Search

Your search keyword '"Moncef Mokni"' showing total 4 results
Start Over Author "Moncef Mokni" Publisher oxford university press (oup)
4 results on '"Moncef Mokni"'

1. In-utero coxsackievirus B4 infection of the mouse thymus

Author

Saïda Abdelkefi, Mahjoub Aouni, Vincent Geenen, Hélène Michaux, Moncef Mokni, Habib Jmii, Aymen Halouani, Firas Elmastour, Hela Jaïdane, Tahar Chakroun, Gwennaëlle Bodart, Famara Sane, and Didier Hober

Subjects
Male, 0301 basic medicine, Myocarditis, Offspring, T cell, Immunology, Coxsackievirus Infections, Thymus Gland, Coxsackievirus, Autoimmune Diseases, Immune tolerance, Serology, Mice, 03 medical and health sciences, 0302 clinical medicine, Pregnancy, T-Lymphocyte Subsets, Immune Tolerance, medicine, Animals, Immunology and Allergy, biology, Uterus, Original Articles, biology.organism_classification, medicine.disease, Infectious Disease Transmission, Vertical, Enterovirus B, Human, 030104 developmental biology, medicine.anatomical_structure, RNA, Viral, Female, Encephalitis, 030215 immunology
Abstract

Summary Type B coxsackievirus (CV-B) infections are involved frequently in the triggering of several autoimmune diseases such as myocarditis, dilated cardiomyopathy, pericarditis, pancreatitis, type 1 diabetes, encephalitis, thyroiditis or Sjögren's syndrome. Serological and virological evidence suggests that maternal infections during pregnancy can play a role in the appearance of these diseases in offspring. The current study aims to explore the effect of an in-utero CV-B infection on the fetal thymus, the central site for programming immunological self-tolerance. In this perspective, female Swiss albino mice were inoculated intraperitoneally or orally with the diabetogenic CV-B4 E2 strain at gestational days 10 or 17. Offspring were killed at different post-inoculation times, and their thymuses were analysed for evidence of infection and alterations in thymic T cell subsets. In-utero CV-B infection of the thymus was demonstrated during the course of vertical transmission, as attested by viral RNA and infectious virus detection in most analysed samples. No histopathological changes were evident. Thymic T cells were not depleted, despite being positive for viral RNA. As evidenced by flow cytometry analysis, CV-B infection of the fetal thymus induced significant changes of thymic T cell populations, particularly with maternal inoculation at gestational day 10. Altogether, these findings suggest that CV-B infection of the fetal thymus may play an important role in the genesis of autoimmune diseases.

