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Over 100 bacteria from pulp and slime samples in a Canadian paper mill were identified by partial sequencing of their 16S rDNAs. Seventy-one percent of the isolates could be assigned to a bacterial genus with a high level of confidence. Another 12% exhibited at least 95% similarity within their 16S rDNA sequence with unidentified organisms that originate from warm or wet environments. Pseudomonas, Bacillus, and Pseudoxan-thomonas isolates were represented at a relatively high proportion in both pulp and slime samples. This is the first time that Pseudoxanthomonas strains have been isolated from pulp and slime samples on a paper machine. [ABSTRACT FROM AUTHOR]

Forty-one bacterial strains isolated from the headbox water of two machines in a Canadian paper mill were associated with the genera Asticcacaulis, Acidovorax, Bacillus, Exiguobacterium, Hydrogenophaga, Pseudomonas, Pseudoxanthomonas, Staphylococcus, Stenotrophomonas based on the sequence of their 16S rRNA genes. The metabolic profile of these strains were determined using Biolog EcoPlate, and the bacteria were divided into four metabolic groups. Metabolic profiles of the bacterial communities colonizing the headbox water of two paper machines was also determined weekly over a 1 year period. The only compound that was not reduced by the bacterial community was 2-hydroxybenzoic acid. Utilization frequency of the other carbon sources in the Biolog EcoPlate ranged from 3 to 100%. The metabolic profiles of the bacterial community did not vary considerably between the two paper machines. However, the metabolic profile varied among the sampling dates. [ABSTRACT FROM AUTHOR]

Asthma often starts before six years of age. However, there remains uncertainty as to when and how a preschool-age child with symptoms suggestive of asthma can be diagnosed with this condition. This delays treatment and contributes to both short- and long-term morbidity. Members of the Canadian Thoracic Society Asthma Clinical Assembly partnered with the Canadian Paediatric Society to develop a joint working group with the mandate to develop a position paper on the diagnosis and management of asthma in preschoolers. In the absence of lung function tests, the diagnosis of asthma should be considered in children one to five years of age with frequent (≥8 days/month) asthma-like symptoms or recurrent (≥2) exacerbations (episodes with asthma-like signs). The diagnosis requires the objective document of signs or convincing parent-reported symptoms of airflow obstruction (improvement in these signs or symptoms with asthma therapy), and no clinical suspicion of an alternative diagnosis. The characteristic feature of airflow obstruction is wheezing, commonly accompanied by difficulty breathing and cough. Reversibility with asthma medications is defined as direct observation of improvement with short-acting ß2-agonists (SABA) (with or without oral corticosteroids) by a trained health care practitioner during an acute exacerbation (preferred method). However, in children with no wheezing (or other signs of airflow obstruction) on presentation, reversibility may be determined by convincing parental report of a symptomatic response to a three-month therapeutic trial of a medium dose of inhaled corticosteroids with as-needed SABA (alternative method), or as-needed SABA alone (weaker alternative method). The authors provide key messages regarding in whom to consider the diagnosis, terms to be abandoned, when to refer to an asthma specialist and the initial management strategy. Finally, dissemination plans and priority areas for research are identified. [ABSTRACT FROM AUTHOR]

Previous research on university--industry collaboration in Canada, using mean impact factors as a proxy, concluded that the scientific impact of such research is not inferior to that of university research. Using field-normalized impact factors and citation counts, this paper re-examines the Canadian case. It shows that, when impact factors are field-normalized, university--industry papers are published, on average, in journals with lower impact factors than papers originating from universities only. However, field-normalized citation values reveal the opposite: the average scientific impact of university--industry papers is significantly above that of both university-only papers and industry-only papers. Collaboration with industries is, thus, far from detrimental to the scientific impact of university research and even increases it significantly. [ABSTRACT FROM AUTHOR]

Decision makers in adult social care are increasingly interested in using evidence from research to support or shape their decisions. The scope and nature of the current landscape of adult social care research (ASCR) need to be better understood. This paper provides a bibliometric assessment of ASCR outputs from 1996 to 2011. ASCR papers were retrieved using three strategies: from key journals; using keywords and noun phrases; and from additional papers preferentially citing or being cited by other ASCR papers. Overall, 195,829 ASCR papers were identified in the bibliographic database Scopus, of which 16 per cent involved at least one author from the UK. The UK output increased 2.45-fold between 1996 and 2011. Among selected countries, those with greater research intensity in ASCR generally had higher citation impact, such as the USA, UK, Canada and the Netherlands. The top five UK institutions in terms of volume of papers in the UK accounted for 26 per cent of total output. We conclude by noting the limitations to bibliometric analysis of ASCR and examine how such analysis can support the strategic development of the field. [ABSTRACT FROM AUTHOR]

