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In the paper of [6], maps of suitability predictions for a handful relevant tree species in 30 × 30 m resolution are presented based on ecograms that are linked with interpolated, modeled soil data (subsoil pH, subsoil texture and derived plant available water to 160 cm). We ignore statistical principles if we accept interpolated tree species suitability predictions based on limited sets of soil properties without verifying them with observed, local site and soil data. Commentary to the paper by Roell, Nord-Larsen et al. 'Mapping tree species ecograms based on soil pH and soil water availability across Denmark'. [Extracted from the article]

Introduction Recycling of domestic waste and a number of employees in the recycling industry is expected to increase. This study aims to quantify current exposure levels of inhalable dust, endotoxin, and microorganisms and to identify determinants of exposure among recycling workers. Methods This cross-sectional study included 170 full-shift measurements from 88 production workers and 14 administrative workers from 12 recycling companies in Denmark. The companies recycle domestic waste (sorting, shredding, and extracting materials from waste). We collected inhalable dust with personal samplers that were analysed for endotoxin (n = 170) and microorganisms (n = 101). Exposure levels of inhalable dust, endotoxin, and microorganisms and potential determinants of exposure were explored by mixed-effects models. Results The production workers were 7-fold or higher exposed to inhalable dust, endotoxin, bacteria, and fungi than the administrative workers. Among production workers recycling domestic waste, the geometric mean exposure level was 0.6 mg/m3 for inhalable dust, 10.7 endotoxin unit (EU)/m3 for endotoxin, 1.6 × 104 colony forming units (CFU)/m³ of bacteria, 4.4 × 104 CFU/m³ of fungi (25 °C), and 1.0 × 103 CFU/m³ of fungi (37 °C). Workers handling paper or cardboard had higher exposure levels than workers handling other waste fractions. The temperature did not affect exposure levels, although there was a tendency toward increased exposure to bacteria and fungi with higher temperatures. For inhalable dust and endotoxin, exposure levels during outdoor work were low compared to indoor work. For bacteria and fungi, indoor ventilation decreased exposure. The work task, waste fraction, temperature, location, mechanical ventilation, and the company size explained around half of the variance of levels of inhalable dust, endotoxin, bacteria, and fungi. Conclusion The production workers of the Danish recycling industry participating in this study had higher exposure levels of inhalable dust, endotoxin, bacteria, and fungi than the administrative workers. Exposure levels of inhalable dust and endotoxin among recycling workers in Denmark were generally below established or suggested occupational exposure limits (OEL). However, 43% to 58% of the individual measurements of bacteria and fungi were above the suggested OEL. The waste fraction was the most influential determinant for exposure, and the highest exposure levels were seen during handling paper or cardboard. Future studies should examine the relationship between exposure levels and health effects among workers recycling domestic waste. [ABSTRACT FROM AUTHOR]

This paper provides an overview of the state of identification of left behind regions and proposes a new methodology for identifying them. Despite increased interest in rising regional inequality, the identification of left behind regions differs greatly, complicating policymaking aimed at addressing these regional challenges. Based on the substantial literature that has emerged in recent years on left behind regions, the paper argues for the importance of both time and space as key elements when identifying left behind regions. This paper applies the proposed identification method to Denmark; it uses longitudinal data from 1980 to 2018 and includes the current wave of interregional inequality and typically adopted variables for identifying left behind regions across the literature. [ABSTRACT FROM AUTHOR]

This paper estimates the individual impact of a worker's job loss on his/her criminal activity. Using a matched employer–employee longitudinal data set on unemployment, crime, and taxes for all residents in Denmark, the paper builds each worker's timeline of job separation, unemployment, and crime. The paper focuses on displaced workers: high-tenure workers who lose employment during a mass-layoff event at any point between 1990 and 1994 (inclusive). Controlling for municipality- and time-specific confounders identifies the individual impact separately from the aggregate impact of the unemployment rate on crime. Placebo tests display no evidence of trends in crime prior to worker separation. Using Denmark's introduction of the Act on an Active Labor Market at the end of 1993, we estimate the impacts of activation and of a reduction in benefit duration on crime: crime is lower during active benefits than during passive benefits and spikes at the end of benefit eligibility. We use policy-induced shifts in the kink formula relating prior earnings to unemployment benefits to estimate the separate impacts of labor income and unemployment benefits on crime: the results suggest that unemployment benefits do not significantly offset the impact of labor income losses on crime. [ABSTRACT FROM AUTHOR]

Why do consolidated democracies incorporate international human rights law (IHRL) treaties into national law? Existing research suggests contrastive accounts of the participation of democracies in IHRL regimes. While overall more likely to ratify, consolidated democracies are sometimes reluctant to accept demanding human rights commitments and less likely than both newly democratic and authoritarian regimes to incorporate international law in their constitutions. To theorize why established democracies commit to IHRL, this paper provides a comparative process tracing of the decisions to incorporate the European Convention on Human Rights (ECHR) into national law in Denmark and Sweden in the early 1990s. Why did these solid democracies with an exceptional commitment to human rights wait over 40 years to give domestic effect to a treaty they had helped create? Assessing rival theories of state commitment to human rights norms, the findings suggest that contextual developments in European law provided an opportunity for domestic political elites to seek insurance by incorporating the ECHR to place constraints on executive power. The argument qualifies claims about material strategizing or socialization to European norms as the primary drivers of incorporation. [ABSTRACT FROM AUTHOR]

In the recent debate on megaprojects (MPs), greater attention is devoted to the functioning of the interorganizational and multiactor networks that are one of the most innovative features in recent years. The complexity of these structures brings out governability issues for an MP's management. Mutual recognition and consent become elements capable of inaugurating more collaborative processes and practices to reduce organizational and management criticalities in MPs. This paper focuses on a neglected relational dimension, namely legitimacy. We argue that legitimacy is instead the central dimension that attributes effectiveness and capacity for action to the organizations involved. Legitimacy regulates the relationship between various organizations--and especially--between organizations and the public sphere. Institutionalist theory assigns a central role to legitimacy in the construction of social processes, defining it as a generalized form of social acceptance toward an actor, an idea, or a project. In this paper, we hypothesize that the legitimacy attributed and "held" by the stakeholders is a crucial element in countering three critical aspects of MPs, namely the uncertainty, complexity, and conflict acting on the construction of public consensus and the quality of relationships between the participating stakeholders. We verify our hypothesis by analyzing a cross-border MP, the Fehmarnbelt Fixed Link between Germany and Denmark. The paper concentrates on the mechanisms with which stakeholders can acquire legitimacy using the Eriksen discursive legitimation scheme. These mechanisms are different (evidence-based, public participation, and legislators' command) and produce different outcomes in terms of increasing or containing these three criticalities. [ABSTRACT FROM AUTHOR]

The purpose of this paper is to explore the relation between territorial stigmatization and community work in Denmark. In the paper, we firstly explore territorial stigmatization, relating it to the Danish context. We show how territorial stigmatization in Denmark happens via a complex amalgamation of bureaucratic practices which identify particular areas as problematic 'ghettos', and how this leads to top–down interventions upon many local residential areas, including local community work. Following this, we draw on participant observations in practices of local community work, and interviews with local community workers, to explore how they practically negotiate these particular political constructions of their work. We argue that local community workers come to take on interstitial roles—that is, they come to be in-between the state and authorities and the local communities themselves. This complex double role is what we call an interstitial position, meant to signify how Danish local community workers are both part of territorial stigmatization and simultaneously trying to escape from and undo this very role. [ABSTRACT FROM AUTHOR]

