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90 results on '"Lucisano A"'

1. One-month dual antiplatelet therapy following stent implantation in patients with acute coronary syndromes and high bleeding risk

Author

Pivato, C A, primary, Musto, C, additional, Paolucci, L, additional, Testa, L, additional, Pacchioni, A, additional, Briguori, C, additional, Esposito, G, additional, Lucisano, L, additional, De Luca, L, additional, Latini, A C, additional, Regazzoli, D, additional, Sardella, G, additional, Indolfi, C, additional, Condorelli, G, additional, and Stefanini, G G, additional

Published
2023
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2. Risk factor variability and cardiovascular risk among patients with diabetes: a nationwide observational study

Author

Antonio Ceriello, Giuseppe Lucisano, Francesco Prattichizzo, Rosalba La Grotta, Stefan Franzén, Soffia Gudbjörnsdottir, Björn Eliasson, and Antonio Nicolucci

Subjects
Epidemiology, Cardiology and Cardiovascular Medicine
Abstract

Aims Cardiovascular risk factor control fluctuates, tends to change over time, and is potentially impacted by multifactorial interactions. Currently, the presence of risk factors, rather than their variability or interplay with one another, is taken into account to define the population at risk. The association between variability of risk factors and cardiovascular morbidity and mortality risk among patients with Type 2 diabetes mellitus (T2DM) remains debatable. Methods and results Using registry-derived data, we identified 29 471 people with T2DM, without cardiovascular disease (CVD) at baseline, and with at least five measurements of risk factors. Variability for each variable was expressed as quartiles of the standard deviation during 3 years (exposure). The incidence of myocardial infarction, stroke, and all-cause mortality was assessed during 4.80 (2.40–6.70) years following the exposure phase. The association between the measures of variability and the risk of developing the outcome was investigated through multivariable Cox proportional-hazards regression analysis with stepwise variable selection. Then, the recursive partitioning and amalgamation (RECPAM) algorithm was used to explore the interaction among the variability of risk factors associated with the outcome. An association between the variability of HbA1c, body weight, systolic blood pressure, and total cholesterol with the outcome considered was found. Among the six classes of risk identified by RECPAM, patients with a high variability of both body weight and blood pressure had the highest risk [Class 6, hazard ratio (HR) = 1.81; 95% confidence interval (CI) 1.61–2.05] compared with patients with low variability of both body weight and total cholesterol (Class 1, reference), despite a progressive reduction in the mean level of risk factors during successive visits. Individuals with high weight variability but low–moderate systolic blood pressure variability (Class 5, HR = 1.57; 95% CI 1.28–1.68), patients with moderate/high weight variability associated with high/very high HbA1c variability (Class 4, HR = 1.33; 95% CI 1.20–1.49), subjects with moderate/high weight variability and with low/moderate HbA1c variability (Class 3, HR = 1.12; 95% CI 1.00–1.25), as well as those with low weight variability associated with high/very high total cholesterol variability (Class 2, HR = 1.14; 95% CI 1.00–1.30) also showed a significant increase in the risk of an event. Conclusion Combined high variability of two risk factors, particularly body weight and blood pressure, is associated with cardiovascular risk among patients with T2DM. These findings highlight the importance of continuous balancing of multiple risk factors.

Published
2023

4. MO700EPIDEMIOLOGICAL ADMISSIONS IN PERITONEAL DIALYSIS IN A SINGLE DIALYSIS CENTER

Author

Vincenzo Panuccio, Rocco Tripepi, Giovanni Tripepi, Silvia Lucisano, and Francesca Mallamaci

Subjects
Cardiovascular event, Transplantation, medicine.medical_specialty, business.industry, medicine.medical_treatment, Peritoneal dialysis, New York Heart Association Classification, Nephrology, Emergency medicine, medicine, Center (algebra and category theory), Hemodialysis, business, Dialysis (biochemistry)
Abstract

Background and Aims The knowledge of the impact of peritoneal dialysis (PD) program in terms of hospitalization rate can provide solid guidance for nephrologists for management purpose. In a historical cohort of adult PD patients, we examined the hospitalization rates and causes of hospital admissions. Method One hundred ninety-one consecutive PD patients between January 1st 2000 to December 31st 2018 were enrolled. The maximum follow up was 194 months. Their mean age was 65±15 years, 110 were males, 56 had co-morbidities and 67 were diabetics. The median PD vintage was 35 months (interquartile range 20-63 months). Results During the follow-up, 163 out of 191 patients (85%) underwent hospital admission for a total of 356 hospitalizations [57 hospitalizations per 100-person-years]. The most frequent cause of admission was infection (20 hospitalizations per 100-person-years) mainly due to peritonitis (12 hospitalizations per 100-person-years) followed by cardiovascular diseases (17 hospitalizations per 100-person-years). Hospitalizations due to miscellaneous causes were 21 per 100-person-years. In the whole group, high NYHA score [Incidence Rate Ratio (IRR): 1.52, 95%CI 1.21-1.89, P65 years) (IRR 1.26, 95%CI 1.02-1.56, P=0.03) and were associated to all-cause hospitalizations. In an analysis by hospitalization type, the factors related to admission for infection diseases was malnutrition (IRR: 1.91, 95%CI 1.16-3.03, P=0.005) and high NYHA score (IRR: 1.52, 95%CI 1.03-2.22, P=0.02). As expected, hospitalizations due to cardiovascular causes were strongly related to older age (>65 years) (IRR 2.02, 95%CI 1.35-3.03, P Conclusion Analyzing the causes and the rate of hospitalization in PD patients allows more accurate management of these high risk category of patients and contributes to a more efficient organization of a renal department.

Published
2021

5. MO802DOES ETELCALCETIDE REVERSE MYELOFIBROTIC BONE CHANGES DUE TO HYPERPARATHYROIDISM? A CASE REPORT

Author

Silvia Lucisano, Esther Oliva, Bruna Greve, Dario Pazzano, Maria Rosaria Fazio, Rocco Tripepi, Francesco Catalano, Elena Sabattini, Giovanna Parlongo, Francesca Mallamaci, Vincenzo Panuccio, and Adele Postorino

Subjects
Etelcalcetide, Transplantation, medicine.medical_specialty, Hyperparathyroidism, Nephrology, business.industry, medicine, Radiology, business, medicine.disease
Abstract

Background and Aims A 21 year old boy with a diagnosis of Autosomal Recessive Polycystic Kidney Disease and Caroli disease reached a final stage of chronic kidney disease (CKD) and started haemodialysis. Method After 3 years in haemodialysis he underwent a kidney transplant from a cadaveric donor. His transplanted kidney worked fairly well until the patients was 31 year old when he developed graft dysfunction (serum creatinine from 2.7 to 5 mg/dL in a very short period). There was a concomitant increase in serum phosphate levels (8.3 mg/dl) and iPTH that progressively increased to 1032 pg/ml despite a traditional therapy. Results At age 32, the patient returned to haemodialysis treatment thrice weekly with a concomitant a progressive worsening of hyperparathyroidism with bone pain . Cinacalcet at a dosage of 30 mg daily treatment was initiated, then it was increased to 120 mg daily without any benefit. Two years later, being the clinical situation without any improvement and being the patient scarcely compliant to the therapy and because a further enlargement of parathyroid glands was observed, a Parathyroidectomy (PTX) was advised. Nevertheless, PTX was not performed because of patient’s refusal. Furthermore, despite Erythropoietic Stimulating Agent (ESA) therapy, he developed severe anemia that required regular and frequent blood transfusions. iPTH increased to 4500 pg/ml [Fig.1] with a parallel rise in alkaline phosphatase >600 UI/L [Fig.2]. A Computed Tomography scan showed multiple bone-thickening lesions. He thus initiated Etelcalcetide 5 mg e.v. 3 times a week, after the HD session but without any benefit. The dosage was then increased to 7.5 mg but the patient gradually became frail and developed pancytopenia and low-grade fever. Hematological evaluation with bone marrow biopsy was performed in December 2019. Bone marrow histology showed severe fibrosis [Myelofibrosis (MF) grade 3] with normal bone marrow cytogenetics. Blood samples for mutations in JAK-2, CALR, and MPL and BCR-ABL rearrangement were negative. There was no evidence for a myeloproliferative neoplasm (MPN) or metastatic lesions. During the following months, while on a 7,5 mg dose of etalcalcetide, there was a gradual reduction in iPTH [Fig.1] and serum alkaline phosphatase [Fig.2], up to 500 pg/dl and 200 IU/L respectively. The patient developed asymptomatic, often severe, hypocalcemia which was managed with therapy. The patient’s clinical conditions gradually improved, anemia responded to lower doses of ESAs. A bone marrow biopsy was repeated after one year (December 2020) and it showed a reduction in fibrosis (MF grade varying from 1-2). Then etelcalcetide dosage was reduced while serum calcium and phosphate levels were in the normal limit. Conclusion Myelofibrosis secondary to renal osteodystrophy is an uncommon complication. It has been rarely reported and usually is associated with primary hyperparathyroidism. Marrow fibrosis and pancytopenia is related to the excessive iPTH that upregulates production of cytokines and paracrine factors in the bone marrow (IL-1a, IL-6, FNF-a, TGF–b, and platelet-derived growth factor) and it has an important stimulatory effect on fibroblast proliferation. It is known that surgical parathyroidectomy is associated with a reduction of bone marrow fibrosis in primary hyperparathyroidism. To our knowledge, this is probably the first case of tertiary hyperparathyroidism in which the effect of etelcalcetide is comparable to parathyroidectomy as far as on calcium-phosphate balance, and a significant improvement in bone marrow fibrosis and hemoglobin. In conclusion, etelcalcetide at least in this patient seems as effective as PTX on bone balance, bone marrow and anemia.

Published
2021

6. Oral potassium binders: increasing flexibility in times of crisis

Author

Andrew H. Frankel, Megan Griffith, Peter Hill, Stephen P. McAdoo, Gaetano Lucisano, Jack Beadle, David C. Thomas, Rakesh Dattani, Richard Corbett, Damien Ashby, Nicholas R. Medjeral-Thomas, and Kieran McCafferty

Subjects
Flexibility (engineering), Transplantation, chemistry, Nephrology, business.industry, Potassium, chemistry.chemical_element, Medicine, business, Manufacturing engineering
Published
2020

7. MO802DOES ETELCALCETIDE REVERSE MYELOFIBROTIC BONE CHANGES DUE TO HYPERPARATHYROIDISM? A CASE REPORT

Author

Panuccio, Vincenzo Antonio, primary, Tripepi, Rocco, additional, Lucisano, Silvia, additional, Postorino, Adele, additional, Parlongo, Giovanna, additional, Fazio, Maria Rosaria, additional, Catalano, Francesco, additional, Pazzano, Dario, additional, Greve, Bruna, additional, Sabattini, Elena, additional, Oliva, Esther, additional, and Mallamaci, Francesca, additional

Published
2021
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9. Arsenic metabolism and urothelial cancer risk: a systematic review and meta-analysis

Author

P Scampoli, Tommaso Staniscia, F Cedrone, F Meo, P Di Giovanni, G Lucisano, and G Di Martino

Subjects
Oncology, medicine.medical_specialty, chemistry, business.industry, Meta-analysis, Internal medicine, Public Health, Environmental and Occupational Health, medicine, Urothelial cancer, chemistry.chemical_element, business, Arsenic
Abstract

Background Arsenic is a toxic metalloid element frequently found in the environment. Chronic arsenic exposure is a critical public health issue in many countries since the identification of arsenic and its compounds as human carcinogens by the World Health Organization. After absorption, inorganic arsenic (iAs) is mainly methylated into monomethylated and dimethylated compounds (MMA, DMA), which are then excreted through the kidney together with unmethylated iAs. Whether the methylation process is to detoxify or potentiate arsenic toxicity, however, remains an ongoing debate. The purpose of this systematic review was to conduct a comprehensive meta-analysis to estimate the association between arsenic exposure and urothelial cancer. Methods 10 observational studies met the inclusion criteria and were included in the systematic review. IAs%, MMA% and DMA% were extracted from each paper. Weighted Mean Differences with 95% confidence intervals were defined according to Cases minus Controls. Pooled risk estimates from individual studies were assessed using random effects models. Meta-regression analysis was performed to estimate the extent of urothelial cancer risk as a function of iAs%, MMA% and DMA%. Results Results showed as patients with urothelial cancer presented higher level of urinary iAs% (WMD 2.70, 95%CI 0.64-4.76), MMA% (WMD 2.81, 95%CI 1.43-4.20) and DMA% (WMD-3.44, 95%CI-6.57–0.30). Conclusions These findings suggest that higher level of iAs% and MMA% and lower level of DMA% were associated with an increased risk of urothelial cancer. Additional population based studies are needed to understand the role of arsenic in cancer development. Understanding the meaning of arsenic metabolism could improve the risk assessment of arsenic toxicity and provide a potential tool for disease prediction and prevention. Key messages Higher level of iAs%, MMA% and DMA% were associated with an increased risk of urothelial cancer. Understanding the meaning of arsenic metabolism could improve the risk assessment of arsenic toxicity.

Published
2019

11. Disease-modifying drugs can reduce disability progression in relapsing multiple sclerosis

Author

Amato, Maria Pia, primary, Fonderico, Mattia, additional, Portaccio, Emilio, additional, Pastò, Luisa, additional, Razzolini, Lorenzo, additional, Prestipino, Elio, additional, Bellinvia, Angelo, additional, Tudisco, Laura, additional, Fratangelo, Roberto, additional, Comi, Giancarlo, additional, Patti, Francesco, additional, De Luca, Giovanna, additional, Brescia Morra, Vincenzo, additional, Cocco, Eleonora, additional, Pozzilli, Carlo, additional, Sola, Patrizia, additional, Bergamaschi, Roberto, additional, Salemi, Giuseppe, additional, Inglese, Matilde, additional, Millefiorini, Enrico, additional, Galgani, Simonetta, additional, Zaffaroni, Mauro, additional, Ghezzi, Angelo, additional, Salvetti, Marco, additional, Lus, Giacomo, additional, Florio, Ciro, additional, Totaro, Rocco, additional, Granella, Franco, additional, Vianello, Marika, additional, Gatto, Maurizia, additional, Di Battista, Giancarlo, additional, Aguglia, Umberto, additional, Logullo, Francesco Ottavio, additional, Simone, Marta, additional, Lucisano, Giuseppe, additional, Iaffaldano, Pietro, additional, and Trojano, Maria, additional

Published
2020
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12. Oral potassium binders: increasing flexibility in times of crisis

Author

Dattani, Rakesh, primary, Hill, Peter, additional, Medjeral-Thomas, Nicholas, additional, Griffith, Megan E, additional, Ashby, Damien, additional, McAdoo, Stephen, additional, Corbett, Richard W, additional, Lucisano, Gaetano, additional, Beadle, Jack, additional, McCafferty, Kieran, additional, Frankel, Andrew, additional, and Thomas, David, additional

Published
2020
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14. Baccharis dracunculifolia DC (Asteraceae) selectively modulates the effector functions of human neutrophils

Author

Ana Elisa Caleiro Seixas Azzolini, Yara M. Lucisano-Valim, Luciana M. Kabeya, A. Caliri, Lamartine Lemos de Melo, Andréa S.G. Figueiredo-Rinhel, Leandro Oliveira Bortot, Jairo Kenupp Bastos, Micássio Fernandes de Andrade, and Everton O.L. Santos

Subjects
Adult, 0301 basic medicine, Luminescence, Neutrophils, Phagocytosis, Pharmaceutical Science, 03 medical and health sciences, chemistry.chemical_compound, Caffeic Acids, Baccharis dracunculifolia, Caffeic acid, Humans, Immunologic Factors, Pharmacology, NADPH oxidase, biology, Plant Extracts, Elastase, Degranulation, Free Radical Scavengers, Flow Cytometry, biology.organism_classification, Plant Leaves, Baccharis, 030104 developmental biology, chemistry, Biochemistry, Spectrophotometry, Myeloperoxidase, biology.protein, Neutrophil degranulation
Abstract

Objectives To examine whether the hydroalcoholic extract from Baccharis dracunculifolia leaves (BdE) modulates the human neutrophil oxidative metabolism, degranulation, phagocytosis and microbial killing capacity. Methods In-vitro assays based on chemiluminescence, spectrophotometry, flow cytometry and polarimetry were used, as well as docking calculations. Key findings At concentrations that effectively suppressed the neutrophil oxidative metabolism elicited by soluble and particulate stimuli ( Conclusions BdE selectively modulates the effector functions of human neutrophils, inhibits the activity of key enzymes and scavenges physiological oxidant species. Caffeic acid contributes to lower the levels of oxidant species. Our findings help to unravel the mechanisms by which these natural products exert immunomodulatory action towards neutrophils.

