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We present a new determination of the evolving galaxy ultraviolet (UV) luminosity function (LF) over the redshift range |$8.5< z< 15.5$| using a combination of several major Cycle-1 JWST imaging programmes – Public Release IMaging for Extragalactic Research, JWST Advanced Deep Extragalactic Survey, and Next Generation Deep Extragalactic Exploratory Public Survey. This multifield approach yields a total of |$\simeq 370$| arcmin2 of JWST /NIRCam imaging, reaching (5- |$\sigma$|⁠) depths of |$\simeq 30$| AB mag in the deepest regions. We select a sample of 2548 galaxies with a significant probability of lying at high redshift (⁠|$p(z> 8.5)> 0.05$|⁠) to undertake a statistical calculation of the UV LF. Our new measurements span |$\simeq 4$|  mag in UV luminosity at |$z=9-12.5$|⁠ , placing new constraints on both the shape and evolution of the LF at early times. Our measurements yield a new estimate of the early evolution of cosmic star-formation rate density (⁠|$\rho _{\rm {SFR}}$|⁠) confirming the gradual decline deduced from early JWST studies, at least out to |$z \simeq 12$|⁠. Finally we show that the observed early evolution of the galaxy UV LF (and |$\rho _{\rm {SFR}}$|⁠) can be reproduced in a |${\rm \Lambda }$| cold dark matter Universe, with no change in dust properties or star-formation efficiency required out to |$z \simeq 12$|⁠. Instead, a progressive trend towards younger stellar population ages can reproduce the observations, and the typical ages required at |$z \simeq$| 8, 9, 10, and 11 all converge on |$\simeq 380-330$|  Myr after the big bang, indicative of a rapid emergence of early galaxies at |$z \simeq 12 - 13$|⁠. This is consistent with the first indications of a steeper drop-off in |$\rho _{\rm {SFR}}$| we find beyond |$z \simeq 13$|⁠ , possibly reflecting the rapid evolution of the halo mass function at earlier times. [ABSTRACT FROM AUTHOR]

Multiple explosion mechanisms have been proposed to explain type Ia supernovae (SNe Ia). Empirical modelling tools have also been developed that allow for fast, customized modelling of individual SNe and direct comparisons between observations and explosion model predictions. Such tools have provided useful insights, but the subjective nature with which empirical modelling is performed makes it difficult to obtain robust constraints on the explosion physics or expand studies to large populations of objects. Machine learning accelerated tools have therefore begun to gain traction. In this paper, we present riddler , a framework for automated fitting of SNe Ia spectral sequences up to shortly after maximum light. We train a series of neural networks on realistic ejecta profiles predicted by the W7 and N100 explosion models to emulate full radiative transfer simulations and apply nested sampling to determine the best-fitting model parameters for multiple spectra of a given SN simultaneously. We show that riddler is able to accurately recover the parameters of input spectra and use it to fit observations of two well-studied SNe Ia. We also investigate the impact of different weighting schemes when performing quantitative spectral fitting and show that best-fitting models and parameters are highly dependent on the assumed weighting schemes and priors. As spectroscopic samples of SNe Ia continue to grow, automated spectral fitting tools such as riddler will become increasingly important to maximise the physical constraints that can be gained in a quantitative and consistent manner. [ABSTRACT FROM AUTHOR]

We present an analysis of the ultraviolet (UV) continuum slopes (β) for a sample of 172 galaxy candidates at 8 < z phot < 16 selected from a combination of JWST NIRCam imaging and COSMOS/UltraVISTA ground-based near-infrared imaging. Focusing primarily on a new sample of 121 galaxies at 〈 z 〉 ≃ 11 selected from ≃ 320 arcmin2 of public JWST imaging data across 15 independent data sets, we investigate the evolution of β in the galaxy population at z ≥ 9. We find a significant trend between β and redshift, with the inverse-variance weighted mean UV slope evolving from 〈β〉 = −2.17 ± 0.06 at z  = 9.5 to 〈β〉 = −2.59 ± 0.06 at z  = 11.5. Based on a comparison with stellar population models including nebular continuum emission, we find that at z > 10.5 the average UV continuum slope is consistent with the intrinsic blue limit of dust-free stellar populations (βint ≃ −2.6). These results suggest that the moderately dust-reddened galaxy population at z < 10 was essentially unattenuated at z ≃ 11. The extremely blue galaxies being uncovered at z > 10 place important constraints on dust attenuation in galaxies in the early Universe, and imply that the already observed galaxy population is likely supplying an ionizing photon budget capable of maintaining ionized intergalactic medium fractions of ≳ 5 per cent at z ≃ 11. [ABSTRACT FROM AUTHOR]

Informal sport is a growth area of sport participation but there has been limited examination of how informal and unstructured forms of participation may contribute to health outcomes that are important for public health. This article aims to address the current lack of data examining the health outcomes associated with informal sport participation and consider the potential role of informal sport within efforts to promote healthier communities through sport. The article seeks to broaden understanding of how informal sport participation can contribute to health outcomes, particularly with regard to increasing physical activity and enhancing mental health and social connection. The article discusses the findings of an Australian mixed-method study that draws on observation, survey, interview and focus group data to examine the prospective health and social benefits of informal sport participation for adults. The findings demonstrate that informal sport participation can contribute to physical and mental health outcomes and facilitate social connection. Analysis of the observation data enabled an examination of the economic value of informal sport in relation to the health benefits it affords. The study provides valuable evidence of the value of informal sport for enhancing community health and broadens understanding of how sport can be utilized as a health promotion resource. The article concludes by suggesting that through leveraging existing infrastructure and the self-organizing aspects of informal sport, local government and health stakeholders can harness its potential to improve public health outcomes and address health inequities. [ABSTRACT FROM AUTHOR]

The concept of relationship completion is embodied as the core belief for end-of-life care in Taiwan, known as the Four Expressions in Life. No studies have been published investigating and trying to understand how music therapy facilitates the Four Expressions in Life. This convergent mixed-methods study examined the effects of music therapy to facilitate relationship completion for patients at the end of life and their families in Taiwan, and explored their personal experiences in music therapy sessions. Thirty-four patients at end-of-life care and 36 of their family members participated in a single music therapy session with a one-group pretest-posttest design using standardized quality-of-life measures for patients at the end of life and families. A nested sample of 5 patients and 9 family members completed semi-structured interviews. Significant differences between the pre and post session scores were revealed for patients in the Life Completion subscale of the QUAL-E (p  < .001), and the global QoL Indicator (p  < .001), and for families in the Completion subscale of the QUAL-E (Fam) (p  < .001), and the Overall Quality of Life (p  < .001). Four themes around opportunities emerged from the interviews: the opportunity for exploration, for connection, for expression, and for healing. The integrated findings suggest that music therapy facilitated relationship completion and improved quality of life for both patients and their families. Furthermore, this study supports that the transformative level of music therapy practice within a single session for end-of-life care is attainable. [ABSTRACT FROM AUTHOR]

Phylogenetic and discrete-trait evolutionary inference depend heavily on an appropriate characterization of the underlying character substitution process. In this paper, we present random-effects substitution models that extend common continuous-time Markov chain models into a richer class of processes capable of capturing a wider variety of substitution dynamics. As these random-effects substitution models often require many more parameters than their usual counterparts, inference can be both statistically and computationally challenging. Thus, we also propose an efficient approach to compute an approximation to the gradient of the data likelihood with respect to all unknown substitution model parameters. We demonstrate that this approximate gradient enables scaling of sampling-based inference, namely Bayesian inference via Hamiltonian Monte Carlo, under random-effects substitution models across large trees and state-spaces. Applied to a dataset of 583 SARS-CoV-2 sequences, an HKY model with random-effects shows strong signals of nonreversibility in the substitution process, and posterior predictive model checks clearly show that it is a more adequate model than a reversible model. When analyzing the pattern of phylogeographic spread of 1441 influenza A virus (H3N2) sequences between 14 regions, a random-effects phylogeographic substitution model infers that air travel volume adequately predicts almost all dispersal rates. A random-effects state-dependent substitution model reveals no evidence for an effect of arboreality on the swimming mode in the tree frog subfamily Hylinae. Simulations reveal that random-effects substitution models can accommodate both negligible and radical departures from the underlying base substitution model. We show that our gradient-based inference approach is over an order of magnitude more time efficient than conventional approaches. [ABSTRACT FROM AUTHOR]