Elites often use merit to explain, justify, and make sense of their advantaged positions. But what exactly do they mean by this? In this paper, we draw on 71 interviews with elites in Denmark and the UK to compare self-justifications of meritocratic legitimacy. Our results indicate that while elites in both countries are united by a common concern to frame their merits as spontaneously recognized by others (rather than strategically promoted by themselves), the package of attributes they foreground vary significantly. In the UK, elites tend to be "talent meritocrats" who foreground their unique capacity for ideational creativity or risk taking, innately good judgment, and "natural" aptitude, intelligence, or academic ability. In contrast, in Denmark, elites are more likely to be "hard work meritocrats" who emphasize their unusual work ethic, extensive experience (as a signal of accumulated hard work), and contributions outside of work, particularly in civil society. We tentatively argue that one explanation for this cross-national variation is the role that different channels of elite recruitment play in amplifying legitimate notions of merit. In the UK, for example, elite private schools act to nurture ideas of exceptionalism and natural talent, whereas in Denmark elite employers socialize the connection between hard work and success. These findings suggest that nationally specific understandings of merit can have quite different implications for the legitimation of inequality. [ABSTRACT FROM AUTHOR]

All countries want to improve the health of their populations and to improve the quality of care and patient safety. Consequently, there is an ongoing need to assess and document population health, the quality of care and patient safety using valid and reliable data. This requires the ability to monitor the same individuals over time as they receive prevention, diagnostics, treatments, care and rehabilitation and experience improvements or deteriorations in their health or healthcare. This is, however, a challenge for most healthcare systems. A prerequisite to such data is the unique personal identifier. This perspective on quality paper describes the experience with the unique personal identifier in Denmark, based on the Danish Civil Registration System (DCRS) as a tool for research in epidemiology, health services research, quality improvement and patient safety. DCRS has been celebrating its 50 years anniversary. [ABSTRACT FROM AUTHOR]

This paper describes children's perceptions and visions for a healthier social and physical environment in the setting of a primary school on the Danish island of Bornholm. Guided by an everyday-life perspective and applying participatory action research methods including social imagination and visual techniques within the framework of future creating workshops, the study engaged 50 children aged 6–9 years in creative processes of identifying health-related problem areas and solutions in their school setting. The study observed that the children were very capable of articulating their thoughts, ideas and visions for a better and healthier school environment. Identified problem areas and solutions differed widely and represented a broad perspective of health including social, physical, environmental and emotional aspects. The paper discusses advantages and challenges of involving children in decision-making processes and concludes that children are visionary and creative agents of change in health promotion projects provided that applied participatory methods are appealing to the children. [ABSTRACT FROM AUTHOR]

Although educational stratification research finds that educational tracking differentiates the development of cognitive skills and academic achievement, little is known about its consequences for noncognitive traits. This paper presents a framework for understanding how track placement affects personality traits and empirically tests its implications using longitudinal survey data from Denmark. I find that enrollment in the vocational track in upper secondary education on average increases conscientiousness by one third of a standard deviation more than enrollment in the academic track does. No other personality traits are affected by track placement. Additional analyses show that the influence of vocational education and training on conscientiousness is greater among students taking on an apprenticeship and learning a skilled trade, suggesting that such training closes the between-track gap in conscientiousness by fostering a skilled worker identity. [ABSTRACT FROM AUTHOR]

Manufacturing in high-income countries is on the decline and Denmark is no exception. Manufacturing employment and the number of firms have been shrinking as a share of the total and in absolute levels. This paper uses a rich linked employer-employee dataset to examine this decline from 1994 to 2007. We propose a different approach to analyze deindustrialization and generate a series of novel stylized facts about the evolution. While most of the decline can be attributed to firm exit and reduced employment at surviving manufacturers, we document that a non-negligible portion is due to firms switching industries, from manufacturing to services. We focus on this last group of firms before, during, and after their sector switch. Overall this is a group of small, highly productive, import intensive firms that grow rapidly in terms of value-added and sales after they switch. By 2007, employment at these former manufacturers equals 8.7 percent of manufacturing employment, accounting for half the decline in manufacturing employment. We focus on the composition of the workforce as firms make their transition. In addition, we identify two types of switchers: one group resembles traditional wholesalers and another group that retains and expands their R&D and technical capabilities. Our findings emphasize that the focus on employment at manufacturing firms overstates the loss in manufacturingrelated capabilities that are actually retained in many firms that switch industries. [ABSTRACT FROM AUTHOR]

Risk-assessment models are widely used in casework involving vulnerable children and families. Internationally, there are a number of different kinds of models with great variation in regard to the characteristics of factors that harm children. Lists of factors have been made but most of them give very little advice on how the factors should be weighted. This paper will address the use of risk-assessment models in six different Danish municipalities. The paper presents a comparative analysis and discussion of differences and similarities between three models: the Integrated Children's System (ICS), the Signs of Safety (SoS) model and models developed by the municipalities themselves (MM). The analysis will answer the following two key questions: (i) to which risk and protective factors do the caseworkers give most weight in the risk assessment? and (ii) does each of the different models ensure a holistic assessment (which is required by law in Denmark)? The study contributes to the discussion about the use of risk-assessment models and whether these newer models have actually made a difference in what is assessed when looking at families at risk. [ABSTRACT FROM AUTHOR]

