27 results on '"Monteiro, M"'
Search Results
2. Long-term changes of ichthyoplankton communities in an Iberian estuary are driven by varying hydrodynamic conditions.
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Monteiro, M, Azeiteiro, U M, Martinho, F, Pardal, M A, and Primo, A L
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FISH larvae , *ICHTHYOPLANKTON , *ESTUARIES , *NUMBERS of species , *FISH as food , *PLANT phenology , *FISH communities , *COMMUNITY change - Abstract
Ichthyoplankton assemblages are key components of estuaries worldwide, playing a vital role as nurseries for fish larvae. Nonetheless, estuaries can be highly affected by ongoing climate change. Impacts of climate variability on ichthyoplankton assemblages will have consequences for marine pelagic food webs and fish populations biology, namely recruitment. This study aims to investigate the influence of environmental variability on an interannual abundance of ichthyoplankton assemblages of the Mondego estuary (Portugal). For this, an ichthyoplankton sampling programme of 13 years (2003–2015) along six distinct sampling stations was analysed to evaluate spatial, seasonal and interannual changes of ichthyoplankton distribution over periods of wet, regular and dry conditions. The ichthyoplanktonic community was dominated by Pomatoschistus spp. across all seasons and conditions, with higher larval abundances during summer and spring. Main changes were related to species seasonality and phenology as well as an increase in the number of marine species during extreme events. The larval fish community showed a strong relationship with the regional and local environment over the study, presenting a distinct yet highly variable structure during the 2009–2013 period. Reported changes will likely trigger major changes in species dominance and abundance, with clear ecological and socio-economic implications. [ABSTRACT FROM AUTHOR]
- Published
- 2022
- Full Text
- View/download PDF
3. Long-term changes of ichthyoplankton communities in an Iberian estuary are driven by varying hydrodynamic conditions.
- Author
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Monteiro, M, Azeiteiro, U M, Martinho, F, Pardal, M A, and Primo, A L
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FISH populations , *MARINE biodiversity , *ESTUARIES , *FISH as food , *NUMBERS of species , *ICHTHYOPLANKTON - Abstract
Ichthyoplankton assemblages are key components of estuaries worldwide, playing a vital role as nurseries for fish larvae. Nonetheless, estuaries can be highly affected by ongoing climate change. Impacts of climate variability on ichthyoplankton assemblages will have consequences for marine pelagic food webs and fish populations biology, namely recruitment. This study aims to investigate the influence of environmental variability on an interannual abundance of ichthyoplankton assemblages of the Mondego estuary (Portugal). For this, an ichthyoplankton sampling programme of 13 years (2003–2015) along six distinct sampling stations was analysed to evaluate spatial, seasonal and interannual changes of ichthyoplankton distribution over periods of wet, regular and dry conditions. The ichthyoplanktonic community was dominated by Pomatoschistus spp. across all seasons and conditions, with higher larval abundances during summer and spring. Main changes were related to species seasonality and phenology as well as an increase in the number of marine species during extreme events. The larval fish community showed a strong relationship with the regional and local environment over the study, presenting a distinct yet highly variable structure during the 2009–2013 period. Reported changes will likely trigger major changes in species dominance and abundance, with clear ecological and socio-economic implications. [ABSTRACT FROM AUTHOR]
- Published
- 2021
- Full Text
- View/download PDF
4. European Society of Endocrinology Clinical Practice Guideline: Endocrine work-up in obesity.
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Pasquali, R., Casanueva, F., Haluzik, M., van Hulsteijn, L., Ledoux, S., Monteiro, M. P., Salvador, J., Santini, F., Toplak, H., and Dekkers, O. M.
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ENDOCRINE diseases ,GONADAL diseases ,OBESITY ,WEIGHT loss ,DISEASE complications ,OVERWEIGHT persons - Abstract
Obesity is an emerging condition, with a prevalence of ~20%. Although the simple measurement of BMI is likely a simplistic approach to obesity, BMI is easily calculated, and there are currently no data showing that more sophisticated methods are more useful to guide the endocrine work-up in obesity. An increased BMI leads to a number of hormonal changes. Additionally, concomitant hormonal diseases can be present in obesity and have to be properly diagnosed - which in turn might be more difficult due to alterations caused by body fatness itself. The present European Society of Endocrinology Clinical Guideline on the Endocrine Work-up in Obesity acknowledges the increased prevalence of many endocrine conditions in obesity. It is recommended to test all patients with obesity for thyroid function, given the high prevalence of hypothyroidism in obesity. For hypercortisolism, male hypogonadism and female gonadal dysfunction, hormonal testing is only recommended if case of clinical suspicion of an underlying endocrine disorder. The guideline underlines that weight loss in obesity should be emphasized as key to restoration of hormonal imbalances and that treatment and that the effect of treating endocrine disorders on weight loss is only modest. [ABSTRACT FROM AUTHOR]
- Published
- 2020
- Full Text
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5. Prevalence of endocrine disorders in obese patients: systematic review and meta-analysis.
