1. HIV-1 Transcription but Not Intact Provirus Levels are Associated With Systemic Inflammation.
- Author
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Olson, Alex, Coote, Carolyn, Snyder-Cappione, Jennifer E, Lin, Nina, and Sagar, Manish
- Subjects
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MONONUCLEAR leukocytes , *HIV , *HIV infections , *VIRAL physiology , *VIRUSES , *INFLAMMATION , *RNA , *FIBRIN fibrinogen degradation products - Abstract
Individuals infected with human immunodeficiency virus (HIV) 1 have increased inflammation, which has been associated with age-associated diseases. Plasma markers, cell-associated virus levels, and ability to stimulate RNA transcription in latently infected cell lines was examined in younger and older HIV-1-infected individuals with suppressed virus. Cell-associated RNA, but not intact provirus level, had positive correlation with plasma D-dimer levels. Compared with the younger group, the older group had higher D-dimer levels and a trend toward more cell-associated RNA but similar levels of intact proviruses. Even though all measured inflammatory markers were relatively higher in the older group, this greater inflammation did not induce more HIV-1 transcription in latently infected cell lines. Inflammation and HIV-1 RNA expression increase with age despite similar levels of intact infectious HIV DNA. While plasma inflammation is correlated with HIV-1 RNA expression in peripheral blood mononuclear cells, it does not induce HIV-1 transcription in latently infected cell lines. [ABSTRACT FROM AUTHOR]
- Published
- 2021
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