Published
2017

15. Differential Activation of Signaling Pathways Involved in Cell Death, Survival and Inflammation by Radiocontrast Media in Human Renal Proximal Tubular Cells

Author

Michele Andreucci, Gaetano Lucisano, Mario Vitale, Giorgio Fuiano, Salvatore Salzano, Antonio Pisani, Teresa Faga, Bernardo Bertucci, Ashour Michael, Oscar Tamburrini, Massimo Sabbatini, M., Andreucci, G., Lucisano, T., Faga, B., Bertucci, O., Tamburrini, Pisani, Antonio, Sabbatini, Massimo, S., Salzano, M., Vitale, G., Fuiano, and A., Michael

Subjects
medicine.medical_specialty, Cell Survival, Pyridines, Protein Kinase, Pyridine, p38 mitogen-activated protein kinases, Protein Kinase Inhibitor, Contrast Media, Pharmacology, Biology, Toxicology, Cell Line, Proinflammatory cytokine, Kidney Tubules, Proximal, Internal medicine, medicine, Humans, Renal cell, Viability assay, Phosphorylation, Protein kinase A, Imidazole, Protein Kinase Inhibitors, Protein kinase B, Inflammation, Toxicity, Cell Death, Kinase, Imidazoles, Endocrinology, Signal transduction, Protein Kinases, Human, Signal Transduction
Abstract

Radiocontrast media (RCM) are widely used in clinical medicine but may lead to radiocontrast-induced nephropathy (RCIN). The pathogenesis of acute renal failure secondary to RCM is not fully understood, but direct toxic effects are believed to be a major cause of RCIN. We have investigated the effect of different types of RCM on signaling pathways known to play a role in cell death, survival, and inflammation. HK-2 cells were incubated with sodium diatrizoate and iomeprol (IOM) at a concentration of 75 mg I/ml for 2 h. Both RCM caused an increase in phosphorylation of p38 mitogen-activated protein kinase (MAPK) (p38) and c-Jun N-terminal kinases (JNKs) and NF-κB (at Ser 276), with sodium diatrizoate having a more drastic effect. Although cell viability was reduced significantly by both RCM, in cells pretreated with IOM the cell viability recovered over a 22-h time period after removal of the RCM. However, viability of diatrizoate-treated cells rose at 5 h but then fell at 22 h after removal of the RCM. The decrease in cell viability in diatrizoate-treated cells corresponded with an increase in phosphorylation of JNKs, p38, and NF-κB and a decrease in phosphorylation of Akt, signal transducer and activator of transcription 3, and forkhead box O3a, as well as poly (ADP-ribose) polymerase and caspase-3 cleavage. The recovery in viability of IOM-treated cells corresponded most notably with an increase in STAT3 phosphorylation and induction of Pim-1 kinase. There was also an increase in interleukin-8 release by diatrizoate-treated cells indicating the possibility of proinflammatory effects of RCM. A knowledge of the signaling pathways by which RCM exert their cytotoxic actions may help in finding future therapies for RCIN.

Published
2010

16. CKD PATHOPHYSIOLOGY AND CLINICAL STUDIES

Author

Paola Achilli, Francesco Marino, Ioannis Karatzas, Steven Fishbane, Alessandro Domenico Quercia, Yu Du, Richard R. Furman, Katarzyna Maresz, Jack F.M. Wetzels, Gerard A. Rongen, Hyun Yul Rhew, Ogo Egbuna, Mariano Rodriguez, Leena Patel, Kiyoto Koibuchi, Anna-Ewa O Kulik, M Weiswasser, Ken Sakai, Antoine Bouquegneau, Myles Wolf, Ilona Kurnatowska, Chantal Loirat, Alberto Ortiz, Stéphane Poitevin, Tilo Hanowski, Elvira Fernández, Abdul Rashid Qureshi, Françoise Dignat-George, Christophe Legendre, Juan Jesus Carrero, Jeffrey Kaupke, Maurizio Postorino, Pablo E. Pergola, Jaco Botha, Bernhard K Kraemer, Mariusz Kusztal, Camille L. Bedrosian, Ada Braun, Marion Sallée, Katarzyna Jankowska, Marcus E. Kleber, Magdalena Kaczmarska, Georg Schlieper, Yeon Soon Jung, Giuseppe Enia, Rosaria Lupica, Beatriz Martínez Fernández, Taro Hoshino, Peter Boor, Mai Ots-Rosenberg, Maria Pina P Madonna, Ayako Tsuchiya, Cesare Guarena, Usama Elewa, Rika Miura, Graciela E. Delgado, Winfried Maerz, Jacek C Szepietowski, Yoshifumi Ubara, Alan G. Jardine, Thiane Gama-Axelsson, Kaoru Tabei, Vincenzo Cantaluppi, Franco Brescia, Carmine Zoccali, Yao Yu, Akihiro Tsuda, Viatcheslav Rakov, Yasemin G Kurt, Sergio Dellepiane, Mahmut Ilker Yilmaz, Winnie Sohn, Bengt Lindholm, Claudia Carmone, Rabab Mohamed Elbehidy, Ye Na Kim, Bertrand Gondouin, Hark Rim, Larry Greenbaum, Dimitrios Arvanitis, Cristina Masini, Michael Chen, Laetitia Dou, Vincenzo Panichi, Leszek Bieniaszewski, Etienne Cavalier, Federica Genovese, Hikmet Tekce, Giovanni Camussi, Mahmut I Yilmaz, Tacyano Tavares Leite, Stéphane Burtey, Yoshiteru Ohno, Atsushi Aikawa, Peter Braunhofer, Johan Vande Walle, Irina Mititiuc, Olivier Devuyst, Amit Sharma, Stefan Degenhardt, Glenn M. Chertow, Henrik S. Rasmussen, Rannveig Skrunes, Dimitra Nastou, E. Marie Freel, Zbigniew Heleniak, Mahmut Gok, Heike Kielstein, Jesús Egido, Steven Zeig, Patrick B. Mark, David Arroyo, Katarzyna Kunicka, Dimosthenis Vlassopoulos, Paweł Poznański, Bruce Spinowitz, Gian Domenico D Fabbri, Jaap Deinum, Yasmine Draz, Marina Foramitti, K. Lysaja, Marian Klinger, Iris Fuhrmann, Cees Vermeer, A. Villari, Piotr Skrzypczyk, Hubert Scharnagl, Emily P. McQuarrie, Giuseppina Pettinato, Kentaro Tanaka, Bożena Werner, Yasuhisa Sakurai, MałGorzata Sojka, Bolesław Rutkowski, Cric Study Investigators, Song Rong, Adrian Covic, Lisa M. Bernard, Carlo Massimetti, Candice Bezerra Torres De Melo, Davide Medica, Jose M. Valdivielso, Martin Flamant, Markus Ketteler, Morten A. Karsdal, Shay Shemesh, Domenico Santoro, Aoi Nabata, Bhupinder Singh, Jean-Marie Krzesinski, Emmanuelle Vidal-Petiot, Tanja B. Grammer, Sandro Feriozzi, Fabio Malberti, Camilla Tøndel, Tayfun Eyileten, Nikolaos Manolios, K K Larsen, Camillo Porta, Junichi Hoshino, Filippo Benedetto, Jesper N. Bech, Larry A. Greenbaum, Rolfdieter Krause, Dimitrie Siriopol, Catherine Delmas-Frenette, Hideaki Shima, Reginaldo Filho, Katarzyna Kilis-Pstrusinska, Stuart M. Sprague, Akifumi Kushiyama, Kiyonori Ito, Katsunori Saito, Ludomir Stefańczyk, Mari Aoe, Juliette Hadchouel, Juergen Floege, Jürgen Floege, Lara Cavalcante Vaz Cunha, Fernanda Macedo de Oliveira Neves, Honami Mori, Mutlu Saglam, Giovanni Tripepi, Yasemin Gulcan Kurt, Mohamed A El-Shahawy, Ewa Aleksandrowicz, Kristin Jäger, Graziella Caridi, Pierre Delanaye, Moriatsu Miyagi, Desmond Padhi, Mai Sugahara, Kiryong Park, Mait Raag, Renata de Almeida Leitão, Thomas D. Wooldridge, Keiji Hirai, Gianluca Trifirò, Elzbieta Prus-Wojtowicz, Naoki Sawa, Murat Karaman, Alexandre Braga Libório, François Vrtovsnik, Ewa Świerblewska, Yuichirou Ueda, Eiji Ishimura, Yusuf Oguz, Masayo Ogawa, Geoffrey A. Block, Frank H Mose, Ho Sik Shin, Yahsou Delmas, Magdalena Okarska-Napierała, Toshiyuki Aoki, Richard Amdur, Hilmi Umut Unal, Stéphan Troyanov, Tammo Lesch, Amal A Alshal, Edward Chong, Ülle Pechter, Alison Taylor, Katsuhito Mori, Mehmet Kanbay, Akinobu Ochi, Claire Cerini, Naobumi Mise, Susumu Ookawara, Joris H. Robben, Hakki Cetinkaya, Anna Masajtis-Zagajewska, Davide Bolignano, Hilmi Umut Ünal, Mitsuru Ichii, Kensuke Hamada, Naoya Sugiyama, Sebahattin Sari, Gianluca Leonardi, Abdulgaffar Vural, Noémie Jourde-Chiche, Sankar D. Navaneethan, N. Dimkovic, Franziska Knöfel, Marios Papasotiriou, Peter Mt Deen, Fadi Fakhouri, Dimitrios Hadjiyannakos, Erling B. Pedersen, Luigi Biancone, Vassilis Filiopoulos, N. Marx, Masayoshi Mori, Zbigniew Zdrojewski, Giovanni F.M. Strippoli, Yoshio Kaku, Masatomo Chikamori, Angels Betriu, Michele Buemi, Kenmei Takaichi, William T. Smith, Izumi Sugimoto, A. Savvaidis, Daijo Inaguma, Giuseppe Costantino, John F Kincaid, Laura Cosmai, Radosław Pietrzak, Roberto Sabbatini, Michał Nowicki, Stephen R. Ash, Kenichi Ishizawa, Masaaki Inaba, Daniela Leonardis, Piotr Grzelak, Jonas Axelsson, Robert A. Fenton, Massimiliano Migliori, Junichiro Yamamoto, Diana J Leeming, Giovanna Parlongo, Philip T. Lavin, Buket Kin Tekce, Dominic S. Raj, James Cotton, David J. Cohen, Shinya Nakatani, Sangeon Gwoo, Shigeko Hara, Frank Schiepe, Philip Awadalla, Gulali Aktas, Massimo Gai, Maria Roszkowska-Blaim, Neil S. Sheerin, Lei Nan, K: Hess, Haruhisa Miyazawa, Silvia Lucisano, Grahame J Elder, François Madore, Helena Ziółkowska, Cai-Li Wang, Einar Svarstad, Giuseppina Lorenzano, Maria Teresa T Muratore, Alex Yang, Graziella D'Arrigo, Doaa Mohammed Youssef, Janni M Jensen, Marta Gracia, Suetonia C. Palmer, Valeria Cernaro, Borja Quiroga, Anton E. Daul, Francesca Mallamaci, Philippe Brunet, Tomoko Honda, Gerjan Navis, Izumi Yoshida, Domenico Trimboli, and Anjay Rastogi

Subjects
Transplantation, medicine.medical_specialty, Nephrology, business.industry, Medicine, business, Intensive care medicine, Pathophysiology
Published
2014

17. CKD NUTRITION, INFLAMMATION AND OXIDATIVE STRESS

Author

Abdelouahed Khalil, Anteo Di Napoli, Stephen Zewinger, Mariusz Flisiński, Domenico Trimboli, Maurizio Bossola, Marina Biagioli, Odile Azoulay, Michele Buemi, Piergiorgio Bolasco, Andreea Ilyes, Ángeles Álvarez, Valeria Cernaro, Polichronis Alivanis, Gabriel Stefan, Mehmet Haberal, Marcelo Costa Batista, Jerzy Chudek, Mujdat Batur Canoz, Branka Mitic, Abdul Rashid Qureshi, Anna Stefańska, Christiaan L. Meuwese, Anna Kamińska, Vera Jankowski, Yeon Soon Jung, Luisa Sereni, Rafał Donderski, Ho Sik Shin, Ciprian Stoica, Peter Stenvinkel, Insa E. Emrich, Rosanna Coppo, Boris Zingerman, Rachid Saile, Sonja Radenkovic, Yener Koc, Ilona Miśkowiec-Wiśniewska, Tatjana Cvetkovic, Danilo Fliser, Grigore Dogaru, Simonetta Palleschi, Milica Bozic, Urszula Spiechowicz-Zatoń, Kevin J. Woollard, Serpil Nebioğlu, Erik W. Holy, Hark Rim, Mahmut Gok, Adriana Arena, Iryna Dudar, Goran Paunovic, Elvira Fernández, Maria Inês Barreto-Silva, Jacek Manitius, Naohito Isoyama, Demet Yavuz, Michael Böhm, Jose M. Valdivielso, Paolo Maria Ghezzi, Silvia Regina Manfredi, Paweł Stróżecki, Yusuf Oguz, Maria L Lusini, Miomir Stojanovic, Gabriel Mircescu, Mikio Sugano, Paula Maria Gliga, Zeynep Bal, Mirela Liana Gliga, Elisa Loiacono, Hilmi Umut Ünal, Viktoria Alekseeva, Sun Chul Kim, Hyun Yul Rhew, José Tarcísio Giffoni de Carvalho, Foteini Lamprianou, Ekrem Kara, Sang-Kyung Jo, Barbara E. Stähli, Abdulkadir Unsal, Francesco Franco, Murat Karaman, Shunsuke Goto, Sumie Goto, Richard J. Johnson, Tamer Sakaci, Christophe Dubois, Roman Junik, Nikolaos Karvouniaris, Nikitas Moschos, Timo Speer, Kathleen Claes, Maria Teresa Ingegneri, Gunnar H. Heine, Pieter Evenepoel, Zahava Gamzo, Juan Jesus Carrero, Keiji Kono, Bertrand Gondouin, Sylwia Rotkegel, Mehmet Kanbay, Sebahattin Sari, Roxanne Darbousset, Shinichi Nishi, Andrzej Brymora, Bahar Gurlek Demirci, Vincenzo Bellizzi, Joanna Siódmiak, Domenico Di Lallo, Ye Na Kim, Latife Atasoy Karakas, Adam M. Zawada, Alexander Akhmedov, Mustafa Sevinc, Tuncay Sahutoglu, Hrvoje Cvija, Giovanni G. Camici, Ayse C Akbasli, Mahmut I Yilmaz, Christos Paliouras, Karolina Paunovic, Bulent Erbay, Carla Cavalheiro da Silva Lemos, Frances Costa-Silva, Marina Davoli, Liesbeth Viaene, Fatma Nurhan Ozdemir, Mehtap Erkmen Uyar, Kentaro Nakai, Adrian Covic, Danijela Tasic, Jarosław Ciepał, Mauro Atti, Gunnar Heine, Stéphane Burtey, Domenico Santoro, Benaya Rozen-Zvi, Simone Vargas, Lucia Rohrer, Gaetano Montalto, Hakki Cetinkaya, Turan Colak, Bert Bammens, Alessandro Amore, Tayfun Eyileten, Paul Leurs, Liliana Viasu, Theodoros Haviatsos, Yalcin Solak, Antonino Sidoti, Carmen de Pablo, Tayfun EyIeten, Vincenzo Savica, Maria Dolores Sanchez-Niño, Yasemin Gulcan Kurt, Gordana Kocic, Joachim Jankowski, Andrea Pisacane, Katarzyna Wyskida, Kenan Keven, Sunna Snaedal, Zorica Dimitrijevic, Nikolaos Papagiannis, Abdülgaffar Vural, Taner Basturk, Mutlu Saglam, Björn Anderstam, Hilmi Umut Unal, Serena Chicca, Aline Trevisan Peres, Maria Eugênia Fernandes Canziani, Alberto Ortiz, Mahmut Ilker Yilmaz, Bengt Lindholm, Stéphane Poitevin, Kiryong Park, Paolo M. Ghezzi, Antonio Pisani, Marialuisa Caiazzo, Noreddine Ghalim, Viktor Krot, Silvia Lucisano, Maria Aparecida Dalboni, Eleonora Riccio, Sarah Seiler, Giorgos Ntetskas, Oskar Svedberg, Carmela Aloisi, Sangeon Gwoo, Peter Bárány, Maria Bożentowicz-Wikarek, Alpaslan Altunoglu, O.M. Loboda, Elbis Ahbap, Dariusz Klein, Tuncer Cayci, Siren Sezer, Rosaria Lupica, Giuseppe Vita, Ruben Poesen, Björn Meijers, Nagba Yendoubé Gbandjaba, Magdalena Olszanecka-Glinianowicz, Burak Sayin, Won Yong Cho, Beata Marie Redublo Quinto, J. J. Carrero, Yuriko Yonekura, Felix C. Tanner, Miguel Cendoroglo, Olof Heimbürger, Cuneyt Akgol, Paola Michelozzi, Sarah Triem, Yoshiharu Ito, Emanouil Anastasakis, GrażYna Odrowa˛ż-Sypniewska, Caren Cristina Grabulosa, Aniceta Brzozowska, Hyung Kyu Kim, Marek Kretowicz, Maria Inês Barreto Silva, Thereza Christina Barja-Fidalgo, Yusuke Yamashita, Hideki Fujii, Simona Stancu, Luigi Tazza, Giuseppe Palladino, Nilufer Bayraktar, Rachel Bregman, Rahman Yavuz, Cengizhan Acikel, Barbara Rossi, Cristina Capusa, Massimo Sabbatini, Myung Gyu Kim, Guido Bellinghieri, Renata de Souza Mendes, Dorin Tarta, Radmila Veličković-Radovanović, Kyrill S. Rogacev, Kostantinos Roufas, and Thomas F. Lüscher