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van Hulsteijn, L. T., Pasquali, R., Casanueva, F., Haluzik, M., Ledoux, S., Monteiro, M. P., Salvador, J., Santini, F., Toplak, H., and Dekkers, O. M.
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META-analysis ,DISEASE prevalence ,DISEASES ,LOGISTIC regression analysis ,OVERWEIGHT persons - Abstract
Objective: The increasing prevalence of obesity is expected to promote the demand for endocrine testing. To facilitate evidence guided testing, we aimed to assess the prevalence of endocrine disorders in patients with obesity. The review was carried out as part of the Endocrine Work-up for the Obesity Guideline of the European Society of Endocrinology. Design: Systematic review and meta-analysis of the literature. Methods: A search was performed in MEDLINE, EMBASE, Web of Science and COCHRANE Library for original articles assessing the prevalence of hypothyroidism, hypercortisolism, hypogonadism (males) or hyperandrogenism (females) in patients with obesity. Data were pooled in a random-effects logistic regression model and reported with 95% confidence intervals (95% CI). Results: Sixty-eight studies were included, concerning a total of 19.996 patients with obesity. The pooled prevalence of overt (newly diagnosed or already treated) and subclinical hypothyroidism was 14.0% (95% CI: 9.7-18.9) and 14.6% (95% CI: 9.2-20.9), respectively. Pooled prevalence of hypercortisolism was 0.9% (95% CI: 0.3-1.6). Pooled prevalence of hypogonadism when measuring total testosterone or free testosterone was 42.8% (95% CI: 37.6-48.0) and 32.7% (95% CI: 23.1-43.0), respectively. Heterogeneity was high for all analyses. Conclusions: The prevalence of endocrine disorders in patients with obesity is considerable, although the underlying mechanisms are complex. Given the cross-sectional design of the studies included, no formal distinction between endocrine causes and consequences of obesity could be made. [ABSTRACT FROM AUTHOR]
- Published
- 2020
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6. α Centauri A as a potential stellar model calibrator: establishing the nature of its core.
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Nsamba, B, Monteiro, M J P F G, Campante, T L, Cunha, M S, and Sousa, S G
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ALPHA Centauri , *STELLAR parallax , *INTERFEROMETRY , *STELLAR dynamics , *STELLAR mass - Abstract
Understanding the physical process responsible for the transport of energy in the core of α Centauri A is of the utmost importance if this star is to be used in the calibration of stellar model physics. Adoption of different parallax measurements available in the literature results in differences in the interferometric radius constraints used in stellar modelling. Further, this is at the origin of the different dynamical mass measurements reported for this star. With the goal of reproducing the revised dynamical mass derived by Pourbaix & Boffin, we modelled the star using two stellar grids varying in the adopted nuclear reaction rates. Asteroseismic and spectroscopic observables were complemented with different interferometric radius constraints during the optimization procedure. Our findings show that best-fitting models reproducing the revised dynamical mass favour the existence of a convective core (≳70 per cent of best-fitting models), a result that is robust against changes to the model physics. If this mass is accurate, then α Centauri A may be used to calibrate stellar model parameters in the presence of a convective core. [ABSTRACT FROM AUTHOR]
- Published
- 2018
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7. Asteroseismic modelling of solar-type stars: internal systematics from input physics and surface correction methods.
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Nsamba, B., Campante, T. L., Monteiro, M. J. P. F. G., Cunha, M. S., Rendle, B. M., Reese, D. R., and Verma, K.
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HEAVY elements ,CHEMICAL elements ,STAR formation ,STELLAR evolution - Abstract
Asteroseismic forward modelling techniques are being used to determine fundamental properties (e.g. mass, radius, and age) of solar-type stars. The need to take into account all possible sources of error is of paramount importance towards a robust determination of stellar properties. We present a study of 34 solar-type stars for which high signal-to-noise asteroseismic data are available from multiyear Kepler photometry. We explore the internal systematics on the stellar properties, that is associated with the uncertainty in the input physics used to construct the stellar models. In particular, we explore the systematics arising from (i) the inclusion of the diffusion of helium and heavy elements; (ii) the uncertainty in solar metallicity mixture; and (iii) different surface correction methods used in optimization/fitting procedures. The systematics arising from comparing results of models with and without diffusion are found to be 0.5 per cent, 0.8 per cent, 2.1 per cent, and 16 per cent in mean density, radius, mass, and age, respectively. The internal systematics in age are significantly larger than the statistical uncertainties. We find the internal systematics resulting from the uncertainty in solar metallicity mixture to be 0.7 per cent in mean density, 0.5 per cent in radius, 1.4 per cent in mass, and 6.7 per cent in age. The surface correction method by Sonoi et al. and Ball & Gizon's two-term correction produce the lowest internal systematics among the different correction methods, namely, ~1 per cent, ~1 per cent, ~2 per cent, and ~8 per cent in mean density, radius, mass, and age, respectively. Stellar masses obtained using the surface correction methods by Kjeldsen et al. and Ball & Gizon's one-term correction are systematically higher than those obtained using frequency ratios. [ABSTRACT FROM AUTHOR]
- Published
- 2018
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8. African histoplasmosis: new clinical and microbiological insights.