Aims In this study, we evaluated the phenotypic virulence characteristics of avian pathogenic Escherichia coli (APEC) isolates from broiler breeders with colibacillosis in Mississippi. Also, the relationship between phenotypic and genotypic virulence patterns was determined. Methods and Results Twenty-eight APEC isolated from lesions of broiler breeders diagnosed with colibacillosis were used for embryo lethality assay and chick challenge study. The percentage of embryo mortality following embryo lethality assay and pathogenicity score following the chick challenge study were used to categorize the isolates based on virulence. Pearson correlation analysis was performed to determine the relationship between embryo mortality, chick pathogenicity, and the presence of virulence-associated genes in the isolates. Overall, 39.3% of the isolates were highly virulent and 3.5% were avirulent, following both assays. There existed a positive correlation between embryo mortality and chick pathogenicity (r  = 0.73, P  < .01), as well as percentage embryo mortality and pathogenicity score with the presence of some virulence genes. Conclusions Even though all the APEC were isolated from lesions of diseased breeders, the virulence potential varied from being avirulent to highly virulent. Further, we identified a positive relationship between phenotypic virulence and the frequency of virulence-associated genes. [ABSTRACT FROM AUTHOR]

With the advent of JWST , we can probe the rest-frame optical emission of galaxies at |$z\gt 3$| with high sensitivity and spatial resolution, making it possible to accurately characterize red, optically faint galaxies and thus move towards a more complete census of the galaxy population at high redshifts. To this end, we present a sample of 148 massive, dusty galaxies from the JWST /Cosmic Evolution Early Release Science survey, colour-selected using solely JWST bands. With deep JWST /NIRCam data from 1.15 to 4.44  |$\mu$| m and ancillary HST /ACS and WFC3 data, we determine the physical properties of our sample using spectral energy distribution fitting with bagpipes. We demonstrate that our selection method efficiently identifies massive (⁠|$\mathrm{\langle \log {\it M}_\star /M_\odot \rangle \sim 10}$|⁠) and dusty (⁠|$\mathrm{\langle {\it A}_V\rangle \sim 2.7\ mag}$|⁠) sources, with a majority at |$z\,\gt\, 3$| and predominantly lying on the galaxy main sequence. The main results of this work are the stellar mass functions (SMFs) of red, optically faint galaxies from redshifts between |$3\,\lt\, z\,\lt\, 8$|⁠ : these galaxies make up a significant relative fraction of the pre- JWST total SMF at |$3\,\lt\, z\,\lt\, 4$| and |$4\,\lt\, z\,\lt\, 6$|⁠ , and dominate the high-mass end of the pre- JWST SMF at |$6\,\lt\, z\,\lt \,8$|⁠ , suggesting that our census of the galaxy population needs amendment at these epochs. While larger areas need to be surveyed in the future, our results suggest already that the integrated stellar mass density at |$\mathrm{\log {\it M}_\star /M_\odot \ge 9.25}$| may have been underestimated in pre- JWST studies by up to |$\sim$| 15–20% at |$z\sim 3{\!-\!}6$|⁠ , and up to |$\sim$| 45% at |$z\sim 6{\!-\!}8$|⁠ , indicating the rapid onset of obscured stellar mass assembly in the early Universe. [ABSTRACT FROM AUTHOR]

Individuals' beliefs about their opinion-related tendencies should interest public opinion researchers for at least two reasons. First, these beliefs could influence opinion-related behaviors. Second, they are likely to indicate tendencies that transcend specific situations and pertain to a wide range of subjects for which opinions can be held. This study investigates the associations of demographic characteristics, material and social resources, and subjective experiences with the belief that one tends to develop independent opinions (i.e. opinion autonomy) and expresses one's minority opinions (i.e. expressed autonomy). Effects are estimated through analyses of three waves of data collected from a sample of the U.S. adult population. Education, age, community rank, financial stress, and shame are revealed to have effects of similar magnitude on expressed autonomy and opinion autonomy. Gender is the only variable investigated associated with only one form of autonomy—expressed autonomy. The findings are interpreted through the lenses of identity and affect control theories. Processes related to maintaining authenticity, perceived self-worthiness, and confidence in oneself as an independent thinker and agent are theorized as underlying the results. [ABSTRACT FROM AUTHOR]

This study investigated the experiences of music therapy private practice business leaders providing services in school, healthcare, and community settings, including clients' homes, during the first 12 months of the COVID-19 pandemic. Qualitative content analysis was utilized to analyze semi-structured interview data collected from 10 business leaders (5 CEOs and 5 clinical directors) recruited from 5 businesses. 8 themes were revealed: (1) significant impact shaped by uncertainty and values, (2) temporal dimensions of change, (3) changing dynamics of relationships, (4) issues leading to burnout, (5) unexpected opportunities for all stakeholders, (6) the weight of being responsive, (7) the ambiguity of role changes, and (8) the collective functioning of the clinical team. In the context of leadership and teamwork, these themes illuminated the challenges these business leaders encountered while also providing insights into the importance of collaborative structures, transparent communication, and flexibility integral to leading organizational change. Further, resilience, robustness, and antifragility provide theoretical constructs through which to consider change processes, providing music therapy professionals with the opportunity to consider core leadership, teamwork, and organizational characteristics essential to music therapy teams. [ABSTRACT FROM AUTHOR]

We present a new determination of the evolving galaxy ultraviolet (UV) luminosity function (LF) over the redshift range 9.5 < z < 12.5 based on a wide-area (>250 arcmin2) data set of JWST NIRCam near-infrared imaging assembled from 13 public JWST surveys. Our relatively large-area search allows us to uncover a sample of 61 robust z > 9.5 candidates detected at ≥8σ, and hence place new constraints on the intermediate-to-bright end of the UV LF. When combined with our previous JWST  + UltraVISTA results, this allows us to measure the form of the LF over a luminosity range corresponding to four magnitudes (M 1500). At these early times we find that the galaxy UV LF is best described by a double power-law function, consistent with results obtained from recent ground-based and early JWST studies at similar redshifts. Our measurements provide further evidence for a relative lack of evolution at the bright-end of the UV LF at z  = 9–11, but do favour a steep faint-end slope (α ≤ −2). The luminosity-weighted integral of our evolving UV LF provides further evidence for a gradual smooth (exponential) decline in co-moving star-formation rate density (ρSFR) at least out to z ≃ 12, with our determination of ρSFR(z  = 11) lying significantly above the predictions of many theoretical models of galaxy evolution. [ABSTRACT FROM AUTHOR]

Acetaminophen (APAP) overdose stands as the primary cause of acute liver failure in the United States. APAP hepatotoxicity involves hepatic glutathione (GSH) depletion and mitochondrial damage. To counteract the toxicity of APAP, the nuclear factor erythroid 2 like 2 (Nrf2) activates the expression of genes responsible for drug detoxification and GSH synthesis. In this study, we present evidence that the elimination of hepatocyte small heterodimer partner, a critical transcriptional repressor for liver metabolism, results in Nrf2 activation and protects mice from APAP-induced acute liver injury. Initial investigations conducted on wildtype (WT) mice revealed a swift downregulation of Shp mRNA within the first 24 h after APAP administration. Subsequent treatment of hepatocyte-specific Shp knockout (Shp Hep−/−) mice with 300 mg/kg APAP for 2 h exhibited comparable bioactivation of APAP with that observed in the WT controls. However, a significant reduction in liver injury was observed in Shp Hep−/− after APAP treatment for 6 and 24 h. The decreased liver injury correlated with a faster recovery of GSH, attributable to heightened expression of Nrf2 target genes involved in APAP detoxification and GSH synthesis. Moreover, in vitro studies revealed that SHP protein interacted with NRF2 protein, inhibiting the transcription of Nrf2 target genes. These findings hold relevance for humans, as overexpression of SHP hindered APAP-induced NRF2 activation in primary human hepatocytes. In conclusion, our studies have unveiled a novel regulatory axis involving SHP and NRF2 in APAP-induced acute liver injury, emphasizing SHP as a promising therapeutic target in APAP overdose-induced hepatotoxicity. [ABSTRACT FROM AUTHOR]

