The purpose of this study was to conduct a randomized clinical trial to assess whether a self-management group intervention can improve mood, self-efficacy, and activity in people with central vision loss due to age-related macular degeneration (AMD). Ninety-two elderly patients with AMD (average age=79) from a university ophthalmology clinic were randomly assigned to the self-management intervention (n=44) or to a wait-list (n=48). All patients were legally blind in at least one eye. The intervention consisted of 6 weekly 2-hour group sessions providing education about the disease, group discussion, and behavioral and cognitive skills training to address barriers to independence. All participants eventually completed the intervention allowing pre-post comparisons for all patients. The battery of measures included the Profile of Mood States (POMS); Quality of Well-Being Scale; and assessments of self-efficacy, participation in activities, and use of vision aids. Participants' initial psychological distress was high (mean total POMS=59.72) and similar to distress experienced by other serious chronic illness populations (e.g. cancer, bone marrow transplant). Analysis of covariance testing the primary hypothesis revealed that intervention participants experienced significantly (p=.04) reduced psychological distress (pre $$\bar x = 61.45$$ ; post $$\bar x = 51.14$$ ) in comparison with wait-list controls (pre $$\bar x = 57.72$$ ; post $$\bar x = 62.32$$ ). Intervention participants also experienced improved (p=.02) self-efficacy (pre $$\bar x = 70.16$$ ; post $$\bar x = 77.27$$ ) in comparison with controls (pre $$\bar x = 67.71$$ ; post $$\bar x = 69.07$$ ). Further, intervention participants increased their use of vision aids (p