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Valero, C, Gago, S, Monteiro, M C, Alastruey-Izquierdo, A, and Buitrago, M J
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African histoplasmosis is defined as the fungal infection caused by Histoplasma capsulatum var. duboisii (Hcd). Studies focused on distinguishing Hcd and H. capsulatum var. capsulatum (Hcc), which coexist in Africa, are scarce or outdated, and African strains are continuously underrepresented. In this work, 13 cases of African patients with histoplasmosis diagnosed in the Spanish Mycology Reference Laboratory have been reviewed showing that 77% had disseminated disease and AIDS as underlying disease although Hcd infection has been classically considered a rare presentation in AIDS patients. Strains isolated from these patients and other clinical and reference strains were studied by assessing classical identificationmethods and performing a three-loci multi-locus sequence analysis (MLSA). Classical identification methods based on biochemical tests and measurement of yeast size proved to be useless in distinguishing both varieties. The MLSA defined an African cluster, with a strong statistical support, that included all strains with African origin. Finally, mating type was also determined by using molecular methods revealing an unequal mating type distribution in African strains. In conclusion, historical statements and classical identification methods were useless to distinguish between varieties, whereas molecular analyses revealed that all strains with African origin grouped together suggesting that traditional classification should be revised. Further investigation is required in order to unravel traditional concepts about Hcd infection and support results obtained in this work. [ABSTRACT FROM AUTHOR]
- Published
- 2018
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9. Precise surface gravities of δ Scuti stars from asteroseismology.
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García Hernández, A., Suárez, J. C., Moya, A., Monteiro, M. J. P. F. G., Guo, Z., Reese, D. R., Pascual-Granado, J., Barceló Forteza, S., Martín-Ruiz, S., Garrido, R., and Nieto, J.
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GRAVITATIONAL mass ,PHOTOMETRY ,BINARY stars ,ECLIPSING binaries ,RADIAL velocity of stars - Abstract
Thework reported here demonstrates that it is possible to accurately determine surface gravities of δ Scuti (δ Sct) stars using the frequency content from high-precision photometry and a measurement of the parallax. Using a sample of 10 eclipsing binary systems with a δ Sct component and the unique δ Sct star discovered with a transiting planet, WASP-33, we were able to refine the Δν–¯ρ relation. Using this relation and parallaxes, we obtained independent values for the masses and radii, allowing us to calculate the surface gravities without any constraints from spectroscopic or binary analysis. A remarkably good agreement was found between our results and those published, extracted from the analysis of the radial velocities and light curves of the systems. This reinforces the potential of Δν as a valuable observable for δ Sct stars and settles the degeneracy problem for the log g determination through spectroscopy. [ABSTRACT FROM AUTHOR]
- Published
- 2017
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10. On the mass estimation for FGK stars: comparison of several methods.
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Pinheiro, F. J. G., Fernandes, J. M., Cunha, M. S., Monteiro, M. J. P. F. G., Santos, N. C., Sousa, S. G., Marques, J. P., Fang, J.-J., Mortier, A., and Sousa, J.
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STELLAR mass ,STELLAR evolution ,BINARY stars ,ASTRONOMICAL observations ,STAR colors ,NUMERICAL analysis - Abstract
Stellar evolutionary models simulate well binary stars when individual stellar mass and system metallicity are known. The mass can be derived directly from observations only in the case of multiple stellar systems, mainly binaries. Yet, the number of such stars for which accurate stellar masses are available is rather small. The main goal of this project is to provide realistic mass estimates for a homogeneous sample of about a thousand FGK single stars, using four different methods and techniques. We present the masses inferred according to each one of these methods as well as a final mass estimate consisting in the median of the four mass estimates. The procedures evaluated here include the use of stellar evolutionary models, mass–luminosity relation and surface gravity spectroscopic observations. By combining the results obtained with different methods, we determine the best mass value for each individual star, as well as the associated error budget. Our results confirm the expected consistency between the different mass estimation methods. None the less, for masses above 1.2 M⊙, the spectroscopic surface gravities seem to overestimate the mass. This result may be a consequence of the spectroscopic surface gravities used in this analysis. Nevertheless, this problem is minimized by the fact that we have several approaches available for deriving stellar masses. Moreover, we suggest an empirical procedure to overcome this issue. [ABSTRACT FROM AUTHOR]
- Published
- 2014
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11. Phytase properties and locations in tissues of transgenic pigs secreting phytase in the saliva.