Highly conserved transport protein particle (TRAPP) complexes regulate subcellular trafficking pathways. Accurate protein trafficking has been increasingly recognized to be critically important for normal development, particularly in the nervous system. Variants in most TRAPP complex subunits have been found to lead to neurodevelopmental disorders with diverse but overlapping phenotypes. We expand on limited prior reports on TRAPPC6B with detailed clinical and neuroradiologic assessments, and studies on mechanisms of disease, and new types of variants. We describe 29 additional patients from 18 independent families with biallelic variants in TRAPPC6B. We identified seven homozygous nonsense (n = 12 patients) and eight canonical splice-site variants (n = 17 patients). In addition, we identified one patient with compound heterozygous splice-site/missense variants with a milder phenotype and one patient with homozygous missense variants. Patients displayed non-progressive microcephaly, global developmental delay/intellectual disability, epilepsy and absent expressive language. Movement disorders including stereotypies, spasticity and dystonia were also observed. Brain imaging revealed reductions in cortex, cerebellum and corpus callosum size with frequent white matter hyperintensity. Volumetric measurements indicated globally diminished volume rather than specific regional losses. We identified a reduced rate of trafficking into the Golgi apparatus and Golgi fragmentation in patient-derived fibroblasts that was rescued by wild-type TRAPPC6B. Molecular studies revealed a weakened interaction between mutant TRAPPC6B (c.454C>T, p.Q152*) and its TRAPP binding partner TRAPPC3. Patient-derived fibroblasts from the TRAPPC6B (c.454C>T, p.Q152*) variant displayed reduced levels of TRAPPC6B as well as other TRAPP II complex-specific members (TRAPPC9 and TRAPPC10). Interestingly, the levels of the TRAPPC6B homologue TRAPPC6A were found to be elevated. Moreover, co-immunoprecipitation experiments showed that TRAPPC6A co-precipitates equally with TRAPP II and TRAPP III, while TRAPPC6B co-precipitates significantly more with TRAPP II, suggesting enrichment of the protein in the TRAPP II complex. This implies that variants in TRAPPC6B may preferentially affect TRAPP II functions compared to TRAPP III functions. Finally, we assessed phenotypes in a Drosophila TRAPPC6B -deficiency model. Neuronal TRAPPC6B knockdown impaired locomotion and led to wing posture defects, supporting a role for TRAPPC6B in neuromotor function. Our findings confirm the association of damaging biallelic TRAPPC6B variants with microcephaly, intellectual disability, language impairments, and epilepsy. A subset of patients also exhibited dystonia and/or spasticity with impaired ambulation. These features overlap with disorders arising from pathogenic variants in other TRAPP subunits, particularly components of the TRAPP II complex. These findings suggest that TRAPPC6B is essential for brain development and function, and TRAPP II complex activity may be particularly relevant for mediating this function. [ABSTRACT FROM AUTHOR]

Strong gravitationally lensed supernovae (glSNe) are a powerful probe to obtain a measure of the expansion rate of the Universe, but they are also extremely rare. To date, only two glSNe with multiple images strongly lensed by galaxies have been found, but their short time delays make them unsuitable for cosmography. Here, we simulate a realistic catalogue of lensed supernovae and study the characteristics of the population of detectable systems for different surveys. Compared to previous studies, our simulations also account for the effect of microlensing and its impact on the glSNe yields. We show that the properties of glSNe in shallow surveys (such as the Zwicky Transient Facility) are determined by the need for large magnifications, which favours systems of four images with short time delays and low image separations. This picture is consistent with the properties of iPTF16geu and SN Zwicky, but is not representative of the population found in deeper surveys, which are limited by the volume of the Universe that is strongly lensed. For deeper surveys, such as the Legacy Survey of Space and Time (LSST), glSNe show longer time delays and greater angular separations, and the inclusion of microlensing results in 8  per cent of glSNe becoming demagnified under the detection threshold. In the 10 yr of the survey LSST should be able to find ≈180 systems, of which 70 will be suited for cosmography enabling a ≈1.2  per cent precision H 0 measurement with LSST glSNe. [ABSTRACT FROM AUTHOR]

Strong gravitational lensing of supernovae is exceedingly rare. To date, only a handful of lensed supernovae are known. Despite this, lensed supernovae have emerged as a promising method for measuring the current expansion rate of the Universe and breaking the Hubble tension. We present an extensive search for gravitationally lensed supernovae within the Zwicky Transient Facility (ZTF) public survey, covering 15 215 transients with good light curves discovered during 4 yr of observations. We cross-match a catalogue of known and candidate lens galaxies with our sample and find three coincident sources, which were due to chance alignment. To search for supernovae magnified by unknown lenses, we test multiple methods suggested in the literature for the first time on real data. This includes selecting objects with extremely red colours, those that appear inconsistent with the host galaxy redshift, and those with bright absolute magnitudes inferred from the host galaxy redshift. We find a few hundred candidates, most of which are due to contamination from activate galactic nuclei, bogus detections, or unlensed supernovae. The false positive rate from these methods presents significant challenges for future surveys. In total, 132 unique transients were identified across all of our selection methods that required detailed manual rejection, which would be infeasible for larger samples. Overall, we do not find any compelling candidates for lensed supernovae, which is broadly consistent with previous estimates for the rate of lensed supernovae from the ZTF public survey alone and the number expected to pass the selection cuts we apply. [ABSTRACT FROM AUTHOR]

Early observations of transient explosions can provide vital clues to their progenitor origins. In this paper, we present the nearby Type Iax (02cx-like) supernova (SN), SN 2020udy, that was discovered within hours (∼7 h) of estimated first light. An extensive data set of ultra-violet, optical, and near-infrared observations was obtained, covering out to ∼150 d after explosion. SN 2020udy peaked at −17.86 ± 0.43 mag in the r band and evolved similarly to other 'luminous' SNe Iax, such as SNe 2005hk and 2012Z. Its well-sampled early light curve allows strict limits on companion interaction to be placed. Main-sequence companion stars with masses of 2 and 6 M⊙ are ruled out at all viewing angles, while a helium-star companion is allowed from a narrow range of angles (140–180° away from the companion). The spectra and light curves of SN 2020udy are in good agreement with those of the 'N5def' deflagration model of a near Chandrasekhar-mass carbon–oxygen white dwarf. However, as has been seen in previous studies of similar luminosity events, SN 2020udy evolves slower than the model. Broad-band linear polarization measurements taken at and after peak are consistent with no polarization, in agreement with the predictions of the companion-star configuration from the early light-curve measurements. The host galaxy environment is low metallicity and is consistent with a young stellar population. Overall, we find the most plausible explosion scenario to be the incomplete disruption of a CO white dwarf near the Chandrasekhar-mass limit, with a helium-star companion. [ABSTRACT FROM AUTHOR]

This article focuses on uses and experiences of everyday sensory technologies by racially and ethnically diverse persons with disabilites, bringing our research to the junction of critical technology studies, migration studies, and critical disability studies. We draw on a large-scale qualitative project that involves new and second-generation migrants with disabilities from a socio-economically disadvantaged area in Sydney, Australia. Findings show the negotiated exchanges of inclusion and exclusion that disabled people from diverse racial and ethnic minority backgrounds encounter with sensory and other technologies. While such technologies have rightfully been criticized for their roles in the surveillance, regulation, exclusion, and financialization of disability and ethnically diverse groups, these negotiations show how processes of agency, awareness, and peer support produce and in turn benefit from encounters with technology in complex ways. We argue the continued emergence of automation warrants both critique and cautious ongoing experimentation. [ABSTRACT FROM AUTHOR]