There is evidence in the literature that technological inventions have an increasing connection to scientific knowledge. This raises two related questions: (1) Are firms increasingly conducting scientific basic research? (2) Is being at the scientific forefront helping firms to be closer to the technological frontier? This paper examines scientific output, as measured by numbers of papers, and technological output, as measured by patents granted to all Canadian firms, during the 1980 to 2005 period. Though the number of firms publishing papers and obtaining patents is increasing, scientific research and patenting by Canadian firms are at near 'homeopathic' levels. Firms that both publish papers and obtain patents (1) perform research that is more basic than firms that only publish scientific papers; (2) publish in more highly cited journals than firms that only perform scientific research; (3) publish papers that are more highly cited; and 4) hold patents that are more frequently cited. [ABSTRACT FROM AUTHOR]

Crops genetically engineered to produce insect-killing proteins from Bacillus thuringiensis (Bt) have revolutionized management of some major pests, but their efficacy is reduced when pests evolve resistance. Practical resistance, which is field-evolved resistance that reduces the efficacy of Bt crops and has practical implications for pest management, has been reported in 26 cases in seven countries involving 11 pest species. This special collection includes six original papers that present a global perspective on field-evolved resistance to Bt crops. One is a synthetic review providing a comprehensive global summary of the status of the resistance or susceptibility to Bt crops of 24 pest species in 12 countries. Another evaluates the inheritance and fitness costs of resistance of Diabrotica virgifera virgifera to Gpp34/Tpp35Ab (formerly called Cry34/35Ab). Two papers describe and demonstrate advances in techniques for monitoring field-evolved resistance. One uses a modified F2 screen for resistance to Cry1Ac and Cry2Ab in Helicoverpa zea in the United States. The other uses genomics to analyze nonrecessive resistance to Cry1Ac in Helicoverpa armigera in China. Two papers provide multi-year monitoring data for resistance to Bt corn in Spain and Canada, respectively. The monitoring data from Spain evaluate responses to Cry1Ab of the corn borers Sesamia nonagrioides and Ostrinia nubilalis , whereas the data from Canada track responses of O. nubilalis to Cry1Ab, Cry1Fa, Cry1A.105, and Cry2Ab. We hope the new methods, results, and conclusions reported here will spur additional research and help to enhance the sustainability of current and future transgenic insecticidal crops. [ABSTRACT FROM AUTHOR]

The article analyzes the factors that helped Canada escape from the effect of prolonged silver agitation in the U.S. despite a strong commercial dependence of the nation on the U.S. The silver agitation was aimed at abolishing the silver certificate currency notes to save money on paper. Financial causes like solidarity of the banking system is held responsible for the reproduction of the same commercial and financial conditions in the two countries. Emergence of local branches of the banks in Canada has not only ensured security to the community, but also resulted risk management at local level.

A key public health response to the COVID-19 pandemic is the mandate to stay home and practice physical distancing. In Canada, with essential activities such as grocery shopping, outdoor exercise and transportation, people need to be able to safely navigate dense, urban spaces while staying at least two metres or six feet apart. This pandemic has exacerbated the health inequities across neighbourhoods in cities like Toronto, Canada which are often segregated along racial and income lines. These inequities impact who has access to urban infrastructure that promotes health and quality of life. Safety in a time of COVID-19 goes beyond just exposure to the virus, it is complicated by notions of who belongs where, and who has access to what resources. The built environment has a role in maintaining and promoting physical and mental health during this pandemic and beyond it. This paper puts forwards three considerations for built environment interventions to promote health equitably: (i) addressing structural determinants of health and embedding anti-racist intersectional principles, (ii) revisiting tactical urbanism as a health promotion tool and (iii) rethinking community engagement processes through equity-based placemaking. This paper outlines four built environment interventions in Toronto, Canada that seek to address the challenges in navigating urban space safely in the short term, including street design that prioritizes pedestrians, protected cycling infrastructure, access to inclusive green space and safe, affordable housing. Longer-term strategies to create health-promoting urban environments that are equitable are discussed and may be valuable to other cities with similar urban equity concerns. [ABSTRACT FROM AUTHOR]