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Forsberg, C. W., Meidinger, R. G., Murray, D., Keirstead, N. D., Hayes, M. A., Fan, M. Z., Ganeshapillai, Jeyabarathy, Monteiro, M. A., Golovan, S. P., and Phillips, J. P.
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TRANSGENIC animals ,SWINE breeding ,PHYTASES ,SALIVARY glands ,SWINE physiology - Abstract
A transgenic Cassie (CA) line of Yorkshire (YK) pigs was developed using a transgene composed of the mouse parotid secretory protein promoter linked to the Escherichia coli phytase gene integrated in chromosome 4. Previous studies documented that salivary secretion of phytase was sufficient to enable efficient digestion of plant feed phytate P. In the present study the catalytic properties and tissue distribution of the phytase in CA pigs were determined by a combination of enzymatic assays, immunohistochemistry, and immunoblots of tissue samples. The E. coli phytase had a mass of 44.82 kDa whereas the phytase secreted in CA saliva had a mass of 52.42 kDa as a result of glycosylation of the enzyme in the parotid gland. Despite the difference in size, the 2 enzymes exhibited similar substrate specificities, and substrate affinity (K
m ) and maximum hydrolytic activity (Vmax ) catalytic properties. Phytase assays showed that the enzyme was present at high specific activity in the salivary glands with low activity in the soft palate and essentially none in the kidney, lean (muscle), liver, or skin of CA pigs and none in YK pigs. This conclusion was supported by immunoblot analysis using a polyclonal anti-phytase antibody. Immunohistochemical analysis of 83 different tissue locations of CA and YK pigs confirmed the ubiquitous presence of phytase in serous cells of the salivary glands and the localized presence of phytase in both serous and mixed cell types in the submucosal glands of the oropharynx; in the pharynx, tonsils, and esophagus; in some Bowman's glands in the nasal mucosa and eustachian tube; and in the prostate gland of CA boars. Furthermore, it showed the absence of phytase from the kidney, lean, liver, and skin of CA pigs. Phytase was not detected in any of the conventional YK tissues tested. The phytase was found to be glycosylated with the allergenic galactose-α-1,3-galactose (a-gal) epitope by immunoblotting using α-gal specific monoclonal antibodies. Galactose-α-1,3-galactose glycosylation of proteins is a common feature of pork and other red meats. The α-gal epitope was shown to be associated with a few proteins in muscle and skin but with the greatest number of proteins in kidney and parotid tissues of CA and YK pigs. The absence of phytase from the major food tissues and the displacement of other α-gal glycosylated proteins in the parotid glands by α-gal glycosylated phytase in conjunction with previously published data support the contention that expression of the novel phytase has minimal influence on pork quality and safety. [ABSTRACT FROM AUTHOR]- Published
- 2014
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12. A large sample of calibration stars for Gaia: log g from Kepler and CoRoT fields.
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Creevey, O. L., Thévenin, F., Basu, S., Chaplin, W. J., Bigot, L., Elsworth, Y., Huber, D., Monteiro, M. J. P. F. G., and Serenelli, A.
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GRAVITY ,INTERFEROMETRY ,BINARY stars ,SEISMOLOGY - Abstract
Asteroseismic data can be used to determine stellar surface gravities with precisions of <0.05 dex by using the global seismic quantities 〈Δν〉 and νmax along with standard atmospheric data such as Teff and metallicity. Surface gravity is also one of the four stellar properties to be derived by automatic analyses for one billion stars from Gaia data (workpackage gsp_phot). In this paper, we explore seismic data from main-sequence F, G, K stars (solar-like stars) observed by the Kepler spacecraft as a potential calibration source for the methods that Gaia will use for object characterization (log g). We calculate log g for some bright nearby stars for which radii and masses are known (e.g. from interferometry or binaries), and using their global seismic quantities in a grid-based method, we determine an asteroseismic log g to within 0.01 dex of the direct calculation, thus validating the accuracy of our method. We also find that errors in adopted atmospheric parameters (mainly [Fe/H]) can, however, cause systematic errors of the order of 0.02 dex. We then apply our method to a list of 40 stars to deliver precise values of surface gravity, i.e. uncertainties of the order of 0.02 dex, and we find agreement with recent literature values. Finally, we explore the typical precision that we expect in a sample of more than 400 Kepler stars which have their global seismic quantities measured. We find a mean uncertainty (precision) of the order of better than 0.02 dex in log g over the full explored range 3.8 < log g < 4.6, with the mean value varying only with stellar magnitude (0.01–0.02 dex). We study sources of systematic errors in log g and find possible biases of the order of 0.04 dex, independent of log g and magnitude, which accounts for errors in the Teff and [Fe/H] measurements, as well as from using a different grid-based method. We conclude that Kepler stars provide a wealth of reliable information that can help to calibrate methods that Gaia will use, in particular, for source characterization with gsp_phot, where excellent precision (small uncertainties) and accuracy in log g is obtained from seismic data. [ABSTRACT FROM AUTHOR]
- Published
- 2013
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13. Towards an effective asteroseismology of solar-like stars: time-dependent convection effects on pulsation frequencies.