Recurrent hyperparathyroidism (HPT) after initial parathyroid surgery occurs rarely in an ectopic location. The rare phenomenon of parathyromatosis may be the cause of this. We present the case of a 59-year-old woman with recurrent HPT, which presented as a new ectopic mediastinal parathyroid gland 13 years after initial 3.5 gland parathyroidectomy. A 1.5 × 1.3 cm lesion was discovered as an incidental finding in the pretracheal region, closely abutting the aortic arch. An aspirate revealed oncocytic cells, which were positive for parathyroid hormone, confirming a mediastinal parathyroid nodule. Sestamibi scan confirmed an avid nodule in the mediastinum. This patient had multiple co-morbidities but was asymptomatic of HPT. It was therefore decided at multi-disciplinary team discussion that she should undergo surveillance. To our knowledge, no such presentations have been reported in the literature. Thus, our case report is a unique addition of an atypical presentation of HPT. [ABSTRACT FROM AUTHOR]

We investigate the ability of human 'expert' classifiers to identify strong gravitational lens candidates in Dark Energy Survey like imaging. We recruited a total of 55 people that completed more than 25 per cent of the project. During the classification task, we present to the participants 1489 images. The sample contains a variety of data including lens simulations, real lenses, non-lens examples, and unlabelled data. We find that experts are extremely good at finding bright, well-resolved Einstein rings, while arcs with g -band signal to noise less than ∼25 or Einstein radii less than ∼1.2 times the seeing are rarely recovered. Very few non-lenses are scored highly. There is substantial variation in the performance of individual classifiers, but they do not appear to depend on the classifier's experience, confidence or academic position. These variations can be mitigated with a team of 6 or more independent classifiers. Our results give confidence that humans are a reliable pruning step for lens candidates, providing pure and quantifiably complete samples for follow-up studies. [ABSTRACT FROM AUTHOR]

We have derived luminosity functions and set constraints on the UV luminosity and SFR density from z ∼ 17 to z ∼ 8, using the three most-studied JWST/NIRCam data sets, the SMACS0723, GLASS Parallel, and CEERS fields. We first used our own selections on two independent reductions of these data sets using the latest calibrations. A total of 18 z ∼ 8, 12 z ∼ 10, 5 z ∼ 13, and 1 z ∼ 17 candidate galaxies are identified over these fields in our primary reductions, with a similar number of candidates in our secondary reductions. We then use these two reductions, applying a quantitative discriminator, to segregate the full set of z ≥ 8 candidates reported over these fields from the literature, into three different samples, 'robust', 'solid', and 'possible'. Using all of these samples, we then derive UV LF and luminosity density results at z ≥ 8, finding substantial differences. For example, including the full set of 'solid' and 'possible' z ≥ 12 candidates from the literature, we find UV luminosity densities, which are ∼7× and ∼20× higher than relying on the 'robust' candidates alone. These results indicate the evolution of the UV LF and luminosity densities at z ≥ 8 is still extremely uncertain, emphasizing the need for spectroscopy and deeper NIRCam + optical imaging to obtain reliable results. Nevertheless, even with the very conservative 'robust' approach to selections, both from our own and those of other studies, we find the luminosity density from luminous (MUV < −19) galaxies to be ∼2 × larger than is easily achievable using constant star formation efficiency models, similar to what other early JWST results have suggested. [ABSTRACT FROM AUTHOR]

Context Vitamin D deficiency is a global public health issue, particularly in nursing home residents. Objective This review critically summarizes the prevalence of vitamin D deficiency in nursing home residents worldwide. In addition, it outlines the effect of vitamin D intervention, alone or in combination with other nutrients or therapies, on improving vitamin D status and associated health outcomes in nursing home residents. Data Sources, Extraction, and Analysis Searches were conducted of electronic databases for articles published from 2010 to May 2021. After screening of the 366 papers initially identified, 58 articles were included. Conclusions A paucity of observational studies in nursing homes suggests a high prevalence of vitamin D deficiency ranging from 8% [25(OH)D <25 nmol/L], up to 94% [25(OH)D <50 nmol/L] in some cohorts where supplement use was low. Reported factors associated with deficiency and suboptimal vitamin D status include lack of sunlight exposure, poor dietary intake of vitamin D, limited vitamin D food fortification, frailty, poor renal function, and low use of vitamin D supplements. Residents who are severely deficient, deficient, or insufficient in vitamin D require remedial vitamin D supplementation prior to maintenance supplementation at doses >800 IU/day. High-dose vitamin D supplementation may reduce respiratory illness; however, supportive data are limited. Oral nutritional supplements, in combination with exercise, may benefit physical function and performance, whereas supplementation with vitamin D– and calcium-fortified foods has been associated with improved quality of life and reduced bone resorption. Globally, vitamin D deficiency is highly prevalent in nursing home residents. There is an urgent need for standardized dietary and supplementation guidelines to prevent deficiency in this vulnerable group. [ABSTRACT FROM AUTHOR]

An open question in SN Ia research is where the boundary lies between 'normal' Type Ia supernovae (SNe Ia) that are used in cosmological measurements and those that sit off the Phillips relation. We present the spectroscopic modelling of one such '86G-like' transitional SN Ia, SN 2021rhu, that has recently been employed as a local Hubble Constant calibrator using a tip of the red-giant branch measurement. We detail its modelling from −12 d until maximum brightness using the radiative-transfer spectral-synthesis code tardis. Please check and correct this paper accordingly. We base our modelling on literature delayed-detonation and deflagration models of Chandrasekhar mass white dwarfs, as well as the double-detonation models of sub-Chandrasekhar mass white dwarfs. We present a new method for 'projecting' abundance profiles to different density profiles for ease of computation. Due to the small velocity extent and low outer densities of the W7 profile, we find it inadequate to reproduce the evolution of SN 2021rhu as it fails to match the high-velocity calcium components. The host extinction of SN 2021rhu is uncertain but we use modelling with and without an extinction correction to set lower and upper limits on the abundances of individual species. Comparing these limits to literature models we conclude that the spectral evolution of SN 2021rhu is also incompatible with double-detonation scenarios, lying more in line with those resulting from the delayed-detonation mechanism (although there are some discrepancies, in particular a larger titanium abundance in SN 2021rhu compared to the literature). This suggests that SN 2021rhu is likely a lower luminosity, and hence lower temperature, version of a normal SN Ia. [ABSTRACT FROM AUTHOR]

Over the last few years, both Atacama Large Millimeter/submillimeter Array (ALMA) and Spitzer observations have revealed a population of likely massive galaxies at z > 3 that was too faint to be detected in Hubble Space Telescope (HST) rest-frame ultraviolet imaging. However, due to the very limited photometry for individual galaxies, the true nature of these so-called HST -dark galaxies has remained elusive. Here, we present the first sample of such galaxies observed with very deep, high-resolution NIRCam imaging from the Early Release Science programme CEERS. 30 HST -dark sources are selected based on their red colours across 1.6–4.4 |$\mu$| m. Their physical properties are derived from 12-band multiwavelength photometry, including ancillary HST imaging. We find that these galaxies are generally heavily dust-obscured (AV ∼ 2 mag), massive (log (M /M⊙) ∼ 10), star-forming sources at z ∼ 2−8 with an observed surface density of ∼0.8 arcmin−2. This suggests that an important fraction of massive galaxies may have been missing from our cosmic census at z > 3 all the way into the Epoch of Reionization. The HST -dark sources lie on the main sequence of galaxies and add an obscured star formation rate density of |$\mathrm{3.2^{+1.8}_{-1.3} \times 10^{-3} \,{\rm M}_{\odot }\,yr^{-1}\,Mpc^{-3}}$| at z ∼ 7, showing likely presence of dust in the Epoch of Reionization. Our analysis shows the unique power of JWST to reveal this previously missing galaxy population and to provide a more complete census of galaxies at z  = 2−8 based on rest-frame optical imaging. [ABSTRACT FROM AUTHOR]