Subjects
Transplantation, medicine.medical_specialty, Framingham Risk Score, Cardiovascular History, business.industry, Hazard ratio, Renal function, medicine.disease, Gastroenterology, Endocrinology, Nephrology, Diabetes mellitus, Internal medicine, medicine, Myocardial infarction, Prospective cohort study, business, Kidney disease
Abstract

Introduction and Aims: Serum p-cresyl sulfate associates with cardiovascular disease in patients at different stages of chronic kidney disease. p-Cresyl sulfate concentrations are determined by intestinal uptake of p-cresol, human metabolism to p-cresyl sulfate and renal clearance. Whether intestinal uptake of p-cresol itself is associated with cardiovascular disease in patients with renal disease has not been studied to date. Methods: We performed a prospective study in patients with chronic kidney disease stage 1-5 (clinicaltrials.gov NCT00441623). Intestinal uptake of p-cresol, under steady state conditions, was estimated from 24h urinary excretion of p-cresyl sulfate. Primary endpoint was time to first cardiovascular event, i.e. cardiac death, myocardial infarction/ischemia, ventricular arythmia, cardiovascular surgery, cerebrovascular accident or symptomatic peripheral arterial disease. Statistical analysis was done using Kaplan Meier estimates and Cox proportional hazard analyses. Results: In a cohort of 200 patients, median 24h urinary excretion of p-cresyl sulfate was 457.47 µmol (IQR 252.68-697.17). After a median follow-up of 52 months, 25 patients reached the primary endpoint (tertile 1/2/3: 5/6/14 events, log rank P 0.0368, see figure). Higher urinary excretion of p-cresyl sulfate was related with cardiovascular events (univariate hazard ratio per 100 µmol increase: 1.112, P 0.0015). In multivariate analysis, urinary excretion of p-cresyl sulfate remained a predictor of cardiovascular events, independent of markers of renal function (Hazard ratio 1.120, P 0.0022) and in different models with other cardiovascular risk factors (Framingham risk factors, cardiovascular history, diabetes mellitus and biochemical parameters). The independent association between urinary excretion of p-cresyl sulfate and outcome persisted after correction for serum p-cresyl sulfate. Conclusions: Intestinal uptake of p-cresol associates with cardiovascular disease independent of renal function. Insights into mechanisms governing intestinal generation and absorption of p-cresol may lead to identification of novel therapeutic targets to reduce cardiovascular disease risk in patients with chronic kidney disease.

Published
2014

18. Renal histopathology

Author

E. J. Kim, J. H. Han, H. M. Koo, F. M. Doh, C. H. Kim, K. I. Ko, M. J. Lee, H. J. Oh, T.-H. Yoo, S.-W. Kang, K. H. Choi, S. H. Han, S. Assady, M. Tchirkov, R. Nasser, T. Mashiach, O. Ben Izhak, P. Housset, R. Guillemain, D. Nochy, M. Roland, C. Amrein, A. Karras, V. Boussaud, V. Pezzela, E. Thervet, S. P. Simic Ogrizovic, G. Basta Jovanovic, S. Radojevic, S. Bojic, R. Naumovic, Z. Karim, K. Cyrine, G. Rim, A. Ezzeddine, H. Hafedh, K. Hayet, B. Soumaya, O. Mondher, B. H. Fethi, E. Y. Fethi, B. A. Taieb, B. M. Hedi, B. M. Fatma, K. Adel, M. Penescu, E. Mandache, A. Zumrutdal, R. Ozelsancak, T. Canpolat, S. Barbouch, I. Mami, M. Mayara, M. Jerbi, A. Harzallah, R. Goucha, H. Ben Maiz, A. Kedher, N. Comi, P. Cianfrone, V. Piraina, R. Talarico, K. Giannakakis, G. Fuiano, G. Lucisano, K. Konat, M. Szotowska, H. Karkoszka, M. Adamczak, A. Wiecek, K. Kwiecien, O. Jercan, L. Mogoanta, I. Miller, X. Pan, J. Xu, H. Ren, W. Zhang, Y. Xu, P. Shen, X. Chen, X. Feng, and N. Chen

Subjects
Transplantation, Nephrology
Published
2013

19. Renal development and cystic diseases

Author

E. Cornec-Le Gall, L. Treguer, T. Sawadogo, S. Benarbia, Y. Le Meur, D. Zittema, E. van den Berg, E. Meijer, W. E. Boertien, A. C. Muller Kobold, C. F. M. Franssen, P. E. de Jong, S. J. L. Bakker, G. J. Navis, R. T. Gansevoort, S. Melemadathil, M. Kamal, L. Tuta, F. Botea, M. T. Sciarrone Alibrandi, M. Nuzzo, S. Delli Carpini, L. Merlino, E. Brioni, L. Zagato, M. Simonini, R. Rivera, P. Manunta, H. C. Park, H. Kim, T. Y. Koo, M. Han, Y. J. Park, K.-H. Oh, J. W. Noh, I. S. Ha, H. I. Cheong, Y.-H. Hwang, C. Ahn, A. Lacquaniti, M. Buemi, R. Lupica, S. Lucisano, V. Chirico, B. Ozucer, R. KazancIoglu, B. Ozturk, M. Alay, B. Veyseller, O. Ozturan, R. Erkoc, L. Obeidova, J. Stekrova, J. Reiterova, V. Elisakova, M. Merta, M. Kohoutova, V. Tesar, B. Gul, S. Cekic, B. Asiltas, S. Dogan, N. Aktas, A. Oruc, I. Dogan, A. Ersoy, M. Gullulu, M. Yurtkuran, and A. Yildiz

Subjects
Transplantation, Nephrology
Published
2013

20. CKD-MBD II

Author

T. Fujii, S. Suzuki, M. Shinozaki, H. Tanaka, S. Bell, S. Cooper, C. Lomonte, P. Libutti, D. Chimienti, F. Casucci, A. Bruno, M. Antonelli, P. Lisi, L. Cocola, C. Basile, A. Negri, E. Del Valle, M. Zanchetta, J. Zanchetta, M. C. Di Vico, M. Ferraresi, A. Pia, E. Aroasio, S. Gonella, E. Mongilardi, R. Clari, I. Moro, G. B. Piccoli, E. Gonzalez-Parra, L. Rodriguez-Osorio, A. Ortiz-Arduan, C. de la Piedra, J. Egido, M. V. Perez Gomez, A. A. Tabikh, B. Afsar, A. Kirkpantur, Y. Imanishi, M. Yamagata, Y. Nagata, M. Ohara, T. Michigami, T. Yukimura, M. Inaba, B. Bieber, B. Robinson, L. Mariani, S. Jacobson, L. Frimat, J. Bommer, R. Pisoni, F. Tentori, P. Ciceri, F. Elli, D. Brancaccio, M. Cozzolino, M. Adamczak, A. Wiecek, P. Kuczera, S. Sezer, Z. Bal, E. Tutal, O. Kal, D. Yavuz, I. Y ld r m, B. Sayin, R. Ozelsancak, S. Ozkurt, S. Turk, N. Ozdemir, R. Lehmann, M. Roesel, P. Fritz, N. Braun, C. Ulmer, W. Steurer, B. Dagmar, G. Ott, J. Dippon, D. Alscher, M. Kimmel, J. Latus, A. Turkvatan, M. Balci, S. Mandiroglu, B. Seloglu, M. Alkis, M. Serin, Y. Calik, S. Erkula, H. Gorboz, F. Mandiroglu, E. Lindley, M. Cruz Casal, S. Rogers, J. Pancirova, J. Kernc, J. B. Copley, D. Fouque, I. Kiss, Z. Kiss, A. Szabo, J. Szegedi, J. Balla, E. Ladanyi, B. Csiky, O. orkossy, M. Torok, S. Turi, C. Ambrus, G. Deak, A. Tisler, I. Kulcsar, V. K d r, A. Altuntas, A. Akp nar, H. Orhan, M. Sezer, V. Filiopoulos, N. Manolios, D. Arvanitis, I. Pani, K. Panagiotopoulos, D. Vlassopoulos, M. E. Rodriguez-Ortiz, A. Canalejo, C. Herencia, J. M. Martinez-Moreno, A. Peralta-Ramirez, P. Perez-Martinez, J. F. Navarro-Gonzalez, M. Rodriguez, M. Peter, K. Gundlach, S. Steppan, J. Passlick-Deetjen, J. R. Munoz-Castaneda, Y. Almaden, M. Rodriguez-Ortiz, J. Martinez-Moreno, I. Lopez, E. Aguilera-Tejero, N. Hanafusa, I. Masakane, S. Ito, S. Nakai, K. Maeda, H. Suzuki, M. Tsunoda, R. Ikee, N. Sasaki, M. Sato, N. Hashimoto, M.-H. Wang, K.-Y. Hung, C.-K. Chiang, J.-W. Huang, K.-C. Lu, C.-L. Lang, K. Okano, T. Yamashita, Y. Tsuruta, A. Hibi, N. Miwa, N. Kimata, K. Tsuchiya, K. Nitta, T. Akiba, L. Harb, H. Komaba, T. Kakuta, T. Suga, M. Fukagawa, H. Kikuchi, H. Shimada, R. Karasawa, M. Suzuki, M. Zhelyazkova-Savova, D. Gerova, D. Paskalev, V. Ikonomov, R. Zortcheva, B. Galunska, G. Jean, P. Deleaval, J.-M. Hurot, C. Lorriaux, B. Mayor, C. Chazot, H. Vannucchi, M. T. Vannucchi, J. C. Martins, J. L. Merino, J. L. Teruel, M. Fernandez-Lucas, J. J. Villafruela, B. Bueno, A. Gomis, V. Paraiso, C. Quereda, F. H. Ibrahim, N. Z. Fadhlina, E. K. Ng, K. M. Thong, B. L. Goh, D. M. Sulaiman, D. A. N. Fatimah, D. O. Evi, S. R. Siti, R. J. Wilson, M. Keith, B. Gros, A. Galan, J. A. Herrero, I. Oyaguez, M. A. Casado, S. Lucisano, G. Coppolino, A. Villari, V. Cernaro, R. Lupica, D. Trimboli, C. Aloisi, and M. Buemi

Subjects
Oncology, Transplantation, medicine.medical_specialty, Nephrology, business.industry, Internal medicine, medicine, business
Published
2013

21. Immune and inflammatory mechanisms

Author

G. Castellano, C. Cafiero, C. Divella, F. Sallustio, M. Gigante, L. Gesualdo, A. H. Kirsch, N. Smaczny, V. Riegelbauer, S. Sedej, A. Hofmeister, T. Stojakovic, M. Brodmann, E. Pilger, A. Rosenkranz, K. Eller, P. Eller, P. Meier, S. Lucisano, A. Arena, V. Donato, M. R. Fazio, D. Santoro, M. Buemi, M. Wornle, A. Ribeiro, S. Koppel, J. Pircher, T. Czermak, M. Merkle, K. Rupanagudi, O. P. Kulkarni, J. Lichtnekert, M. N. Darisipudi, S. R. Mulay, B. Schott, G. Hartmann, H.-J. Anders, A. Pletinck, G. Glorieux, E. Schepers, M. Van Landschoot, S. Eloot, W. Van Biesen, R. Vanholder, A. Castoldi, V. Oliveira, M. Amano, C. Aguiar, A. Caricilli, P. Vieira, M. Burgos, M. Hiyane, W. Festuccia, N. Camara, S. Djudjaj, S. Rong, H. Lue, A. Bajpai, B. Klinkhammer, M. Moeller, J. Floege, J. Bernhagen, T. Ostendorf, P. Boor, S. Ito, R. Aoki, K. Hamada, T. Edamatsu, Y. Itoh, M. Osaka, M. Yoshida, E. Oliva, F. Maritati, A. Palmisano, F. Alberici, C. Buzio, A. Vaglio, C. Grabulosa, E. Cruz, J. Carvalho, S. Manfredi, M. Canziani, L. Cuppari, B. Quinto, M. Batista, M. Cendoroglo, M. Dalboni, Z. Niemir, A. Swierzko, M. Polcyn-Adamczak, M. Cedzynski, A. Sokolowska, A. Szala, T. Baudoux, J.-M. Hougardy, A. Pozdzik, M.-H. Antoine, C. Husson, E. De Prez, J. Nortier, H.-F. Ni, J.-F. Chen, M.-H. Zhang, M.-M. Pan, B.-C. Liu, M. Machcinska, K. Bocian, G. Korczak-Kowalska, M. Tami Amano, V. Andrade-Oliveira, M. da Silva, M. Y. S. Miyagi, N. Olsen Camara, L. Xu, Y. Jin, F. Zhong, J. Liu, Q. Dai, W. Wang, N. Chen, F. Grosjean, C. Tribioli, V. Esposito, D. Catucci, G. Azar, M. Torreggiani, G. Merlini, C. Esposito, L. H. Fell, A. M. Zawada, K. S. Rogacev, S. Seiler, D. Fliser, G. H. Heine, N. Neprintseva, N. Tchebotareva, I. Bobkova, L. Kozlovskaya, G. M. Virzi, A. Brocca, M. de Cal, C. Bolin, G. Vescovo, C. Ronco, A. Fuchs, K. Eidenschink, A. Steege, C. Fellner, C. Bollheimer, W. Gronwald, J. Schroeder, B. Banas, M. C. Banas, A. Luthe, S. S. Seiler, K. Rogacev, D. Trimboli, G. Graziani, J. Haroche, R. Lupica, V. Cernaro, G. Montalto, G. Pettinato, E. Cho, J.-W. Lee, M.-G. Kim, S.-K. Jo, W.-Y. Cho, and H.-K. kim

Subjects
Transplantation, Immune system, Nephrology, business.industry, Immunology, Medicine, business
Published
2013