- Author
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Grigahcène, A., Dupret, M.-A., Sousa, S. G., Monteiro, M. J. P. F. G., Garrido, R., Scuflaire, R., and Gabriel, M.
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STELLAR oscillations ,STARS ,HELIOSEISMOLOGY ,ASTEROSEISMOLOGY ,OSCILLATIONS ,MAXIMUM likelihood statistics ,CONVECTION (Astrophysics) - Abstract
ABSTRACT Since the early days of helioseismology, adiabatic models have shown their limits for a precise fitting of individual oscillation frequencies. This discrepancy, which also exists for solar-type stars, is known to originate near the surface superadiabatic convective region where the interaction between oscillations and convection is likely to have a large effect on the frequencies. We present an asteroseismic study to address the adequacy of time-dependent convection (TDC) non-adiabatic models to better reproduce the observed individual frequencies. We select, for this purpose, three solar-like stars, in addition to the Sun, to which we fit the observed frequencies in a grid of TDC non-adiabatic models. The best model selection is done by applying a maximum likelihood method. The results are compared to pure adiabatic and near-surface corrected adiabatic models. We show that, first, TDC models give very good agreement for the mode frequencies and average lifetimes. In the solar case, the frequency discrepancy is reduced to <1.75 μHz over 95 per cent of the modes considered. Secondly, TDC models give an asteroseismic insight into the usually unconstrained ad hoc stellar parameters, such as the mixing-length parameter α
MLT . [ABSTRACT FROM AUTHOR]- Published
- 2012
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14. A more realistic representation of overshoot at the base of the solar convective envelope as seen by helioseismology.
- Author
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Christensen-Dalsgaard, J., Monteiro, M. J. P. F. G., Rempel, M., and Thompson, M. J.
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CIRCUMSTELLAR matter , *HELIOSEISMOLOGY , *ASTRONOMICAL models , *CONVECTION (Astrophysics) , *DIFFUSION , *SYMMETRY (Physics) , *SOLAR energy - Abstract
The stratification near the base of the Sun's convective envelope is governed by processes of convective overshooting and element diffusion, and the region is widely believed to play a key role in the solar dynamo. The stratification in that region gives rise to a characteristic signal in the frequencies of solar p modes, which has been used to determine the depth of the solar convection zone and to investigate the extent of convective overshoot. Previous helioseismic investigations have shown that the Sun's spherically symmetric stratification in this region is smoother than that in a standard solar model without overshooting, and have ruled out simple models incorporating overshooting, which extend the region of adiabatic stratification and have a more-or-less abrupt transition to subadiabatic stratification at the edge of the overshoot region. In this paper we consider physically motivated models which have a smooth transition in stratification bridging the region from the lower convection zone to the radiative interior beneath. We find that such a model is in better agreement with the helioseismic data than a standard solar model. [ABSTRACT FROM AUTHOR]
- Published
- 2011
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15. Atmospheric parameters and pulsational properties for a sample of δ Sct, γ Dor and hybrid Kepler targets.
- Author
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Catanzaro, G., Ripepi, V., Bernabei, S., Marconi, M., Balona, L., Kurtz, D. W., Smalley, B., Borucki, W. J., Bruntt, H., Christensen-Dalsgaard, J., Grigahcène, A., Kjeldsen, H., Koch, D. G., Monteiro, M. J. P. F. G., Suárez, J. C., Szabó, R., and Uytterhoeven, K.
