1. P5323HDL-C and all-cause mortality in a high-risk population: impact of LDL-C
- Author
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Laurence S. Sperling, Marc Allard-Ratick, Anurag Mehta, Chang Liu, Matthew L. Topel, A Quyyumi, Pratik B. Sandesara, and Devinder S. Dhindsa
- Subjects
business.industry ,Population impact ,Medicine ,Cardiology and Cardiovascular Medicine ,business ,All cause mortality ,Demography - Abstract
Background Previous studies have shown increased cardiovascular (CV) risk with both high (>60mg/dl) and low concentrations of high-density lipoprotein cholesterol (HDL-C). The effect of elevated HDL-C levels (>60mg/dL) at differing LDL-C concentrations on outcomes is unknown. Purpose To study the relationship between elevated HDL-C levels (>60mg/dl) in relation to LDL-C concentration (greater vs less than 70mg/dL) and adverse CV outcomes in an at-risk population. Methods Participants included 5,746 individuals (mean age 63.3±12.4 years, 35% female, 23% African American) enrolled in the cardiovascular biobank. Individuals were stratified by HDL-C categories ( Results Over a median follow-up of 6.2 years (25th-75th percentiles = 3.3–8.0 years), a total of 286 MIs, 691 CV deaths and 1,093 all-cause deaths occurred. Individuals with HDL-C ≥60 mg/dL (n=632) had an increased risk of all-cause mortality with an LDL-C ≥70mgdL (HR 1.59; 95% CI=1.10–2.29, p=0.013) after adjustment for the aforementioned variables. This association was not statistically significant with LDL-C Conclusion Elevated HDL-C levels is associated with increased all-cause mortality with an LDL-C ≥70mg/dL, though does not appear to be associated with worse outcomes when LDL-C is
- Published
- 2019