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DearEditor, Bullous pemphigoid (BP), mucous membrane pemphigoid (MMP) and pemphigus vulgaris (PV) are autoimmune blistering diseases that present with mucocutaneous blistering and erosions. 10 What is the best way to treat skin wounds in BP, MMP and/or PV, including how should blisters or erosions be best washed and managed and does treatment vary according to body site?. [Extracted from the article]

In primary SS (pSS), clinical features in SS can be divided into two facets: the patient perceived manifestations such as dryness, pain and fatigue, and the systemic manifestations. In the past decades, with efforts made by an international collaboration, consensual clinical indexes were developed for assessing both facets: one patient reported outcome, the EULAR SS Patients Reported Index (ESSPRI), and one activity index for systemic manifestations, the EULAR SS Disease Activity Index (ESSDAI). In addition, objective measures were developed to quantify the importance and consequence of ocular and oral dryness, few being specific of pSS. Work is ongoing to develop indexes combining all these approaches. Recent changes in the assessment of pSS patients, and the emergence of new targeted therapies, have put a greater emphasis on the design of clinical trials in pSS, and led for the first time to a positive randomized clinical trial. [ABSTRACT FROM AUTHOR]

In the article, the authors present their study on the association between tonsillectomy (TE) and glandular inflammation in Sjögren's disease, which is characterized by B cell hyperactivity and focal lymphocytic infiltration of salivary glands. Other topics include the association of TE with long-term risk of respiratory, infectious, and allergic diseases, and the history of appendectomy (AE) and TE.

The guideline will be developed using the methods and processes outlined in Creating Clinical Guidelines: Our Protocol [ 1 ]. This development process to produce guidance, advice and recommendations for practice has National Institute for Health and Care Excellence (NICE) accreditation. [ABSTRACT FROM AUTHOR]

Primary SS (pSS) is a systemic autoimmune disease characterized by lymphocytic infiltration of the exocrine glands leading to glandular dysfunction, resulting in dryness of the eyes, mouth and other mucosal surfaces. Systemic manifestations also occur in the majority of patients. There has been increasing interest in recent years, with a number of publications regarding the classification criteria, diagnostic tools, disease activity, damage, impact and potential treatments. This article reviews recent advances in the diagnosis and treatment of ocular and oral involvement in pSS. Recent stand-out developments include measurement of tear osmolarity as a marker in dry eye disease diagnosis, new devices measuring tear constituents and meibomian gland structure and treatment of its dysfunction. Lip biopsy is still valuable despite emerging evidence of non-invasive diagnostic techniques, notably salivary gland ultrasound. [ABSTRACT FROM AUTHOR]

The article presents a study conducted to review the treatment of the glandular and systemic features of primary Sjögren's syndrome (pSS). Topics covered include the process of diagnosing pSS, the eligibility and exclusion criteria used in developing the guideline in treating and managing patients with pSS, and the guidelines for treatment of sicca manifestations, management of ocular manifestations of pSS, and miscellaneous treatments for dry eye and ocular complications.