Background: Diabetes mellitus (DM) is a well-established risk factor for active tuberculosis (TB) infection. Despite the worldwide rapid increase in the prevalence of prediabetes, its impact on the risk of active TB remains largely unknown. This study aimed to investigate the relationship between prediabetes and risk of active TB in a large cohort study.Methods: A total of 119 352 participants were screened from a community-based health screening programme in Northern Taiwan. Diabetes mellitus and prediabetes were defined by baseline fasting plasma glucose (FPG) and prescription of anti-diabetic drugs. Incident cases of active TB were identified from the National Tuberculosis Registry. Kaplan-Meier curves and Cox regression analysis were employed to estimate the hazard ratios for prediabetes and DM compared with normoglycaemia. Spline regression was performed to investigate the dose-response relationship between FPG level and risk of TB disease.Results: At baseline, 27 404 (22.96%) participants had prediabetes and 10 943 (9.17%) participants had DM. After an average follow-up of 7.2 years, 322 TB cases occurred. The adjusted hazard ratio of developing active TB disease was 0.73 [95% confidence interval (CI) 0.55-0.97] for prediabetic and 1.48 (95% CI 1.11-1.98) for diabetic participants compared with normoglycaemic individuals. Spline regression revealed a U-shaped association between FPG level and risk of active TB disease, with the lowest risk at FPG around110 mg/dl. Sensitivity analyses were conducted to exclude factors such as potential confounders (including body mass index), misclassification of glycaemic level, and selection bias, and results showed that those factors could not explain the lower risk of active TB.Conclusions: Prediabetes was associated with a 27% reduced risk of active TB disease compared with normoglycaemia. The biological mechanism of this inverse association and its implication for global nutrition transition and TB control should be further investigated. [ABSTRACT FROM AUTHOR]

Background Diabetes mellitus and human immunodeficiency virus (HIV) are independent risk factors for poor outcomes among people with tuberculosis (TB). To date, information on the joint impact of diabetes and HIV on TB outcomes is limited. We aimed to estimate (1) the association between hyperglycemia and mortality and (2) the effect of joint exposure to diabetes and HIV on mortality. Methods We conducted a retrospective cohort study among people with TB in the state of Georgia between 2015 and 2020. Eligible participants were 16 or older, did not have a previous TB diagnosis, and were microbiologically confirmed or clinical cases. Participants were followed during TB treatment. Robust Poisson regression was used to estimate risk ratios for all-cause mortality. Interaction between diabetes and HIV was assessed on the additive scale using the attributable proportion and on the multiplicative scale with product terms in regression models. Results Of 1109 participants, 318 (28.7%) had diabetes, 92 (8.3%) were HIV positive, and 15 (1.4%) had diabetes and HIV. Overall, 9.8% died during TB treatment. Diabetes was associated with an increased risk of death among people with TB (adjusted risk ratio [aRR] = 2.59; 95% confidence interval [CI], 1.62–4.13). We estimated that 26% (95% CI, −43.4% to 95.0%) of deaths among participants with diabetes mellitus and HIV were due to biologic interaction. Conclusions Diabetes alone and co-occurring diabetes and HIV were associated with an increased risk of all-cause mortality during TB treatment. These data suggest a potential synergistic effect between diabetes and HIV. [ABSTRACT FROM AUTHOR]

Aligned with best practice guidelines for patients presenting with a disorder of consciousness (DoC), music therapy interventions with this population aim to increase arousal and awareness to support emergence to consciousness. There is a significant evidence base supporting music therapy for adults with a DoC; however, there are currently no published tools that systematically capture behavioral responses of this population during rehabilitative music therapy interventions. Further, the developmentally specific response to severe brain injury in the pediatric population means pediatric-specific research is required. The Music Interventions in Pediatric DoC Behavior Observation Record (Music Behavior Record [MBR]) was developed to objectively record responses during music therapy interventions for children presenting with a DoC. To establish content validity and inter-rater reliability, a pragmatic pilot study was undertaken. Results established that the MBR has content validity with 100% agreement among participants. Overall fair-substantial inter-rater reliability in >70% of the behavioral responses recorded in the MBR indicate the MBR is an early but promising tool to objectively capture responses during music therapy interventions. The use of the MBR may ultimately support clinical advancement and intervention research to optimize consciousness recovery for the pediatric DoC population. [ABSTRACT FROM AUTHOR]

We reduce and analyse the available JWST ERO and ERS NIRCam imaging (SMACS0723, GLASS, CEERS) in combination with the latest deep ground-based near-infrared imaging in the COSMOS field (provided by UltraVISTA DR5) to produce a new measurement of the evolving galaxy UV luminosity function (LF) over the redshift range z  = 8 − 15. This yields a new estimate of the evolution of UV luminosity density (ρUV), and hence cosmic star formation rate density (ρSFR) out to within <300 Myr of the Big Bang. Our results confirm that the high-redshift LF is best described by a double power law (rather than a Schechter) function up to z ∼ 10, and that the LF and the resulting derived ρUV (and thus ρSFR), continues to decline gradually and steadily up to z ∼ 15 (as anticipated from previous studies which analysed the pre-existing data in a consistent manner to this study). We provide details of the 61 high-redshift galaxy candidates, 47 of which are new, that have enabled this new analysis. Our sample contains 6 galaxies at z ≥ 12, one of which appears to set a new redshift record as an apparently robust galaxy candidate at z ≃ 16.4, the properties of which we therefore consider in detail. The advances presented here emphasize the importance of achieving high dynamic range in studies of early galaxy evolution, and re-affirm the enormous potential of forthcoming larger JWST programmes to transform our understanding of the young Universe. [ABSTRACT FROM AUTHOR]

Background Hepatitis C virus (HCV) infection causes dysregulation and suppression of immune pathways involved in the control of tuberculosis (TB) infection. However, data on the role of chronic hepatitis C as a risk factor for active TB are lacking. We sought to evaluate the association between HCV infection and the development of active TB. Methods We conducted a cohort study in Georgia among adults tested for HCV antibodies (January 2015–September 2020) and followed longitudinally for the development of newly diagnosed active TB. Data were obtained from the Georgian national programs of hepatitis C and TB. The exposures of interest were untreated and treated HCV infection. A Cox proportional hazards model was used to calculate adjusted hazard ratios (aHRs). Results A total of 1 828 808 adults were included (median follow-up time: 26 months; IQR: 13–39 months). Active TB was diagnosed in 3163 (0.17%) individuals after a median of 6 months follow-up (IQR: 1–18 months). The incidence rate per 100 000 person-years was 296 among persons with untreated HCV infection, 109 among those with treated HCV infection, and 65 among HCV-negative persons. In multivariable analysis, both untreated (aHR = 2.9; 95% CI: 2.4–3.4) and treated (aHR = 1.6; 95% CI: 1.4–2.0) HCV infections were associated with a higher hazard of active TB, compared with HCV-negative persons. Conclusions Adults with HCV infection, particularly untreated individuals, were at higher risk of developing active TB disease. Screening for latent TB infection and active TB disease should be part of clinical evaluation of people with HCV infection, especially in high-TB-burden areas. [ABSTRACT FROM AUTHOR]

Objective Survivors of breast cancer with persistent cancer-related fatigue (CRF) report less exercise participation compared with survivors of breast cancer without CRF. Although CRF predicts other domains of self-efficacy among survivors, the effect of CRF on exercise self-efficacy (ESE)—an important predictor of exercise participation—has not been quantified. This study examined the relationship between CRF, ESE, and exercise participation and explored the lived experience of engaging in exercise among survivors of breast cancer with persistent CRF. Methods Fifty-eight survivors of breast cancer (3.7 [SD = 2.4] years after primary treatment) self-reported CRF, ESE, and exercise participation (hours of moderate-intensity exercise per week). Regression and mediation analyses were conducted. Survivors who reported clinically significant CRF and weekly exercise were purposively sampled for 1-on-1 interviews (N = 11). Thematic analysis was performed across participants and within higher versus lower ESE subsets. Results Greater CRF predicted lower ESE (β  = −0.32) and less exercise participation (β  = −0.08). ESE mediated the relationship between CRF and exercise participation (β  = −0.05, 95% CI = −0.09 to −0.02). Qualitative data showed that survivors of breast cancer with higher ESE perceived exercise as a strategy to manage fatigue, described self-motivation and commitment to exercise, and had multiple sources of support. In contrast, survivors with lower ESE described less initiative to manage fatigue through exercise, greater difficulty staying committed to exercise, and less support. Conclusions Survivors of breast cancer with persistent CRF may experience decreased ESE, which negatively influences exercise participation. Clinicians should screen for or discuss confidence as it relates to exercise and consider tailoring standardized exercise recommendations for this population to optimize ESE. This may facilitate more sustainable exercise participation and improve outcomes. Impact This study highlights the behavioral underpinnings of CRF as a barrier to exercise. Individualized exercise tailored to optimize ESE may facilitate sustainable exercise participation among survivors of breast cancer with CRF. Strategies for clinicians to address ESE are described and future research is suggested. Lay Summary Women with fatigue after breast cancer treatment may have lower confidence about their ability to engage in exercise. Individually tailoring exercise to build confidence as it relates to exercise may result in more consistent exercise and better health-related outcomes. [ABSTRACT FROM AUTHOR]

