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Your search keyword '"Muller, David A."' showing total 183 results
Start Over Author "Muller, David A." Publisher oxford university press / usa
183 results on '"Muller, David A."'

11. Secondary retensioning of a tether-based device for transapical transcatheter mitral valve implantation.

Author

Beyer, Martin, Muller, David, Marco, Federico De, Badhwar, Vinay, Obadia, Jean-Francois, Praz, Fabien, Modine, Thomas, Tonino, Pim, Dahle, Gry, Cerillo, Alfredo, Ludwig, Sebastian, and Conradi, Lenard

Subjects
*MITRAL valve, *HEART valve prosthesis implantation, *MITRAL valve surgery, *CONSORTIA
Abstract

Open in new tab Download slide OBJECTIVES Relevant paravalvular leakage (PVL) due to prosthesis dislodgement is a rare but potentially severe complication after transcatheter mitral valve implantation (TMVI). Due to the epicardial anchoring mechanism of the Tendyne® TMVI system, repositioning of the valve stent may be possible by retensioning of the tether. This multicentre study aimed to investigate the procedural and short-term safety as well as efficacy of retensioning manoeuvres. METHODS From 2017 to 2021, N  = 18 patients who underwent secondary tether retensioning were identified. Baseline, procedural and follow-up data were available from N  = 11 patients and analysed according to the Mitral Valve Research Consortium definitions. Continuous variables are shown as median with interquartile range. RESULTS All patients [age 75 years (73.5, 85.0), 64% male (N  = 7), EuroSCORE II 6.2% (5.8, 11.6)] presented with post-procedural PVL [63.6% (N  = 7) with PVL ≥3+]. Of these, 54% (N  = 6) showed signs of haemolysis. The majority were severely symptomatic [New York Heart Association ≥III (91%, N  = 10)]. Procedural outcomes revealed no acute complications and no mortality. At discharge, PVL was completely eliminated in 91% (N  = 10) of patients with 1 case of remaining moderate PVL. At 30 days, Mitral Valve Research Consortium device success was achieved in 82% (N  = 9) of patients. Two patients required open surgical mitral valve replacement due to persistent and recurrent PVL. In 89% (N  = 8) of patients with successful retensioning procedure, New York Heart Association class was I/II. There was no 30-day mortality. CONCLUSIONS This multicentre study demonstrates technical feasibility, procedural safety and acute efficacy of retensioning procedures in the majority of patients. The potential to retension the tether in transapical TMVI may provide additional management advantages in populations at high surgical risk. [ABSTRACT FROM AUTHOR]

Published
2024
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12. Lung cancer risk discrimination of prediagnostic proteomics measurements compared with existing prediction tools.

Author

Feng, Xiaoshuang, Wu, Wendy Yi-Ying, Onwuka, Justina Ucheojor, Haider, Zahra, Alcala, Karine, Smith-Byrne, Karl, Zahed, Hana, Guida, Florence, Wang, Renwei, Bassett, Julie K, Stevens, Victoria, Wang, Ying, Weinstein, Stephanie, Freedman, Neal D, Chen, Chu, Tinker, Lesley, Nøst, Therese Haugdahl, Koh, Woon-Puay, Muller, David, and Colorado-Yohar, Sandra M

Subjects
LUNG cancer, DISEASE risk factors, RECEIVER operating characteristic curves, PROTEOMICS, EARLY detection of cancer
Abstract