22. Experimental models of CKD

Author

R. Kanlaya, K. Sintiprungrat, V. Thongboonkerd, N. Torremade, R. Bindels, J. Hoenderop, E. Fernandez, A. Dusso, J. M. Valdivielso, T. Krueger, P. Boor, C. Schafer, R. Westenfeld, V. Brandenburg, G. Schlieper, W. Jahnen-Dechent, M. Ketteler, W. Jee, X. Li, B. Richards, J. Floege, J. G. Goncalves, D. Canale, A. C. de Braganca, M. H. M. Shimizu, R. M. A. Moyses, L. Andrade, A. C. Seguro, R. A. Volpini, S. Romoli, A. Migliorini, H.-J. Anders, O. Eskova, N. Neprintseva, N. Tchebotareva, I. Bobkova, L. Kozlovskaya, I. Simic, M. Tabatabaeifar, T. Wlodkowski, H. Denc, G. Mollet, C. Antignac, F. Schaefer, I. A. Ekaterina, L. Giardino, M. P. Rastaldi, L. Van den Heuvel, E. Levtchenko, C. Okina, T. Okamoto, M. Kamata, J. Murano, K. Kobayashi, K. Takeuchi, F. Kamata, T. Sakai, S. Naito, T. Aoyama, T. Sano, Y. Takeuchi, K. Kamata, D. Thomasova, H. A. Bruns, H. Liapis, T. Iwashita, H. Hasegawa, K. Takayanagi, T. Shimizu, J. Asakura, S. Okazaki, Y. Kogure, M. Hatano, H. Hara, M. Inamura, M. Iwanaga, T. Mitani, T. Mitarai, V. J. Savin, M. Sharma, C. Wei, J. Reiser, E. T. McCarthy, R. Sharma, J.-F. Gauchat, B. Eneman, K. Freson, C. Van Geet, D. E. Choi, J. Y. Jeong, Y. K. Chang, K.-R. Na, K. W. Lee, Y. T. Shin, H.-F. Ni, J.-F. Chen, M.-H. Zhang, M.-M. Pan, B.-C. Liu, S. S. Kim, T. Suzuki, M. Iyoda, K. Matsumoto, Y. Shindo-Hirai, Y. Kuno, Y. Wada, Y. Yamamoto, T. Shibata, T. Akizawa, J. M. Munoz-Felix, J. M. Lopez-Novoa, C. Martinez-Salgado, J. Ehling, J. Babickova, F. Gremse, F. Kiessling, T. Lammers, M. Lech, R. Gunthner, G. Lorenz, M. Ryu, R. Grobmayr, H. Susanti, K. S. Kobayashi, R. A. Flavell, S. Rayego-Mateos, J. Morgado, A. B. Sanz, S. Eguchi, J. Pato, G. Keri, J. Egido, A. Ortiz, M. Ruiz-Ortega, M. Leduc, L. Geerts, B. Grouix, F. Sarra-Bournet, A. Felton, L. Gervais, S. Abbott, J.-S. Duceppe, B. Zacharie, C. Penney, P. Laurin, L. Gagnon, M. G. Detsika, P. Duann, E. A. Lianos, K. I. Leong, C.-K. Chiang, C.-C. Yang, C.-T. Wu, L.-P. Chen, K.-Y. Hung, S.-H. Liu, F. F. Carvalho, V. P. Teixeira, W. S. Almeida, N. Schor, D. M. Small, N. C. Bennett, J. Coombes, D. W. Johnson, G. C. Gobe, N. Montero, A. Prada, M. Riera, M. Orfila, J. Pascual, E. Rodriguez, C. Barrios, G. Kokeny, K. Fazekas, L. Rosivall, M. M. Mozes, N. Hornigold, J. Hughes, A. Mooney, A. Benardeau, W. Riboulet, A. Vandjour, B. Jacobsen, C. Apfel, K. Conde-Knape, J.-F. Bienvenu, T. Tanaka, J. Yamaguchi, M. Nangaku, T. Niwa, D. Bolati, H. Shimizu, M. Yisireyili, F. Nishijima, A. Brocca, G. Virzi, M. de Cal, C. Ronco, G. Priante, E. Musacchio, C. Valvason, L. Sartori, A. Piccoli, B. Baggio, M. Perkuhn, M. Weibrecht, S. Zok, I. V. Martin, F. Schoth, T. Ostendorf, C. Kuhl, A. Karabaeva, A. Essaian, O. Beresneva, M. Parastaeva, I. Kayukov, A. Smirnov, I. Audzeyenka, M. Kasztan, A. Piwkowska, D. Rogacka, S. Angielski, M. Jankowski, C. L. Bockmeyer, K. Kokowicz, P. A. Agustian, S. Zell, J. Wittig, J. U. Becker, R. Nishizono, M. P. Venkatareddy, M. A. Chowdhury, S. Q. Wang, A. Fukuda, L. T. Wickman, Y. Yang, R. C. Wiggins, M. R. Fazio, V. Donato, S. Lucisano, V. Cernaro, R. Lupica, D. Trimboli, G. Montalto, C. Aloisi, A. T. Mazzeo, M. Buemi, O. Gawrys, K. H. Olszynski, M. Kuczeriszka, K. Gawarecka, E. Swiezewska, M. Chmielewski, M. Masnyk, J. Rafalowska, E. Kompanowska-Jezierska, W.-C. Lee, Y.-Y. Chau, L.-C. Lee, C.-H. Chiu, C.-T. Lee, J.-B. Chen, W.-K. Kim, and S. J. Shin

Subjects
Transplantation, medicine.medical_specialty, Nephrology, business.industry, Medicine, business, Intensive care medicine
Published
2013

23. Clinical nephrology - miscellaneous

Author

C. Bantis, P. Heering, N.-M. Kouri, M. Siekierka-Harreis, M. Stangou, C. Schwandt, G. Efstratiadis, L.-C. Rump, K. Ivens, I. Haddiya, T. Houssaini Squalli, I. Laouad, B. Ramdani, R. Bayahia, G. G. Dimas, T. J. Tegos, S. G. Spiroglou, C. G. Pitsalidis, A. S. Sioulis, I. M. Karamouzis, C. G. Savopoulos, M. I. Karamouzis, A. G. Orologas, A. I. Hatzitolios, D. M. Grekas, D. Maixnerova, E. Jancova, I. Rychlik, R. Rysava, M. Merta, J. Reiterova, A. Kolsky, E. Honsova, J. Skibova, V. Tesar, Z. Kendi Celebi, R. Calayoglu, K. Keven, I. Kurultak, P. Mescigil, B. Erbay, O. Karatan, N. Duman, S. Erturk, G. Nergizoglu, S. Kutlay, S. Sengul, K. Ates, F. Marino, C. Martorano, M. Bellantoni, R. Tripepi, C. Zoccali, K. Ishizuka, Y. Harita, Y. Kajiho, H. Tsurumi, T. Asano, K. Nishiyama, N. Sugawara, H. Chikamoto, Y. Akioka, Y. Yamaguchi, T. Igarashi, M. Hattori, P. J. Heering, M. Sahay, D. V. Monova, S. V. Monov, Y.-y. Wang, H. Cheng, G.-q. Wang, H.-r. Dong, Y.-p. Chen, C.-j. Wang, Y.-l. Tang, E. Buti, E. Dervishi, F. Bergesio, G. Ghiandai, A. Mjeshtri, N. Paudice, A. L. Caldini, C. Nozzoli, E. E. Minetti, L. Sun, J. Feng, L. Yao, Q. Fan, J. Ma, L. Wang, T. Kirsanova, L. Merkusheva, N. Ruinihina, N. Kozlovskaya, G. Elenshleger, K. Turgutalp, U. Karabulut, T. Ozcan, I. Helvaci, A. Kiykim, A. Kaul, D. Bhadhuaria, R. sharma, N. Prasad, A. Gupta, C. Clajus, J. Schmidt, H. Haller, P. Kumpers, S. David, A. M. Sevillano, M. Molina, E. Gutierrez, E. Morales, E. Gonzalez, E. Hernandez, M. Praga, J. L. Conde Olasagasti, C. Vozmediano Poyatos, M. L. Illescas, S. Tallon, J. J. Uson Carrasco, A. Roca Munoz, F. Rivera Hernandez, G. Ismail, R. Jurubita, A. Andronesi, R. Bobeica, D. Zilisteanu, E. Rusu, C. Achim, A. Huerta, J. Caro, E. Gutierrez-Solis, A. Pasquariello, G. Pasquariello, M. Innocenti, G. Grassi, M. F. Egidi, O. Ozturk, A. Yildiz, C. B. Gul, K. Dilek, L. Tylicki, A. Jakubowska, E. Weber, S. Lizakowski, D. Swietlik, B. Rutkowski, A. Postorino, S. Costa, S. Cristadoro, G. Magazzu, G. Bellinghieri, V. Savica, M. Buemi, D. Santoro, Y. Lu, P. Shen, X. Li, Y. Xu, X. Pan, W. Wang, X. Chen, W. Zhang, H. Ren, N. Chen, B. P. Mitic, T. Cvetkovic, P. Vlahovic, R. Velickovic Radovanovic, V. Stefanovic, S. Kostic, V. Djordjevic, Q. Ao, Q. Ma, Q. Cheng, X. Wang, S. Liu, R. Zhang, S. Ozturk, S. Ozmen, D. Akin, R. Danis, M. Yilmaz, S. Hajri, S. Barbouche, H. Okpa, E. Oviasu, L. Ojogwu, N. Fotouhi, A. Ghaffari, F. Hamzavi, H. Nasri, M. Ardalan, A. Stott, A. Ullah, H. Anijeet, S. Ahmed, H. S. Kohli, R. Rajachandran, M. Rathi, V. Jha, V. Sakhuja, E. Yenigun, F. Dede, D. Turgut, E. Koc, H. Akoglu, S. Piskinpasa, R. Ozturk, A. Odabas, D. Bajcsi, G. Abraham, E. Kemeny, S. Sonkodi, P. Legrady, A. Letoha, K. Constantinou, Z. Ondrik, B. Ivanyi, G. Lucisano, N. Comi, P. Cianfrone, C. Summaria, V. Piraina, R. Talarico, C. Camastra, G. Fuiano, I. Proletov, E. Saganova, O. Galkina, E. Bogdanova, I. Zubina, V. Sipovskii, A. Smirnov, E. Bailly, D. Pierre, R. Kerdraon, O. Grezard, E. Gnappi, M. Delsante, M. Galetti, U. Maggiore, L. Manenti, M. J. Hasan, M. A. Muqueet, M. Mostafi, I. Chowdhury, W. Haque, T. Khan, Y.-J. Kang, E. J. Bae, H. S. Cho, S.-H. Chang, D. J. Park, G. Xu, H. Lin, Z. Hu, X. Yu, C. Xing, C. Mei, L. Zuo, Z. Ni, X. Ding, D. Li, Q. Zhang, X. Feng, and L. Lin

Subjects
Transplantation, medicine.medical_specialty, Nephrology, business.industry, medicine, Clinical nephrology, Intensive care medicine, business
Published
2013

24. Epidemiology and outcome research in CKD 5D

Author

L. Coentrao, C. Ribeiro, C. Santos-Araujo, R. Neto, M. Pestana, W. Kleophas, A. Karaboyas, Y. LI, J. Bommer, R. Pisoni, B. Robinson, F. Port, G. Celik, B. Burcak Annagur, M. Yilmaz, T. Demir, F. Kara, K. Trigka, P. Dousdampanis, N. Vaitsis, S. Aggelakou-Vaitsi, K. Turkmen, I. Guney, F. Turgut, L. Altintepe, H. Z. Tonbul, E. Abdel-Rahman, P. Sclauzero, G. Galli, G. Barbati, M. Carraro, G. O. Panzetta, M. Van Diepen, M. Schroijen, O. Dekkers, F. Dekker, A. Sikole, G. Severova- Andreevska, L. Trajceska, S. Gelev, V. Amitov, S. Pavleska- Kuzmanovska, H. Rayner, R. Vanholder, M. Hecking, B. Jung, M. Leung, F. Huynh, T. Chung, S. Marchuk, M. Kiaii, L. Er, R. Werb, C. Chan-Yan, M. Beaulieu, P. Malindretos, P. Makri, G. Zagkotsis, G. Koutroumbas, G. Loukas, E. Nikolaou, M. Pavlou, E. Gourgoulianni, M. Paparizou, M. Markou, E. Syrgani, C. Syrganis, J. Raimann, L. A. Usvyat, V. Bhalani, N. W. Levin, P. Kotanko, X. Huang, P. Stenvinkel, A. R. Qureshi, U. Riserus, T. Cederholm, P. Barany, O. Heimburger, B. Lindholm, J. J. Carrero, J. H. Chang, J. Y. Sung, J. Y. Jung, H. H. Lee, W. Chung, S. Kim, J. S. Han, K. Y. Na, A. Fragoso, A. Pinho, A. Malho, A. P. Silva, E. Morgado, P. Leao Neves, N. Joki, Y. Tanaka, M. Iwasaki, S. Kubo, T. Hayashi, Y. Takahashi, K. Hirahata, Y. Imamura, H. Hase, C. Castledine, J. Gilg, C. Rogers, Y. Ben-Shlomo, F. Caskey, J. S. Sandhu, G. S. Bajwa, S. Kansal, J. Sandhu, A. Jayanti, M. Nikam, L. Ebah, A. Summers, S. Mitra, J. Agar, A. Perkins, R. Simmonds, A. Tjipto, S. Amet, V. Launay-Vacher, M. Laville, A. Tricotel, C. Frances, B. Stengel, J.-Y. Gauvrit, N. Grenier, G. Reinhardt, O. Clement, N. Janus, L. Rouillon, G. Choukroun, G. Deray, A. Bernasconi, R. Waisman, A. P. Montoya, A. A. Liste, R. Hermes, G. Muguerza, R. Heguilen, E. L. Iliescu, V. Martina, M. A. Rizzo, P. Magenta, L. Lubatti, G. Rombola, M. Gallieni, C. Loirat, H. Mellerio, M. Labeguerie, B. Andriss, E. Savoye, M. Lassale, C. Jacquelinet, C. Alberti, Y. Aggarwal, J. Baharani, S. Tabrizian, S. Ossareh, M. Zebarjadi, P. Azevedo, F. Travassos, I. Frade, M. Almeida, J. Queiros, F. Silva, A. Cabrita, R. Rodrigues, C. Couchoud, J. Kitty, S. Benedicte, C. Fergus, C. Cecile, B. Sahar, V. Emmanuel, J. Christian, E. Rene, H. Barahimi, M. Mahdavi-Mazdeh, M. Nafar, M. Petruzzi, M. De Benedittis, M. Sciancalepore, L. Gargano, P. Natale, M. C. Vecchio, V. Saglimbene, F. Pellegrini, G. Gentile, P. Stroumza, L. Frantzen, M. Leal, M. Torok, A. Bednarek, J. Dulawa, E. Celia, R. Gelfman, J. Hegbrant, C. Wollheim, S. Palmer, D. W. Johnson, P. J. Ford, J. C. Craig, G. F. Strippoli, M. Ruospo, B. El Hayek, B. Hayek, E. Baamonde, E. Bosch, J. I. Ramirez, G. Perez, A. Ramirez, A. Toledo, M. M. Lago, C. Garcia-Canton, M. D. Checa, B. Canaud, B. Lantz, A. Granger-Vallee, P. Lertdumrongluk, N. Molinari, J. Ethier, M. Jadoul, B. Gillespie, C. Bond, S. Wang, T. Alfieri, P. Braunhofer, B. Newsome, M. Wang, B. Bieber, M. Guidinger, L. Zuo, X. Yu, X. Yang, J. Qian, N. Chen, J. Albert, Y. Yan, S. Ramirez, M. Beresan, A. Lapidus, M. Canteli, A. Tong, B. Manns, J. Craig, G. Strippoli, M. Mortazavi, B. Vahdatpour, S. Shahidi, A. Ghasempour, D. Taheri, S. Dolatkhah, A. Emami Naieni, M. Ghassami, M. Khan, K. Abdulnabi, P. Pai, M. Vecchio, M. A. Muqueet, M. J. Hasan, M. A. Kashem, P. K. Dutta, F. X. Liu, L. Noe, T. Quock, N. Neil, G. Inglese, M. Motamed Najjar, B. Bahmani, A. Shafiabadi, J. Helve, M. Haapio, P.-H. Groop, C. Gronhagen-Riska, P. Finne, R. Sund, M. Cai, S. Baweja, A. Clements, A. Kent, R. Reilly, N. Taylor, S. Holt, L. Mcmahon, M. Carter, F. M. Van der Sande, J. Kooman, R. Malhotra, G. Ouellet, E. L. Penne, S. Thijssen, M. Etter, A. Tashman, A. Guinsburg, A. Grassmann, C. Barth, C. Marelli, D. Marcelli, G. Von Gersdorff, I. Bayh, L. Scatizzi, M. Lam, M. Schaller, T. Toffelmire, Y. Wang, P. Sheppard, L. Neri, V. A. Andreucci, L. A. Rocca-Rey, S. V. Bertoli, D. Brancaccio, G. De Berardis, G. Lucisano, D. Johnson, A. Nicolucci, C. Bonifati, S. D. Navaneethan, V. Montinaro, M. Zsom, A. Bednarek-Skublewska, G. Graziano, J. N. Ferrari, A. Santoro, A. Zucchelli, G. Triolo, S. Maffei, S. De Cosmo, V. M. Manfreda, L. Juillard, A. Rousset, F. Butel, S. Girardot-Seguin, T. Hannedouche, M. Isnard, Y. Berland, P. Vanhille, J.-P. Ortiz, G. Janin, P. Nicoud, M. Touam, E. Bruce, B. Grace, P. Clayton, A. Cass, S. Mcdonald, Y. Furumatsu, T. Kitamura, N. Fujii, S. Ogata, H. Nakamoto, K. Iseki, Y. Tsubakihara, C.-C. Chien, J.-J. Wang, J.-C. Hwang, H.-Y. Wang, W.-C. Kan, N. Kuster, L. Patrier, A.-S. Bargnoux, M. Morena, A.-M. Dupuy, S. Badiou, J.-P. Cristol, J.-M. Desmet, V. Fernandes, F. Collart, N. Spinogatti, J.-M. Pochet, M. Dratwa, E. Goffin, J. Nortier, D. S. Zilisteanu, M. Voiculescu, E. Rusu, C. Achim, R. Bobeica, S. Balanica, T. Atasie, S. Florence, S. Anne-Marie, L. Michel, C. Cyrille, A. Strakosha, N. Pasko, S. Kodra, N. Thereska, A. Lowney, E. Lowney, R. Grant, M. Murphy, L. Casserly, T. O' Brien, W. D. Plant, J. Radic, D. Ljutic, V. Kovacic, M. Radic, K. Dodig-Curkovic, M. Sain, I. Jelicic, T. Hamano, C. Nakano, S. Yonemoto, A. Okuno, M. Katayama, Y. Isaka, M. Nordio, A. Limido, M. Postorino, M. Nichelatti, M. Khil, I. Dudar, V. Khil, I. Shifris, M. Momtaz, A. R. Soliman, M. I. El Lawindi, P. Dzekova-Vidimliski, S. Pavleska-Kuzmanovska, I. Nikolov, G. Selim, T. Shoji, R. Kakiya, N. Tatsumi-Shimomura, Y. Tsujimoto, T. Tabata, H. Shima, K. Mori, S. Fukumoto, H. Tahara, H. Koyama, M. Emoto, E. Ishimura, Y. Nishizawa, and M. Inaba