Background Hepatitis C virus (HCV) and hepatitis B virus (HBV) coinfection are associated with increased mortality in people with HIV (PWH), and hyperglycemia is a common comorbidity in PWH. In this study, we used routinely collected clinical data to assess the associations between HBV and HCV seropositivity with all-cause mortality and whether this relationship differs by hyperglycemia status. Methods Eligible participants included adult PWH (≥15 years) who initiated antiretroviral therapy between May 2005 and June 2016 in Myanmar. HBV and HCV serostatus and hyperglycemia were measured at enrollment to HIV care using HBV surface antigen, HCV antibody tests, and random blood glucose (≥140 mg/dL), respectively. Results Among 27 722 PWH, 2260 (8%) were HBV seropositive, 2265 (9%) were HCV seropositive, 178 (0.6%) were HBV-HCV seropositive, and 1425 (5%) had hyperglycemia. During the median follow-up (interquartile range) of 3.1 (1.5–5.1) years, 3655 (13%) PWH died, and the overall mortality rate was 3.8 (95% CI, 3.7–3.9) per 100-person-years (PY). The mortality rate (per 100 PY) among PWH who were HBV seropositive was 4.6, among PWH who were HCV seropositive it was 5.1, and among PWH who were HBV-HCV seropositive it was 7.1. When stratified by glycemic status, the mortality rate was higher among patients with hyperglycemia compared with those with euglycemia (5.4 vs 4.0 per 100 PY), and the difference in mortality rate between patients with hyperglycemia and euglycemia was highest among those with HCV seropositivity (9.8 vs 5.0 per 100 PY). Conclusions Increased mortality rates associated with HBV and HCV seropositivity in PWH differed by their glycemic status. PWH with HCV seropositivity and hyperglycemia had the highest mortality rates. [ABSTRACT FROM AUTHOR]

Background Long-term glucocorticoid therapy is a key component of immunosuppression for kidney transplant recipients (KTRs), leading to significant cumulative glucocorticoid exposure. The aims of this study are to investigate the prevalence of adrenal insufficiency (AI) in KTRs taking prednisolone and to develop a screening algorithm to identify patients at the highest risk of AI. Methods In this cross-sectional cohort study, 67 KTRs receiving prednisolone underwent a short synacthen test (SST) and measurement of cumulative glucocorticoid exposure. Results A total of 72% (n  = 48) of participants failed the SST. Participants with AI had a higher daily prednisolone dose (4.9 versus 4.2 mg/day; P  = .002) and greater cumulative glucocorticoid exposure (289 versus 111 mg/kg; P  = .03) than those with intact adrenal function. Participants with AI had lower baseline cortisol than participants with intact adrenal function (143 versus 303 nmol/L; P  < .001). Morning cortisol of >288 nmol/L predicted a normal SST with 100% specificity [95% confidence interval (CI) 92–100] and 70% sensitivity (95% CI 56–78%), therefore excluding AI. Conclusions Our results suggest KTRs are at a higher risk for AI than previously reported. A morning serum cortisol measurement is a useful screening tool in this cohort, reducing the need for stimulatory testing by 44%. KTRs with AI need education regarding glucocorticoid sick rules, similar to patients with other forms of AI. [ABSTRACT FROM AUTHOR]

Background: Anti-programmed cell death 1 (anti-PD-1) and PD ligand 1 (PD-L1) immune checkpoint therapies (ICTs) provided durable responses only in a subset of cancer patients. Thus, biomarkers are needed to predict nonresponders and offer them alternative treatments. We recently implicated discoidin domain receptor tyrosine kinase 2 (DDR2) as a contributor to anti-PD-1 resistance in animal models; therefore, we sought to investigate whether this gene family may provide ICT response prediction.Methods: We assessed mRNA expression of DDR2 and its family member DDR1. Transcriptome analysis of bladder cancer (BCa) models in which DDR1 and 2 were perturbed was used to derive DDR1- and DDR2-driven signature scores. DDR mRNA expression and gene signature scores were evaluated using BCa-The Cancer Genome Atlas (n = 259) and IMvigor210 (n = 298) datasets, and their relationship to BCa subtypes, pathway enrichment, and immune deconvolution analyses was performed. The potential of DDR-driven signatures to predict ICT response was evaluated and independently validated through a statistical framework in bladder and lung cancer cohorts. All statistical tests were 2-sided.Results: DDR1 and DDR2 showed mutually exclusive gene expression patterns in human tumors. DDR2high BCa exhibited activation of immune pathways and a high immune score, indicative of a T-cell-inflamed phenotype, whereas DDR1high BCa exhibited a non-T-cell-inflamed phenotype. In IMvigor210 cohort, tumors with high DDR1 (hazard ratio [HR] = 1.53, 95% confidence interval [CI] = 1.16 to 2.06; P = .003) or DDR2 (HR = 1.42, 95% CI = 1.01 to 1.92; P = .04) scores had poor overall survival. Of note, DDR2high tumors from IMvigor210 and CheckMate 275 (n = 73) cohorts exhibited poorer overall survival (HR = 1.56, 95% CI = 1.20 to 2.06; P < .001) and progression-free survival (HR = 1.77 95%, CI = 1.05 to 3.00; P = .047), respectively. This result was validated in independent cancer datasets.Conclusions: These findings implicate DDR1 and DDR2 driven signature scores in predicting ICT response. [ABSTRACT FROM AUTHOR]

Before the end of the Epoch of Reionization, the Hydrogen in the Universe was predominantly neutral. This leads to a strong attenuation of Ly α lines of z ≳ 6 galaxies in the intergalactic medium. Nevertheless, Ly α has been detected up to very high redshifts (z ∼ 9) for several especially UV luminous galaxies. Here, we test to what extent the galaxy's local environment might impact the Ly α transmission of such sources. We present an analysis of dedicated Hubble Space Telescope (HST) imaging in the CANDELS/EGS field to search for fainter neighbours around three of the most UV luminous and most distant spectroscopically confirmed Ly α emitters: EGS-zs8-1, EGS-zs8-2, and EGSY-z8p7 at z spec = 7.73, 7.48, and 8.68, respectively. We combine the multiwavelength HST imaging with Spitzer data to reliably select z ∼ 7–9 galaxies around the central, UV-luminous sources. In all cases, we find a clear enhancement of neighbouring galaxies compared to the expected number in a blank field (by a factor ∼3–9×). Our analysis thus reveals ubiquitous overdensities around luminous Ly α emitting sources in the heart of the cosmic reionization epoch. We show that our results are in excellent agreement with expectations from the Dragons simulation, confirming the theoretical prediction that the first ionized bubbles preferentially formed in overdense regions. While three UV luminous galaxies already have spectroscopic redshifts, the majority of the remaining fainter, surrounding sources are yet to be confirmed via spectroscopy. JWST follow-up observations of the neighbouring galaxies identified here will thus be needed to confirm their physical association and to map out the ionized regions produced by these sources. [ABSTRACT FROM AUTHOR]

