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Your search keyword '"Krex, Dietmar"' showing total 12 results
Start Over Author "Krex, Dietmar" Publisher oxford university press / usa
12 results on '"Krex, Dietmar"'

1. Quality of life in the GLARIUS trial randomizing bevacizumab/irinotecan versus temozolomide in newly diagnosed, MGMT-nonmethylated glioblastoma.

Author

Schäfer, Niklas, Proescholdt, Martin, Steinbach, Joachim P., Weyerbrock, Astrid, Hau, Peter, Grauer, Oliver, Goldbrunner, Roland, Friedrich, Franziska, Rohde, Veit, Ringel, Florian, Schlegel, Uwe, Sabel, Michael, Ronellenfitsch, Michael W., Uhl, Martin, Grau, Stefan, Hänel, Mathias, Schnell, Oliver, Krex, Dietmar, Vajkoczy, Peter, and Tabatabai, Ghazaleh

Published
2018
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2. Molecular differences in IDH wildtype glioblastoma according to MGMT promoter methylation.

Author

Kessler, Tobias, Sahm, Felix, Sadik, Ahmed, Stichel, Damian, Hertenstein, Anne, Reifenberger, Guido, Zacher, Angela, Sabel, Michael, Tabatabai, Ghazaleh, Steinbach, Joachim, Sure, Ulrich, Krex, Dietmar, Grosu, Anca-L., Bewerunge-Hudler, Melanie, Jones, David, Pfister, Stefan M., Weller, Michael, Opitz, Christiane, Bendszus, Martin, and von Deimling, Andreas

Published
2018
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5. End-of-life caregivers' perception of medical and psychological support during the final weeks of glioma patients: a questionnaire-based survey.

Author

Heese, Oliver, Vogeler, Eva, Martens, Tobias, Schnell, Oliver, Tonn, Jörg-Christian, Simon, Matthias, Schramm, Johannes, Krex, Dietmar, Schackert, Gabriele, Reithmeier, Thomas, Nikkhah, Guido, Sabel, Michael, Steiger, Hans-Jakob, Schlegel, Uwe, Löffler, Markus, Weller, Michael, and Westphal, Manfred

Published
2013
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7. Differential Retinoic Acid Signaling in Tumors of Long- and Short-term Glioblastoma Survivors.

Author

Barbus, Sebastian, Tews, Björn, Karra, Daniela, Hahn, Meinhard, Radlwimmer, Bernhard, Delhomme, Nicolas, Hartmann, Christian, Felsberg, Jörg, Krex, Dietmar, Schackert, Gabriele, Martinez, Ramon, Reifenberger, Guido, and Lichter, Peter

Subjects
CANCER research, TRETINOIN, GLIOBLASTOMA multiforme, CARRIER proteins, PEROXISOMES
Abstract

Although the prognosis of most glioblastoma patients is poor, 3%–5% patients show long-term survival of 36 months or longer after diagnosis. To study the differences in activation of biochemical pathways, we performed mRNA and protein expression analyses of primary glioblastoma tissues from 11 long-term survivors (LTS; overall survival ≥ 36 months) and 12 short-term survivors (STS; overall survival ≤ 6 months). The mRNA expression ratio of the retinoic acid transporters fatty acid–binding protein 5 (FABP5) and cellular retinoic acid–binding protein 2 (CRABP2), which regulate the differential delivery of retinoic acid to either antioncogenic retinoic acid receptors or prooncogenic nuclear receptor peroxisome proliferator–activated receptor delta, was statistically significantly higher in the tumor tissues of STS than those of LTS (median ratio in STS tumors = 3.64, 10th–90th percentile = 1.43–4.54 vs median ratio in LTS tumors = 1.42, 10th–90th percentile = −0.98 to 2.59; P < .001). High FABP5 protein expression in STS tumors was associated with highly proliferating tumor cells and activation of 3-phosphoinositide-dependent protein kinase-1 and v-akt murine thymoma viral oncogene homolog. The data suggest that retinoic acid signaling activates different targets in glioblastomas from LTS and STS. All statistical tests were two-sided. [ABSTRACT FROM PUBLISHER]

Published
2011
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8. The Stem Cell Marker Prominin-1/CD133 on Membrane Particles in Human Cerebrospinal Fluid Offers Novel Approaches for Studying Central Nervous System Disease.

Author

Huttner, Hagen B., Janich, Peggy, Köhrmann, Martin, Jászai, József, Siebzehnrubl, Florian, Blümcke, Ingmar, Suttorp, Meinolf, Gahr, Manfred, Kuhnt, Daniela, Nimsky, Christopher, Krex, Dietmar, Schackert, Gabriele, Löwenbrück, Kai, Reichmann, Heinz, Jüttler, Eric, Hacke, Werner, Schellinger, Peter D., Schwab, Stefan, Wilsch-Bräuninger, Michaela, and Marzesco, Anne-Marie

Subjects
GLIOMAS, NERVOUS system tumors, NERVOUS system, HEMATOPOIETIC stem cells, BONE marrow cells
Abstract

Cerebrospinal fluid (CSF) is routinely used for diagnosing and monitoring neurological diseases. The CSF proteins used so far for diagnostic purposes (except for those associated with whole cells) are soluble. Here, we show that human CSF contains specific membrane particles that carry prominin- 1/CD133, a neural stem cell marker implicated in brain tumors, notably glioblastoma. Differential and equilibrium centrifugation and detergent solubility analyses showed that these membrane particles were similar in physical properties and microdomain organization to small membrane vesicles previously shown to be released from neural stem cells in the mouse embryo. The levels of membrane particle-associated prominin-1/CD133 declined during childhood and remained constant thereafter, with a remarkably narrow range in healthy adults. Glioblastoma patients showed elevated levels of membrane particle- associated prominin-1/CD133, which decreased dramatically in the final stage of the disease. Hence, analysis of CSF for membrane particles carrying the somatic stem cell marker prominin-1/CD133 offers a novel approach for studying human central nervous system disease. [ABSTRACT FROM AUTHOR]

Published
2008
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