Subjects
Transplantation, medicine.medical_specialty, Nephrology, business.industry, Epidemiology, Medicine, business, Intensive care medicine, Outcome (game theory)
Published
2012

25. Peritoneal dialysis

Author

J. Liu, Y. Liu, Y. Xu, X. Zhao, J. Qian, B. Sun, C. Xing, R. Kanda, C. Hamada, T. Nakano, K. Wakabayashi, H. Io, S. Horikoshi, Y. Tomino, N. Ishimatsu, T. Miyamoto, H. Morimoto, J. Nakamata, R. Baba, K. Kanegae, R. Serino, N. Kabashima, Y. Otsuji, Y. Doi, M. Tamura, T. Kusumoto, K. Fukami, S.-I. Yamagishi, S. Ueda, Y. Kaida, T. Hazama, Y. Nakayama, R. Ando, N. Obara, S. Okuda, M. Matsumoto, Y. Furuno, H. Bang-Gee, L. Mazzotta, A. Rosati, A. Carlini, V. T. Henriques, E. Zangiacomi Martinez, J. C. Divino-Filho, R. Pecoits-Filho, J. A. Cardeal Da Costa, T. Gama Axelsson, B. Lindholm, J. J. Carrero, O. Heimburger, P. Stenvinkel, A. R. Qureshi, M. Akazawa, T. Uno, E. Kanda, Y. Maeda, M. Aktsiali, S. Antonopoulou, K. Tsiolaki, N. Bakirtzi, A. Patrinou, M. Georgopoulou, P. Liaveri, N. Afentakis, G. Tsirpanlis, T. Hasegawa, H. Nishiwaki, M. Hirose, D. Komukai, H. Tayama, F. Koiwa, A. Yoshimura, S. L. Lui, S. Lui, S. Yung, C. Tang, F. Ng, W. K. Lo, T. M. Chan, H. M. Koo, F. M. Doh, D. E. Yoo, H. J. Oh, T.-H. Yoo, K. H. Choi, S.-W. Kang, D. S. Han, S. H. Han, N. Fernandes, M. G. Bastos, M. R. Gianotti Franco, A. Chaoubah, M. D. Gloria Lima, S. Kang, J. Do, K. Cho, J. Park, K. Yoon, J.-B. Chen, B.-C. Cheng, T.-C. Chen, Y.-J. Su, C.-H. Wu, Y. Park, J. Jeon, M. Tsikeloudi, P. Pateinakis, K. Patsatsi, E. Manou, D. Sotiriadis, D. Tsakiris, L. Teixeira, A. Rodrigues, M. J. Carvalho, A. Cabrita, D. Mendonca, M. Bruschi, G. Candiano, L. Santucci, S. Luzio, R. Cannavo, G. M. Ghiggeri, E. Verrina, Y. Varadarajan, B. Raju, K.-H. Cho, J.-W. Park, K.-W. Yoon, T.-W. Kim, M. Kimmel, N. Braun, J. Latus, M. D. Alscher, D. Struijk, S. Van Esch, R. T. Krediet, T. Van den Beukel, T. Hoekstra, L. Tirapani, K. De Andrade Bastos, M. Bastos, F. Dekker, T. Yasuhisa, H. Kanai, K. Harada, Y. Kawai, H. Sugiyama, Y. Ito, K. Tsuruya, H. Yoshida, H. Maruyama, S. Goto, M. Nakayama, H. Nakamoto, H. Morinaga, S. Matsuo, H. Makino, M. C. DI Gioia, P. Gallar, N. Laso, I. Rodriguez, G. Cobo, A. Oliet, J. Hynostroza, J. C. Herrero, C. Mon, M. Ortiz, A. Vigil, T. Tomo, J. Portoles, S. Uta, A. M. Tato, P. Lopez-Sanchez, M. Rivera, R. Rodriguez-Pena, G. Del Peso, M. Ortega, C. Felipe, E. Tsampikaki, G. Aperis, A. Kaikis, C. Paliouras, N. Karvouniaris, M. Maragaki, P. Alivanis, B. Kortus-Gotze, T. Hoferhusch, J. Hoyer, F. Martino, M. Kaushik, M. P. Rodighiero, C. Creapldi, C. Ronco, A. Lacquaniti, V. Donato, M. R. Fazio, S. Lucisano, V. Cernaro, R. Lupica, M. Buemi, C. Aloisi, N. Bavbek Ruzgaresen, S. Secilmis, H. Yilmaz, A. Akcay, M. Duranay, N. Akalin, M. R. Altiparmak, S. Trabulus, A. S. Yalin, R. Ataman, K. Serdengecti, K. Schneider, B. Bator, B. Niko, F. Peter, C. Ulmer, L. Joerg, K. Martin, B. Dagmar, O. German, R. Fabian, D. Juergen, S. Stephan, A. Dominik, P. Fritz, B. Rettenmaier, S. Hirschburger, S. Segerer, D. Biegger, T. Lang, G. Ott, M. Habib, M. Korte, M. Hagen, F. Dor, M. Betjes, R. Zietse, C. Scharpf, T. I. Chang, D. H. Shin, D.-S. Han, H. Y. Choi, Y. K. Lee, B. S. Kim, T. H. Yoo, H. C. Park, H. Y. Lee, N. Horimoto, K. Tuji, S. Kitamura, R. Isshiki, M. Iwagami, D. Tsutsumi, Y. Mochida, K. Ishioka, M. Oka, K. Maesato, H. Moriya, T. Ohtake, S. Hidaka, S. Kobayashi, C. Higuchi, Y. Tanihata, M. Ishii, H. Sugimoto, N. Sato, A. Kyono, T. Ogawa, H. Nishimura, K. Otsuka, J.-Y. Do, C. Du Halgouet, A. Latifa, V. Anne Sophie, D. Emmanuel, R. Christine, V. Francois, T. Grzelak, L. Czyzewska-Majchrzak, M. Kramkowska, H. Witmanowski, K. Czyzewska, K. Janda, M. Krzanowski, P. Dumnicka, W. Sulowicz, M. Rroji, S. Seferi, M. Barbullushi, E. Likaj, E. Petrela, N. Thereska, G. Cabiddu, E. Dessi, A. Arceri, P. Laura, E. Manca, M. Conti, R. Cao, A. Pani, C.-T. Liao, O. Vega Vega, A. Mendoza de la Garza, R. Correa-Rotter, A. Ueda, K. Nagai, M. Morimoto, A. Hirayama, S. Owada, Y. Tonozuka, C. Saito, K. Yamagata, A. Matsuda, Y. Tayama, M. Iwanaga, C. Noiri, M. Hatano, T. Kiba, K. Kanozawa, H. Katou, H. Hasegawa, T. Mitarai, S. Ros-Ruiz, L. Fuentes-Sanchez, C. Jironda-Gallegos, E. Gutierrez-Vilches, P. Garcia-Frias, D. Hernandez-Marrero, S. Lee, X. Lai, W. Chen, Z. Guo, M. Braide, V. Cristina, S. G. Popa, M. Maria, M. Eugen, P. DI Loreto, N. Spahia, L. O. Sanchez Macias, K. I. Lares Castellanos, J. A. Hernandez Pacheco, R. Correa Rotter, A. Pedro Ventura, S. Olivia, V. Joana, F. Francisco, C. Maria Joao, C. Antonio, A. S. Rodrigues, N. Atas, Y. Erten, K. Onec, S. Inal, S. Topal, A. Akyel, B. Celik, G. U. Okyay, Y. Tavil, M. Zeiler, T. Monteburini, R. M. Agostinelli, R. Marinelli, S. Santarelli, C. Yaylaci, G. Sahin, G. Guz, S. Sindel, A. Pinho, A. Malho Guedes, A. Fragoso, H. Carreira, I. Pinto, I. Bernardo, P. Leao, B. Kusnierz-Cabala, A. Krasniak, E. Chowaniec, B. Tabor-Ciepiela, K. Turkmen, O. Ozbek, M. Kayrak, C. Samur, I. Guler, H. Z. Tonbul, K. Rusai, R. Herzog, K. Kratochwill, L. Kuster, C. Aufricht, C.-M. Meier, D. Fliser, M. K. Schilling, M. Klingele, M. Fukasawa, M. Takeda, M. Kamiyama, Y. R. Song, H. J. Kim, S. G. Kim, J.-K. Kim, J. W. Noh, J. W. Yoon, and J.-R. Koo