Published
2016

2. Transplantation - clinical II

Author

Handan Ozdemir, Himanshu V Patel, Tingli Wang, Izumi Yamamoto, Anna Perri, Eva Svobodova, Alberto Mella, Alexander Kildushevsky, Ole Øyen, Nicolas Congy-Jolivet, Sergio Luis-Lima, Yuangao Zou, Hideki Fuji, Tolga Yildirim, Norihiko Goto, Marian Klinger, Leonídio Dias, Won Seok Yang, Lanlan Wang, Tatjana Cvetkovic, Barbara Assenzio, Filiz Bakar, Samantha Mantovani, Halil Yazici, Vijay Thanaraj, Priyadarshini S Shah, Solbjørg Sagedal, Francesca Sidoti, Anupma Kaul, Giordano Zampi, Dharmendra Bhadauria, Moncef Mokni, Tatjana Jevtovic Stoimenov, Tine Thurison, Alessia Di Nauta, Christos S. Katsouras, Franca Sinesi, Denisa Mendonça, Jude Yagan, Atsushi Miki, Giorgos Spanos, F. Zalamea Jarrin, Maria Cristina Di Vico, Francesca Greco, Marco Ballestri, Veena R Shah, Takashi Yokoo, António Castro Henriques, Pranjal R Modi, Vito Fanelli, Andrey Vatazin, Jiri Fronek, Siren Sezer, Anna Teresa Mazzeo, Takayuki Yamamoto, Karen Stopper, Jerzy Chudek, Antonij Slavcev, Deepak Shankar Ray, Takaaki Kimura, Claudio Musetti, Christina Dörje, Lidija Orlić, Osman Ilhan, Rahmi Yilmaz, Francesca Damiano, Mehmet Gokhan Caglayan, Marcel Naik, Ken Kitamura, Maarten B. Rookmaaker, Arjan D. van Zuilen, Pablo Raffaele, Trond Jenssen, Yosu Luque, Masato Fujisawa, Katerina K. Naka, Giuseppe Paolo Segoloni, Ioannis Gkirdis, Leonardo Caroti, Maarten Naesens, Klemens Budde, Rossana Cavallo, Nanna von der Lippe, Ilaria Mastromauro, A. Azzebi, Rigas Kalaitzidis, Fredrik B. Brekke, António Cabrita, Sławomir Zmonarski, Flavio Vincenti, Alessandro De Vincenzi, Hela Ghezaiel, Vasilis Koutlas, Elena Cremaschi, Dorota Kamińska, Mark A. J. Devonald, Kostas C. Siamopoulos, Mahmut Altindal, Mehtap Ekmen Uyar, Dobrin Svinarov, Abdulrahman Housawi, Sanjin Rački, Wissal Sahtout, Ramazan Cetinkaya, Emre Tutal, Luísa Lobato, Mehmet Sukru Sever, Umberto Maggiore, Momir Mikov, Dorry L. Segev, Inés Beired Val, Stefania Bussolino, Fernando Gil Catalinas, Steffen Thiel, Anna Kotsia, Olesja Rissling, Halil Ermis, Borelli K. Zlatkov, Adam Varga, Efrat Harel, Eva Pokorna, P. Chudoba, Saliha Uyanık, Kostas Pappas, Maria Vittoria Mauro, Viktorija Dragojevic-Simic, Alexey Zulkarnaev, Vural Taner Yilmaz, Mikiko Yoshikawa, Luciana Mascia, Aureliusz Kolonko, Yasunaru Sakuma, Manoj R Gumber, Jens Bollerslev, Maria Boratyńska, Kathy Denesyk, Lionel Rostaing, Fabrizio Fop, Carlo Massimetti, Tak Mao Chan, Jamal Rizvi, Predrag Vlahovic, Anna Maria Degli Antoni, Yasuo Takeuchi, Bård Waldum, Pieter Evenepoel, Dai Kohguchi, Aurelio Rodríguez-Hernández, Marcin Protasiewicz, Yudo Tannno, Samira Ben Amor, Sofia Pedroso, Rusudana Kantaria, Nikola Stefanović, Renzo Bonofilgio, Kristin Godang, Hans-H. Neumayer, Aydin Turkmen, Bosiljka Devcic, Oktawia Mazanowska, Tomasz Dawiskiba, Zeynep Bal, Donatella Vizza, J. Portoles Perez, Maggie Ming Yee Mok, Veronika Fedulkina, Josefina Santos, Byung Ha Chung, Altagracia Bello Ovalle, Lampros Lakkas, Jean-Luc Taupin, Anis Belarbia, Anil Chandraker, Andrea Ranghino, Sharmas Vali, Yaeni Kim, Yong-Soo Kim, Dorota Bartoszek, Sakuma Yasunaru, Mirosław Banasik, Malgorzata Kaminska, Cheol Whee Park, Jonathan Visentin, Fulvia Giaretta, Nobuo Tsuboi, Nathan T. James, Tiziana Cena, Tri Q. Nquyen, Giovanni Piotti, Huseyin Kocak, Armando Torres, Milagros Sierra Carpio, Gabriela Pimentel Guzmán, O. Lafuente Covarrubias, B. Sanchez Sobrino, Yuliya V Smedbraaten, Morten W. Fagerland, Pankaj R Shah, Amin Amro, Maria Granito, Davide Diena, Hargovind L Trivedi, Kenan Keven, Hyuk Y Kwon, Bei Cai, Alena Parikova, Ercan Turkmen, Jean J. Filipov, Marc-Olivier Timsit, Alastair Ferraro, Nicoline M.H. Veldhuijzen, Ibrahim Aliosmanoglu, Koji Nanmoku, R K Sharma, Neven Vavic, Anders Hartmann, Nilgun Aysuna, Geir Mjøen, Barbara Sandor, Gianni Cappelli, Louise Moist, José-Carlos Oliveira, Salima Kejji, Alena Verflova, Haralampos Harisis, Babak J. Orandi, Cristina Izzo, Andras Toth, Ana González-Rinne, Ivana Mikolašević, Mehmet Haberal, Petra Reinke, Akimitsu Kobayashi, Marion Rabant, Agnieszka Sas, Giulia