1. CAPRISA 004 Tenofovir Microbicide Trial: No Impact of Tenofovir Gel on the HIV Transmission Bottleneck.
- Author
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Valley-Omar, Ziyaad, Sibeko, Sengeziwe, Anderson, Jeffrey, Goodier, Sarah, Werner, Lise, Arney, Leslie, Naranbhai, Vivek, Treurnicht, Florette, Abrahams, Melissa-Rose, Bandawe, Gama, Swanstrom, Ronald, Karim, Quarraisha Abdool, Karim, Salim S. Abdool, and Williamson, Carolyn
- Subjects
TENOFOVIR ,HIV infection transmission ,BACTERICIDES ,IMMUNODEFICIENCY ,COMPARATIVE studies ,VIRUS diseases - Abstract
Alterations of the genital mucosal barrier may influence the number of viruses transmitted from a human immunodeficiency virus–infected source host to the newly infected individual. We used heteroduplex tracking assay and single-genome sequencing to investigate the effect of a tenofovir-based microbicide gel on the transmission bottleneck in women who seroconverted during the CAPRISA 004 microbicide trial. Seventy-seven percent (17 of 22; 95% confidence interval [CI], 56%–90%) of women in the tenofovir gel arm were infected with a single virus compared with 92% (13 of 14; 95% CI, 67%–>99%) in the placebo arm (P = .37). Tenofovir gel had no discernable impact on the transmission bottleneck. [ABSTRACT FROM AUTHOR]
- Published
- 2012
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