STUDY QUESTION Does maternal infection with severe acute respiratory syndrome Coronavirus-2 (SARS-CoV-2) in first trimester pregnancy have an impact on the fetal development as measured by nuchal translucency thickness and pregnancy loss? SUMMARY ANSWER Nuchal translucency thickness at the first trimester scan was not significantly different in pregnant women with versus without SARS-CoV-2 infection in early pregnancy and there was no significantly increased risk of pregnancy loss in women with SARS-CoV-2 infection in the first trimester. WHAT IS KNOWN ALREADY Pregnant women are more vulnerable to viral infections. Previous coronavirus epidemics have been associated with increased maternal morbidity, mortality and adverse obstetric outcomes. Currently, no evidence exists regarding possible effects of SARS-CoV-2 in first trimester pregnancies. STUDY DESIGN, SIZE, DURATION Cohort study of 1019 women with a double test taken between 17 February and 23 April 2020, as a part of the combined first trimester risk assessment, and 36 women with a first trimester pregnancy loss between 14 April and 21 May 2020, prior to the double test. The study period was during the first SARS-CoV-2 epidemic wave in Denmark. PARTICIPANTS/MATERIALS, SETTING, METHODS Cohort 1 included pregnant women with a double test taken within the study period. The excess serum from each double test was analyzed for SARS-CoV-2 antibodies. Results were correlated to the nuchal translucency thickness and the number of pregnancy losses before or at the time of the first trimester scan. Cohort 2 included women with a pregnancy loss before the gestational age for double test sample. Serum from a blood test taken the day the pregnancy loss was identified was analyzed for SARS-CoV-2 antibodies. The study was conducted at a public university hospital serving ∼12% of pregnant women and births in Denmark. All participants in the study provided written informed consent. MAIN RESULTS AND THE ROLE OF CHANCE Eighteen (1.8%) women had SARS-CoV-2 antibodies in the serum from the double test suggestive of SARS-CoV-2 infection in early pregnancy. There was no significant difference in nuchal translucency thickness for women testing positive for previous SARS-CoV-2 infection (n = 16) versus negative (n = 966) (P  = 0.62). There was no significantly increased risk of pregnancy loss for women with antibodies (n = 1) (OR 3.4, 0.08–24.3 95% CI, P  = 0.27). None of the women had been hospitalized due to SARS-CoV-2 infection. None of the women with pregnancy loss prior to the double test (Cohort 2) had SARS-CoV-2 antibodies. LIMITATIONS, REASONS FOR CAUTION These results may only apply to similar populations and to patients who do not require hospitalization due to SARS-CoV-2 infection. A limitation of the study is that only 1.8% of the study population had SARS-CoV-2 antibodies suggestive of previous infection. WIDER IMPLICATION OF THE FINDINGS Maternal SARS-CoV-2 infection had no effect on the nuchal translucency thickness and there was no significantly increased risk of pregnancy loss for women with SARS-CoV-2 infection in first trimester pregnancy. Evidence concerning COVID-19 in pregnancy is still limited. These data indicate that infection with SARS-CoV-2 in not hospitalized women does not pose a significant threat in first trimester pregnancies. Follow-up studies are needed to establish any risk to a fetus exposed to maternal SARS-CoV-2 infection. STUDY FUNDING/COMPETING INTEREST(S) Prof. H.S.N. and colleagues received a grant from the Danish Ministry of Research and Education for research of COVID-19 among pregnant women. The Danish government was not involved in the study design, data collection, analysis, interpretation of data, writing of the report or decision to submit the paper for publication. A.I. J.O.-L. J.B.-R. D.M.S. J.E.-F. and E.R.H. received funding from a Novo Nordisk Foundation (NNF) Young Investigator Grant (NNF15OC0016662) and a Danish National Science Foundation Center Grant (6110-00344B). A.I. received a Novo Scholarship. J.O.-L. is funded by an NNF Pregraduate Fellowship (NNF19OC0058982). D.W. is funded by the NNF (NNF18SA0034956, NNF14CC0001, NNF17OC0027594). A.M.K. is funded by a grant from the Rigshospitalet's research fund. H.S.N. has received speaker's fees from Ferring Pharmaceuticals, Merck Denmark A/S and Ibsa Nordic (outside the submitted work). N.l.C.F. has received a grant from Gedeon Richter (outside the submitted work). A.M.K. has received speaker's fee from Merck (outside the submitted work). The other authors did not report any potential conflicts of interest. TRIAL REGISTRATION NUMBER N/A [ABSTRACT FROM AUTHOR]

This paper presents estimates based on individual data of downward nominal and real wage rigidities for 13 sectors in Belgium, Denmark, Spain, and Portugal. Our methodology follows the approach recently developed for the International Wage Flexibility Project, whereby resistance to nominal and real wage cuts is measured through departures of observed individual wage change histograms from an estimated counterfactual wage change distribution that would have prevailed in the absence of rigidity. Our estimates of wage rigidities are set against structural features of the labour markets studied, including the wage bargaining level and the degree of product market competition. [ABSTRACT FROM AUTHOR]

Over the past decade, horizon scanning has been recognised as part of forward-looking government processes in a number of industrialised countries. It helps policy-makers in addressing the diversity of future societal and environmental challenges and in addressing the potential of emerging areas of science and technology in an integrated way. This paper discusses the usefulness of horizon scanning as an additional tool for future-oriented technology analysis activities, such as technology foresight and scenario building. Analysing the national horizon scans of the UK, the Netherlands and Denmark in a joint horizon pilot project initiated under the ERA-Net ForSociety, this paper makes a series of recommendations regarding horizon scanning processes at the national level and the construction of common future-oriented policies. [ABSTRACT FROM AUTHOR]

In Denmark, third mission activities were for the first time explicitly formulated as mandatory in the University Act of May 2003, and the purpose of this paper is to analyze current third mission experiences from two younger Danish universities (University of Southern Denmark and Aalborg University). The two case studies show that third mission activities are perceived and implemented in different ways, depending on factors both internal and external to the university. Third mission activities are becoming more strategic for the universities and their collaboration partners, and the paper concludes that there is a need for universities, policy-makers and society in general to find a balance between commercialization and open access to university-generated knowledge, a balance between third mission activities aiming at industry demand and broader societal considerations, and a balance between the allocation of financial and other resources among the three missions. [ABSTRACT FROM AUTHOR]

Study Question: Is there a difference in testicular function in early adulthood between men born with cryptorchidism and men born with normally descended testes?Summary Answer: In men from the general population, a history of cryptorchidism was associated with lower total testis volume and impaired semen quality as well as altered serum levels of reproductive hormones.What Is Known Already: The association between cryptorchidism and testicular function is well documented in studies based on sub-fertile or infertile men recruited from a clinical setting. However, the association has not previously been investigated in men from the general population, who were unselected regarding fertility status.Study Design, Size, Duration: This is a cross-sectional population-based study of 6376 young Danish men examined from 1996 to 2017.Participants/materials, Setting, Methods: This study is based on young men from the greater Copenhagen area, Denmark (median age of 19 years) who were unselected regarding fertility status and semen quality. The young men delivered a semen sample, had a blood sample drawn and underwent a physical examination including assessment of testis volume. Participants completed a questionnaire regarding cryptorchidism at birth, current lifestyle and their mother's pregnancy, after consulting their mother. The differences in markers of testicular function, including testis volume, semen parameters and reproductive hormones between men with and without a history of cryptorchidism were investigated with multiple linear regression analyses.Main Results and the Role Of Chance: The participation rate was 24% for the entire study period. Overall, a history of cryptorchidism was associated with reduced testicular function. In the adjusted models, a history of cryptorchidism was associated with a 3.5 ml lower total testis volume, determined by orchidometer (P < 0.001), 28% lower sperm concentration (95% CI: -37 to -20) and 26% lower inhibin B/FSH ratio (95% CI: -50 to -22) compared to men without a history of cryptorchidism, suggesting a reduced spermatogenetic capacity. Men with a history of cryptorchidism also had a slightly reduced Leydig cell function expressed as a 6% lower testosterone/LH ratio (95% CI: -12 to -0.7). The significant effect sizes and different markers of testicular function pointing in the same direction across the different models based on a large sample size support that the results are not chance findings.Limitations, Reasons For Caution: Information on cryptorchidism at birth and treatment modus was obtained by retrospective self-report, and each participant only delivered one semen sample.Wider Implications Of the Findings: The results suggest that men with a history of cryptorchidism could be at increased risk of experiencing fertility problems. However, among these men there is a wide variation in semen quality and further research is needed in order to identify the subgroup of boys born with cryptorchidism who are at the greatest risk of impaired semen quality when reaching adulthood.Study Funding/competing Interest(s): The study received financial support from the Research fund of Rigshospitalet, Copenhagen University Hospital; the European Union (Contract numbers BMH4-CT96-0314, QLK4-CT-1999-01422, QLK4-CT-2002-00603. FP7/2007-2013, DEER Grant agreement no. 212844); the Danish Ministry of Health; the Danish Environmental Protection Agency; A.P. Møller and wife Chastine McKinney Møllers Foundation; and Svend Andersens Foundation. None of the founders had any role in the study design, collection, analysis or interpretation of data, writing of the paper or publication decisions. The authors have nothing to declare.Trial Registration Number: N/A. [ABSTRACT FROM AUTHOR]