Ligabue, Soumava Gupta, Dmytro Khadzhynov, Soon Bae Kim, Fatih Yılmaz, Gunilla Høyer-Hansen, Fotios Zarzoulas, Semra Bozfakioglu, O. Guliyev, Mehtap Erkmen Uyar, Yasuyuki Nakada, Zeynep Kendi Celebi, Alejandro Jiménez-Sosa, Christophe Legendre, Haralampos Pappas, José Davide, Sandro Feriozzi, Keitaro Yokoyama, Mustafa Arici, Esteban Porrini, Niraj M. Desai, Dany Anglicheau, Enrico Eugenio Minetti, Shunji Narumi, Federica Civiletti, Bahar Gurlek Demirci, Pierre Merville, Pablo Klin, Natalia Negrín-Mena, Roberta Fenoglio, Pratik Das, Marco Quaglia, Abdelatif Achour, Martina Pavletic Persic, Turan Colak, Hallvard Holdaas, Hyun Seon Kim, Charlie Martinez, Nemanja Jacimovic, Sung H Son, Carlo Buzio, Francesco Fontana, Giorgos Tzeltzes, Anders Åsberg, Andrea Kantor, Sébastien Lepreux, Ana Aldea-Perona, Laure-Hélène Noël, Takafumi Yamakawa, Daniela Perugini, Magdalena Szotowska, Ichiro Ohkido, Antonio Gil Paraíso, Aruna V Vanikar, Nurhan Ozdemir Acar, Manuela Guedes de Almeida, Bo Ying Choy, Charles S. Craik, Antoine Bello, Andrzej Wiecek, Bang-Gee Hsu, Massimo Rittà, Cristina Giraldi, Björn Meijers, Gwendaline Guidicelli, Henri Kreis, Chul Woo Yang, Augusto Vaglio, Marit Elizabeth Von Düring, Kouji Nannmoku, Riccardo Magistroni, Yunus Erdem, Katrien De Vusser, Marta Artamendi Larrañaga, Hiroyasu Yamamoto, Luigi Biancone, Giorgos Nakas, Rita Marcela Fortunato, Enma Huarte Loza, Nemanja Rancic, Andrea Airoldi, Katarzyna Koscielska-Kasprzak, Francesca Leone, Kazunari Yoshida, R. Llopez Carratala, Miyeon Kim, Andrea Cossarizza, Gabriele Guglielmetti, G. Tognarelli, Burak Sayin, José Manuel González-Posada, Jin Kong, Bulent Altun, Ingrid Os, Anne Theakstone, Shantanu Bhattacharjya, Piotr Kuczera, Gian Domenico D Fabbri, Lionel Couzi, Yosra Guedri, Nurhan Ozdemir, Cristina Costa, Chung Hee Baek, Emil P. Dimitrov, Ester Gallo, Dirk Kuypers, Hermann Hernandez Vargas, Massimo Gai, Rohit Rungta, Jun-Seok Kim, Piero Stratta, Takashi Yagisawa, Cihat Burak Sayin, Antonio Amoroso, Faisal Rehman, Maria Zanazzi, P. Dominguez Apiñaniz, Teresa Papalia, Franco Brescia, Vesna Lukenda, Ruben Poesen, Gea Imperato, P. Carta, Davide Medica, Alessandra Palmisano, S. Karsten Alvarez, Rozenn Clément, Jelena Katic, F Ersoy, Vladimir Hanzal, Safa Nouira, Manisha Sahay, K. Kalmár-Nagy, Michele Battista, Eun J Whang, Kalman Toth, Andrew A. House, Anna Varberg Reisæter, Hyung Jin Cho, Evangelia Dounousi, Irini Tzalavra, Sabri Ferdaws, Gultekin Suleymanlar, Limei Luo, Ayhan Dinckan, Ilaria Deambrosis, Begum Erdemir, Akinori Nukui, Thomas Schachtner, Karsten Midtvedt, Cecilia Dall Anesse, Ewelina Sikora-Grabka, Domingo Marrero, Ming-Che Lee, Vivek B Kute, Lourdes Pérez-Tamajón, Ana Coloma Lopez, Maria Messina, Ozgur Akin Oto, Lorraine Kwan, Robert A. Montgomery, Aris Bechlioulis, Olga Balafa, Isabel Fonseca, Aida Larti, Magdalena Krajewska, Akira Kurosawa, Toshihisa Iwabuchi, Janka Slatinska, Teppei Ohyama, Agnieszka Hałoń, Daisuke Ishii, Dag Olav Dahle, Su-Kil Park, Soumaya Ben Abdelkrim, Won Y Choi, Fatma Nurhan Ozdemir Acar, Sanda Mrabet, Lorenzo Di Maria, Saliha Yildirim, Oliver Staeck, Aleksandra Kovacevic, Elisa Buti, Yasar Caliskan, Lampros K. Michalis, Makoto Tsujita, Paweł Madej, Michalis Mitsis, Eduardo Salido, Ondrej Viklicky, Kiranmai Ismal, Yoshihiko Watarai, Dimitris Evangelou, Hege Pihlstrøm, Dorsaf Zellama, Chul Soo Yoon, Radmila Veličković Radovanović, Thomas Bachelet, Duck Jong Han, Paolo Gigliotti, Shinichi Nishi, Danilo Lofaro, Nassim Kamar, Fabian Halleck, Charlotte Ng, Erik H. Strøm, Aki Mafune, Sara De Biasi, Selami Kocak Toprak, António Castro-Henriques, Fabiola Pagani, Alaattin Yildiz, Marcin Adamczak, Pablo Bridoux, Marina Colic, Anara Amanova, Kyeong Woo Nho, Anna V. Reisæter, Bum Soon Choi, Hugo Sanabria, Enrique Ramalle Gómara, Ayse Serra Artan, Walther H. Boer, Takahisa Hiramitsu, Narayan Prasad, Albane Sartorius, Juan De Francesco, Daniele Cagna, Jorge Malheiro, Himmet Bora Uslu, Alun Williams, Vincenzo Cantaluppi, Yunying Shi, La Salete Martins, Pål-Dag Line, Péter Szakály, and Takaaki Kobayashi