Although it is widely acknowledged that animal personality plays a key role in ecology, current debate focuses on the exact role of personality in mediating life-history trade-offs. Crucial for our understanding is the relationship between personality and resource acquisition, which is poorly understood, especially during early stages of development. Here we studied how among-individual differences in behavior develop over the first 6 months of life, and their potential association with resource acquisition in a free-ranging population of fallow deer (Dama dama). We related neonate physiological (heart rate) and behavioral (latency to leave at release) anti-predator responses to human handling to the proportion of time fawns spent scanning during their first summer and autumn of life. We then investigated whether there was a trade-off between scanning time and foraging time in these juveniles, and how it developed over their first 6 months of life. We found that neonates with longer latencies at capture (i.e. risk-takers) spent less time scanning their environment, but that this relationship was only present when fawns were 3–6 months old during autumn, and not when fawns were only 1–2 months old during summer. We also found that time spent scanning was negatively related to time spent foraging and that this relationship became stronger over time, as fawns gradually switch from a nutrition rich (milk) to a nutrition poor (grass) diet. Our results highlight a potential mechanistic pathway in which neonate personality may drive differences in early-life resource acquisition of a large social mammal. [ABSTRACT FROM AUTHOR]

Gross–Hacking–Keel–Kontsevich [ 13 ] discuss compactifications of cluster varieties from positive subsets in the real tropicalization of the mirror. To be more precise, let |${\mathfrak {D}}$| be the scattering diagram of a cluster variety |$V$| (of either type– |${\mathcal {A}}$| or |${\mathcal {X}}$|⁠), and let |$S$| be a closed subset of |$\left (V^\vee \right)^{\textrm {trop}} \left ({\mathbb {R}}\right)$| —the ambient space of |${\mathfrak {D}}$|⁠. The set |$S$| is positive if the theta functions corresponding to the integral points of |$S$| and its |${\mathbb {N}}$| -dilations define an |${\mathbb {N}}$| -graded subalgebra of |$\Gamma (V, \mathcal {O}_V){ [x]}$|⁠. In particular, a positive set |$S$| defines a compactification of |$V$| through a Proj construction applied to the corresponding |${\mathbb {N}}$| -graded algebra. In this paper, we give a natural convexity notion for subsets of |$\left (V^\vee \right)^{\textrm {trop}} \left ({\mathbb {R}}\right)$|⁠ , called broken line convexity , and show that a set is positive if and only if it is broken line convex. The combinatorial criterion of broken line convexity provides a tractable way to construct positive subsets of |$\left (V^\vee \right)^{\textrm {trop}} \left ({\mathbb {R}}\right)$| or to check positivity of a given subset. [ABSTRACT FROM AUTHOR]

Samples of young Type Ia supernovae have shown 'early excess' emission in a few cases. Similar excesses are predicted by some explosion and progenitor scenarios and hence can provide important clues regarding the origin of thermonuclear supernovae. They are, however, only predicted to last up to the first few days following explosion. It is therefore unclear whether such scenarios are intrinsically rare or whether the relatively small sample size simply reflects the difficulty in obtaining sufficiently early detections. To that end, we perform toy simulations covering a range of survey depths and cadences, and investigate the efficiency with which young Type Ia supernovae are recovered. As input for our simulations, we use models that broadly cover the range of predicted luminosities. Based on our simulations, we find that in a typical 3 d cadence survey, only ∼10 per cent of Type Ia supernovae would be detected early enough to rule out the presence of an excess. A 2 d cadence, however, should see this increase to ∼15 per cent. We find comparable results from more detailed simulations of the Zwicky Transient Facility surveys. Using the recovery efficiencies from these detailed simulations, we investigate the number of young Type Ia supernovae expected to be discovered assuming some fraction of the population comes from scenarios producing an excess at early times. Comparing the results of our simulations to observations, we find that the intrinsic fraction of Type Ia supernovae with early flux excesses is |$\sim 28^{+13}_{-11}{{\ \rm per\ cent}}$|⁠. [ABSTRACT FROM AUTHOR]

In the new era of time-domain surveys, Type Ia supernovae are being caught sooner after explosion, which has exposed significant variation in their early light curves. Two driving factors for early-time evolution are the distribution of 56Ni in the ejecta and the presence of flux excesses of various causes. We perform an analysis of the largest young SN Ia sample to date. We compare 115 SN Ia light curves from the Zwicky Transient Facility to the turtls model grid containing light curves of Chandrasekhar mass explosions with a range of 56Ni masses, 56Ni distributions, and explosion energies. We find that the majority of our observed light curves are well reproduced by Chandrasekhar mass explosion models with a preference for highly extended 56Ni distributions. We identify six SNe Ia with an early-time flux excess in our gr -band data (four 'blue' and two 'red' flux excesses). We find an intrinsic rate of 18 ± 11 per cent of early flux excesses in SNe Ia at z < 0.07, based on three detected flux excesses out of 30 (10 per cent) observed SNe Ia with a simulated efficiency of 57 per cent. This is comparable to rates of flux excesses in the literature but also accounts for detection efficiencies. Two of these events are mostly consistent with circumstellar material interaction, while the other four have longer lifetimes in agreement with companion interaction and 56Ni-clump models. We find a higher frequency of flux excesses in 91T/99aa-like events (44 ± 13 per cent). [ABSTRACT FROM AUTHOR]

Background The objective of this study was to evaluate the effectiveness of formal hepatitis C virus (HCV) education on engagement in therapy in persons experiencing homelessness in an on-site shelter-based model of care. As policies to eliminate Medicaid access restrictions to HCV treatment are expanded, patient education is paramount to achieving HCV elimination targets in difficult-to-engage populations including persons experiencing homelessness. Methods This prospective study was conducted at 4 shelters in San Francisco and Minneapolis from August 2018 to January 2021. Of the 162 HCV Ab–positive participants, 150 participated in a 30-minute HCV education session. Posteducation changes in knowledge, beliefs, barriers to care, and willingness to accept therapy scores were assessed. Results Following education, knowledge scores (mean change, 4.4 ± 4.4; P  < .001) and willingness to accept therapy (70% to 86%; P  = .0002) increased. Perceived barriers to HCV care decreased (mean change, –0.8 ± 5.2; P  = .001). Higher baseline knowledge was associated with lesser gain in knowledge following education (coef. –0.7; P  < .001). Posteducation knowledge (odds ratio, 1.2; P  = .008) was associated with willingness to accept therapy. Conclusions An HCV educational intervention successfully increased willingness to engage in HCV therapy in persons experiencing homelessness in an on-site shelter-based HCV model of care. [ABSTRACT FROM AUTHOR]

The division between stripped-envelope supernovae (SE-SNe) and superluminous supernovae (SLSNe) is not well-defined in either photometric or spectroscopic space. While a sharp luminosity threshold has been suggested, there remains an increasing number of transitional objects that reach this threshold without the spectroscopic signatures common to SLSNe. In this work, we present data and analysis on four SNe transitional between SE-SNe and SLSNe; the He-poor SNe 2019dwa and 2019cri, and the He-rich SNe 2019hge and 2019unb. Each object displays long-lived and variable photometric evolution with luminosities around the SLSN threshold of Mr < −19.8 mag. Spectroscopically however, these objects are similar to SE-SNe, with line velocities lower than either SE-SNe and SLSNe, and thus represent an interesting case of rare transitional events. [ABSTRACT FROM AUTHOR]

Open in new tab Download slide Open in new tab Download slide OBJECTIVES Surgical resection is recommended as adjunctive treatment for multidrug-resistant (MDR) tuberculosis (TB) in certain scenarios; however, data are limited. We sought to evaluate the impact of surgery by comparing TB outcomes among patients with cavitary disease who received medical versus combined medical and surgical treatment. METHODS A cohort of all patients with cavitary MDR or extensively drug-resistant (XDR) TB treated in Tbilisi, Georgia, between 2008 and 2012. Patients meeting indications for surgery underwent adjunctive resection in addition to medical treatment. We compared TB outcomes (proportions achieving cure/complete) among patients who received adjunctive surgery to those who received medical treatment alone using an adjusted robust Poisson regression. RESULTS Among 408 patients, 299 received medical treatment alone and 109 combined medical and surgical treatment. Patients in the non-surgical group were older and had higher rates of tobacco and alcohol use and bilateral disease compared to the surgical group. Patients in the surgical group had higher rates of XDR disease (28% vs 15%). Favourable outcomes were higher among the surgical versus non-surgical group cohort (76% vs 41%). After adjusting for multiple factors, the association between adjunctive resection and favourable outcome remained (adjusted risk ratio 1.6, 95% confidence interval 1.3–2.0); the relationship was also observed in secondary models that excluded patients with bilateral disease (contraindication for surgery) and patients receiving <6 months of treatment. Major postoperative complications occurred among 8 patients (7%) with no postoperative mortality. CONCLUSIONS Adjunctive surgery is safe and may improve the effectiveness of treatment among select patients with cavitary MDR- and XDR-TB. [ABSTRACT FROM AUTHOR]