The United States and Canada began major efforts to acquire territory in North America's interior in the nineteenth century. In 1803, the United States purchased approximately 827,192 square miles of territory from France. Canada began to govern 1,409,900 square miles of territory known as Rupert's Land in 1869. Historical accounts of American and Canadian officials' efforts in Washington and Ottawa to obtain these vast territories are abundant. Historians have devoted less attention, however, to expansionists who supported American expansion in Louisiana and Canadian expansion in Rupert's Land. Daniel Clark, U.S. Consul to New Orleans, used his office to promote American acquisition of Spanish Louisiana. Canadian John Christian Schultz, an influential "doctor" and businessperson at Red River, became the owner of the only newspaper in the settlement and used it to advocate for Canadian possession of Rupert's Land. Clark arrived in Louisiana from Ireland in 1786 and Schultz from Upper Canada between 1859 and 1861. Clark and Schultz were opportunists who understood that American and Canadian territorial ambitions presented them with opportunities to advance their business and political careers. Far less important to both men were the futures of other residents of New Orleans and Red River. Clark and Schultz for example, both argued that representative local government should not be immediately introduced in their regions. [ABSTRACT FROM AUTHOR]

Careful planning of an ambulance service is critical to reduce response times to emergency calls and make assistance more effective. However, the demand for emergency services is highly variable, and good prediction of the number of future emergency calls, and their spatial and temporal distribution, is challenging. In this work, we propose a Bayesian approach to predict the number of emergency calls in future time periods for each zone of the served territory. The number of calls is described by a generalized linear mixed effects model, and inference, in terms of posterior predictive distributions, is obtained through Markov chain Monte Carlo simulation. Our approach is applied in a large city in Canada. The paper demonstrates that using a model for areal data provides good results in terms of predictive accuracy and allows flexibility in accounting for the main features of the dataset. Moreover, it shows the computational efficiency of the approach despite the huge dataset. [ABSTRACT FROM AUTHOR]

While attention to the ethical issues that migrants face in accessing tuberculosis care has increased in the last few years, most of the attention has focused on challenges that refugees face when emigrating. Less attention has been given to ethical challenges that arise in the context of providing tuberculosis treatment and care to non-refugee migrants in high-income countries (HIC), particularly those that do not face immediate danger or violence. In this paper, we analyze some of the ethical challenges associated with treating migrants with tuberculosis in the Canadian context. In particular, we will discuss (i) inter- and intra-jurisdictional issues that challenge quotidian public health governance structures, and (ii) the ethical imperative for the Canadian government and its provinces to clearly differentiate access to healthcare from a person's immigration status to help overcome power imbalances that may exist between public health workers and their clients. The arguments presented herein could potentially apply to other HIC with some form of universal health coverage. [ABSTRACT FROM AUTHOR]

Background: Rigorously designed longitudinal studies can inform how best to reduce the widening health gap between Indigenous and non-Indigenous children.Methods: A systematic review was performed to identify and present the breadth and depth of longitudinal studies reporting the health and well-being of Indigenous children (aged 0-18 years) globally. Databases were searched up to 23 June 2020. Study characteristics were mapped according to domains of the life course model of health. Risk of bias was assessed using the National Institutes of Health (NIH) Study Quality Assessment Tools. Reported level of Indigenous involvement was also appraised; PROSPERO registration CRD42018089950.Results: From 5545 citations, 380 eligible papers were included for analysis, representing 210 individual studies. Of these, 41% were located in Australia (n = 88), 22.8% in the USA (n = 42), 11.9% in Canada (n = 25) and 10.9% in New Zealand (n = 23). Research tended to focus on either health outcomes (50.9%) or health-risk exposures (43.8%); 55% of studies were graded as 'good' quality; and 89% of studies made at least one reference to the involvement of Indigenous peoples over the course of their research.Conclusions: We identified gaps in the longitudinal assessment of cultural factors influencing Indigenous child health at the macrosocial level, including connection to culture and country, intergenerational trauma, and racism or discrimination. Future longitudinal research needs to be conducted with strong Indigenous leadership and participation including holistic concepts of health. This is critical if we are to better understand the systematic factors driving health inequities experienced by Indigenous children globally. [ABSTRACT FROM AUTHOR]

The fifty-sixth annual conference of the American Association for Public Opinion Research (AAPOR) was held at the Hilton Montreal Bonaventure in Montreal, Quebec on May 17 to 20, 2001. The conference theme was Making Connections. Some eight hundred public opinion researchers accepted the invitation to meet colleagues and friends and to participate in the interdisciplinary program. The special character of the annual conference clearly distinguishes it from other professional meetings. Despite steady growth in attendance over recent years, it is a relatively small conference. Its limited duration, its submission review process and its carefully variegated slate of paper session topics constrain the number of opportunities for being on the program. With the traditional meals and social events, the AAPOR conference presents a higher quality, more intimate and more interdisciplinary experience than can be found at many academic, governmental, or commercial meetings. The structure of the meeting limits, among other things, opportunities to attract new AAPOR members, the willingness of exhibitors and publishers to display their wares, the range of topics covered in the program and the conference revenue that AAPOR could employ for worthwhile purposes.

