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Start Over Author "Rachel S. Knipe" Publisher oxford university press (oup)
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1. P099 <break /> ROCK Isoforms ROCK 1 and ROCK 2 are Critical for the Development of Pulmonary Fibrosis in Several Different Cell Specific Mechanisms

Author

Paula Grasberger, Andrew M. Tager, Barry S. Shea, Alicia Franklin, Rachel S. Knipe, Neil Ahluwalia, James K. Liao, David Lagares, and Clemens K. Probst

Subjects
Gene isoform, Kinase, macromolecular substances, General Medicine, Biology, medicine.disease, Actin cytoskeleton, Cell biology, Fibroblast migration, Endothelial stem cell, Pulmonary fibrosis, medicine, ROCK1, ROCK2
Abstract

Background and Rationale: The actin cytoskeleton directs many pro-fibrotic cellular responses in pulmonary fibrosis, including epithelial cell apoptosis, endothelial cell barrier disruption and fibroblast migration and differentiation. The Rho kinases ROCK1 and ROCK2 regulate the actin cytoskeleton, making them logical targets for anti-fibrotic therapy. We used a genetic approach to identify the …

Published
2016

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