Likelihood-based phylogenetic inference posits a probabilistic model of character state change along branches of a phylogenetic tree. These models typically assume statistical independence of sites in the sequence alignment. This is a restrictive assumption that facilitates computational tractability, but ignores how epistasis, the effect of genetic background on mutational effects, influences the evolution of functional sequences. We consider the effect of using a misspecified site-independent model on the accuracy of Bayesian phylogenetic inference in the setting of pairwise-site epistasis. Previous work has shown that as alignment length increases, tree reconstruction accuracy also increases. Here, we present a simulation study demonstrating that accuracy increases with alignment size even if the additional sites are epistatically coupled. We introduce an alignment-based test statistic that is a diagnostic for pairwise epistasis and can be used in posterior predictive checks. [ABSTRACT FROM AUTHOR]

Background Medication adherence is a common reason for treatment deferment in persons experiencing homelessness. We evaluated adherence to hepatitis C virus (HCV) therapy following HCV education in a shelter-based care model. Methods Prospective study conducted at 4 homeless shelters in Minneapolis, Minnesota and San Francisco, California from November 2018 to January 2021. Sixty-three patients underwent HCV education and treatment. Multivariable modeling evaluated factors associated with (1) medication and (2) overall (composite score of medication, laboratory, and clinic visit) adherence. Results Median age was 56 years; 73% of participants were male, 43% were Black, 52% had psychiatric illness, and 81% used illicit drugs and 60% used alcohol in the past year. Following education, 52% were extremely confident in their ability to be adherent to HCV therapy. Medication adherence by patient and provider report was 88% and 48%, respectively, and 81% achieved HCV cure. Active alcohol use was associated with less confidence in medication adherence (43% vs 78%, P =.04). Older age was positively (coefficient = 0.3) associated with overall adherence to HCV treatment whereas prior therapy was associated with both medication (odds ratio, 0.08) and overall treatment (coefficient = –0.87) nonadherence. Conclusions Despite imperfect adherence, sustained virologic response rates were still high. Expanding opportunities to treat persons experiencing homelessness in a structured and supportive setting is critical to HCV elimination efforts. [ABSTRACT FROM AUTHOR]

We test the adequacy of ultraviolet (UV) spectra for characterizing the outer structure of Type Ia supernova (SN) ejecta. For this purpose, we perform spectroscopic analysis for ASASSN-14lp, a normal SN Ia showing low continuum in the mid-UV regime. To explain the strong UV suppression, two possible origins have been investigated by mapping the chemical profiles over a significant part of their ejecta. We fit the spectral time series with mid-UV coverage obtained before and around maximum light by HST , supplemented with ground-based optical observations for the earliest epochs. The synthetic spectra are calculated with the one-dimensional MC radiative transfer code tardis from self-consistent ejecta models. Among several physical parameters, we constrain the abundance profiles of nine chemical elements. We find that a distribution of 56Ni (and other iron-group elements) that extends towards the highest velocities reproduces the observed UV flux well. The presence of radioactive material in the outer layers of the ejecta, if confirmed, implies strong constraints on the possible explosion scenarios. We investigate the impact of the inferred 56Ni distribution on the early light curves with the radiative transfer code turtls , and confront the results with the observed light curves of ASASSN-14lp. The inferred abundances are not in conflict with the observed photometry. We also test whether the UV suppression can be reproduced if the radiation at the photosphere is significantly lower in the UV regime than the pure Planck function. In this case, solar metallicity might be sufficient enough at the highest velocities to reproduce the UV suppression. [ABSTRACT FROM AUTHOR]

Background High rates of loss to follow-up (LFU) exist among patients with multidrug and extensively drug-resistant tuberculosis (M/XDR TB). We aimed to identify long-term clinical outcomes of patients who were LFU during second-line TB treatment. Methods We conducted a follow-up study among adults who received second-line TB treatment in the country of Georgia during 2011–2014 with a final outcome of LFU. We attempted to interview all LFU patients, administered a structured questionnaire, and obtained sputum samples. Active TB at follow-up was defined by positive sputum Xpert-TB/RIF or culture. Results Follow-up information was obtained for 461 patients. Among these patients, 107 (23%) died and 177 (38%) were contacted. Of those contacted, 123 (69%) consented to participate and 92 provided sputum samples. Thirteen (14%) had active TB with an estimated infectious time period for transmitting drug-resistant TB in the community of 480 days (interquartile range = 803). In multivariable analysis, positive culture at the time of LFU was associated with active TB at the time of our study (adjusted risk ratio = 13.3; 95% confidence interval, 4.2–42.2) Conclusions Approximately one quarter of patients on second-line TB treatment who were LFU died. Among those LFU evaluated in our study, 1 in 7 remained in the community with positive sputum cultures. To reduce death and transmission of disease, additional strategies are needed to encourage patients to complete treatment. [ABSTRACT FROM AUTHOR]

The detonation of a helium shell on top of a carbon–oxygen white dwarf has been argued as a potential explosion mechanism for Type Ia supernovae (SNe Ia). The ash produced during helium shell burning can lead to light curves and spectra that are inconsistent with normal SNe Ia, but may be viable for some objects showing a light-curve bump within the days following explosion. We present a series of radiative transfer models designed to mimic predictions from double-detonation explosion models. We consider a range of core and shell masses, and systematically explore multiple post-explosion compositions for the helium shell. We find that a variety of luminosities and time-scales for early light-curve bumps result from those models with shells containing 56Ni, 52Fe, or 48Cr. Comparing our models to SNe Ia with light-curve bumps, we find that these models can reproduce the shapes of almost all of the bumps observed, but only those objects with red colours around maximum light (B − V ≳ 1) are well matched throughout their evolution. Consistent with previous works, we also show that those models in which the shell does not contain iron-group elements provide good agreement with normal SNe Ia of different luminosities from shortly after explosion up to maximum light. While our models do not amount to positive evidence in favour of the double-detonation scenario, we show that provided the helium shell ash does not contain iron-group elements, it may be viable for a wide range of normal SNe Ia. [ABSTRACT FROM AUTHOR]

Background Among pediatric patients with multidrug-resistant tuberculosis (MDR-TB), limited data exist regarding treatment outcomes in the context of the new and repurposed second-line TB drugs (SLDs). We aimed to describe the treatment outcomes among pediatric MDR-TB patients receiving new and repurposed SLDs including the proportion who achieved favorable outcomes. Methods We conducted a retrospective cohort study among pediatric patients (age ≤18 years) treated for MDR-TB in the country of Georgia from 2009 to 2016. A "new and repurposed" SLD regimen was defined as a regimen that included linezolid, bedaquiline, and/or delamanid. Favorable treatment outcome was defined by treatment completion or documented microbial "cure" status at the end of treatment. We assessed the association between the use of the new and repurposed SLDs with MDR-TB treatment outcomes using bivariate analyses and log-binomial regression. Results There were 124 pediatric MDR-TB patients (median age: 13.7; interquartile range: 4.6-16.0) initiating treatment; 119 (96.0%) had a treatment outcome recorded and were included in our analyses. Eighteen (15.1%) patients received new and repurposed SLDs from 2015 or later. After adjusting for potential confounders, the proportion achieving favorable MDR-TB treatment outcomes was higher among patients treated with SLD regimens that included new and/or repurposed drugs when compared with those treated without (adjusted risk ratio: 1.17; 95% confidence interval: 0.51-2.72). Conclusions We observed a high proportion of favorable treatment outcomes among pediatric patients with MDR-TB receiving the new and repurposed SLDs. Further studies to evaluate the efficacy and children's tolerability of the new and repurposed SLDs are still warranted. [ABSTRACT FROM AUTHOR]