Subjects
Transplantation, Nephrology
Published
2012

26. AKI - Clinical

Author

E. Gok Oguz, R. Olmaz, K. Turgutalp, N. Muslu, M. A. Sungur, A. Kiykim, W. Van Biesen, J. Vanmassenhove, G. Glorieux, R. Vanholder, S. Chew, K. Forster, T. Kaufeld, J. Kielstein, T. Schilling, A. Haverich, H. Haller, B. Schmidt, P. Hu, X. Liang, Y. Chen, R. LI, F. Jiang, Z. LI, W. Shi, C. C. W. Lim, C. M. L. Chia, A. K. Tan, C. S. Tan, R. Ng, S. Subramani, A. Perez de Jose, C. Bernis Carro, R. Madero Jarabo, J. Bustamante, J. A. Sanchez Tomero, W. Chung, H. Ro, J. H. Chang, H. H. Lee, J. Y. Jung, L. Fazzari, A. Giuliani, J. Scrivano, L. Pettorini, U. Benedetto, R. Luciani, A. Roscitano, A. Napoletano, D. Coclite, E. Cordova, G. Punzo, R. Sinatra, P. Mene, N. Pirozzi, L. Shavit, R. Manilov, N. Algur, Y. Wiener-Well, I. Slotki, C. Pipili, C. S. Vrettou, K. Avrami, F. Economidou, K. Glynos, S. Ioannidou, V. Markaki, E. Douka, S. Nanas, A. De Pascalis, P. Cofano, S. Proia, A. Valletta, O. Vitale, F. Russo, E. Buongiorno, V. Filiopoulos, D. Biblaki, D. Lazarou, D. Chrysis, M. Fatourou, S. Lafoyianni, D. Vlassopoulos, O. Zakiyanov, V. Kriha, J. Vachek, J. Svarcova, T. Zima, V. Tesar, M. Kalousova, M. Kaushik, C. Ronco, D. Cruz, L. Zhang, W. Zhang, N. Chen, A. A. Ejaz, G. Kambhampati, N. Ejaz, B. Dass, V. Lapsia, A. A. Arif, A. Asmar, M. Shimada, M. Alsabbagh, R. Aiyer, R. Johnson, T.-H. Chen, C.-H. Chang, M.-Y. Chang, Y.-C. Tian, C.-C. Hung, J.-T. Fang, C.-W. Yang, Y.-C. Chen, V. Cantaluppi, A. D. Quercia, F. Figliolini, S. Giacalone, A. Pacitti, M. Gai, C. Guarena, G. Leonardi, L. Biancone, G. Camussi, G. P. Segoloni, M. De Cal, P. Lentini, A. Clementi, G. M. Virzi, E. Scalzotto, A. Lacquaniti, V. Donato, M. R. Fazio, S. Lucisano, V. Cernaro, R. Lupica, M. Buemi, I. Helvaci, E. Anik, M. Wani, D. I. Wani, D. M. A. Bhat, D. K. Banday, D. M. S. Najar, D. A. R. Reshi, D. N. A. Palla, P. Iglesias, T. Olea, C. Vega-Cabrera, M. Heras, M. A. Bajo, G. Del Peso, M. J. Arias, R. Selgas, J. J. Diez, E. Daher, P. L. Costa, E. N. S. Pereira, R. D. P. Santos, K. L. Abreu, G. Silva Junior, E. D. B. Pereira, M. Raimundo, S. Crichton, Y. Syed, J. Martin, C. Whiteley, D. Bennett, M. Ostermann, A. Gjyzari, N. Thereska, A. Koroshi, M. Barbullushi, S. Kodra, A. Idrizi, A. Strakosha, E. Petrela, J. Lemmich Smith, A. Klimenko, E. Tuykhmenev, S. Villevalde, Z. Kobalava, S. Avdoshina, E. Tyukhmenev, M. Efremovtseva, H. Hayashi, S. Suzuki, K. Kataoka, Y. Kondoh, H. Taniguchi, D. Sugiyama, K. Nishimura, W. Sato, S. Maruyama, S. Matsuo, Y. Yuzawa, D. Geraldine, F. Muriel, H. Alexandre, R. Eric, P. Fu, M. Pozzato, F. Ferrari, P. Cecere, P. Mesiano, A. Vallero, S. Livigni, F. Quarello, L. Hudier, O. Decaux, A. Haddj-Elmrabet, L. Mandart, M. Lino-Daniel, F. Bridoux, E. Renaudineau, T. Sawadogo, P. Le Pogamp, C. Vigneau, D. Famee, H. M. Koo, H. J. Oh, S. H. Han, K. H. Choi, S.-W. Kang, M. Mehdi, M. Nicolas, C. Mariat, P. Shah, V. B. Kute, A. Vanikar, M. Gumber, H. Patel, H. Trivedi, C. Manetos, S. Poulaki, E.-S. Tripodaki, A. Papastylianou, C. Routsi, K. Uchida, U. Kensuke, K. Yamagata, C. Saitou, M. Okada, G. Chita, M. Davies, Y. Veriawa, S. Naicker, P. Mukhopadhyay, D. Mukherjee, R. Mishra, M. Kar, D. Zickler, H. Wesselmann, R. Schindler, E. Gutierrez, J. Egido, A. Rubio-Navarro, I. Buendia, L. M. Blanco-Colio, O. Toldos, F. Manzarbeitia, A. De Lorenzo, R. Sanchez, M. Praga, J. A. Moreno, M. Y. Kim, N. R. Kang, H. R. Jang, J. E. Lee, W. Huh, Y.-G. Kim, D. J. Kim, S.-C. Hong, J.-S. Kim, H. Y. Oh, T. Okamoto, K. Kamata, S. Naito, H. Tazaki, S. Kan, L.-G. Anne-Kathrin, K. Matthias, T. Speer, L. Andreas, G. Heinrich, V. Thomas, A. Poppleton, F. Danilo, C.-F. Lai, V.-C. Wu, C.-C. Shiao, T.-M. Huang, K.-D. Wu, M. Bedford, C. Farmer, J. Irving, P. Stevens, F. Patera, F. Mattozzi, S. Battistoni, R. M. Fagugli, M. Y. Park, S. J. Choi, J. G. Kim, S. D. Hwang, H. Xie, H. Chen, S. Xu, Q. He, J. Liu, W. Hu, Z. Liu, M. Dalboni, R. Blaya, B. M. Quinto, R. Narciso, M. Oliveira, J. Monte, M. Durao, M. Cendoroglo, M. Batista, A. L. Hanemann, A. Liborio, A. Martins, M. C. C. Pinheiro, G. Meneses, R. De Paula Pessoa, M. Sousa, F. S. M. Bezerra, P. L. M. M. Albuquerque, J. B. Lima, C. B. Lima, M. D. S. B. Veras, T. Nemoto Matsui, C. Totoli, M. C. Cruz Andreoli, M. P. Vilela Coelho, N. K. Guimaraes de Souza, A. L. Ammirati, F. De Carvalho Barreto, B.-H. Ferraz Neto, B. Fortunato Cardoso Dos Santos, A. Abraham, G. Abraham, M. Mathew, P. M. A. Duarte, F. B. Duarte, E. M. Barros, F. Q. S. Castro, H. Palomba, I. Castro, S. R. Sousa, A. N. Jesus, T. Romano, E. Burdmann, L. Yu, S. H. Kwon, J. Y. You, Y. K. Hyun, S. A. Woo, J. S. Jeon, H. J. Noh, D. C. Han, L. Tozija, Z. Petronievic, G. Selim, I. Nikolov, O. Stojceva-Taneva, K. Cakalaroski, A. Lukasz, J. Beneke, J. Menne, M. Schiffer, N. Polanco, E. Hernandez, V. Gutierrez Millet, E. Gonzalez Monte, E. Morales, L. Francisco Javier, G.-F. Nuria, M.-G. Jose Maria, M. Bes Rastrollo, A. Angioi, M. Conti, R. Cao, A. Atzeni, G. Pili, V. Matta, E. Murgia, P. Melis, V. Binda, A. Pani, F. Thome, F. Leusin, E. Barros, C. Morsch, A. Balbinotto, C. Pilla, V. Premru, J. Buturovic-Ponikvar, R. Ponikvar, A. Marn-Pernat, B. Knap, J. Kovac, J. Gubensek, B. Kersnic, L. Krnjak, M. Prezelj, J. Granatova, M. Havrda, Z. Hruskova, K. Kratka, O. Remes, M. Mokrejsova, M. Bolkova, V. Lanska, I. Rychlik, M. D. Uniacke, R. J. Lewis, S. Harris, P. Roderick, N. Martin, K. Ulrich, B. Jan, B. Jorn, B. Reinhard, K. Jan, H. Hermann, F. Meyer Tobias, R. Leyla, M. W. Schmidt Bernhard, S. Harald, S. Jurgen, K. Tanja, S. Mario, E. Sang Hi, M. Claus, V. Frank, S. Aleksej, S. Sengul, S. Robert, W. Karin, G. Feikah, F. Menne Tobias, N. Meyer Tobias, G. Beutel, S. Fleig, J. Steinhoff, T. Meyer, C. Hafer, J. Bramstedt, V. Busch, M. Vischedyk, U. Kuhlmann, W. Ries, S. Mitzner, S. Mees, S. Stracke, J. Nurnberger, P. Gerke, M. Wiesner, B. Sucke, M. Abu-Tair, A. Kribben, N. Klause, F. Merkel, S. Schnatter, E. Dorresteijn, O. Samuelsson, R. Brunkhorst, G. Stec-Hus Registry, A. Reising, F.-C. Bange, M. Hiss, F. Vetter, S. M. Bode-Boger, J. Martens-Lobenhoffer, B. M. W. Schmidt, J. T. Kielstein, H. S. Shin, Y. S. Jung, and H. Rim

Subjects
Transplantation, Nephrology
Published
2012

27. Renal histopathology

Author

F. Marie-Lucile, N. Laure-Helene, C. Yosr, M. Anne, F. Fadi, C. Levi, V. Meas-Yedid, C. Daniliuc, A. Karras, J. C. Olivo-Marin, L. Mouthon, E. Guiard, M. Roland, L. Guillevin, C. Jacquot, D. Nochy, E. Thervet, Q. Chen, C. Skerka, B. Uzonyi, S. Lindner, C. Licht, B. Hoppe, M. Riedl, M. Kirschfink, S. Habbich, G. Wolf, L. Strain, T. H. Goodship, P. F. Zipfel, H. Kfoury, A. Alsuwaida, K. Alsaad, F. Alhejaili, M. Alghonaim, J. Alwakeel, S. Husain, N. Aloudah, L. Besso, M. Tamagnone, G. Daidola, M. Burdese, L. Repetto, G. Pasquale, L. Colla, L. Biancone, P. Stratta, G. P. Segoloni, J. Bacalja, A. M. Bauer Segvic, S. Bulimbasic, A. Pacic, M. Knotek, M. Sabljar Matovinovic, K. Galesic, D. Galesic Ljubanovic, E. Zakharova, E. Stolyarevich, O. Vorobjova, H. Tamouza, J. M. Chemouny, M. Flamant, L. Raskova Kafkova, M. Demion, M. Laurent, F. Walker, B. A. Julian, E. Tissandie, M. K. Tiwari, J. Novak, N. O. Camara, M. Benhamou, F. Vrtovsnik, R. C. Monteiro, I. C. Moura, S. Samavat, P. Ahmadpoor, P. Torbati, R. Ghaderi, F. Poorrezagholi, F. Samadian, M. Nafar, A. MII, A. Shimizu, T. Kaneko, F. Yasuda, M. Fukui, Y. Masuda, Y. Iino, Y. Katayama, C. Muller, J. Markovic-Lipkovski, S. Simic-Ogrizovic, R. Naumovic, S. Cirovic, D. Mitrovic, G. Muller, A. Wozniak, M. Janicka-Jedynska, J. Zurawski, E. Kaczmarek, J. Zachwieja, S. Khilji, T. Dorman, P. O'kelly, L. Lampty, K. Leung, A. Shadivan, C. Varghese, J. Walshe, T. Saito, M. Kawano, T. Saeki, I. Mizushima, Y. Yamaguchi, N. Imai, H. Nakashima, H. Umehara, M. Shvetsov, O. Popova, N. Chebotareva, A. Ivanov, I. Bobkova, D. Cremasco, M. Ceol, L. Peruzzi, G. Mazzucco, M. Giuseppina, G. Vezzoli, R. Cristofaro, A. D'angelo, F. Anglani, D. Del Prete, G. Coppolino, N. Comi, D. Bolignano, V. Piraina, R. Talarico, A. Colombo, G. Lucisano, G. Fuiano, P. Bernich, A. Lupo, T. R. Of Renal Biopsies, M. P. Rastaldi, O. C. Jercan, P. Messa, D. Alexandru, L. Mogoanta, and V. Uribe Villegas

Subjects
Transplantation, Nephrology
Published
2012

28. Mineral and bone disease - CKD 5D

Author

M. Hecking, A. Kainz, B. Bielesz, M. Plischke, G. Beilhack, W. H. Hoerl, G. Sunder-Plassmann, C. Bieglmayer, S. Benchetrit, J. Green, J. Bernheim, E. Golan, N. Oyake, K. Suzuki, S. Itoh, K. Tanabe, A. Fujimori, S. Okada, K. Yamamoto, M. Sakai, N. Kamiura, P. Solenne, F. Guebre-Egziabher, J. Bacchetta, J. Drai, M. Richard, R. Chapurlat, D. Fouque, Z. Nowak, K. Grzegorz, K. Maria, W. Zofia, K. Zamboch, J. Zahalkova, Z. Kosatikova, P. Skypalova, J. Skarda, J. Cunha, M. Boim, V. Ferreira, M. Naves, H. Kikuchi, H. Shimada, Y. Takimoto, R. Karasawa, M. Shimotori, K. Ikarashi, N. Saito, S. Miyazaki, S. Sakai, M. Suzuki, H. Ogata, A. Takeshima, M. Yamamoto, K. Asakura, T. Kato, K. Shishido, F. Koiwa, M. Mizobuchi, E. Kinugasa, T. Akizawa, F. Londrino, V. Corbani, M. Ardini, V. Falqui, T. Zattera, G. Rombola', Y. Takeshige, K. Matsuzaka, P. Ciceri, E. Volpi, I. Brenna, F. Elli, E. Borghi, D. Brancaccio, M. Cozzolino, K. Farrand, J. B. Copley, J. Heise, M. Fridman, M. Keith, A. Silverberg, R. Wilson, L. Poole, G. Jean, E. Bresson, C. Chazot, F. Maduell, M. Arias, A. Sentis, N. Rodriguez, S. Jimenez, B. Alemany, N. Perez, M. Vera, N. Fontsere, M. Carrera, A. Cases, M. Sonikian, T. Miha, I. Skarakis, I. Karatzas, A. Karaitianou, V. Tomanoski, D. Petkovic, I. Curic, R. Hrvacevic, N. Kaperonis, C. Kourvelou, A. Sgantzos, D. Nastou, G. Ntatsis, S. Ziakka, F. Karakasis, V. Nikolopoulos, D. Zoubaniotou, A. Koutsovasili, A. Zagorianakos, V. Kolovos, N. Papagalanis, V. Forni, M. Pruijm, E. Tousset, C. Zweiacker, I. Menetrey, L. Berwert, R. Bullani, A. Cherpillod, L. Gabutti, T. Gauthier, G. Halabi, C. Mathieu, P. Meier, O. Phan, S. Pianca, C. Schoenholzer, D. Teta, B. Von Albertini, B. Vrijens, M. Burnier, N. Kurita, M. Fukagawa, Y. Onishi, T. Yamaguchi, T. Hasegawa, S. Fukuma, K. Kurokawa, S. Fukuhara, P. Urena, I. Bridges, C. Christiano, S. Cournoyer, K. Cooper, M. Farouk, N. Kopyt, M. Rodriguez, D. Zehnder, A. Covic, Y. Tominaga, T. Hiramitsu, T. Yamamoto, K. Nanmoku, Y. Matsuda, T. Tsuzuki, C.-L. Lang, K.-C. Lu, M.-H. Wang, S.-Y. Liu, J.-W. Huang, C.-K. Chiang, K.-Y. Hung, C. Bantis, N.-M. Kouri, E. Tsandekidou, S. Frangidis, A. Tsiandoulas, E. Liakou, G. Bamichas, M. Stangou, A. Papagianni, G. Efstratiadis, T. Natse, D. Memmos, P. Messa, G. Cannella, S. Mazzaferro, X. Yu, B. Bieber, M. Guidinger, X. Yang, F. Tentori, R. Pisoni, J. Qian, N. Chen, Y. Yan, M. Wang, L. Zuo, H. Wang, J. Albert, S. Ramirez, F. Caccetta, M. Caroppo, F. Musio, A. Mudoni, A. Accogli, M. D. Zacheo, V. Nuzzo, G. Selim, O. Stojceva-Taneva, L. Tozija, S. Gelev, V. Pusevski, P. Dzekova-Vidimliski, I. Rambabova-Busletic, A. Sikole, P. Esposito, R. Coppo, F. Malberti, A. Dal Canton, K. Moriwaki, H. Komaba, T. Kakuta, V. Cernaro, R. Lupica, V. Donato, A. Lacquaniti, M. R. Fazio, S. Lucisano, M. Buemi, S. Okuno, E. Ishimura, N. Tsuboniwa, K. Norimine, K. Yamakawa, T. Yamakawa, S. Shoji, K. Mori, Y. Nishizawa, M. Inaba, M. Dahaba, S. Seck, M. Cisse, Y. Jotoku, Y. Sato, N. Dimkovic, E. Asicioglu, A. Kahveci, H. Arikan, M. Koc, S. Tuglular, C. Ozener, R. Kido, T. Yamaguch, A. Krasniak, M. Drozdz, G. Chmiel, P. Podolec, M. Pasowicz, M. Kowalczyk-Michalek, W. Sulowicz, G. Perez-Suarez, E. Baamonde, E. Bosch, J. I. Ramirez, B. El Hayek, M. D. M. Lago, C. Garcia, M. D. Checa, R. Hiramatsu, Y. Ubara, K. Salas, E. S. Vicent, J. C. Gonzalez Oliva, M. Fulquet, V. Duarte, M. Pou, A. Saurina, J. Macias, M. Ramirez de Arellano, P. Matias, C. Jorge, M. Mendes, T. Amaral, C. Ferreira, I. Aires, C. Gil, A. Ferreira, C. Arcal, J. M. Campistol, S. Seferi, M. Rroji, E. Likaj, E. Petrela, M. Barbullushi, N. Zeneli, S. Mumajesi, N. Thereska, C. Vulpio, M. Bossola, E. Stigliano, G. Fadda, A. P. S. Gueiros, J. O. Borba Junior, A. B. d. M. D. S. Lordsllen, J. E. d. B. Gueiros, N. Itami, K. Tuneyama, S. Uemura, H. Hamada, J. Takada, K. Takahashi, K. Adamidis, T. Apostolou, C. Pleros, T. Oikonomaki, E. Kyratzi, D. Exarchos, G. Metaxatos, S. Dracopoulos, N. Nikolopoulou, P. Delanaye, B. Dubois, J.-M. Krzesinski, E. Cavalier, V. De la Fuente, M. T. Gil, P. Gutierrez, P. Delgado, J. Ribero, L. Arenas, S. Sezer, E. Tutal, Z. Bal, M. Erkmen Uyar, F. N. Ozdemir Acar, R. Azevedo de Oliveira, F. Carvalho Barreto, L. Dos Reis, J. Cunha Ferreira, Z. Maria Leme Britto, R. Maria Moyses, V. Jorgetti, R. Ozelsancak, B. Gurlek Demirci, D. Torun, L. Veljancic, M. Radojevic, Z. Paunic, N. Vavic, K. Obrencevic, Z. Kovacevic, and J. Pejovic

