The article presents an analysis of neighborhood change in Cleveland, Ohio in the 1980s using two-wave panel design and causal modeling. Studies have shown that poverty predicts rates of births to unmarried mothers, juvenile delinquency, crime and drug-related problems in urban neighborhoods. Economic deprivation theory postulates that high rates of juvenile delinquency, crime and drug-related problems are associated with poor neighborhoods and suggests that a rise in poverty increases a sense of economic injustice, which results in higher rates of violence. In this article authors study interrelationships among neighborhoods' poverty levels and types of social conditions described in the urban poverty literature by examining factors related to neighborhood poverty in Cleveland at the beginning and end of the 1980s. It demonstrates the usefulness of panel analysis using LISREL (Linear Structural Relations) version 7.2. It reports that the Cleveland economy grew steadily throughout the 1950s, 1960s and much of the 1970s, with the emphasis on manufacturing enterprises. In the early 1980s both Cleveland and its suburbs lost a large number of manufacturing jobs either permanently or to the furthest suburbs. In the city of Cleveland 90,000 manufacturing jobs were lost between 1979 and 1983. Along with jobs loss, Cleveland lost population and investment in new housing mostly to its suburban areas.