1. Capability of complement fixation by in vivo bound antibodies in pemphigus skin lesions
- Author
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Hitoshi Hatano, Seiichi Kurihara, Takeji Nishikawa, Makoto Sugawara, and Takashi Harada
- Subjects
Pathology ,medicine.medical_specialty ,integumentary system ,medicine.diagnostic_test ,biology ,Acantholysis ,Complement Fixation Tests ,Fluorescent Antibody Technique ,Complement C3 ,Dermatology ,medicine.disease ,Complement fixation test ,Complement system ,Pemphigus ,In vivo ,Immunology ,Skin biopsy ,medicine ,biology.protein ,Humans ,Antibody ,Direct fluorescent antibody ,Autoantibodies - Abstract
Summary Skin biopsy was performed in five cases of pemphigus; direct immunofluorescence (IF) studies demonstrated intercellularly bound IgG and C3 in each case. Sections of lesional skin, containing in vivo bound IgG were, in two cases, capable of further binding C3in vitro from normal human serum, an effect most marked in relation to areas of acantholysis. This work provides additional evidence that the complement system is involved in the process of pemphigus acantholysis.
- Published
- 1978