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Your search keyword '"Hawkins, Cynthia"' showing total 37 results
Start Over Author "Hawkins, Cynthia" Publisher oxford university press / usa
37 results on '"Hawkins, Cynthia"'

2. CAP-ACP Workload Model for Advanced Diagnostics in Precision Medicine.

Author

Park, Paul C, Kurek, Kyle C, DeCoteau, John, Howlett, Christopher J, Hawkins, Cynthia, Izevbaye, Iyare, Carter, Michael D, Redpath, Margaret, Lo, Bryan, Alex, Deepu, Yousef, George, Yip, Stephen, and Maung, Raymond

Subjects
EMPLOYEES' workload, TUMORS, ONCOLOGY
Abstract

Objectives: In precision medicine, where oncologic management is tailored to the individual's clinical and genetic profiles, advanced diagnostic testing provides prognostic information and guides management in a growing number of malignancies. There is a need to capture the work pathologists perform to meet this demand by providing medically relevant, timely, and accurate testing results. This work includes not only direct patient consults (interpretation of results and issuing reports) but the administrative and medical oversight as well as the research needed to provide the necessary quality assurance, quality control, direction, and framework for the laboratory.Methods: An expert panel of Canadian pathologists involved in advanced diagnostics was convened to establish and beta test a model for workload assessment in advanced diagnostics.Results: All aspects of the advanced diagnostics workload were detailed and applied to models based on members' experience, including medical oversight, administration, and the introduction of new testing and platforms. Models for biomarker testing were developed for simple and complex or multiplexed assays, and a detailed model was developed to assess the workload for next-generation sequencing-based assays.Conclusions: This paper provides the first detailed proposal for capturing an advanced diagnostic workload to enable appropriate pathologist allotment for performing all the steps required to run an advanced diagnostic service. [ABSTRACT FROM AUTHOR]

Published
2022
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6. MetaFusion: a high-confidence metacaller for filtering and prioritizing RNA-seq gene fusion candidates.

Author

Apostolides, Michael, Jiang, Yue, Husić, Mia, Siddaway, Robert, Hawkins, Cynthia, Turinsky, Andrei L, Brudno, Michael, and Ramani, Arun K

Subjects
GENE fusion, RNA sequencing
Abstract

Motivation Current fusion detection tools use diverse calling approaches and provide varying results, making selection of the appropriate tool challenging. Ensemble fusion calling techniques appear promising; however, current options have limited accessibility and function. Results MetaFusion is a flexible metacalling tool that amalgamates outputs from any number of fusion callers. Individual caller results are standardized by conversion into the new file type Common Fusion Format. Calls are annotated, merged using graph clustering, filtered and ranked to provide a final output of high-confidence candidates. MetaFusion consistently achieves higher precision and recall than individual callers on real and simulated datasets, and reaches up to 100% precision, indicating that ensemble calling is imperative for high-confidence results. MetaFusion uses FusionAnnotator to annotate calls with information from cancer fusion databases and is provided with a Benchmarking Toolkit to calibrate new callers. Availability and implementation MetaFusion is freely available at https://github.com/ccmbioinfo/MetaFusion. Supplementary information Supplementary data are available at Bioinformatics online. [ABSTRACT FROM AUTHOR]

Published
2021
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12. Pediatric low-grade gliomas: next biologically driven steps.

Author

Jones, David T. W., Kieran, Mark W., Bouffet, Eric, Alexandrescu, Sanda, Bandopadhayay, Pratiti, Bornhorst, Miriam, Ellison, David, Fangusaro, Jason, Fisher, Michael J., Foreman, Nicholas, Fouladi, Maryam, Hargrave, Darren, Hawkins, Cynthia, Jabado, Nada, Massimino, Maura, Mueller, Sabine, Perilongo, Giorgio, van Meeteren, Antoinette Y. N. Schouten, Tabori, Uri, and Warren, Katherine

Published
2018
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14. Pediatric low-grade gliomas: implications of the biologic era.

Author

Packer, Roger J., Pfister, Stephan, Bouffet, Eric, Avery, Robert, Bandopadhayay, Pratiti, Bornhorst, Miriam, Bowers, Daniel C., Ellison, David, Fangusaro, Jason, Foreman, Nicholas, Fouladi, Maryam, Gajjar, Amar, Haas-Kogan, Daphne, Hawkins, Cynthia, Cheng-Ying Ho, Hwang, Eugene, Jabado, Nada, Kilburn, Lindsay B., Lassaletta, Alvaro, and Ligon, Keith L.

Published
2017
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15. Pediatric high-grade glioma: biologically and clinically in need of new thinking.

Author

Jones, Chris, Karajannis, Matthias A., Jones, David T. W., Kieran, Mark W., Monje, Michelle, Baker, Suzanne J., Becher, Oren J., Yoon-Jae Cho, Gupta, Nalin, Hawkins, Cynthia, Hargrave, Darren, Haas-Kogan, Daphne A., Jabado, Nada, Xiao-Nan Li, Mueller, Sabine, Nicolaides, Theo, Packer, Roger J., Persson, Anders I., Phillips, Joanna J., and Simonds, Erin F.

Published
2017
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18. FoxG1 Interacts with Bmi1 to Regulate Self-Renewal and Tumorigenicity of Medulloblastoma Stem Cells.

