Search

This article discusses the influence of circadian rhythms on cardiac physiology and disease. The circadian clock, which generates oscillations in gene and protein expression with a period of approximately 24 hours, regulates various physiological processes including cardiovascular function. Disruptions in circadian rhythms can lead to cardiovascular disorders such as myocardial infarction, cardiomyopathy, and heart failure. Aging is also associated with alterations in circadian rhythms, which can increase the risk of cardiovascular diseases. Non-pharmacological interventions such as physical exercise, meal timing, and light therapy, as well as pharmacological interventions like chronotherapy, can help promote circadian resynchronization and improve patient outcomes. Advancements in omics technology and data analytics may contribute to the development of personalized chronotherapy for individuals at risk of cardiovascular diseases. Understanding the interplay between circadian rhythms and cardiovascular health offers potential strategies for promoting heart health and healthy aging. [Extracted from the article]

"Physick to Physiology: Tales from an Oxford Life in Medicine" by Keith Dorrington is a historical book that explores various topics in medicine and physiology. The author, a medical tutor at University College in Oxford, provides insights into medical practice, the history of medical sciences, evidence-based medicine, and the future of clinical practice. The book covers a range of subjects, including altitude acclimatization, autonomic learning in exercise, the central nervous system and hypertension, congenital absence of pain, pharmacology of anesthesia, awareness during surgery, cognitive decline from anesthesia, and knowledge acquisition at university. It uses historical examples to provide context to modern-day clinical practice and presents diverse perspectives on medical controversies. The book is accessible to general readers and offers thought-provoking insights into the field of medicine. [Extracted from the article]

Google Scholar Google Preview OpenURL Placeholder Text WorldCat COPAC 7 Duckworth A. Grit: The power of passion and perseverance. Google Scholar Google Preview OpenURL Placeholder Text WorldCat COPAC I What is the role of a scientific researcher within society? Beyond the issue of researchers pursuing hot topics or sexy narratives, our impacts within society are highly limited by society's receptivity to the solutions we may offer. [Extracted from the article]

Here, we review the highlights of cardiovascular basic science published in 2021 and early 2022 on behalf of the European Society of Cardiology Council for Basic Cardiovascular Science. We begin with non-coding RNAs which have emerged as central regulators cardiovascular biology, and then discuss how technological developments in single-cell 'omics are providing new insights into cardiovascular development, inflammation, and disease. We also review recent discoveries on the biology of extracellular vesicles in driving either protective or pathogenic responses. The Nobel Prize in Physiology or Medicine 2021 recognized the importance of the molecular basis of mechanosensing and here we review breakthroughs in cardiovascular sensing of mechanical force. We also summarize discoveries in the field of atherosclerosis including the role of clonal haematopoiesis of indeterminate potential, and new mechanisms of crosstalk between hyperglycaemia, lipid mediators, and inflammation. The past 12 months also witnessed major advances in the field of cardiac arrhythmia including new mechanisms of fibrillation. We also focus on inducible pluripotent stem cell technology which has demonstrated disease causality for several genetic polymorphisms in long-QT syndrome and aortic valve disease, paving the way for personalized medicine approaches. Finally, the cardiovascular community has continued to better understand COVID-19 with significant advancement in our knowledge of cardiovascular tropism, molecular markers, the mechanism of vaccine-induced thrombotic complications and new anti-viral therapies that protect the cardiovascular system. [ABSTRACT FROM AUTHOR]

All correspondence relating to this paper should be sent to: cardiopulse@unicatt.it B Nobel Prize winner Ferid Murad talks about research, motivation, washing dishes, building swimming pools, and new therapeutic targets. In a conversation in 1981, after his seminar at the University of Virginia where Prof. Murad was a professor, he told Furchgott that EDRF might be NO. [Extracted from the article]

Policy focus gives scientists an incentive to pursue specific research subjects and influences a trend of scientific research. This study examines how public grant is allocated for stem cell research in Japan and shows that scientists are likely to advance their research toward the direction led by policy. Since Japanese scientists discovered a method to generate induced pluripotent stem cell (iPSC) in 2006, public financial and institutional support has skewed toward iPSC. The 2012 Nobel Prize in Physiology or Medicine for iPSC has also had an impact on policy and scientists' selection of stem cells. Scientists in the top universities are likely to select iPSC research. In addition, iPSC research obtains more amount of public grant funding than other stem cell research. However, scientists' age has no relevant impact on selecting iPSC research. Finally, this study concludes that targeted public funding skews knowledge portfolio by scientists in a nascent field. [ABSTRACT FROM AUTHOR]

Tautz argues that in terms of the three-phase process, the Von Frisch story covers only the first phase of the model, and the attraction experiments of Wenner cover only the third phase. Von Frisch hypothesized that bees either followed the waggle dance instructions to get to the unknown goal or flew to the goal on their own, without using the waggle dance instructions. Graph The classic story of the honey bee waggle dance tells how bees recruit nestmates to a food source. [Extracted from the article]

The article announces that Jeffrey C. Hall, Michael Rosbash, and Michael W. Young receiving a share of the 2017 Nobel Prize for Physiology or Medicine for their discoveries of molecular mechanisms controlling the circadian rhythm.

Howard Walter Florey was from Adelaide and became a Rhodes Scholar at Oxford. The British Medical Bulletin (BMB) has an extensive archive dating back to 1943. He describes the hunt for new antibiotics, stimulated by the find of penicillin in Oxford in 1940 and shows that its discovery was the result of many scientists working in the field. [Extracted from the article]

Prof Evans' early studies in signalling pathways allowed him to look at vascular responses to flow-induced frictional forces - shear stress - from a different context and understand how mechanics affects cardiovascular disease at the molecular level. B CardioPulse meets Giovanni G. Camici, PhD, and Paul Evans, PhD, the two scientists whose hard work and dedication has been recognized by the ESC Council on Basic Cardiovascular Science (CBCS) with the 2021 Outstanding Achievement Award. As this has been found to be an important mediator of age-dependent CVD, the team started to study interleukin 1-alpha, tumour necrosis factor alpha, and interleukin 1-beta and found that they could blunt certain features of age-dependent CVD. [Extracted from the article]

The article discusses biochemist Dr. Satoshi Ōmura who won the Nobel Prize in Physiology or Medicine for developing a therapy to treat roundworm parasite-causing infection and mentions the therapeutic use of ivermectin and MDR1, a membrane protein.

The article discusses contribution of scientists Paul Nurse and Pierre Thuriaux for research in Cell Cycle Control and fission yeast mutants. It informs about Nurse's inspiration to investigate cell division cycle inspired by work of researcher Lee Hartwell for isolating and analyzing budding yeast mutants arrested at specific points in cell cycle. It also informs about the 2001 Nobel Prize in Medicine or Physiology won by Nurse.

The article explores the article "Mutations of Bacteria from Virus Sensitivity to Virus Resistance" by Salvador Edward Luria and Max Debrück which appeared in the November 20, 1943 issue of the journal. The article reportedly had significant impacts on genetics which include that sophisticated statistical analysis can emphasize biological processes that cannot be observed directly. It notes that the authors won the 1969 Nobel Prize in Medicine or Physiology.

The author discusses the recipients of the Nobel Prize in Physiology or Medicine 2015 including microbiologist Satoshi Ōmura of Japan, parasitologist William C. Campbell of Drew University in New Jersey, and pharmaceutical chemist Youyou Tu of China. The author mentions that the 2015 Prize honors their work such as the development of artemisinin, an antimicrobial that targets Plasmodium falciparum, and the discovery of avermectins which targets parasitic worms such as Onchocerca volvulus.