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STELLAR oscillations ,SPECTRUM analysis ,FREQUENCY spectra ,SEISMOLOGY ,KEPLER'S laws ,STARS ,MATHEMATICAL models - Abstract
We report spectroscopic observations for 19 δ Sct candidates observed by the Kepler satellite both in long and short cadence mode. For all these stars, by using spectral synthesis, we derive the effective temperature, the surface gravity and the projected rotational velocity. An equivalent spectral-type classification has been also performed for all stars in the sample. These determinations are fundamental for modelling the frequency spectra that will be extracted from the Kepler data for asteroseismic inference. For all the 19 stars, we also present periodograms obtained from Kepler data. We find that all stars show peaks in both low- (γ Dor; g-mode) and high-frequency (δ Sct; p-mode) regions. Using the amplitudes and considering 5 cycles d as a boundary frequency, we classified three stars as pure γ Dor, four as γ Dor-δ hybrid Sct, five as δ Sct-γ Dor hybrid and six as pure δ Sct. The only exception is the star KIC 05296877, which we suggest could be a binary. [ABSTRACT FROM AUTHOR]
- Published
- 2011
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16. Cross-cultural adaptation and validation of the VISA-P questionnaire for Portuguese-speaking (Portugal) patients with patellar tendinopathy.
- Author
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Chaves, P, Ribeiro, D, Gomes, J, Monteiro, M, Marote, S, Frutuoso, S, Araújo, FA, and Paço, M
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CONFERENCES & conventions ,QUESTIONNAIRES ,JUMPER'S knee ,RESEARCH methodology evaluation - Abstract
Introduction Patellar tendinopathy is a condition frequently verified in individuals who practice regular physical activity, therefore functional evaluation is crucial to monitor symptoms. The VISA-P was developed for English-speaking population to evaluate patients with this condition, and there is a need to adapt this tool to Portuguese (Portugal). Objectives To cross-cultural adapt and validate the VISA-P questionnaire for Portuguese-speaking (Portugal) patellar tendinopathy patients Methodology The VISA-P questionnaire was translated and cross-culturally adapted into Portuguese (VISA-P-Por) according to specific guidelines, using six steps: Translation, synthesis, back translation, expert committee review, pretesting (n = 10), and appraisal of the adaptation process. The resulting VISA-P-Por was then subjected to an analysis of the psychometric properties (construct validity, reproducibility [agreement and reliability], internal consistency and floor and ceiling effects) in 73 patellar tendinopathy patients and 73 asymptomatic people. Participants completed the questionnaire at baseline and after a minimum interval of 48 hours. Results The Visa-P-Por questionnaire revealed a high level of agreement, presenting semantic and content validity. Construct validity showed differences between both groups (p < 0,001) and the questionnaire exhibited very good internal consistency, with an excellent α Cronbach (0,91). Concerning reproducibility, agreement levels were considered optimal which can be proven by the Bland Altman graph, the standard error of measurement (5,74) and the minimally important change (15,91 points), as well as the excellent ICC value (0,92). There were no ceiling and floor effects detected. Conclusion The VISA-P-Por questionnaire is a valid and reliable tool, with psychometric properties comparable with the original version. Thus, it can be recommended as a robust tool for measuring clinical severity and functional impact of patellar tendinopathy in Portuguese-speaking (Portugal) patients. [ABSTRACT FROM AUTHOR]
- Published
- 2020
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17. Seismic tests of the structure of rapidly oscillating Ap stars: HR 1217.
- Author
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Cunha, M. S., Fernandes, J. M. M. B., and Monteiro, M. J. P. F. G.
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STELLAR oscillations ,STARS ,MAGNETIC fields ,GALAXIES - Abstract
ABSTRACT HR 1217 is probably the best studied multiperiodic rapidly oscillating Ap star, which makes this star a test case for the seismic analysis of these complex stars. In this paper, we combine the observational data available for HR 1217 and use these data to constrain theoretical models appropriate for this star. In particular, we try to establish which unknown model parameters are the most relevant to reproduce the seismic data. We find that the interior chemical composition has more impact in the theoretical oscillation spectrum of HR 1217 than parameters related to the modelling of convection. Models with lower abundances of heavy elements and larger abundances of helium produce oscillation spectra that are closer to that observed. However, like Matthews et al., we show that it is difficult to find a plausible model that can reproduce the seismic observations of HR 1217, when the uncertainties in the observables are not taken into account, unless a complementary effect is added in order to account for a decrease in the expected large frequency separations. [ABSTRACT FROM AUTHOR]
- Published
- 2003
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18. Monitoring of exposure to acrylonitrile by determination of N-(2-cyanoethyl)valine at the N-terminal position of haemoglobin.
- Author
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Tavares, R., Borba, H., Monteiro, M., Proença, MJ., Lynce, N., Rueff, J., Bailey, E., Sweetman, G.M.A., Lawrence, R.M., and Farmer, P.B.
