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Congenital dyserythropoietic anaemias (CDAs) are a group of rare hereditary disorders characterized by ineffective erythropoiesis, the characteristic morphology of erythroid precursors and the development of secondary haemochromatosis.[1] Patients with CDA present variable grades of hyporegenerative anaemia with inadequate reticulocyte values and variable intensity of haemolysis. Skeletal abnormalities (acral dysostosis) affecting distal limbs are a rare feature observed in about 10% of patients with CDA Type I. Nail plate hypoplasia, absent nails and/or syndactyly in a patient with anaemia, can be the clue to suspect CDA. CPD questions Learning objective To gain up-to-date knowledge on the nail and skeletal abnormalities in patients with congenital dyserythropoietic anaemia. [Extracted from the article]

The article presents a case study of a 43-year-old woman who developed skin diseases called demodicidoses. Multiple follicular hyperkeratotic spicules has been observed on physical examination. The patient had undergone diagnostic assessment called Demodex Filliculorum by means of reflectance confucal microscopy.

The article presents a case study of an 80-year-old man with a multiple infiltrated violaceous nodules on the left leg. It mentions that the patient was diagnosed with a testicular diffuse large B-cell lymphoma (DLBCL) as well as underwent chemotherapy, radiotherapy and orchidectomy. It also notes his skin biopsy which discovered a diffuse dermal infiltration of lymphocytic cells comprising of centroblasts and immunoblasts.