Subjects
Transplantation, Nephrology
Published
2012

29. Clinical Nephrology - Epidemiology I

Author

Edward R Smith, Harin Rhee, Luciano De Paola, Martin L Ford, Piergiorgio Messa, Evgenios Dafnis, Knud Rasmusen, Spencer Andrew, Chi-Chih Hung, Yalcin Solak, Lison Dominique, Hilmi Umut Unal, Paul Mitchell, Kunihiro Yamagata, Konstantinos Sombolos, Luigi Russo, Zeynep Biyik, Eva Maria Wiberg, Takayuki Hamano, Ryohei Yamamoto, Sebastjan Bevc, Chakravarthi Rajkumar, Masahiro Kikuya, Chao-Yu Guo, Zdravko Kraev, Anna Koteva, Masaaki Nakayama, Fabio Manfredini, Haruhisa Hoshi, Vassilios Vargiemezis, Takuo Hirose, Sang Heon Song, Yasuyuki Nagasawa, Laurie A. Tomlinson, Francesco Rapisarda, Mani Khorsand Askari, Rajiv Agarwal, Chun-Yu Yen, Ragai Fouda, Davide Bolignano, Hung-Chen Chen, Pavlos Nikolaidis, Yoshifumi Ubara, Miroslav Tisljar, Mutlu Saglam, Chang Seong Kim, Luca De Nicola, Kayser Caglar, Adamasco Cupisti, Tsuyoshi Watanabe, Luigi Catizone, Anatoliy Gozhenko, Boletis John, Antonio Bellasi, Kouji Arase, Biagio Di Iorio, Silvio V. Bertoli, Hsiao-Han Wang, Atsuhiro Kanno, Georgi Mihaylov, Sankar D. Navaneethan, Alberto Forteza, D'haese Patrick, Hambach Ramona, Hoda Shabpirai, Mei-Li Yang, Jasenka Crnjakovic Palmovic, Taku Obara, Breda Pečovnik Balon, Soo Wan Kim, Manuel-Y.-Keenoy Begona, Edgar Almeida, Marinella Ruospo, Kunitoshi Iseki, Daniel Robinson, Jie Jin Wang, António Sampaio, Antonio Barillà, Letizia Gargano, Renato Rapanà, Danica Galešić Ljubanović, Graziella D'Arrigo, Stefania Rastelli, Jacobs Jeffrey, Ivica Horvatić, Dominique Charmot, Catarina Teixeira, Soo-Bong Lee, Seong Kwon Ma, Jose Cortina, Carmine Zoccali, Manuel Praga, Azusa Hara, Chikako Nakano, Sheren Salah, Kentaro Tanaka, Toshiki Moriyama, Francesca Mallamaci, Van Sprundel Marc, Stephan B. Felix, Matthias Hellberg, Stela Bulimbasic, Tsuneo Konta, Konstantinos Siamopoulos, Petar Shikov, Saeid Abdi, Eduardo Gutiérrez, Arturo Evangelista, Peter Höglund, Luigi Lombardi, Nikan Zerafatjou, Mohammed Salem, Ole Simonsen, Dina Alsayed, Enrique Morales, Yutaka Imai, Wei-Ming Wang, Suetonia C. Palmer, Hassan Ghasemi, Violeta Sánchez, Hiroshi Tsuji, Samuel Iff, Henry Völzke, Il Young Kim, Kazuhisa Amaka, Mariacristina Vecchio, Kazuhiko Tsuruya, Naohiko Fujii, Marcello Tonelli, Shiho Terata, Dimitrios Vlahakos, Ihor Mysula, Wong Germaine, Benjamin Dvorsak, Mahmut Ilker Yilmaz, Halil Yaman, Mário Raimundo, Jeong Woo Park, Giorgia De Berardis, Alessandro Zuccalà, Eun Hui Bae, Naomi Clyne, Friedlinde Ernst, Michihiro Satoh, Takanao Hashimoto, Isao Matsui, Gaetano Lucisano, Christos Argyropoulos, Kazunori Inoue, Te-Hui Kuo, Joon Seok Choi, Sebastiano Cutrupi, Hiroshi Satoh, Ryusuke Inoue, Hirohito Metoki, Giovanni Tripepi, Giovanni F.M. Strippoli, Halil Zeki Tonbul, Ming-Fei Liu, Francis B. Gabbai, Miguel Leal, François Guido, Tina Stropnik Galuf, Jonathan C. Craig, Akihiro Shimomura, Ulrich John, Dong Won Lee, Vincenzo Bellizzi, Ihm-Soo Kwak, Lawrence P. McMahon, Radovan Hojs, M. Paz Sanz, Valeria Saglimbene, Belén Redal-Baigorri, Eun-Young Seong, Stephen G Holt, Robert Ekart, Dawlat Belal, Raab Michael, Yasser M Abdelhamid, Hideaki Yoshida, Takayoshi Ohkubo, Roberto Minutolo, Konstantinos Xynos, Graziella Bonanno, Shigeko Hara, Carmela Marino, Christian Schwahn, Kazuhito Totsune, Shang-Jyh Hwang, Patrizia Pizzini, James G. Heaf, Hakki Cetinkaya, Carlota Lavinas, Martina Ferreira, Daniele Ciurlino, Wei-Hung Lin, Fabrizio Fabrizi, Hamdy Ahmed, Fabio Pellegrini, Antonio Costa, Andrea Pota, Yukiko Ohmoto, Abduzhappar Gaipov, Nina Hojs, Reza Afshar, Felice Nappi, Hiromi Rakugi, Ming-Cheng Wang, Kei Asayama, Christos Iatrou, Krešimir Galešić, Yoshitsugu Obi, Borka Bozic, Stefan Krivoshiev, Oleksandr Susla, Cecília Teixeira, Droste Jos, Ali Davati, Domenico Russo, Yoshitaka Isaka, Suleyman Turk, Inês Henriques, Koichi Asahi, Toshihiro Ishigami, Maurizio Postorino, Giuseppe Conte, Cristina Nogueira, Satoshi Mikami, Jasna Bacalja, Mahmut Gok, Deng-Chi Yang, Sylvia Stracke, Rosenbaum David, Giorgio Fuiano, Shouichi Fujimoto, De Schryver Antoon, Dimitrios Tsakiris, Raquel Bellot, Hiroshi Sato, and Pasquale Fatuzzo

Subjects
Transplantation, medicine.medical_specialty, Nephrology, business.industry, Epidemiology, medicine, Clinical nephrology, Intensive care medicine, business
Published
2012

30. Cardiovascular complications in CKD 5D

Author

M. Fusaro, M. Noale, G. Tripepi, A. D'angelo, D. Miozzo, M. Gallieni, P.-V. Study Group, M. Tsamelesvili, C. Dimitriadis, A. Papagianni, C. Raidis, G. Efstratiadis, D. Memmos, R. Mutluay, C. Konca Degertekin, U. Derici, S. M. Deger, F. Akkiyal, S. Gultekin, S. Gonen, G. Tacoy, T. Arinsoy, S. Sindel, C. Sanchez-Perales, E. Vazquez, E. Merino, P. Perez Del Barrio, F. J. Borrego, M. J. Borrego, A. Liebana, M. Krzanowski, K. Janda, P. Dumnicka, A. Krasniak, W. Sulowicz, Y.-O. Kim, S.-A. Yoon, Y.-S. Yun, H.-C. Song, B.-S. Kim, M. A. Cheong, A. Pasch, S. Farese, J. Floege, W. Jahnen-Dechent, T. Ohtake, R. Furuya, M. Iwagami, D. Tsutsumi, Y. Mochida, K. Ishioka, M. Oka, K. Maesato, H. Moriya, S. Hidaka, S. Kobayashi, A. Guedes, A. Malho Guedes, A. Pinho, A. Fragoso, A. Cruz, P. Mendes, E. Morgado, I. Bexiga, A. P. Silva, P. Neves, N. Oyake, K. Suzuki, S. Itoh, S. Yano, K. Turkmen, H. Kayikcioglu, O. Ozbek, M. Saglam, A. Toker, H. Z. Tonbul, S. Gelev, L. Trajceska, E. Srbinovska, S. Pavleska, V. Amitov, G. Selim, P. Dzekova, A. Sikole, H. Bouarich, S. Lopez, C. Alvarez, I. Arribas, P. DE Sequera, D. Rodriguez, S. Tanaka, T. Kanemitsu, M. Sugahara, M. Kobayashi, L. Uchida, Y. Ishimoto, N. Kotera, S. Tanimoto, K. Tanabe, K. Hara, T. Sugimoto, N. Mise, B. Goldstein, M. Turakhia, C. Arce, W. Winkelmayer, B. E.-D. Zayed, K. Said, M. Nishimura, Y. Okamoto, T. Tokoro, M. Nishida, T. Hashimoto, N. Iwamoto, H. Takahashi, T. Ono, N. Sato, J. Raimann, L. A. Usvyat, J. Sands, N. W. Levin, P. Kotanko, M. Iwasaki, N. Joki, Y. Tanaka, N. Ikeda, T. Hayashi, S. Kubo, T.-A. Imamura, Y. Takahashi, K. Hirahata, Y. Imamura, H. Hase, K. Claes, B. Meijers, B. Bammens, D. Kuypers, M. Naesens, Y. Vanrenterghem, P. Evenepoel, G. Boscutti, L. Calabresi, M. Bosco, S. Simonelli, E. Boer, C. Vitali, M. Martone, P. L. Mattei, G. Franceschini, E. Baligh, E. El-Shafey, A. Ezaat, A. Zawada, K. Rogacev, B. Hummel, O. Grun, A. Friedrich, B. Rotter, P. Winter, J. Geisel, D. Fliser, G. H. Heine, J.-I. Makino, K.-S. Makino, T. Ito, S. Genovesi, A. Santoro, P. Fabbrini, E. Rossi, D. Pogliani, A. Stella, G. Bonforte, G. Remuzzi, S. Bertoli, C. Pozzi, S. Pasquali, L. Cagnoli, F. Conte, I. Buzadzic, J. Tosic, N. Dimkovic, Z. Djuric, J. Popovic, I. Pejin Grubisa, N. Barjaktarevic, A. DI Napoli, D. DI Lallo, M. F. Salvatori, F. Franco, S. Chicca, G. Guasticchi, M. Onofriescu, S. Hogas, V. Luminita, A. Mugurel, V. Gabriel, F. Laura, M. Irina, C. Adrian, E. Bosch, E. Baamonde, C. Culebras, G. Perez, B. El Hayek, J. I. Ramirez, A. Ramirez, C. Garcia, M. Lago, A. Toledo, M. D. Checa, T. Taira, T. Hirano, K. Nohtomi, T. Hyodo, T. Chiba, A. Saito, Y. K. Kim, E. J. Choi, C. W. Yang, Y.-S. Kim, P. S. Lim, W. Ming Ying, J. Ya-Chung, I. Zaripova, I. Kayukov, A. Essaian, A. Nimgirova, H. Young, M. Dungey, E. L. Watson, R. Baines, J. O. Burton, A. C. Smith, K. Yamazaki, M. Bossola, L. Colacicco, D. Scribano, C. Vulpio, L. Tazza, T. Okada, N. Okada, I. Michibata, T. Yura, N. Montero, M. Soler, M. Pascual, C. Barrios, E. Marquez, E. Rodriguez, M. A. Orfila, H. Cao, E. Arcos, J. Comas, J. Pascual, M. Ferrario, F. Garzotto, T. Sironi, S. Monacizzo, F. Basso, D. N. Cruz, U. Moissl, C. Tetta, M. G. Signorini, S. Cerutti, C. Ronco, I. Mostovaya, M. Grooteman, M. Van den Dorpel, L. Penne, N. Van der Weerd, A. Mazairac, C. Den Hoedt, R. Levesque, M. Nube, P. Ter Wee, M. Bots, P. Blankestijn, J. Liu, K. L. MA, X. Zhang, B. C. Liu, I.-D. Vladu, R. Mustafa, D. Cana-Ruiu, C. Vaduva, C. Grauntanu, E. Mota, R. Singh, N. Abbasian, C. Stover, N. Brunskill, J. Burton, K. Herbert, A. Bevington, M. Wu, R.-N. Tang, M. Gao, H. Liu, L. Chen, L.-L. LV, B.-C. Liu, M. Nikodimopoulou, S. Liakos, S. Kapoulas, C. Karvounis, D. Fedak, M. Kuzniewski, D. Paulina, B. Kusnierz-Cabala, M. Kapusta, B. Solnica, A. Junque, E. S. Vicent, L. Moreno, M. Fulquet, V. Duarte, A. Saurina, M. Pou, J. Macias, M. Lavado, M. Ramirez de Arellano, M. Ryuzaki, H. Nakamoto, S. Kinoshita, E. Kobayashi, C. Takimoto, T. Shishido, G. Enia, C. Torino, R. Tripepi, V. Panuccio, M. Postorino, A. Clementi, M. Garozzo, G. Bonanno, R. Boito, G. Natale, T. Cicchetti, A. Chippari, D. Logozzo, G. Alati, S. Cassani, A. Sellaro, C. Zoccali, B. Quiroga, E. Verde, S. Abad, A. Vega, M. Goicoechea, J. Reque, J. M. Lopez-Gomez, J. Luno, C. Cabre Menendez, V. Moles, J. P. Vives, D. Villa, J. Vinas, T. Compte, M. Arruche, C. Diaz, J. Soler, J. Aguilera, A. Martinez Vea, A. De Mauri, P. David, M. M. Conte, D. Chiarinotti, C. E. Ruva, M. De Leo, A.-S. Bargnoux, M. Morena, I. Jaussent, L. Chalabi, P. Bories, J.-J. Dion, P. Henri, M. Delage, A.-M. Dupuy, S. Badiou, B. Canaud, J.-P. Cristol, E. Sironi, F. Pieruzzi, E. Galbiati, M. R. Vigano, S. Anpalakhan, S. Rocha, N. Chitalia, R. Sharma, J. C. Kaski, J. Chambers, D. Goldsmith, D. Banerjee, V. Cernaro, A. Lacquaniti, R. Lupica, S. Lucisano, M. R. Fazio, V. Donato, M. Buemi, I. Segalen, U. Vinsonneau, T. Tanquerel, G. Quiniou, Y. Le Meur, E. Seibert, M. Girndt, K. Zohles, C. Ulrich, A. Kluttig, S. Nuding, C. Swenne, J. Kors, K. Werdan, R. Fiedler, N. C. Van der Weerd, M. P. Grooteman, M. A. Van den Dorpel, M. J. Nube, J. Wetzels, D. W. Swinkels, P. M. Ter Wee, A. Khandekar, J. Khandge, J. E. Lee, S. J. Moon, K. H. Choi, H. Y. Lee, B. S. Kim, E. Tuaillon, A. Rodriguez, L. Chenine, J.-P. Vendrell, Y.-M. Sue, C.-H. Tang, Y.-C. Chen, P. Segura, M. J. Garcia Cortes, J. M. Gil, M. M. Biechy, D. Poulikakos, A. Shah, M. Persson, P. Dattolo, M. Amidone, S. Michelassi, L. Moriconi, G. Betti, P. Conti, A. Rosati, A. Mannarino, V. Panichi, F. Pizzarelli, K. Klejna, B. Naumnik, E. Koc-Zorawska, M. Mysliwiec, S. Dimitrie, H. Simona, O. Mihaela, O. Gabriela, S. Radu, P. Octavian, H. Akdam, H. Akar, Y. Yenicerioglu, O. Kucuk, I. Kurt Omurlu, S. Thambiah, R. Roplekar, P. Manghat, I. Fogelman, W. Fraser, G. Hampson, E. Likaj, G. Caco, S. Seferi, M. Rroji, M. Barbullushi, N. Thereska, A. Serban, V. Carmen, S. Cristian, L. Silvia, and A. Covic

Subjects
Transplantation, medicine.medical_specialty, Nephrology, business.industry, medicine, Intensive care medicine, business
Published
2012

31. Coupled plasma filtration adsorption for the treatment of a patient with acute respiratory distress syndrome and acute kidney injury: a case report

Author

Aida Giancotti, Giovanni Matera, Maria Capria, Giorgio Fuiano, Nicolino Comi, Roberta Talarico, Gaetano Lucisano, Pierangela Presta, L. Rametti, and Angela Quirino

Subjects
Transplantation, medicine.medical_specialty, coupled plasma filtration adsorption, II. Clinical Reports, business.industry, medicine.medical_treatment, Acute kidney injury, Acute diseases, Case Reports, Acute respiratory distress, acute respiratory distress syndrome, medicine.disease, Plasma filtration, cytokines, Sepsis, Pneumonia, acute kidney injury, Nephrology, Extracorporeal blood purification, Anesthesia, Hemofiltration, medicine, pneumonia, Intensive care medicine, business
Abstract

Coupled plasma filtration adsorption (CPFA) is an extracorporeal blood purification therapy based on non-specific pro- and anti-inflammatory mediator adsorption on a special resin cartridge coupled with continuous veno-venous haemofiltration or continuous veno-venous haemodiafiltration and is one of the emerging treatments for septic patients. However, in the literature, there are limited data about its efficacy in treating patients with acute diseases but without the traditional criteria for sepsis. We describe the case of a 43-year-old male who developed acute respiratory distress syndrome secondary to pneumonia and acute kidney injury, whose clinical conditions rapidly improved after early CPFA therapy.