Although there is some evidence of declining intergenerational mobility in wealthy countries, the sources of these changes are not well understood. This paper examines the changes in intergenerational mobility in Denmark, which has one of the highest levels of intergenerational mobility in the world. We show that mobility has been declining for both men and women since the late 1950s across the most recent cohorts who are now old enough to measure permanent adult income, and that these changes were concentrated among children born into the middle three-fifths of the income distribution. We examine the sources of this decline by testing hypotheses related to demographic processes, returns to education, and work experience. Our results highlight the importance of both parent and child work experience and family structure in the family of origin among both men and women as well as, to a lesser degree, marital status, assortative mating, and childbearing among women. Although education was an important driver of parent-child income rank associations (IRA) in each cohort, it played little role in accounting for increases in those associations across cohorts. [ABSTRACT FROM AUTHOR]

After an extensive period of public controversy, the Danish parliament legalised stem cell research on 'spare' embryos in 2003. This paper argues that this legalisation was dependent on a perception of acceptability among the public and explores how public debate can serve a 'performatory function' in establishing such a situation of perceived legitimacy. The intention of this paper, however, is not to examine the Danish controversies in order to unravel the substantial ethico-political issues in the governance of stem cell research, but rather to understand the specific processes through which the formation of public opinion has contributed to the shaping of the acceptability of stem cell research. The paper analyses the various constructions of legitimate voices and their representation in the policy process and demonstrates that the framing of representation changed during the policy process. This change in framing made it possible to obtain a compromise, and can therefore be seen as a necessary precondition for the decision to permit stem cell research. [ABSTRACT FROM AUTHOR]

The aim of this article is to present an alternative method for science mapping, which remedies some of the classic limitations to e.g. using co-citation analysis as a mapping tool. With the emergence of new, more complex and interdisciplinary areas of research it becomes important to adjust our understandings of how to study these areas, and the argument of the present paper is that in order to provide high-resolution maps of emerging scientific areas, we need to start in the 'cognitive colleges' of the research areas themselves. To do so, a mixed methods design with co-nomination as its backbone is proposed. The potential and limitations of the alternative approach to science mapping are discussed based on an empirical example of mapping an vaguely defined research area in Denmark. [ABSTRACT FROM AUTHOR]

Background The Nordic countries represent a unique case study for the COVID-19 pandemic due to socioeconomic and cultural similarities, high-quality comparable administrative register data and notable differences in mitigation policies during the pandemic. We aimed to compare weekly excess mortality in the Nordic countries across the three full pandemic years 2020–2022. Methods Using data on weekly all-cause mortality from official administrative registers in Denmark, Finland, Norway and Sweden, we employed time series regression models to assess mortality developments within each pandemic year, with the period 2010–2019 used as reference period. We then compared excess mortality across the countries in 2020–2022, taking differences in population size and age- and sex-distribution into account. Results were age- and sex-standardized to the Danish population of 2020. Robustness was examined with a variety of sensitivity analyses. Results While Sweden experienced excess mortality in 2020 [75 excess deaths per 100 000 population (95% prediction interval 29–122)], Denmark, Finland and Norway experienced excess mortality in 2022 [52 (14–90), 130 (83–177) and 88 (48–128), respectively]. Weekly death data reveal how mortality started to increase in mid-2021 in Denmark, Finland and Norway, and continued above the expected level through 2022. Conclusion Although the Nordic countries experienced relatively low pandemic excess mortality, the impact and timing of excess mortality differed substantially. These estimates—arguably the most accurate available for any region in capturing pandemic-related excess deaths—may inform future research and policy regarding the complex mortality dynamics in times of a health crisis such as the COVID-19 pandemic. [ABSTRACT FROM AUTHOR]

The article discusses the highlights of the International Media Conference at the University of Copenhagen in Denmark held on December 1-4, 1997. It was a four-day conference which was organized into four sections, focusing on history, aesthetics, cognition and social issues, The program featured speakers from Great Britain, France and Germany and the papers were delivered at plenaries which provided a chance for distanced observation.

Denmark has accepted refugees from a large variety of countries and for more than four decades. Denmark has also frequently changed policies and regulations concerning integration programmes, transfer payments, and conditions for permanent residency. Such policy variation in conjunction with excellent administrative data provides an ideal laboratory to evaluate the effects of different immigration and integration policies on the outcomes of refugee immigrants. In this article, we first describe the Danish experience with refugee immigration over the past four decades. We then review different post-arrival refugee policies and summarize studies that evaluate their effects on the labour market performance of refugees. Lastly, we discuss and contrast these findings in the context of international studies of similar policies and draw conclusions for policy. [ABSTRACT FROM AUTHOR]

Background. According to the World Health Organization, depression ranks as a major contributor to the global burden of disease. A large proportion of adult depressions had their first appearance in adolescence. Brief and reliable rating scales are needed for early detection. Objective. The aim of this study is to validate the WHO-5 and the HSCL-6 for detection of depression among adolescents. Methods. The project is a GP multicentre study conducted in Denmark and Norway. A total of 294 adolescents (14-16 years) responded by answering a paper- or web-based questionnaire and later completed a Composite International Diagnostic Interview, which was used as the gold standard. Depression was defined by ICD-10 criteria. Criterion validity was examined, the likelihood ratios measured and cut-offs for depression were calculated using the Youden index. Results. The prevalence of depression was 11.8% in our sample. The optimal cut-off point was 11 for the WHO-5 test and 9 for the HSCL-6 test. There were no gender differences. For the WHO-5 and the HSCL-6, respectively, the sensitivity was 0.88 [95% confidence interval (CI): 0.74-0.96] and 0.85 (95% CI: 0.70-0.94), the specificity was 0.80 (95% CI: 0.75-0.85) and 0.79 (95% CI: 0.74-0.84) and the likelihood ratio was 4.5 and 3.8 (P = 0.39). We observed no statistically significant diagnostic differences with respect to nationality or administration procedure. Conclusions. The WHO-5 and the HSCL-6 may both serve as valid case finding instruments for depression in young people in primary care. [ABSTRACT FROM AUTHOR]

This paper investigates the political coalitions giving rise to diverse types of interactions between revenue systems and welfare states. It has been widely acknowledged that coordinated economies with larger public sectors have somewhat regressive tax systems, with a heavy reliance on the taxation of consumption and wages over capital and property. Liberal economies, alternatively, have had more progressive tax systems but smaller welfare states. I suggest that the divergence in the mechanisms for representing employers—through industrial relations and party systems—helps to explain how different models of taxing and spending develop over the course of the twentieth century. Industrial coordination encourages higher levels of tax consent among employers, by simultaneously expanding employers' support for social programmes and giving employers the leverage to restrict taxation of capital and to push consumption taxes. The paper evaluates the role of employers and industrial coordination in the architecture of tax regimes in Denmark and the USA in the early 1900s and 1960s. [ABSTRACT FROM PUBLISHER]

