1. Maternal Bereavement During Pregnancy and the Risk of Stillbirth: A Nationwide Cohort Study in Sweden.
- Author
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László, Krisztina D., Svensson, Tobias, Li, Jiong, Obel, Carsten, Vestergaard, Mogens, Olsen, Jørn, and Cnattingius, Sven
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PERINATAL death , *BEREAVEMENT , *CONFIDENCE intervals , *STATISTICAL correlation , *REPORTING of diseases , *HEALTH status indicators , *LONGITUDINAL method , *EVALUATION of medical care , *MEDICAL record linkage , *PREGNANCY , *RESEARCH funding , *PHYSIOLOGICAL stress , *PSYCHOLOGICAL stress , *PROPORTIONAL hazards models , *RETROSPECTIVE studies , *DESCRIPTIVE statistics - Abstract
Increasing evidence suggests that maternal stress during pregnancy may influence pregnancy outcomes. In a nationwide Swedish study including almost 3 million births taking place during 1973–2006, we investigated whether maternal bereavement during pregnancy is associated with stillbirth risk. Through individual record linkage between several population-based registers, we obtained information on demographic, health-related, and pregnancy-related factors and deaths of mothers' first-degree relatives. There were 11,071 stillbirths (3.8 per 1,000 births) in the cohort. After adjustment for potential confounders, infants of mothers who had lost any first-degree relative the year before or during pregnancy had an 18% higher risk of stillbirth than unexposed offspring (95% confidence interval (CI): 1.06, 1.31). Corresponding hazard ratios were 1.67 (95% CI: 1.18, 2.36) for maternal loss of an older child, 2.06 (95% CI: 1.44, 2.94) for loss of a sibling, and 1.07 (95% CI: 0.95, 1.21) for loss of a parent. The relationship between maternal bereavement and stillbirth did not vary by time of death or by whether the relative's death was expected or unexpected. Death of a close relative is one of the most severe sources of stress, and future studies need to investigate whether less severe but more common stressors also increase stillbirth risk. [ABSTRACT FROM PUBLISHER]
- Published
- 2013
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