1. Timing of Food Intake Drives the Circadian Rhythm of Blood Pressure
- Author
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Dingguo Zhang, Paramita Pati, Thomas H. Neder, Malgorzata Kasztan, Jennifer S. Pollock, Jennifer A Valcin, Binli Tao, Karen L. Gamble, Bryan K. Becker, Jodi R. Paul, Chunhua Jin, Jackson Colson, David M. Pollock, Megan K Rhoads, McKenzi A King, and Shannon M. Bailey
- Subjects
Male ,0301 basic medicine ,time-restricted feeding ,medicine.medical_specialty ,Mean arterial pressure ,Renal cortex ,Period (gene) ,030204 cardiovascular system & hematology ,Mice ,Eating ,03 medical and health sciences ,0302 clinical medicine ,Internal medicine ,medicine ,Animals ,Circadian rhythm ,Original Research ,Mice, Knockout ,Suprachiasmatic nucleus ,business.industry ,Sodium ,ARNTL Transcription Factors ,blood pressure ,Circadian Rhythm ,Mice, Inbred C57BL ,PER2 ,Bmal1 ,030104 developmental biology ,Blood pressure ,Endocrinology ,medicine.anatomical_structure ,circadian rhythms ,Renal physiology ,AcademicSubjects/SCI00960 ,sodium excretion ,business ,Research Article - Abstract
Timing of food intake has become a critical factor in determining overall cardiometabolic health. We hypothesized that timing of food intake entrains circadian rhythms of blood pressure (BP) and renal excretion in mice. Male C57BL/6J mice were fed ad libitum or reverse feeding (RF) where food was available at all times of day or only available during the 12-h lights-on period, respectively. Mice eating ad libitum had a significantly higher mean arterial pressure (MAP) during lights-off compared to lights-on (113 ± 2 mmHg vs 100 ± 2 mmHg, respectively; P 0.05); however, RF induced a diurnal rhythm of MAP (79 ± 3 mmHg vs 95 ± 2 mmHg, lights-off vs lights-on phase; P, Graphical Abstract Graphical Abstract
- Published
- 2020