Background We sought to develop a proteomics-based risk model for lung cancer and evaluate its risk-discriminatory performance in comparison with a smoking-based risk model (PLCOm2012) and a commercially available autoantibody biomarker test. Methods We designed a case-control study nested in 6 prospective cohorts, including 624 lung cancer participants who donated blood samples at most 3 years prior to lung cancer diagnosis and 624 smoking-matched cancer free participants who were assayed for 302 proteins. We used 470 case-control pairs from 4 cohorts to select proteins and train a protein-based risk model. We subsequently used 154 case-control pairs from 2 cohorts to compare the risk-discriminatory performance of the protein-based model with that of the Early Cancer Detection Test (EarlyCDT)-Lung and the PLCOm2012 model using receiver operating characteristics analysis and by estimating models' sensitivity. All tests were 2-sided. Results The area under the curve for the protein-based risk model in the validation sample was 0.75 (95% confidence interval [CI] = 0.70 to 0.81) compared with 0.64 (95% CI = 0.57 to 0.70) for the PLCOm2012 model (P difference =.001). The EarlyCDT-Lung had a sensitivity of 14% (95% CI = 8.2% to 19%) and a specificity of 86% (95% CI = 81% to 92%) for incident lung cancer. At the same specificity of 86%, the sensitivity for the protein-based risk model was estimated at 49% (95% CI = 41% to 57%) and 30% (95% CI = 23% to 37%) for the PLCOm2012 model. Conclusion Circulating proteins showed promise in predicting incident lung cancer and outperformed a standard risk prediction model and the commercialized EarlyCDT-Lung. [ABSTRACT FROM AUTHOR]

Published
2023
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14. Body Size at Different Ages and Risk of 6 Cancers: A Mendelian Randomization and Prospective Cohort Study.

Author

Mariosa, Daniela, Smith-Byrne, Karl, Richardson, Tom G, Ferrari, Pietro, Gunter, Marc J, Papadimitriou, Nikos, Murphy, Neil, Christakoudi, Sofia, Tsilidis, Konstantinos K, Riboli, Elio, Muller, David, Purdue, Mark P, Chanock, Stephen J, Hung, Rayjean J, Amos, Christopher I, O'Mara, Tracy A, Amiano, Pilar, Pasanisi, Fabrizio, Rodriguez-Barranco, Miguel, and Krogh, Vittorio

Subjects
OBESITY complications, OBESITY, SEQUENCE analysis, RESEARCH funding, TUMORS, BODY mass index, LONGITUDINAL method, BODY size
Abstract

It is unclear if body weight in early life affects cancer risk independently of adult body weight. To investigate this question for 6 obesity-related cancers, we performed univariable and multivariable analyses using 1) Mendelian randomization (MR) analysis and 2) longitudinal analyses in prospective cohorts. Both the MR and longitudinal analyses indicated that larger early life body size was associated with higher risk of endometrial (odds ratioMR = 1.61, 95% confidence interval = 1.23 to 2.11) and kidney (odds ratioMR = 1.40, 95% confidence interval = 1.09 to 1.80) cancer. These associations were attenuated after accounting for adult body size in both the MR and cohort analyses. Early life body mass index (BMI) was not consistently associated with the other investigated cancers. The lack of clear independent risk associations suggests that early life BMI influences endometrial and kidney cancer risk mainly through pathways that are common with adult BMI. [ABSTRACT FROM AUTHOR]

Published
2022
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28. Coronary artery embolism and culture-negative endocarditis post Bentall's procedure.

Author

McNeill, Jared, Chew, Hong, Andresen, David, Muller, David, Granger, Emily, and Wang, Louis W

Subjects
INFECTIVE endocarditis, CORONARY arteries, PROSTHETIC heart valves, ENDOCARDITIS, EMBOLISMS, MYOCARDIAL infarction
Abstract

Infective endocarditis is an important cause of morbidity and mortality, which classically presents with fevers and nonspecific symptoms. Afebrile infective endocarditis with negative blood cultures makes diagnosis more challenging and delays in treatment can occur increasing the likelihood of complications. The presence of prosthetic heart valves places patients at an increased risk of infective endocarditis and the case described below highlights the importance of considering this diagnosis even if classic clinical features such as fever and raised inflammatory markers are not present, as well as discussing an unusual complication of infective endocarditis; coronary artery embolism leading to myocardial infarction. [ABSTRACT FROM AUTHOR]

Published
2021
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