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Start Over Author "Marina Morigi" Publisher oxford university press (oup)
3 results on '"Marina Morigi"'

1. Mesenchymal stem cells and kidney repair

Author

Marina Morigi and Ariela Benigni

Subjects
Kidney repair, Transplantation, Kidney, business.industry, Mesenchymal stem cell, Mesenchymal Stem Cells, Acute Kidney Injury, Bioinformatics, Microvesicles, Paracrine signalling, medicine.anatomical_structure, Nephrology, Immunology, Animals, Humans, Medicine, Stem cell, business, Tropism, Homing (hematopoietic)
Abstract

Acute renal failure (ARF; acute kidney injury-according to the more recent classification) is emerging as a public health problem. Despite major advances in supportive therapy, the mortality and morbidity among patients remain dismally high. In the attempt to yield innovative interventions fostering the limited capability of regeneration of the kidney, several studies have tested stem cell-based technology mainly employing mesenchymal stem cells (MSC) of different origins. The results of this approach provide the exciting prospect of a powerful treatment to repair acutely damaged organs by virtue of the unique MSC tropism for the damaged tissue, as well as their paracrine action. In the present review, we discuss the mechanisms underlying the regenerative processes triggered by MSC therapy in preclinical models of ARF by analysing modalities of cell-to-cell communication through the release of soluble factors and microvesicles/exosomes by MSC into the damaged renal tissue. Key receptors involved in MSC homing, engraftment and survival at the sites of injury are also elucidated. A translation of basic discoveries of MSC biology into effective care is still limited to the preliminary data of a phase I clinical trial, and further studies are needed to definitively assess the efficacy of MSC-based therapy in humans.

Published
2012

2. Human Bone Marrow Mesenchymal Stem Cells Accelerate Recovery of Acute Renal Injury and Prolong Survival in Mice

Author

Cinzia Rota, Daniela Corna, Carla Zoja, Martino Introna, Ariela Benigni, Giuseppe Remuzzi, Barbara Imberti, Andrea Remuzzi, Alessandro Rambaldi, Mauro Abbate, Marina Morigi, Daniela Rottoli, and Norberto Perico

Subjects
Pathology, medicine.medical_specialty, Stromal cell, Apoptosis, Bone Marrow Cells, Mice, SCID, Biology, Kidney, Mesenchymal Stem Cell Transplantation, urologic and male genital diseases, Mice, medicine, Animals, Humans, Renal stem cell, Cell Proliferation, Stem cell transplantation for articular cartilage repair, Body Weight, Mesenchymal stem cell, Acute kidney injury, Kidney metabolism, Cell Differentiation, Mesenchymal Stem Cells, Cell Biology, medicine.disease, Endothelial stem cell, Phenotype, medicine.anatomical_structure, Immunology, Molecular Medicine, Female, Bone marrow, Cisplatin, Developmental Biology
Abstract

Transplantation of bone marrow mesenchymal stem cells (BM-MSC) or stromal cells from rodents has been identified as a strategy for renal repair in experimental models of acute kidney injury (AKI), a highly life-threatening clinical setting. The therapeutic potential of BM-MSC of human origin has not been reported so far. Here, we investigated whether human BM-MSC treatment could prevent AKI induced by cisplatin and prolong survival in an immunodeficient mouse model. Results showed that human BM-MSC infusion decreased proximal tubular epithelial cell injury and ameliorated the deficit in renal function, resulting in reduced recipient mortality. Infused BM-MSC became localized predominantly in peritubular areas and acted to reduce renal cell apoptosis and to increase proliferation. BM-MSC also induced protection against AKI-related peritubular capillary changes consisting of endothelial cell abnormalities, leukocyte infiltration, and low endothelial cell and lumen volume density as assessed by morphometric analysis. These findings indicate that human MSC of bone marrow origin hold potential to prolong survival in AKI and should be considered for testing in a clinical trial. Disclosure of potential conflicts of interest is found at the end of this article.

