1. Cigarette Smoking and Prostate Cancer Recurrence After Prostatectomy
- Author
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Alison M. Mondul, Patrick C. Walsh, Elizabeth A. Platz, Cari L. Meinhold, Elizabeth B. Humphreys, Corinne E. Joshu, and Misop Han
- Subjects
Male ,Risk ,Cancer Research ,medicine.medical_specialty ,medicine.medical_treatment ,Brief Communication ,Metastasis ,Prostate cancer ,Recurrence ,Internal medicine ,Biomarkers, Tumor ,Odds Ratio ,medicine ,Humans ,Cumulative incidence ,Aged ,Proportional Hazards Models ,Retrospective Studies ,Aged, 80 and over ,Prostatectomy ,business.industry ,Smoking ,Hazard ratio ,Prostatic Neoplasms ,Cancer ,Retrospective cohort study ,Prostate-Specific Antigen ,medicine.disease ,United States ,Surgery ,Prostate-specific antigen ,Oncology ,Smoking Cessation ,Neoplasm Recurrence, Local ,business ,Follow-Up Studies - Abstract
Toward the establishment of evidence-based recommendations for the prevention of prostate cancer recurrence after treatment, we examined the association between smoking and prostate cancer recurrence in a retrospective cohort study of 1416 men who underwent radical prostatectomy. Surgeries were performed by a single surgeon at Johns Hopkins Hospital between January 1, 1993, and March 31, 2006. Smoking status at 5 years before and 1 year after surgery was assessed by survey. Prostate cancer recurrence was defined as confirmed re-elevation of prostate-specific antigen levels, local recurrence, metastasis, or prostate cancer death. The cumulative incidence of recurrence was 34.3% among current smokers, 14.8% among former smokers, and 12.1% among never smokers, with a mean follow-up time of 7.3 years. Men who were current smokers at 1 year after surgery were more likely than never smokers to have disease recurrence after adjusting for pathological characteristics, including stage and grade (hazard ratio for recurrence = 2.31, 95% confidence interval = 1.05 to 5.10). This result suggests an association between cigarette smoking and risk of prostate cancer recurrence.
- Published
- 2011