Relatedness has often been shown to have a central role in regional diversification. Knowledge flows between related industries are an important source of innovation, leading to industry growth and the establishment of new industries. Earlier studies have focused on dynamic diversification into new industries, but in this study, we emphasize static diversification, that is, changes in the balance between existing industries in a region. We use linked employer–employee data from Denmark and construct a range of measures at the level of regional industries. The role of relatedness in static diversification 2008–2013 is then analyzed based on industry characteristics in 2008. We find that relatedness plays a more important role in regions that are either spatially peripheral or economically non-peripheral, while relatedness has no relationship to static diversification on average. In addition to the empirical result, we contribute by comparing indices of relatedness, suggesting an alternative employment-weighted index, and conceptualizing relatedness as itself a disparity dimension of diversity. We finally ask how static and dynamic diversification affect disparity. We find that human capital intensity plays an important role in the link between diversification and the evolution of disparity. [ABSTRACT FROM AUTHOR]

Background Little is known about how pharmaceutical companies lobby authorities or experts regarding procurement or the use of vaccines and antivirals. This paper investigates how members of Denmark's pandemic planning committee experienced lobbying efforts by Roche, manufacturer of Tamiflu, the antiviral that was stockpiled before the 2009 A(H1N1) pandemic. Methods Analysis of interviews with six of seven members of the Danish core pandemic committee, supplemented with documentary analysis. We sought to identify (1) arguments and (2) tactics used in lobbying, and to characterize interviewees' views on the impact of (3) lobbying and (4) scientific evidence on the decision to stockpile Tamiflu. Results Roche lobbied directly (in its own name) and through a seemingly independent third party. Roche used two arguments: (1) the procurement agreement had to be signed quickly because the drug would be delivered on a first-come, first-served basis and (2) Denmark was especially vulnerable to an influenza crisis because it had smaller Tamiflu stocks than other countries. Most interviewees suspected that lobbying had an impact on Tamiflu procurement. Conclusions Our study highlights risks posed by pharmaceutical lobbying. Arguments and tactics deployed by Roche are likely to be repeated whenever many countries are negotiating drug procurements in a monopolistic market. [ABSTRACT FROM AUTHOR]

School-based interventions for increasing physical activity among children are widespread, however there is still a lack of knowledge about how school context factors are linked to implementation quality and effectiveness of programmes. The aim of this paper is to examine teacher-perceived effectiveness of a Danish national classroom-based health programme 'Active Around Denmark' and in particular, to investigate whether perceptions vary as a function of school social context factors. After completion of the programme all teachers (N=5.892) received an electronic questionnaire. 2.097 completed the questionnaire (response rate 36%) and 1.781 datasets could be used for analysis. The teachers were asked about their perceptions of changes in children's attitudes towards and levels of physical activity after the competition. Our results indicated that certain contextual factors, such as schools' prioritization of health promotion, teachers' support by their school principal in implementation as well as teacher's satisfaction with the school' physical environment made a significant difference in teacher-perceived effectiveness. To conclude, teacher-perceived effectiveness of the health programme does vary as a function of school social context factors. [ABSTRACT FROM AUTHOR]

Background: Approximately 30–40% of heart patients develop anxiety and/or depression, which might influence recovery and long-term survival. Research has suggested that support from relatives may decrease anxiety and depression among heart patients; however, the results are inconsistent and often based on small study populations. Aim: The paper aimed to investigate the association between having supportive relatives and the occurrence of anxiety and depression in heart patients. Methods: A population-based cross-sectional study among Danish patients diagnosed with ischemic heart disease, atrial fibrillation, heart failure, or heart valve disease. Presence of supportive relatives was measured as the degree to which the patients felt that they had relatives they could count on, while symptoms of anxiety and depression were measured by the Hospital Anxiety and Depression Scale (HADS). Multiple logistic regression analyses accounting for confounders were used to examine the association between supportive relatives and anxiety/depression. Results: The questionnaire was answered by 2496 heart patients, corresponding to 50% of the invited population. Patients with low or some degree of supportive relatives had a higher odds ratio (OR) of anxiety than patients with a high degree (OR = 2.20, 95% confidence interval (CI): 1.28–2.37; OR = 1.75, 95% CI: 1.57–3.08, respectively). Likewise, patients with low or some degree of supportive relatives had a higher OR of depression than patients with a high degree (OR = 1.96, 95% CI: 1.40–2.66; OR = 1.93, 95% CI: 1.37–2.60, respectively). Conclusions: The presence of supportive relatives was found to be associated with lower occurrence of anxiety and depression. Health professionals should focus on including relatives in the treatment and rehabilitation of heart patients. [ABSTRACT FROM AUTHOR]

Action on the social determinants of health (SDH) through intersectoral policymaking is often suggested to promote health and health equity. This paper argues that the process of intersectoral policymaking influences how the SDH are construed and acted upon in municipal policymaking. We discuss how the intersectoral policy process legitimates certain practices in the setting of Danish municipal health promotion and the potential impact this can have for long-term, sustainable healthy public policy. Based on ethnographic fieldwork, we show how the intention of intersectoriality produces a strong concern for integrating health into non-health sectors to ensure productive collaboration. To encourage this integration, health is often framed as a means to achieve the objectives of non-health sectors. In doing so, the intersectoral policy process tends to favor smaller-scale interventions that aim to introduce healthier practices into various settings, e.g. creating healthy school environments for increased physical activity and healthy eating. While other more overarching interventions on the health impacts of broader welfare policies (e.g. education policy) tend to be neglected. The interventions hereby neglect to address more fundamental SDH. Based on these findings, we argue that intersectoral policymaking to address the SDH may translate into a limited approach to action on so-called 'intermediary determinants' of health, and as such may end up corrupting the broader SDH. Further, we discuss how this corruption affects the intended role of non-health sectors in tackling the SDH, as it may impede the overall success and long-term sustainability of intersectoral efforts. [ABSTRACT FROM AUTHOR]

Background Major emergency abdominal surgery is associated with a high risk of morbidity and mortality. Given the ageing and increasingly frail population, understanding the impact of frailty on complication patterns after surgery is crucial. The aim of this study was to evaluate the association between clinical frailty and organ-specific postoperative complications after major emergency abdominal surgery. Methods A prospective cohort study including all patients undergoing major emergency abdominal surgery at Copenhagen University Hospital Herlev, Denmark, from 1 October 2020 to 1 August 2022, was performed. Clinical frailty scale scores were determined for all patients upon admission and patients were then analysed according to clinical frailty scale groups (scores of 1–3, 4–6, or 7–9). Postoperative complications were registered until discharge. Results A total of 520 patients were identified. Patients with a low clinical frailty scale score (1–3) experienced fewer total complications (120 complications per 100 patients) compared with patients with clinical frailty scale scores of 4–6 (250 complications per 100 patients) and 7–9 (277 complications per 100 patients) (P < 0.001). A high clinical frailty scale score was associated with a high risk of pneumonia (P = 0.009), delirium (P < 0.001), atrial fibrillation (P = 0.020), and infectious complications in general (P < 0.001). Patients with severe frailty (clinical frailty scale score of 7–9) suffered from more surgical complications (P = 0.001) compared with the rest of the cohort. Severe frailty was associated with a high risk of 30-day mortality (33% for patients with a clinical frailty scale score of 7–9 versus 3.6% for patients with a clinical frailty scale score of 1–3, P < 0.001). In a multivariate analysis, an increasing degree of clinical frailty was found to be significantly associated with developing at least one complication. Conclusion Patients with frailty have a significantly increased risk of postoperative complications after major emergency abdominal surgery, especially atrial fibrillation, delirium, and pneumonia. Likewise, patients with frailty have an increased risk of mortality within 90 days. Thus, frailty is a significant predictor for adverse events after major emergency abdominal surgery and should be considered in all patients undergoing major emergency abdominal surgery. [ABSTRACT FROM AUTHOR]

