an exercise group (EG) and a control group (CG). The QoL was assessed for both groups at the end of the trial. Results: A larger proportion of OP patients reported some problems with Mobility as compared to the AFIP (37.5% versus 31.2% respectively, p = 0.001) and in performing Usual Activities (45% versus 23.9%, p = 0.002). OP patients (77.5%) experienced some Pain/Discomfort, compared to 48.1% of the AFIP (p = 0.001). Anxiety/Depression was reported by 40% of OP patients and 18.8% of the AFIP (p = 0.001). Concerning the exercise trial, the results indicated a positive trend for Mobility and Usual Activities in the EG, while the CG markers remained unchanged. Conclusions: Overall, results confirm that OP significantly affected QoL in postmenopausal women. In particular, OP negatively influenced the markers Mobility, Usual Activities, Pain/Discomfort and Anxiety/Depression. Exercise programs tailored to OP patients can improve some markers linked to QoL. Evidence suggests that health policy makers in Europe can consider including OP-adapted exercise programmes in guidelines for OP management. Key messages: Osteoporosis negatively affects the quality of life for postmenopausal women. In particular, Mobility, Usual Activities, Pain/Discomfort and Anxiety/Depression markers were affected. Exercise can improve some markers linked to quality of life (Mobility and Usual Activities). Thus, it could be proposed as a treatment for osteoporosis in postmenopausal women. [ABSTRACT FROM AUTHOR]

Despite the potential for changes during transit or preservation, the physicochemical properties of leaves are typically measured in a laboratory setting. A suite of laboratory methods adapted for use in the field is described here. The equipment is portable and operable in remote environments. Each technique has been validated against laboratory standards and has been tested throughout the tropics in a variety of ecological contexts. The properties of canopy and understorey leaves from Central Panama are reported here. The results show clear differences between leaves growing in different light regimes. Canopy leaves are tougher and possess greater concentrations of protein, phenols, and tannins. The implication of these results to the resource availability hypothesis, which proposes trade‐offs between physiology and defences against herbivory, is discussed. [ABSTRACT FROM PUBLISHER]

Strong gravitational lensing provides a powerful test of cold dark matter (CDM) as it enables the detection and mass measurement of low-mass haloes even if they do not contain baryons. Compact lensed sources such as active galactic nuclei (AGNs) are particularly sensitive to perturbing subhaloes, but their use as a test of CDM has been limited by the small number of systems which have significant radio emission that is extended enough to avoid significant lensing by stars in the plane of the lens galaxy, and red enough to be minimally affected by differential dust extinction. Narrow-line emission is a promising alternative as it is also extended and, unlike radio, detectable in virtually all optically selected AGN lenses. We present first results from a Wide Field Camera 3 (WFC3) grism narrow-line survey of lensed quasars, for the quadruply lensed AGN HE 0435–1223. Using a forward modelling pipeline that enables us to robustly account for spatial blending, we measure the [O III] 5007 Å flux ratios of the four images. We find that the [O III] fluxes and positions are well fit by a simple smooth mass model for the main lens. Our data rule out a M600 > 108(107.2)M⊙ Navarro–Frenk–White perturber projected within ~1.0 (0.1) arcsec of each of the lensed images, where M600 is the perturber mass within its central 600 pc. The non-detection is broadly consistent with the expectations of ΛCDM for a single system. The sensitivity achieved demonstrates that powerful limits on the nature of dark matter can be obtained with the analysis of ~20 narrow-line lenses. [ABSTRACT FROM AUTHOR]

Objectives: To evaluate the efficacy of transcutaneous electrical nerve stimulation (TENS) as analgesia during colonoscopy.Design: In a randomised controlled trial, patients undergoing diagnostic colonoscopy were assigned to one of three groups: standard medication only (midazolam); active TENS plus standard medication; or non-functioning TENS and standard medication. Efficacy of TENS was determined using numerical rating scores for pain and the post-procedural evaluation questionnaire.Setting: Patients undergoing diagnostic colonoscopy in a teaching hospital.Main Outcome: There was no statistically significant differences between the three groups. However in the active TENS group there was a greater variation in "physical discomfort" and "psychological distress", suggesting TENS may be effective in subgroup of patients. [ABSTRACT FROM AUTHOR]

Background Many tropical forest tree species delay greening their leaves until full expansion. This strategy is thought to provide newly flushing leaves with protection against damage by herbivores by keeping young leaves devoid of nutritive value. Because young leaves suffer the greatest predation from invertebrate herbivores, delayed greening could prevent costly tissue loss. Many species that delay greening also produce anthocyanin pigments in their new leaves, giving them a reddish tint. These anthocyanins may be fungicidal, protect leaves against UV damage or make leaves cryptic to herbivores blind to the red part of the spectrum. Methods A comprehensive survey was undertaken of seedlings, saplings and mature trees in two diverse tropical forests: a rain forest in western Amazonia (Yasuní National Park, Ecuador) and a deciduous forest in Central America (Barro Colorado Island, Panamá). A test was made of whether individuals and species with delayed greening or red-coloured young leaves showed lower mortality or higher relative growth rates than species that did not. Key results At both Yasuní and Barro Colorado Island, species with delayed greening or red young leaves comprised significant proportions of the seedling and tree communities. At both sites, significantly lower mortality was found in seedlings and trees with delayed greening and red-coloured young leaves. While there was little effect of leaf colour on the production of new leaves of seedlings, diameter relative growth rates of small trees were lower in species with delayed greening and red-coloured young leaves than in species with regular green leaves, and this effect remained when the trade-off between mortality and growth was accounted for. Conclusions Herbivores exert strong selection pressure on seedlings for the expression of defence traits. A delayed greening or red-coloured young leaf strategy in seedlings appears to be associated with higher survival for a given growth rate, and may thus influence the species composition of later life stages. [ABSTRACT FROM AUTHOR]

Presents a study which evaluated the effects of the immunization of gilts against ovarian steroids on ovulation rate and litter size. Materials and methods; Reproductive responses of gilts immunized against androstenedione; Implication of the observed increase in serum binding of hydrogen-labeled steroids on the immunization procedure.

Examines the ecosystem integrity of the Panama Canal, and challenges for conservation in a biologically diverse watershed area adjacent to canal. Description of watershed area; Determination of how much land remains forested in an area; Tree species diversity; Identification of bird species in an area; Activity which affects the area, including hunting, human population, canal's water supply, and greenhouse gases.

Presents a letter to the editor about a 48-year-old female with Wilson's disease who has developed progressive and increasingly disfiguring skin wrinkling over a 4-year period while on penicillamine treatment.