Innovative health technologies are not well regulated under current pathways, leading regulators to adopt contextual, life-cycle regulatory models, which authorize drugs based on earlier clinical evidence subject to the conduct of post-market trials that confirm clinical benefit and safety. In this paper, we evaluate all drugs authorized in Canada under the Notice of Compliance with conditions (NOC/c) policy from 1998 to 2021 to analyze its function, identify challenges and areas for improvement, and make recommendations to inform Health Canada's regulatory reforms. We analyzed a sample of 148 drugs authorized between 1998 and 2021, including characteristics about the pre- and post-market clinical trials, finding that most NOC/c authorizations are based on one, single-arm clinical trial using a surrogate endpoint. Post-market trials are more likely to be randomized, Phase III trials but mostly use surrogate endpoints. Based on our findings, we recommend increasing decision-making transparency throughout the regulatory process, developing comprehensive eligibility criteria for selecting appropriate health technologies, modernizing pre-market evidence requirements, adopting a more active role in designing post-market trials, and utilizing automatic expiry, stronger penalties, and ongoing disclosure of the status of post-market trials to promote compliance. [ABSTRACT FROM AUTHOR]

Climate change has facilitated the introduction, establishment, and movement of invasive species in northern regions, enabling the colonization of previously unsuitable areas. While the responses of insects to these changes have been increasingly studied, our understanding of how such alterations impact trophic interactions still requires further research to make reliable predictions about the spread of diseases in a warming world. Phytoplasmas, a group of obligate parasitic unculturable Mollicutes, primarily rely on leafhoppers (Hemiptera: Cicadellidae) for transmission, spread, and survival. Phytoplasmas are associated with over 600 diseases affecting more than 1,000 plant species, including berries, grapevines, and other small fruits. In North America, diseases such as grapevine yellows, blueberry stunt, and strawberry green petal diseases have been linked to phytoplasma strains transmitted by known leafhopper species. However, the number of phytoplasma diseases has significantly increased in North America over the past decade, suggesting the presence of unidentified vectors or an abundance of leafhopper vectors. This short review provides an overview of the current knowledge on leafhoppers as vectors of phytoplasmas to berries, focusing on the last decade's research in Canada. This paper also explores the potential implications of climate change on this pathosystem, including the anticipated range expansion of leafhopper species, changes in phytoplasma acquisition and transmission, and the risk of new leafhopper-transmitted plant-pathogen introductions through the arrival of new leafhopper species. [ABSTRACT FROM AUTHOR]

This paper studies the effects of carbon pricing on inflation dynamics. We construct a sample of carbon taxes implemented in Europe and Canada over three decades and estimate the response of inflation and price components to carbon pricing. Our empirical results suggest that carbon taxes did not significantly increase inflation, with dynamic effects estimated around zero in most specifications. Instead we find support for relative price changes, increasing the cost of energy but leaving the price of other goods and services unaffected. This is consistent with previous findings on the limited aggregate economic costs of carbon taxes. Based on the cross-section of taxes in Europe, we provide suggestive evidence that the response of inflation was especially muted in countries with revenue-neutral carbon taxes and autonomous central banks that can accommodate potential inflationary pressure associated with carbon pricing. [ABSTRACT FROM AUTHOR]

This paper presents a model of the relationship between relative attributes, relative preferences, and market share. It shows how parameters in the model may be estimated, using survey data to illustrate the estimation procedure. Use of the model and data for a new product are also discussed. The eventual market share of solar energy for residential heating in Canada is predicted using the procedures developed. [ABSTRACT FROM AUTHOR]

While reports of twin pairs concordant for insanity began to appear in the 19th century, the first modern psychiatric twin study that fulfilled Galton's 1875 promise of the value of the twin method was published by the German Psychiatrist and Geneticist Hans Luxenburger in 1928. Luxenburger introduced four major methodological advances: the use of representative sampling, proband-wise concordance, rigorous zygosity diagnoses, and age correction. He used a narrow Kraepelinian diagnostic approach diagnosis and ascertained twins hospitalized, on a specific day, in all large Bavarian asylums. We include a brief biography of Luxenburger, summarize the findings of his paper and provide a full English translation in the appendix. Luxenburger presents evidence that the frequency of twinning in those with severe mental illness were as expected and reports proband-wise concordance for probable and definite dementia praecox (MZ—76%, DZ—0%) and manic-depressive insanity (MZ—75%, DZ—0%). He also examined eccentricity and hyperthymic or hypothymic personality in the dementia praecox and manic-depressive pairs, respectively. Luxenburger's substantial contributions to the history of psychiatric genetics should be considered in the context of his intimate but ambivalent relationship with the racial-hygiene policy of the German National Socialists. [ABSTRACT FROM AUTHOR]