Search

Your search keyword '"Zimmerman, Matthew"' showing total 8 results
Start Over Author "Zimmerman, Matthew" Publisher oxford university press (oup)
8 results on '"Zimmerman, Matthew"'

2. Drug concentration at the site of disease in children with pulmonary tuberculosis

Author

Lopez-Varela, Elisa, primary, Abulfathi, Ahmed A., additional, Strydom, Natasha, additional, Goussard, Pierre, additional, van Wyk, Abraham C., additional, Demers, Anne Marie, additional, Deventer, Anneen Van, additional, Garcia-Prats, Anthony J., additional, van der Merwe, Johannes, additional, Zimmerman, Matthew, additional, Carter, Claire L., additional, Janson, Jacques, additional, Morrison, Julie, additional, Reuter, Helmuth, additional, Decloedt, Eric H., additional, Seddon, James A., additional, Svensson, Elin M., additional, Warren, Rob, additional, Savic, Radojka M., additional, Dartois, Véronique, additional, and Hesseling, Anneke C., additional

Published
2022
Full Text
View/download PDF

3. Superior Efficacy of a Bedaquiline, Delamanid, and Linezolid Combination Regimen in a Mouse Tuberculosis Model

Author

Pieterman, Elise D., Keutzer, Lina, van der Meijden, Aart, van den Berg, Sanne, Wang, Han, Zimmerman, Matthew D., Simonsson, Ulrika S. H., Bax, Hannelore, I, de Steenwinkel, Jurriaan E. M., Pieterman, Elise D., Keutzer, Lina, van der Meijden, Aart, van den Berg, Sanne, Wang, Han, Zimmerman, Matthew D., Simonsson, Ulrika S. H., Bax, Hannelore, I, and de Steenwinkel, Jurriaan E. M.

Abstract

Background: The treatment success rate of drug-resistant (DR) tuberculosis is alarmingly low. Therefore, more effective and less complex regimens are urgently required. Methods: We compared the efficacy of an all oral DR tuberculosis drug regimen consisting of bedaquiline (25 mg/kg), delamanid (2.5 mg/kg), and linezolid (100 mg/kg) (BDL) on the mycobacterial load in the lungs and spleen of tuberculosis-infected mice during a treatment period of 24 weeks. This treatment was compared with the standard regimen of isoniazid, rifampicin, pyrazinamide, and ethambutol (HRZE). Relapse was assessed 12 weeks after treatment. Two logistic regression models were developed to compare the efficacy of both regimens. Results: Culture negativity in the lungs was achieved at 8 and 20 weeks of treatment with BDL and HRZE, respectively. After 14 weeks of treatment only 1 mouse had relapse in the BDL group, while in the H RZE group relapse was still observed at 24 weeks of treatment. Predictions from the final mathematical models showed that a 95% cure rate was reached after 20.5 and 28.5 weeks of treatment with BDL and HRZE, respectively. Conclusion: The BDL regimen was observed to be more effective than HRZE and could be a valuable option for the treatment of DR tuberculosis.

Published
2021
Full Text
View/download PDF

6. Enrichment of malondialdehyde–acetaldehyde antibody in the rheumatoid arthritis joint

Author

Mikuls, Ted R., primary, Duryee, Michael J., additional, Rahman, Rafid, additional, Anderson, Daniel R., additional, Sayles, Harlan R., additional, Hollins, Andrew, additional, Michaud, Kaleb, additional, Wolfe, Frederick, additional, Thiele, Geoffrey E., additional, Sokolove, Jeremy, additional, Robinson, William H., additional, Lingampalli, Nithya, additional, Nicholas, Anthony P., additional, Talmon, Geoffrey A., additional, Su, Kaihong, additional, Zimmerman, Matthew C., additional, Klassen, Lynell W., additional, and Thiele, Geoffrey M., additional

Published
2017
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results