Published
2011

32. Baccharis dracunculifolia DC (Asteraceae) selectively modulates the effector functions of human neutrophils

Author

Figueiredo-Rinhel, Andréa S G, primary, de Melo, Lamartine L, additional, Bortot, Leandro O, additional, Santos, Everton O L, additional, Andrade, Micássio F, additional, Azzolini, Ana Elisa C S, additional, Kabeya, Luciana M, additional, Caliri, Antonio, additional, Bastos, Jairo K, additional, and Lucisano-Valim, Yara Maria, additional

Published
2017
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33. Sesquiterpene lactones fromLychnophora pohlii: neutrophil chemiluminescence inhibition and free radical scavenger activity

Author

Cristiane Fernanda Fuzer Grael, Ana Elisa Caleiro Seixas Azzolini, Luciana M. Kabeya, Christiane O. Jordão, Alexandre Kanashiro, João Luis Callegari Lopes, and Yara Maria Lucisano-Valim

Subjects
Neutrophils, Pharmaceutical Science, Asteraceae, Sesquiterpene, Peroxide, law.invention, Lactones, chemistry.chemical_compound, law, Lactate dehydrogenase, Animals, Chemiluminescence, Pharmacology, chemistry.chemical_classification, Reactive oxygen species, Chemistry, Free Radical Scavengers, Free radical scavenger, Respiratory burst, Enzyme, Biochemistry, Luminescent Measurements, Female, Rabbits, Reactive Oxygen Species, Oxidation-Reduction, Sesquiterpenes
Abstract

Excessive production of reactive oxygen species (ROS) by polymorphonuclear leucocytes (PMNLs) is thought to contribute to the pathology of many inflammatory diseases. Sesquiterpene lactones (STLs) seem to be important contributors to the anti-inflammatory activity of many species of Lychnophora (Asteraceae), which have been widely used in Brazilian folk medicine because of this pharmacological property. In this study, the inhibitory effects of three STLs isolated from Lychnophora pohlii (lychnopholide, centratherin and goyazensolide) on rabbit PMNL oxidative burst were evaluated by the luminol-enhanced chemiluminescence (CL-lum) assay. All STLs tested showed concentration-dependent inhibitory activity on CL-lum but were not cytotoxic to PMNLs (evaluated by lactate dehydrogenase release) under the assessed conditions. Moreover, goyazensolide, the most active STL, had no free radical scavenger property, as assessed by 1,1-diphenyl-2-picrylhydrazyl radical assay, and had no inhibitory effect on the luminol-horseradish peroxidase-hydrogen peroxide chemiluminescence. Taken together, the results of this investigation suggest that the concomitant presence of methacrylate ester and hydroxyl groups contributes to a high inhibitory effect on PMNL oxidative metabolism. This effect was not mediated by free radical scavenger or cytotoxic effects, but probably by inhibition of enzymes involved in the signal transduction pathways of the ROS generation process.

Published
2006

34. MP463FGF23 KINETICS AND REMOVAL ON HAEMODIAFILTRATION

Author

Daniela Caccamo, Michele Buemi, Annamaria Bruzzese, Giuseppe Costantino, Valeria Canale, Domenico Santoro, Valeria Cernaro, and Silvia Lucisano

Subjects
Transplantation, Chromatography, Nephrology, business.industry, Kinetics, Medicine, business
Published
2016

35. SP607THE PREVALENCE AND CORRELATES OF SEXUAL DYSFUNCTION IN WOMEN ON HEMODIALYSIS: A MULTINATIONAL, CROSS-SECTIONAL STUDY

Author

Valeria Saglimbene, Suetonia Palmer, Patrizia Natale, Marco Scardapane, Marinella Ruospo, Jonathan Craig, Letizia Gargano, Giuseppe Lucisano, Marietta Török, Eduardo Celia, Ruben Gelfman, Anna Bednarek Skublewska, Jan Dulawa, Paul Stroumza, Miguel Leal, Angelo Murgo, Staffan Schon, Charlotta Wollheim, Jörgen Hegbrant, and Giovanni Strippoli

Subjects
Transplantation, Nephrology
Published
2016

36. Hormones

Author

L. Simoes-Silva, M. Moreira-Rodrigues, J. Quelhas-Santos, C. Fernandes-Cerqueira, M. Pestana, I. Soares-Silva, B. Sampaio-Maia, L. Bankir, F. Leopold, B. Nadine, R. Roussel, B. Balkau, M. Michel, B. Daniel, I. Kurnatowska, P. Grzelak, M. Kaczmarska, A. Masajtis-Zagajewska, L. Stefanczyk, M. Nowicki, S. Niemczyk, L. Niemczyk, K. Szamotulska, Z. Bartoszewicz, I. Dubchak, U. Syta, J. Matuszkiewicz-Rowinska, M. Dudek, D. Brodowska, L. Wozniacki, M. Gomolka, A. Rymarz, A. Lacquaniti, V. Donato, M. R. Fazio, S. Lucisano, V. Cernaro, R. Lupica, and M. Buemi

Subjects
Transplantation, Nephrology
Published
2012

37. Bone and mineral diseases - 2

Author

Tineke M. De Schutter, Rl Pisoni, Domenico Russo, Ellen Neven, Francesca Tentori, Donald A. Molony, Shigekazu Nakajima, Bm Robinson, Da Mendelssohn, Patrick C. D'Haese, Gunnar H. Heine, Kikumi Tsuda, Hiroaki Egawa, Saling Huang, Geert J. Behets, Matthias Klingele, Geoffrey A. Block, Hal Morgenstern, Allan Manning, Philipp Ege, Fred Senatore, Vincenzo Bellizzi, Danilo Fliser, Sh Jacobson, Jutta Passlick-Deetjen, V. E. Andreucci, Kevin J. Martin, Mirjam E. Peter, Gaetano Lucisano, Masafumi Fukagawa, Gregory Bell, Sonja Steppan, Biagio Di Iorio, Antonio Bellasi, Yoshiteru Ushirogawa, Fiita Romero de Vorsmann, Brian Bieber, Sarah Seiler, Karen Pickthorn, and Anne-Kathrin Lerner-Gräber

Subjects
Transplantation, Mineral, Nephrology, business.industry, Environmental chemistry, Medicine, business
Published
2012

38. SP640PREVALENCE AND CORRELATES OF SEXUAL DYSFUNCTION IN WOMEN ON HEMODIALYSIS: A MULTINATIONAL CROSS-SECTIONAL STUDY

Author

Paul Stroumza, Miguel C. Leal, Suetonia C. Palmer, Marietta Török, Jörgen Hegbrant, Jan Duława, Letizia Gargano, Staffan Schön, Angelo M. Murgo, Jonathan C. Craig, Eduardo Celia, Anna Bednarek Skublewska, Valeria Saglimbene, Ruben Gelfman, Marinella Ruospo, Giuseppe Lucisano, Marco Scardapane, Charlotta Wollheim, Patrizia Natale, and Giovanni F.M. Strippoli

Subjects
Transplantation, medicine.medical_specialty, Sexual dysfunction, Nephrology, Cross-sectional study, business.industry, medicine.medical_treatment, Internal medicine, medicine, Hemodialysis, medicine.symptom, business
Published
2017

39. Benchmarking activities based on person centered measures: a diabetes case study from Italy

Author

Soren E. Skovlund, S Gentile, Maria Chiara Rossi, Antonio Nicolucci, Giacomo Vespasiani, Giuseppe Lucisano, Angela Bulotta, and B Pintaudi

Subjects
Distress, Nursing, business.industry, Order (business), Diabetes mellitus, Usual care, Public Health, Environmental and Occupational Health, Medicine, Person centered, Benchmarking, business, medicine.disease
Abstract

Issue/problem A wide consensus exists about the role of patient involvement in the management of diabetes (DM) in order to achieve the desired therapeutic goals. However, major problems in dealing with psycho-social problems have been documented in usual care. In particular, diabetes-related distress (DRD) is common amongst people with DM and hampers efforts to self-manage their condition. The BENCH-D AMD study, part of the DAWN 2 initiatives in Italy, aims to evaluate whether a benchmarking activity based on …

Published
2014

40. SP607THE PREVALENCE AND CORRELATES OF SEXUAL DYSFUNCTION IN WOMEN ON HEMODIALYSIS: A MULTINATIONAL, CROSS-SECTIONAL STUDY

Author

Saglimbene, Valeria, primary, Palmer, Suetonia, additional, Natale, Patrizia, additional, Scardapane, Marco, additional, Ruospo, Marinella, additional, Craig, Jonathan, additional, Gargano, Letizia, additional, Lucisano, Giuseppe, additional, Török, Marietta, additional, Celia, Eduardo, additional, Gelfman, Ruben, additional, Bednarek Skublewska, Anna, additional, Dulawa, Jan, additional, Stroumza, Paul, additional, Leal, Miguel, additional, Murgo, Angelo, additional, Schon, Staffan, additional, Wollheim, Charlotta, additional, Hegbrant, Jörgen, additional, and Strippoli, Giovanni, additional

Published
2016
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41. MP463FGF23 KINETICS AND REMOVAL ON HAEMODIAFILTRATION

Author

Cernaro, Valeria, primary, Lucisano, Silvia, additional, Canale, Valeria, additional, Bruzzese, Annamaria, additional, Caccamo, Daniela, additional, Costantino, Giuseppe, additional, Buemi, Michele, additional, and Santoro, Domenico, additional

Published
2016
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43. The role of the complement system in the neutrophil functions stimulatedin vitroby an alkali-insoluble cell wall fraction ofParacoccidioides brasiliensis

Author

Célio Lopes Silva, L.S. Pereira Crott, José Elpídio Barbosa, and Y.M. Lucisano Valim

Subjects
Paracoccidioides brasiliensis, General Medicine, Biology, biology.organism_classification, Complement factor B, Molecular biology, Paracoccidioides, Complement system, Respiratory burst, Classical complement pathway, Infectious Diseases, Biochemistry, Alternative complement pathway, Opsonin
Abstract

We investigated the capacity of an alkali-insoluble cell wall polysaccharide fraction (F1) of Paracoccidioides brasiliensis to induce rat polymorphonuclear neutrophil (PMN) migratory and chemiluminescence (CL) responses. Normal rat serum pre-incubated with F1 induced a chemotactic neutrophil response which was fully abolished by heat-inactivation. The participation of the alternative complement pathway was more effective than that of the classical pathway since depletion of factor B by heating at 50°C reduced PMN migration, whereas blockade of the classical pathway with EGTA left the migratory response practically unchanged. Opsonized serum F1 induced a significant release of oxygen radicals from PMN as measured by CL. The complement system was also found to be involved in this activity since serum inactivation at 56°C altered the CL response. In addition to complement-derived fragments, other serum opsonins, probably cross-reacting antibodies, were required for optimal interaction between PMN and opsoniz...

Published
1993

44. EXPERIMENTAL ISCHEMIA

Author

V. Colombaro, A.-E. Decleves, V. Voisin, L. Giordano, I. Jadot, I. Habsch, B. Flamion, N. Caron, J. P. Ngo, M. Kett, J. Pearson, D. Smith, A. Abdelkader, S. Kar, J. Bertram, B. Gardiner, R. Evans, T. W. Emans, C. P. Ow, J. A. Joles, R. G. Evans, S. C. Malpas, M. P. Koeners, G. R. Dube, S. B. Campos-Bilderback, R. M. Sandoval, D. Bosukonda, P. Keck, R. Leger, P. Bey, W. Carlson, B. A. Molitoris, V. Cernaro, A. Sfacteria, S. Lucisano, R. Lupica, A. M. Bruzzese, C. Aloisi, F. Montuori, G. Lorenzano, L. Visconti, and M. Buemi

Subjects
Transplantation, Nephrology
Published
2014

45. Fingolimod versus interferon beta/glatiramer acetate after natalizumab suspension in multiple sclerosis

Author

Iaffaldano, Pietro, primary, Lucisano, Giuseppe, additional, Pozzilli, Carlo, additional, Brescia Morra, Vincenzo, additional, Ghezzi, Angelo, additional, Millefiorini, Enrico, additional, Patti, Francesco, additional, Lugaresi, Alessandra, additional, Zimatore, Giovanni Bosco, additional, Marrosu, Maria Giovanna, additional, Amato, Maria Pia, additional, Bertolotto, Antonio, additional, Bergamaschi, Roberto, additional, Granella, Franco, additional, Coniglio, Gabriella, additional, Tedeschi, Gioacchino, additional, Sola, Patrizia, additional, Lus, Giacomo, additional, Ferrò, Maria Teresa, additional, Iuliano, Gerardo, additional, Corea, Francesco, additional, Protti, Alessandra, additional, Cavalla, Paola, additional, Guareschi, Angelica, additional, Rodegher, Mariaemma, additional, Paolicelli, Damiano, additional, Tortorella, Carla, additional, Lepore, Vito, additional, Prosperini, Luca, additional, Saccà, Francesco, additional, Baroncini, Damiano, additional, and Comi, Giancarlo, additional

Published
2015
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48. The effect of antibody isotype and antigenic epitope density on the complement-fixing activity of immune complexes: a systematic study using chimaeric anti-NIP antibodies with human Fc regions

Author

P. J. Lachmann and Y M Lucisano Valim

Subjects
Erythrocytes, Immunology, Antigen-Antibody Complex, Biology, Epitope, Epitopes, Classical complement pathway, Antigens, CD, Animals, Humans, Immunology and Allergy, Complement Activation, Linear epitope, Complement component 2, Chimera, Antibodies, Monoclonal, Nitrohydroxyiodophenylacetate, Molecular biology, Immune complex, Immunoglobulin A, Immunoglobulin Fc Fragments, Receptors, Complement, Complement system, Immunoglobulin Isotypes, Immunoglobulin G, Lectin pathway, Complement C3b, Receptors, Complement 3b, Alternative complement pathway, Research Article
Abstract

SUMMARYA systematic study has been carried out to investigate the role of immunoglobulin isotype, epitope density, and antigen/antibody ratio on the capacity of immune complexes to activate the classical and alternative pathways of human complement and for the complexes subsequently to bind to erythrocyte C3b-C4b receptors (CR1). For this purpose, a series of chimaeric monoclonal anti-NIP antibodies was used, which all shared the same combining site but had different human constant domains. Antigen epitope density was varied by coupling different numbers of NIP hapten molecules to bovine serum albumin. All three parameters affect complement fixation. In general, complement activation is better in antibody excess and at equivalence than it is in antigen excess, and better at high epitope density than at low epitope density, although the effects are variable for different immunoglobulin isotypes and for the two pathways. It has been confirmed that IgG1 and IgG3 are good activators of the classical pathway and are tolerant to variations in both epitope density and antigen/antibody ratio. IgG4 and IgA do not activate the classical pathway in any circumstances. IgG2 activates the classical pathway only at high epitope density and at equivalence or antibody excess. IgM activates the classical pathway well only at the higher epitope densities and at equivalence or antibody excess but, in addition, shows an interesting and unexpected prozone phenomenon where immune complex in antibody excess inhibits complement activation by the classical pathway. The results of the alternative pathway activation are strikingly different. IgA is by far the best activator of the alternative pathway and is relatively tolerant to epitope density and to antigen/antibody ratio. IgM, IgG1 and IgG3 do not significantly activate the alternative pathway in any circumstances. IgG2 is the best IgG subclass for alternative pathway activation but requires high epitope density and equivalence or antibody excess. Binding to CR1 in general parallels the amount of complement fixed independent to the pathway by which it is fixed. However, IgG1 and IgG3 complexes in antigen excess activate complement well but bind poorly to CR1. Nascently formed complexes seem to bind complement in a way that is similar to that bound by preformed complexes, but are then less able to bind to red cell CR1. These observations help to explain the pathogenesis of complement activation in various autoimmune and immune complex diseases such as systemic lupus erythematosus, autoimmune thyroiditis and others.

Published
1991

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