- Abstract
A selected ion monitoring gas chromatography-mass spectrometry (GC-MS) procedure was developed to determine the interaction product formed by acrylonitrile (ACN) with the N-terminal amino group in haemoglobin. The product, N-(2-cyanoethyl)valine (CEV), was analysed following its release from the protein by a modified Edman degradation procedure. Quantitation was achieved using N-(2-cyanoe-thyl)-[2H8]Val-Leu-Ser as internal standard. The limit of detection of the assay was 1 pmol CEV/g globin. A close to linear dose-response relationship was found for adduct formation in rats treated with ACN by gavage. On the basis of a linear extrapolation, a dose of 1 mg/kg body wt yielded 248 pmol CEV/g globin. Two groups of workers who were exposed to ACN contained 1984 ± SD 2066 (n = 9) and 2276 ± SD 1338 (n = 7) pmol CEV/g globin respectively. These values were highly significantly greater (P < 0.01 following a one-way analysis of variance with a logarithmic transformation of the data) than those in a group of control workers in the same factory (31.1 ± SD 18.5 pmol CEV/g globin, n = 11). The concentrations of N-terminal CEV in globin samples from 13 smoking and 10 non-smoking mothers and from their newborns were determined. Adduct levels in the smokers averaged 217 ± 85.1 pmol CEV/g globin, significantly higher than the levels in non-smokers, which were undetectable. Individual values in the mothers were very highly correlated with the levels in their babies (which averaged 99.5 ± 53.8 praol CEV/g globin), which demonstrates that transplacental transfer of ACN occurs. Significant correlations were also found between the number of cigarettes smoked per day by the mother and the CEV levels in both the mothers‘ and newborns’ globin. There was, however, no correlation between the CEV levels and those of the ethylene oxide adduct N-(2-hydroxyethyl)valine in samples from either the mothers or babies. [ABSTRACT FROM PUBLISHER]
- Published
- 1996
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19. On the mechanisms of genotoxicity and metabolism of quercetin.
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Gaspar, J., Rodrigues, A., Laires, A., Silva, F., Costa, S., Monteiro, M. J., Monteiro, C., and Rueff, J.
- Published
- 1994
20. Quercetin and the mutagenicity of wines.
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Gaspar, J., Laires, A., Monteiro, M., Laureano, O., and Ramos, E.
- Published
- 1993
21. Superior orbital ‘petrositis’ and late ischaemic monocular blindness induced by intense UV radiation exposure.
- Author
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Penatti, C. A. A., Monteiro, M. L., Marchiori, P. E., and Scaff, M.
- Subjects
NEUROPATHY ,ISCHEMIA ,NEUROMUSCULAR diseases ,EDEMA ,ELECTRIC shock - Abstract
Many physical agents cause neuropathies. The most common are chronic pressure, vibration and temperature. In general, these lesions occur at work, as a result of accidents or through chronic exposure to the physical agent. Radiation leading to peripheral neuropathy is also related to radiotherapy in cancer treatment, as an undesirable side‐effect. We present here a case report of short, intense UV radiation exposure at work, leading to delayed‐onset ocular neuropathy. A clear cause–effect relationship is shown, demonstrated using magnetic resonance imaging scans. We suggest that the mechanism was thermal and ischaemic. [ABSTRACT FROM PUBLISHER]
- Published
- 2002
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22. Reversible renal failure and SZ alpha1-antitrypsin phenotype. Association with liver disease and ethanol abuse.
- Author
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Nunes, J. P., Faria, M. S., Costa, E., Oliveira, J. P., Carneiro, F., Monteiro, M. C., Faria, V., and Guerra, L.
- Published
- 1995
23. O18 Development of help and surveillance technologies for dependent elderly people at home.
- Author
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Rodrigues, V, Monteiro, M J, Soares, S, Valente, A, Silva, S, Sousa, M, Duarte, D, Rainho, C, and Barroso, I
- Subjects
- *
AGING , *CONFERENCES & conventions , *PATIENT compliance , *PUBLIC health surveillance - Published
- 2019
- Full Text
- View/download PDF
24. Matrix metalloproteinase 9 and its tissue inhibitor 1 in obesity.
- Author
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Lopes, A, Alves, M, Pontes, J, Dias, N, Figueiredo, J, Santos, R, Loureiro, H, Castanheira, J, Osório, N, Monteiro, M, and Caseiro, A
- Subjects
OBESITY ,CONFERENCES & conventions ,MATRIX metalloproteinases ,TISSUE inhibitors of metalloproteinases ,CHEMICAL inhibitors - Published
