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Start Over Author "Hale, Colin" Publisher oxford university press / usa
1 results on '"Hale, Colin"'

1. Pharmacokinetics of ß-d-N4-Hydroxycytidine, the Parent Nucleoside of Prodrug Molnupiravir, in Nonplasma Compartments of Patients With Severe Acute Respiratory Syndrome Coronavirus 2 Infection.

Author

FitzGerald, Richard, Dickinson, Laura, Else, Laura, Fletcher, Thomas, Hale, Colin, Amara, Alieu, Walker, Lauren, Penchala, Sujan Dilly, Lyon, Rebecca, Shaw, Victoria, Greenhalf, William, Bullock, Katie, Lavelle-Langham, Lara, Reynolds, Helen, Painter, Wendy, Holman, Wayne, Ewings, Sean, Griffiths, Gareth, and Khoo, Saye

Subjects
SALIVA analysis, COVID-19, PRODRUGS, NUCLEOSIDES, ANTIVIRAL agents, TEARS (Body fluid)
Abstract

ß-d-N4-hydroxycytidine (NHC), the parent nucleoside of molnupiravir, a COVID-19 antiviral, was quantified at SARS-CoV-2 transmission sites in 12 patients enrolled in AGILE Candidate-Specific Trial-2. Saliva, nasal, and tear NHC concentrations were 3%, 21%, and 22% that of plasma. Saliva and nasal NHC were significantly correlated with plasma (P  < .0001). Clinical Trials Registration. NCT04746183. [ABSTRACT FROM AUTHOR]

Published
2022
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