Background: Gambling products differ in terms of their harm potential. Products are also constantly developing and changing. However, little research has addressed changes and trends in the types of gambling that are associated with harms. The current study explores trends in the gambling product categories identified as harmful in longitudinal helpline data from three Nordic countries. Methods: We use data collected by national helplines in Denmark (StopSpillet), Finland (Peluuri) and Sweden (Stödlinjen) in their daily operations (N = 46 646). The data consist of information collected on gamblers and concerned significant others who have contacted these helplines between January 2019 and December 2022. We analyse which gambling products are mentioned as harmful by clients. The analysis uses linear regression with the interaction term (country) times time regressed over the outcome variable (proportion per month). Results: The results show that an increased share of contacts concern online gambling. Online casino products have become the most harmful category across contexts. The share of reported harms from online betting and new emerging online forms is also increasing. The share of land-based products as a reported source of harms has decreased across 2019-22. Conclusions: The results suggest that online gamlbing environments, and particularly online casino products, are associated with increasing harms to help-seekers. The harmfulness of different gambling products may not be stable, but change over time. Further harm prevention efforts are needed to address the online gambling field, including emerging formats. [ABSTRACT FROM AUTHOR]

Background. According to the World Health Organization, depression ranks as a major contributor to the global burden of disease. A large proportion of adult depressions had their first appearance in adolescence.Aim. Because primary health care professionals lack valid instruments for early identification of depression, we sought to validate HSCL-10. The design of study is a GP multicentre study conducted in Norway and Denmark. The setting of the study is adolescents (14–16 years) responded by answering a questionnaire and later completed a Composite International Diagnostic Interview, which was used as the gold standard. Depression was defined by International Classification of Diseases-10 (ICD-10). Both internal and external validity were examined, the likelihood between pretest and posttest measured and a cut-off point for depression calculated by using the Youden index.Results. The Hopkins Symptom Checklist-10 test (HSCL-10) met the criteria for external and internal validity. When analysed separately, the criteria were met both in Denmark and in Norway and both for paper and web. The optimal cut-off point for the HSCL-10 test was 16 (HSCL-10 = 16/10 items = 1.6), with no gender differences. For girls and boys, respectively, it yielded a sensitivity of 87.5% and 87.5%, specificity of 72.4% and 87.9% and likelihood of 3.2 and 7.2.Conclusion. HSCL-10 is a suitable and valid instrument for detecting depression in young people in primary care. [ABSTRACT FROM PUBLISHER]

This paper analyses the importance of financial disincentives for workers in Denmark. Based on a panel survey which is merged to a number of administrative registers it is possible to calculate precise measures of the economic incentives for labour‐force participants between employment in a full time job and being on unemployment insurance benefits and considering also the fixed costs of work. The results indicate large disincentive effects for some groups, especially low paid women. In 1996, 6 per cent of Danish men and 13 per cent of the women had a lower disposable net income if working in a full‐time job compared to being on unemployment benefits. The effect of these financial disincentives is analysed in simple reduced form models of on‐the‐job search, unemployed search behaviour, unemployment risk, and transitions out of the labour force. We find that the net compensation rate in unemployment has a significant impact on women's propensity to leave the labour force, on measures of search intensity, on the risk of being hit by unemployment, and on one of our flexibility measures, i .e. the maximum acceptable commuting time to a job. The net compensation rate has no impact on the willingness to move to another place to get a job. However, here we find a significant impact from measures related to job attitude. We end the paper reporting the results from including attitude variables along with economic variables. We find a number of significant effects from attitude variables. However, the main conclusion is that economic incentives dominate the present analysis of unemployment traps. [ABSTRACT FROM PUBLISHER]

Hidradenitis suppurativa is a chronic condition in which boil‐like lumps develop in the armpits and groins, under the breasts and around the buttocks. There is often a delay in making a diagnosis, as it is often misdiagnosed as infection. The lesions are often painful and the condition greatly impairs quality of life. Measuring the severity of a disease allows doctors to see whether it improves as a result of treatment. Although there are several methods that can be used to measure the severity of hidradenitis suppurativa in the research setting, they can be too cumbersome for use in a busy general clinic. Patient Global Assessment (PtGA) is a method that has proved to be useful in assessing disease severity in other chronic conditions such as rheumatoid arthritis. In this paper, the authors from Wales, Denmark and the USA developed a PtGA specifically for use by patients with hidradenitis suppurativa, developing it with focus groups of patients with the condition. They then recruited 441 patients with hidradenitis suppurativa attending clinics in the USA and Denmark, either face to face or by telephone. The researchers measured the severity of disease using the PtGA along with other methods: Hidradenitis Suppurativa Quality of Life (HiSQOL – a measure specific to people with hidradenitis suppurativa), Dermatology Life Quality Index (DLQI), Hospital Anxiety and Depression Scale (HADS) and measures of pain. They found that the PtGA gave consistent results on repeat testing and provided an accurate measure of disease severity, as it correlated well with the HiSQOL and pain scale. It was less effective at determining changes in disease activity. The authors conclude that the PtGA could be a useful quick tool in the busy clinic setting. Linked Article: Kirby et al. Br J Dermatol 2021; 184:681–687. Linked Article: Kirby et al. Br J Dermatol 2021; 184:681–687. [ABSTRACT FROM AUTHOR]

This paper derives a generalised dynamic arbitrage model for the aggregated real user cost of capital attributable to the agricultural firm. The applicability of the model is demonstrated by analysing structural differences in investment incentives between the crop, dairy and hog industries for different farm sizes in Denmark and Sweden during the period between 1984 and 1995. The results indicate notable differences in user costs between countries, farm sizes and farming systems. Although larger farms are found to be characterised by a lower user cost, this result is mitigated by the structure of asset composition. [ABSTRACT FROM PUBLISHER]

Objectives Adrenocortical carcinoma (ACC) is a malignant tumor originating from the adrenal cortex. The aim of the study was to report the incidence of ACC and survival of ACC in Denmark. The secondary objective was to describe the impact of treatment with mitotane on survival. Design Retrospective population study of patients diagnosed with ACC between 2003 and 2019 in Denmark. Methods Individuals at risk for ACC were identified in the national Danish Health registries, and diagnosis of ACC was confirmed by review of the health records. Data on demographics, presentation, treatment, recurrence, and death was evaluated. Results 138 patients were included in the study with more females (59.4%) than males (40.6%). Incidence rate was 1.4 per million per year. The incidence rate ratio significantly increased only in females by 1.06 [95% confidence interval (CI): 1.02-1.12] per year. Overall median survival was 1.93 (95% CI: 1.24-3.00) years with no differences between males and females. The proportion of patients treated with mitotane (either as adjuvant treatment or as part of a chemotherapeutic regime) was 72.3%. Survival was significantly decreased in women not treated with mitotane compared to women treated with mitotane (either as adjuvant or as part of a chemotherapeutic regime) hazards ratio.30 (95% CI:.10-.89), adjusted for European Network for the Study of Adrenal Tumours score, age at diagnosis, and year of diagnosis, but survival was unaffected by mitotane treatment in men. Conclusion Incidence of ACC in Denmark was 1.4 per million per year and increased in women but not in males during the study period 2003-2019. [ABSTRACT FROM AUTHOR]

