1. Elevated Levels of Microbial Translocation Markers and CCL2 Among Older HIV-1-Infected Men.
- Author
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Scully, Eileen, Lockhart, Ainsley, Huang, Lisa, Robles, Yvonne, Becerril, Carlos, Romero-Tejeda, Marisol, Albrecht, Mary A., Palmer, Christine D., Bosch, Ronald J., Altfeld, Marcus, Kuritzkes, Daniel R., and Lin, Nina H.
- Subjects
HIV infection genetics ,HIV infections ,THERAPEUTICS ,CHEMOKINES ,ANTIRETROVIRAL agents ,LIPOPOLYSACCHARIDES ,OLDER HIV-positive persons ,GENE expression in mammals ,T cells ,ANTI-HIV agents ,AGING ,BACTERIAL physiology ,HIV ,IMMUNITY ,IMMUNOLOGY technique ,INFLAMMATION ,INFLAMMATORY mediators ,RESEARCH funding ,GENOTYPES ,PHYSIOLOGY - Abstract
The aging of the human immunodeficiency virus type 1 (HIV-1)-infected population obligates a focus on the interaction between aging, comorbid conditions, and HIV-1. We recruited a cohort of HIV-1-infected men aged ≤ 35 years or ≥ 50 years who were receiving fully suppressive antiretroviral therapy (ART). We analyzed plasma markers of inflammation; T-cell activation, exhaustion, proliferation; and innate cellular subsets and functional capacity. Levels of lipopolysaccharide and the plasma marker of chemokine (C-C motif) ligand 2 were significantly elevated in older HIV-infected men despite comparable cellular phenotypes. Compared with similarly age-stratified uninfected subjects, older HIV-1-infected adults were also more frequently in the upper quartile of soluble CD14 expression. [ABSTRACT FROM AUTHOR]
- Published
- 2016
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