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Although statistically unlikely, early-onset breast cancer tends to be more aggressive and leads to greater mortality than breast cancer among women of screening age. Young African American women are disproportionately impacted by early-onset breast cancer compared to women of other races. Given the racial disparities and because young women are typically not the primary audience for breast cancer educational messaging, there is a need to identify recommendations for age-appropriate breast cancer education for African American women below mammogram eligibility. Through N  = 30 key informant interviews with young African American breast cancer survivors, family members of young survivors, community organization leaders and healthcare providers, we identified breast cancer educational message content and communication channels relevant for these women. Participants recommended that message content should emphasize the need to address family cancer history and self-advocacy in healthcare encounters in addition to concerns about loss of womanhood, financial costs and opportunity costs associated with preventive healthcare visits. Breast cancer messages for this audience should consider the influences of earlier life stage, culture and race. Recommended communication channels highlighted use of social media and videos. Findings will inform future age-appropriate educational messaging aimed at eliminating early-onset breast cancer disparities disproportionately impacting young African American women. [ABSTRACT FROM AUTHOR]

Objective: This study aims to investigate possible improvements in the neurocognitive performance in patients with treatment-resistant depression (TRD) following the clinical dose of low-frequency, rTMS when administered to the RDLPFC and SMA. Because depression is often associated with neurocognitive deficits, this information will help provide additional support for the benefits of rTMS. Method: Participants consisted of 10 patients with TRD who received rTMS to the RDLPFC (1200 pulses @ 1Hz, 110% of motor threshold (MT)) and SMA (1200 pulses @ 1Hz, 100% MT) for 10 sessions. Each subject completed CNS Vital Signs before beginning rTMS and after 10 sessions (2 weeks). The sample was 50% male, 100% Caucasian, and of a mean age of 48.5 years (SD = 9.58). All participants had obtained a High School diploma, with more than 70% having at least an Associates Degree. Results: From baseline to two weeks, significant improvements were found for both depressive, F(1, 9) = 17.17, p = .003, η2 = .656, and anxious, F(1, 9) = 26.89, p = .001, η2 = .749, symptoms. When controlling for mood changes, significant improvement in executive functioning were also observed, F(1, 7) = 12.26, p = .010, η2 = .637. Significant differences did not exist for measures of complex attention or cognitive flexibility (p's > .718). Conclusion(s): Results support the efficacy of rTMS to improve mood symptoms associated with TRD and suggest that the clinical dose of rTMS applied to the RDLPFC and SMA here can make relatively quick (2 weeks) improvements to executive function abilities. [ABSTRACT FROM AUTHOR]