Recurrent event data are frequently encountered in long-term follow-up studies. In many applications, the gap times between two successive recurrent events are natural outcomes of interest. Investigation on patterns of associations among recurrent gap times within subjects is an important inferential issue. In this paper, we introduce flexible functions of previous gap times to create a class of summary measures of serial associations for a sequence of recurrent gap times through Kendall's tau. Such a general class of serial association measures provides a useful tool to quantify the predictive abilities of event history with different aspects. Non-parametric estimators of the proposed measures of serial associations are developed by generalizing the existing estimator of Kendall's tau for two serial gap times, in which inverse probability of censoring weights is used to overcome the induced dependent censoring. Various tests are further constructed for testing the constancy of serial associations over different events. Our method is applied to Denmark schizophrenia data and the results show that association structures are different for distinct ages of onset of schizophrenia. [ABSTRACT FROM AUTHOR]

Linked Article:Todberg et al. Br J Dermatol 2022; 187:89–98. Microbes living in our digestive tract contribute to human health by enabling us to digest essential nutrients, by protecting the intestinal barrier from infection and in developing the immune system. In patients with several inflammatory and auto‐immune diseases, researchers have found differences in the amount and type of different microbes in the gut compared with healthy individuals and these changes may contribute to the disease process. To date, studies of gut microbes in patients with psoriasis have been inconclusive; they have relied chiefly on cloning the microbial genes using a technique called rRNA sequencing analysis. In this paper, the authors from Denmark studied the gut flora using samples of faeces from 53 patients with psoriasis who were not on systemic treatment. They compared the samples with those from 52 age‐ and sex‐matched healthy people who acted as controls, who were also matched for body mass index (BMI). In addition, they studied samples from 21 partners of the patients with psoriasis, who shared a similar diet and lifestyle. To allow for seasonal variation, they took four to six samples from 18 patients and 19 healthy controls over a 9‐ to 12‐month time period. The authors used a newer and more sensitive technique, 'shotgun metagenomic sequencing analysis' (the term metagenomic refers to genetic material in the environment, in this case the microbes in the gut). This technique involves breaking up the microbial DNA into small fragments and using a computer program to reassemble them by recognizing the base pair patterns at the ends of the fragments. One disadvantage is that the technique cannot distinguish between live and dead bacteria. The faecal samples from the patients with psoriasis had a different pattern and a less diverse range of bacterial species than those from their partners or the healthy controls. This difference was slightly, but not significantly, more noticeable in patients with more severe disease. There was no seasonal variation seen in the sequential samples. The authors excluded other contributory factors such as obesity or diabetes. Further study is needed first but it is possible that improving the diversity and richness of gut bacteria, using diet or drugs, could be beneficial in patients with psoriasis. Linked Article:Todberg et al. Br J Dermatol 2022; 187:89–98. [ABSTRACT FROM AUTHOR]

Denmark was the first nation in Europe to promote the use of Fully Documented Fisheries (FDF) through Remote Electronic Monitoring (REM) and CCTV camera systems, with pilot schemes in place since 2008. In theory, such a scheme could supplement and even potentially replace expensive control and monitoring programmes; and when associated with a catch quota management (CQM) system, incentivize positive changes in fishing patterns in a results-based management approach. New data flows are, however, required to ensure the practical implementation of such a scheme. This paper reviews the quality of the FDF data collected during 2008-2014 and their potential in strengthening information on cod discards. The analyses demonstrate the improved reporting of discards in logbooks and overall discard reductions, but they also show that some uncertainties around the absolute estimates of discard quantities have remained. Regular validation of weight estimation methods and close collaboration between scientific monitoring and control are important to support the use of reported discards as a reliable source of information. We discuss the potential of electronic monitoring in the context of the EU landing obligation. [ABSTRACT FROM AUTHOR]

Background: Reminders are routinely applied in surveys to increase response rates and reduce the possibility of bias. This study examines the effect of multiple reminders on the response rate, non-response bias, prevalence estimates and exposure–outcome relations in a national self-administered health survey. Methods: Data derive from the Danish National Health Survey 2010, in which 298 550 individuals (16 years of age or older) were invited to participate in a cross-sectional survey using a mixed-mode approach (paper and web questionnaires). At least two reminders were sent to non-respondents, and 177 639 individuals completed the questionnaire (59.5%). Response patterns were compared between four groups of individuals (first mailing respondents, second mailing respondents, third mailing respondents and non-respondents). Results: Multiple reminders led to an increase in response rate from 36.7 to 59.5%; however, the inclusion of second and third mailing respondents did not change the overall characteristics of respondents compared with non-respondents. Furthermore, only small changes in prevalence estimates and exposure–outcome relationships were observed when including second and third mailing respondents compared with only first mailing respondents. Conclusions: Multiple reminders were an effective way to increase the response rate in a national Danish health survey. However, when differences do exist between respondents and non-respondents, the results suggest that second and third mailings are unlikely to eliminate these differences. Overall, multiple reminders seemed to have only minor effect on response patterns and study conclusions in the present study. [ABSTRACT FROM AUTHOR]

Background Clinical features of diabetic kidney disease alone cannot differentiate between the histopathology that defines diabetic nephropathy (DN) and non-diabetic nephropathy (NDN). A kidney biopsy is necessary to make the definitive diagnosis of DN. However, there is no consensus on when to perform a kidney biopsy in individuals with diabetes and kidney disease. Furthermore, the implications of NDN versus DN for management, morbidity and kidney prognosis are unclear. To address the gap in knowledge, we aimed to create a national retrospective cohort of people with diabetes and a performed kidney biopsy. Methods Adults diagnosed with diabetes in Denmark between 1996 and 2020 who had a kidney biopsy performed were included. The cohort was established by linking a nationwide diabetes registry with the Danish Pathology Registry. Data from 11 national registries and databases were compiled. The type of kidney disease was classified using a three-step analysis of Systematized Nomenclature of Medicine codes reported in relation to the histopathological examinations of kidney tissue. The final cohort and classification of kidney disease was as follows: out of 485 989 individuals with diabetes 2586 were included, 2259 of whom had type 2 diabetes. We were able to classify 599 (26.5%) with DN, 703 (31.1%) with NDN and 165 (7.3%) with mixed disease in individuals with type 2 diabetes. In individuals with type 1 diabetes, 132 (40.4%) had DN, 73 (22.3%) NDN and 39 (11.9%) mixed disease. The remaining could not be classified or had normal histology. The overall median (Q1–Q3) follow-up time was 3.8 (1.6–7.2) years. Conclusions This cohort is a novel platform based on high-quality registry data for important longitudinal studies of the impact of kidney disease diagnosis on prognosis. With regular updates of data from the Danish registries, the presented follow-up will increase over time and is only limited by emigration or death. [ABSTRACT FROM AUTHOR]