Published
2008

3. Experimental pathology - 2

Author

Antonio C. Cordeiro, Dave Martin, Ralf Westenfeld, Maria Pia Rastaldi, Giuseppe Grandaliano, D. van der Giezen, Monique Kerroch, Laura Giardino, Xiaomei Li, Heidi Hedman, Mariarosa Arra, Hans J. Baelde, O. van Oostrom, Hung-Chun Chen, Vasiliki Mavroeidi, Vittoria Esposito, Kojiro Nagai, Giuseppe Remuzzi, Miriam Galbusera, Djurdjica Jovovic, Gianluigi Forloni, Anna Granqvist, Ryota Shirai, Jack F.M. Wetzels, Hidenori Arai, Tetsuhiro Tanaka, R. Goldschmeding, Vivette D. D'Agati, Sabine Leh, Caroline Le Van Kim, Ram Sharma, Benedicte Y. De Winter, Kerstin Ebefors, Alessandro Corbelli, Enrica Tosetto, Takanori Kumagai, Carla Zoja, Samih H. Nasr, Nicoletta Serpieri, Alain C. Borczuk, Karl F. Hilgers, Noemi Maggi, Mariadelfina Molinaro, Yongxi Chen, J.W. Leeuwis, Helmut Geiger, Oliver Jung, Jer-Ming Chang, Fieke Mooren, Irene L. Noronha, Garyfalia Perysinaki, Akira Mima, Piergiorgio Messa, Lei Qu, C. Migotto, Makoto Araki, Toru Kita, Georg Schlieper, Angela D'Angelo, Raghu Kalluri, Hanae Wakabayashi, Dimitrios Moisiades, Ikumi Sato, Monica Ceol, Aineng Liao, Marcus J. Moeller, A. Dendooven, Eduardo Barbosa-Sicard, Kostas Stylianou, Margarete Goppelt-Struebe, Young Sook Lee, Akiko Fujita, Toshio Miyata, Dino Martini, Luigi Villa, Bruce D. Hammock, Daniela Croci, Alireza Showraki, Fabio Sallustio, Ji Dong, Atsushi Fukatsu, Ioannis Petrakis, Tarak Srivastava, J. Joles, Virginia J. Savin, Qiuhua Huang, Antonio Dal Canton, Giuseppe Castellano, Masaomi Nangaku, Toshiro Fujita, Fatemmeh Emamghorashi, Luca De Benedictis, Weiming Wang, Alexandre C. Santana, Dorella Del Prete, Sanja Citlucanin, Filippo Mangione, Christian Ott, Vincenzo Costantino, Ciro Esposito, Toshio Doi, Annika Lindskog, Thilo Krueger, Bart Smeets, Pierre-Louis Tharaux, Lydia Nakopoulou, Gianluigi Zaza, Caroline A.J. Horvath, Cécile Rahuel, Paola Simonini, Sandra Uhlig, Juergen Floege, Kostas Perakis, Osamu Yokosuka, Bjarne M. Iversen, Marzia Pesaresi, Kristien J. Ledeganck, Masami Ikehata, Motoko Yanagita, Francesco Paolo Schena, Zoran Miloradovic, Nan Chen, Marina Morigi, Glen Markovitz, Novella Calvaresi, Astrid Fuss, Eugene Daphnis, Makoto Ogawa, Hiroshi Nishi, Franca Anglani, Sara Gastoldi, Markus P. Schlaich, Jin Huang, Naoki Morito, Roland E. Schmieder, Jeff Hodgin, Jean-Claude Dussaule, Christina Kastrinaki, Anne A. Filipe, Christos Chatziantoniou, Yuki Hamano, Kunihiro Yamagata, Wim Verelst, Satoru Takahashi, Johannes Bogers, Christian Delles, Zhangsuo Liu, Silvia Berra, Mukut Sharma, Nevena Mihailovic-Stanojevic, Ellen T. McCarthy, Sven Kroening, Markus Ketteler, Fernanda Cobuci, Enrico Pertile, Seyed Mohammad Owji, Jasmina Markovic-Lipkovski, Ji Young Han, Takashi Okude, Sandrine Placier, C. Snijckers, Reiko Inagi, Marianne C. Verhaar, Yves Colin, Genyang Cheng, Rita de Cássia Cavaglieri, Stavros Stratakis, Daniela Rottoli, Jenny Nyström, Takeshi Matsubara, Willi Jahnen-Dechent, Börje Haraldsson, Fabrizio Grosjean, Noriyuki Iehara, Anna Pezzotta, Ya Li, Silvia Armelloni, Keigyou Yoh, Shiro Ueda, T.Q. Nguyen, Marina Noris, Chiara Pagani, Francesca Castoldi, Ralf P. Brandes, Yoshihiko Ueda, Federica Mezzabotta, Markus P. Schneider, Michael Hultström, Emilia Tiralongo, Jürgen Floege, Deborah Mattinzoli, Ichiro Kojima, Jiansheng Li, Mohammad Moatamedfard, Monica Locatelli, Yu Wang, Dominique Guerrot, E.J. Robertson, Simona Buelli, Il Soo Ha, Christophe Morriseau, Felix Jansen, Min Li, Ju Hyung Kang, Peter Boor, Kazuo Torikoshi, Vincent Brandenburg, Antonia Loverre, Gert A. Verpooten, Liqiang Meng, and Kerstin Amann

Subjects
010309 optics, Transplantation, Pathology, medicine.medical_specialty, Nephrology, business.industry, 010401 analytical chemistry, 0103 physical sciences, medicine, Experimental pathology, business, 01 natural sciences, 0104 chemical sciences
Published
2009

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