Author

Manoranjan, Branavan, Wang, Xin, Hallett, Robin M., Venugopal, Chitra, Mack, Stephen C., McFarlane, Nicole, Nolte, Sara M., Scheinemann, Katrin, Gunnarsson, Thorsteinn, Hassell, John A., Taylor, Michael D., Lee, Cathy, Triscott, Joanna, Foster, Colleen M., Dunham, Christopher, Hawkins, Cynthia, Dunn, Sandra E., and Singh, Sheila K.

Subjects
PROTEIN-protein interactions, NEOPLASTIC cell transformation, MEDULLOBLASTOMA, CANCER cells, BRAIN tumors, CHILDHOOD cancer, CANCER-related mortality
Abstract

Brain tumors represent the leading cause of childhood cancer mortality, of which medulloblastoma (MB) is the most frequent malignant tumor. Recent studies have demonstrated the presence of several MB molecular subgroups, each distinct in terms of prognosis and predicted therapeutic response. Groups 1 and 2 are characterized by relatively good clinical outcomes and activation of the Wnt and Shh pathways, respectively. In contrast, groups 3 and 4 ('non-Shh/Wnt MBs') are distinguished by metastatic disease, poor patient outcome, and lack a molecular pathway phenotype. Current gene expression platforms have not detected brain tumor-initiating cell (BTIC) self-renewal genes in groups 3 and 4 MBs as BTICs typically comprise a minority of tumor cells and may therefore go undetected on bulk tumor analyses. Since increasing BTIC frequency has been associated with increasing tumor aggressiveness and poor patient outcome, we investigated the subgroup-specific gene expression profile of candidate stem cell genes within 251 primary human MBs from four nonoverlapping MB transcriptional databases (Amsterdam, Memphis, Toronto, Boston) and 74 NanoString-subgrouped MBs (Vancouver). We assessed the functional relevance of two genes, FoxG1 and Bmi1, which were significantly enriched in non-Shh/Wnt MBs and showed these genes to mediate MB stem cell self-renewal and tumor initiation in mice. We also identified their transcriptional regulation through reciprocal promoter occupancy in CD15+ MB stem cells. Our work demonstrates the application of stem cell data gathered from genomic platforms to guide functional BTIC assays, which may then be used to develop novel BTIC self-renewal mechanisms amenable to therapeutic targeting. S TEM C ells 2013;31:1266-1277 [ABSTRACT FROM AUTHOR]

Published
2013
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20. Genome-wide profiling using single-nucleotide polymorphism arrays identifies novel chromosomal imbalances in pediatric glioblastomas.

Author

Qu, Hui-Qi, Jacob, Karine, Fatet, Sarah, Ge, Bing, Barnett, David, Delattre, Olivier, Faury, Damien, Montpetit, Alexandre, Solomon, Lauren, Hauser, Peter, Garami, Miklos, Bognar, Laszlo, Hansely, Zoltan, Mio, Robert, Farmer, Jean-Pierre, Albrecht, Steffen, Polychronakos, Constantin, Hawkins, Cynthia, and Jabado, Nada

Published
2010
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21. Astrocytic Inclusions in Epilepsy.

Author

Hazrati, Lili-Naz, Kleinschmidt-DeMasters, B. K., Handler, Michael H., Smith, Mary Lou, Ochi, Ayako, Otsubo, Hiroshi, Rutka, James T., Go, Cristina, Weiss, Shelly, and Hawkins, Cynthia E.

Published
2008
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26. DIPG-36. CLINICAL, RADIOLOGICAL, AND HISTO-MOLECULAR CHARACTERISTICS OF DIFFUSE INTRINSIC PONTINE GLIOMA IN PATIENTS WHO SURVIVE LESS THAN 3 MONTHS FROM DIAGNOSIS: A REPORT FROM THE INTERNATIONAL DIPG REGISTRY.

Author

Dahl, Nathan, Lane, Adam, Bandopadhayay, Pratiti, Minturn, Jane, Dodgshun, Andrew, Parkin, Sara, Shih, Chie-Schin, Hassall, Tim, Hansford, Jordan, Samson, Yvan, Cai, LinBo, Leary, Sarah, Ma, Jie, Bartels, Ute, Hawkins, Cynthia, Monje-Diesseroth, Michelle, Fisher, Paul, Tsui, Karen, Ziegler, David, and DeWire-Schottmiller, Mariko

Published
2019
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34. DIPG-13. A NOVEL MOUSE MODEL REVEALS UNEXPECTED MECHANISMS OF ACTION OF ACVR1 MUTATIONS IN DIFFUSE INTRINSIC PONTINE GLIOMA.

Author

Fortin, Jerome, Tian, Ruxiao, Zarrabi, Ida, Hill, Graham, Williams, Eleanor, Sanchez-Duffhues, Gonzalo, Thorikay, Midory, Ramachandran, Parameswaran, Siddaway, Robert, Wong, Jong, Haight, Jillian, You-Ten, Annick, Snow, Bryan, Wakeham, Andrew, Schramek, Daniel, Bullock, Alex, Dijke, Peter ten, Hawkins, Cynthia, and Mak, Tak

Published
2019
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37. GENETIC ANALYSIS OF CONGENITAL GLIOBLASTOMA.

Author

Castellano-Sanchez, Amilcar A, Shehata, Bahig, Djalilvand, Azita, Hawkins, Cynthia, Yost, Robert B, Greco, Claudia, Ohgaki, Hiroko, Perry, Arie, and Brat, Daniel J

Published
2005

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