- 2019
- Full Text
- View/download PDF
25. Interleukin 6 and Matrix Metalloproteinase 8 in obesity.
- Author
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Alves, M, Lopes, A, Pontes, J, Dias, N, Figueiredo, J, Santos, R, Loureiro, H, Castanheira, J, Osório, N, Monteiro, M, and Caseiro, A
- Subjects
OBESITY risk factors ,CONFERENCES & conventions ,ADIPOSE tissues ,INTERLEUKINS ,MATRIX metalloproteinases - Published
- 2019
- Full Text
- View/download PDF
26. Association between serum levels of C-reactive protein and lipid profile.
- Author
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Lopes, A, Alves, M, Pontes, J, Dias, N, Figueiredo, J, Santos, R, Loureiro, H, Castanheira, J, Osório, N, Monteiro, M, and Caseiro, A
- Subjects
CONFERENCES & conventions ,C-reactive protein ,CARDIOVASCULAR diseases risk factors ,LIPIDS - Published
- 2019
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- View/download PDF
27. (134) Early Impact of Androgen Deprivation Therapy on Endothelial Function and Metabolic Parameters in Prostate Cancer Patients: A Prospective Study.
- Author
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Cintra, A R, Linhares, B L, Da Rocha, E L, Monteiro, M M F, Da Trindade, K M, Lopes, M S R, Linhares-Filho, J P P, Da Silva, M J, Palmeira, H T, Bessa Jr, J, Miranda, E P, and Reges, R
- Subjects
- *
ANDROGEN deprivation therapy , *PROSTATE cancer patients , *GLYCOSYLATED hemoglobin , *BRACHIAL artery , *DYSLIPIDEMIA , *PROSTATE cancer , *INSULIN resistance - Abstract
Introduction: Androgen deprivation therapy (ADT) is considered one of the mainstays in the treatment of prostate cancer. ADT slows cancer progression, alleviates cancer-related symptoms, and is associated with survival gains. Despite these proven benefits, this treatment is related to several side effects, such as increased cardiovascular risk, changes in body composition and various metabolic changes. Although the well-established association between circulating testosterone level and endothelial integrity, the direct effects of ADT on endothelial function remain controversial. Objective: This study aimed to investigate the impact of ADT on endothelial function, through the analysis of vascular parameters of the brachial artery and measurement of serum inflammatory markers. It was also our aim to evaluate the early impact of ADT on body composition and metabolic parameters. Methods: We prospectively evaluated men with moderate to high-risk prostate cancer treated with ADT from January to December 2022 at our institution. Smokers and those who quit smoking less than five years ago, decompensated diabetics (glycated hemoglobin > 9%) and those who had already had a cardiovascular event were excluded. High-resolution B-mode ultrasound was used to assess vascular diameter and endothelium-dependent flow-mediated vasodilation (FMD) of the brachial artery. Our metabolic and inflammatory profile included measurement of serum total cholesterol and fractions, triglycerides, fasting glucose, glycated hemoglobin, basal insulin, C-reactive protein and assessment of body fat distribution through bioelectrical impedance. Subjects were evaluated at baseline and 3 months after starting ADT with goserelin acetate 10.80 mg. Results: A total of 32 men were included. The mean age was 69 years and the prevalence of diabetes was 31.25%. FMD demonstrated a worsening trend after ADT, which did not reach statistical significance after 3 months (mean 3.39 ± 6.83 vs 1.16 ± 7.65; p = 0.14) (figure 1). Baseline brachial artery diameter also showed a tendency to worsen with ADT compared to baseline (0.44 ± 0.06 vs 0.42 ± 0.06; p = 0.06). With regard to the metabolic profile, ADT significantly increased insulin resistance: fasting glucose (mean 104.10 ± 18.96 vs 110.60 ± 25.29; p = 0.01), fasting insulin levels (mean 13.05 ± 8.76 vs 16.82 ± 11.36; p = 0.003), glycated hemoglobin (mean 5.89% ± 0.46 vs 6.15% ± 0.67; p = 0.008) and homeostatic model assessment insulin resistance (mean 3.47 ± 2.55 vs 5.05 ± 4.50; p = 0.005) increased significantly after 3 months. Triglycerides concentrations (mean 142.30 ± 69.66 vs 165.50 ± 93.04; p = 0.03) were higher after 3 months of ADT. Abdominal circumference (mean 98.66 ± 10.16 vs 99.76 ± 9.39; p = 0.02) and body mass index (mean 27.46 ± 4.06 vs 27.76 ± 3.89; p = 0.02) also increased after ADT. Conclusions: Although not statistically significant, the present study demonstrated a trend towards a decrease in brachial artery FMD. We also observed an important and surprisingly early worsening of the metabolic profile with ADT, especially increased insulin resistance and dyslipidemia, which represent well-established risk factors for cardiovascular events. Disclosure: No. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
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