Background Previous research has indicated that children conceived through medically assisted reproduction (MAR) generally have cognitive outcomes comparable to or better than naturally conceived children. However, previous studies have been limited in their ability to examine this relationship at a population level and consider variations across different types of MAR. Methods This study utilizes data from all live births in Denmark between 2006 and 2009 (n  = 259 608), including a subset of births resulting from MAR conceptions (n  = 13 566). The dependent variable is the standardized test scores obtained in the second and third grades of primary schools. A comparison is made between the test scores of children spontaneously conceived (SC) and those conceived through intrauterine insemination (IUI) and assisted reproductive technologies (ART). Ordinary least squares regressions are employed, with a baseline model adjusted only for birth year, as well as models that additionally account for conception-related confounders and sociodemographic family characteristics. Results In the baseline analysis, ART- and IUI-conceived children displayed better test scores compared with their SC peers. However, after adjusting for relevant factors, ART-conceived children performed worse than SC peers, while IUI-conceived children performed equally well as SC peers and better than ART-conceived children. Conclusions These results likely reflect differences in the selection process of potential parents into the type of MAR, as well as the consequences of variations in fecundability. Nevertheless, the differences observed across conception types were overshadowed by test score disparities in socioeconomic background. [ABSTRACT FROM AUTHOR]

Background: A trial of initial non-operative management is recommended in stable patients with adhesional small bowel obstruction. However, recent retrospective studies have suggested that early operative management may be of benefit in reducing subsequent recurrences. This study aimed to compare recurrence rates and survival in patients with adhesional small bowel obstruction treated operatively or non-operatively. Methods: This was a prospective cohort study conducted at six acute hospitals in Denmark, including consecutive patients admitted with adhesional small bowel obstruction over a 4-month interval. Patients were stratified into two groups according to their treatment (operative versus non-operative) and followed up for 1 year after their index admission. Primary outcomes were recurrence of small bowel obstruction and overall survival within 1 year of index admission. Results: A total of 201 patients were included, 118 (58.7 per cent) of whom were treated operatively during their index admission. Patients undergoing operative treatment had significantly better 1-year recurrence-free survival compared with patients managed non-operatively (operative 92.5 per cent versus non-operative 66.6 per cent, P <0.001). However, when the length of index admission was taken into account, patients treated non-operatively spent significantly less time admitted to hospital in the first year (median 3 days non-operative versus 6 days operative, P <0.001). On multivariable analysis, operative treatment was associated with decreased risks of recurrence (HR 0.22 (95 per cent c.i. 0.10–0.48), P <0.001) but an increased all-cause mortality rate (HR 2.48 (95 per cent c.i. 1.13–5.46), P = 0.024). Conclusion: Operative treatment of adhesional small bowel obstruction is associated with reduced risks of recurrence but increased risk of death in the first year after admission. Registration number: NCT04750811 (http://www.clinicaltrials.gov).prior (registration date: 11 February 2021). Most patients with adhesional small bowel obstruction are treated non-operatively. However, recent registry studies suggest that operative management may be of benefit, reducing the risk of recurrent small bowel obstruction. In this prospective multicentre study, we found that operative treatment of adhesional small bowel obstruction was associated with reduced risk of recurrence but increased risk of all-cause mortality rate. [ABSTRACT FROM AUTHOR]

Background: OECD countries over the past two decades have implemented a range of labour market integration initiatives to improve the employment chances of disabled and chronically ill individuals. This article presents a systematic review and evidence synthesis on effectiveness of government interventions to influence employers’ employment practices concerning disabled and chronically ill individuals in five OECD countries. A separate paper reports on interventions to influence the behaviour of employees. Methods: Electronic and grey literature searches to identify all empirical studies reporting employment effects and/or process evaluations of government policies aimed at changing the behaviour of employers conducted between 1990 and 2008 from Canada, Denmark, Norway, Sweden and the UK. Results: Few studies provided robust evaluations of the programmes or their differential effects and selection of participants into programmes may distort the findings of even controlled studies. A population-level effect of legislation to combat discrimination by employers could not be detected. Workplace adjustments had positive impacts on employment, but low uptake. Financial incentives such as wage subsidies can work if they are sufficiently generous. Involving employers in return-to-work planning can reduce subsequent sick leave and be appreciated by employees, but this policy has not been taken up with the level of intensity that is likely to make a difference. Some interventions favour the more advantaged disabled people and those closer to the labour market. Conclusions: Future evaluations need to pay more attention to differential impact of interventions, degree of take-up, non-stigmatizing implementation and wider policy context in each country. [ABSTRACT FROM AUTHOR]

The objective of this project was to develop a theory- and evidence-based adolescent smoking cessation intervention using both new and existing materials. We used the Intervention Mapping framework for planning health promotion programmes. Based on a needs assessment, we identified important and changeable determinants of cessation behaviour, specified change objectives for the intervention programme, selected theoretical change methods for accomplishing intervention objectives and finally operationalized change methods into practical intervention strategies. We found that guided practice, modelling, self-monitoring, coping planning, consciousness raising, dramatic relief and decisional balance were suitable methods for adolescent smoking cessation. We selected behavioural journalism, guided practice and Motivational Interviewing as strategies in our intervention. Intervention Mapping helped us to develop as systematic adolescent smoking cessation intervention with a clear link between behavioural goals, theoretical methods, practical strategies and materials and with a strong focus on implementation and recruitment. This paper does not present evaluation data. [ABSTRACT FROM PUBLISHER]

Life-course epidemiology seeks to better understand the mechanisms that lead to the development of chronic diseases. An example is the mechanism leading from body size to coronary heart disease (CHD); one way to acquire a better understanding of this mechanism is to investigate to what extent it works through other risk factors. In this paper, the dynamic path analysis model is presented as a tool to analyze these dynamic mechanisms in life-course epidemiology. A key feature of dynamic path analysis is its ability to decompose the total effect of a risk factor into a direct effect (not mediated by other variables) and indirect effects (mediated through other variables). This is illustrated by examining the associations between repeated measurements of body mass index (BMI) and systolic blood pressure (SBP) and the risk of CHD in a sample of Danish men between 1976 and 2006. The effect of baseline BMI on the risk of CHD is decomposed into a direct effect and indirect effects going through later BMI, concurrent SBP, or later SBP. In conclusion, dynamic path analysis is a flexible tool that by the decomposition of effects can be used to increase the understanding of mechanisms that underlie the etiology of chronic disease. [ABSTRACT FROM AUTHOR]

This article analyzes how a group of multilingual children in their early adolescence use various forms of language play and position themselves symbolically through involvement in signifying practices. By developing a conceptual framework that combines insights on language play (Cook 2000) and the signifying self (Kramsch 2009), it demonstrates how the children as sign makers and symbolic subjects (re)signify their own learning space. The analysis reveals how, during a reading and joint text construction activity in Danish, they explore the symbolic possibilities of signs and subjectivities, while moving in and out of the text and back and forth between imagined and real worlds. These findings illustrate how the children's interest both shapes their playful interaction and takes shape through it. It furthermore shows how language play contributes to paving the way for a resignification of a potentially vulnerable learner position to a subject position as audible. The paper argues that a detailed focus on children's signifying practices that includes the interactional development of interest can broaden our understanding of language play and its transformative potential. [ABSTRACT FROM AUTHOR]

Since 1955, the professor's privilege had allowed Danish professors to retain intellectual property rights (IPRs) over the results of their research. This changed in 2000, when Denmark, the first of several countries to do so, abolished the professor's privilege and granted IPRs over research results to universities. In this paper we show that in the first years following the abolition, a considerable amount of patenting activity has moved out of professors' hands into those of their universities. We also show that the bulk of academic patenting consists of inventions owned by business companies, and this holds true both before and after the abolition of the privilege. In this respect, the Danish case confirms the European pattern as described in the recent literature and provides useful suggestions on the likely effects of re-distribution of IPRs between universities and their faculties. [ABSTRACT FROM AUTHOR]