1. Attempts to induce mycetoma in monkeys and mice usingMadurella mycetomi
- Author
-
Leila L. Cavanagh
- Subjects
Male ,Pathology ,medicine.medical_specialty ,Injections, Intradermal ,Injections, Subcutaneous ,medicine.medical_treatment ,Freund's Adjuvant ,Madura foot ,Biology ,Lesion ,Mice ,medicine ,Animals ,Mycetoma ,Saline ,Antilymphocyte Serum ,Foot ,Inoculation ,Madurella mycetomi ,Haplorhini ,General Medicine ,Cortisone ,Radiation Effects ,Disease Models, Animal ,Infectious Diseases ,Cortisone acetate ,Macaca ,Mitosporic Fungi ,medicine.symptom ,Adjuvant ,Injections, Intraperitoneal - Abstract
In an attempt to produce an animal model of a mycetoma (Madura foot) Madurella mycetomi was inoculated on 3 occasions into a monkey's paw. Groups of mice were inoculated once in the footpad and treated with anti-mouse-lymphocytic serum, cortisone acetate and whole body X-irradiation respectively; half of the groups received the fungus suspended in saline and in half the fungus was emulsified in Freund's adjuvant. An attempt was also made to produce intraperitoneal grains of M. mycetomi in mice.The monkey developed a transient lesion. The footpad inoculations in the mice caused inflammatory swelling which was severe and persistent in the animals which received the fungus emulsified in Freund's adjuvant but grains were not produced.
- Published
- 1974