Subjects
Transplantation, medicine.medical_specialty, Nephrology, business.industry, Medicine, business, Surgery
Published
2012

3. Central nervous system infection following vertical transmission of Coxsackievirus B4 in mice

Author

Habib Jmii, Firas Elmastour, Sarah J. Richardson, Mahjoub Aouni, Moncef Mokni, Didier Hober, Aymen Halouani, Eseoghene Ifie, Hela Jaïdane, and Famara Sane

Subjects
0301 basic medicine, Microbiology (medical), Virus quantification, Pregnancy, General Immunology and Microbiology, biology, Transmission (medicine), Offspring, 030106 microbiology, Central nervous system, General Medicine, Coxsackievirus, medicine.disease, biology.organism_classification, Virology, Virus, 03 medical and health sciences, 030104 developmental biology, Infectious Diseases, medicine.anatomical_structure, In utero, Immunology, medicine, Immunology and Allergy
Abstract

Coxsackie B viruses (CV-B) are important pathogens associated with several central nervous system (CNS) disorders. CV-B are mainly transmitted by the faecal-oral route, but there is also evidence for vertical transmission. The outcome of in utero CV-B infections on offspring's CNS is poorly explored. The aim of this study was to investigate vertical transmission of CV-B to the CNS. For this purpose, pregnant Swiss albino mice were intraperitoneally inoculated with CV-B4 E2 at gestational days 10G or 17G. Different CNS compartments were collected and analyzed for virus infection and histopathological changes. Using plaque assays, we demonstrated CV-B4 E2 vertical transmission to offspring's CNS. Viral RNA persisted in the CNS up to 60 days after birth, as evidenced by a sensitive semi-nested(sn) reverse transcripton(RT)-PCR method. This was despite infectious particles becoming undetectable at later time points. Persistence was associated with inflammatory lesions, lymphocyte infiltration and viral dsRNA detected by immunohistochemistry. Offspring born to dams mock- or virus-infected at day 17G were challenged by the same virus at day 21 after birth (-+ and ++ groups, respectively). Sn-RT-PCR and histology results compared between both ++ and -+ groups, show that in utero infection did not enhance CNS infection during challenge of the offspring with the same virus.

Published
2016

Catalog

Books, media, physical & digital resources
See catalog results