31 results on '"Krogh, V"'
Search Results
2. Socio-economic position across the lifecourse and risk of breast cancer: findings from EPIC-Italy
- Author
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Berger, E, primary, Krogh, V, primary, Palli, D, primary, Panico, S, primary, Sacerdote, C, primary, Tumino, R, primary, Vineis, P, primary, Severi, G, primary, Castagné, R, primary, and Delpierre, C, primary
- Published
- 2019
- Full Text
- View/download PDF
3. Social determinants of systemic inflammation over the life course: a multi-cohort study
- Author
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Berger, E, primary, Castagné, R, additional, Kivimäki, M, additional, Krogh, V, additional, Steptoe, A, additional, Stringhini, S, additional, Vineis, P, additional, Delpierre, C, additional, and Kelly-Irving, M, additional
- Published
- 2018
- Full Text
- View/download PDF
4. Dietary cadmium intake in an Italian population
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Malavolti, M, primary, Malagoli, C, additional, Bottecchi, I, additional, Vescovi, L, additional, Modenesi, M, additional, Castiglia, P, additional, Sieri, S, additional, Krogh, V, additional, and Vinceti, M, additional
- Published
- 2015
- Full Text
- View/download PDF
5. Circulating 25-Hydroxyvitamin D3 in Relation to Renal Cell Carcinoma Incidence and Survival in the EPIC Cohort
- Author
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Muller, D. C., primary, Fanidi, A., additional, Midttun, O., additional, Steffen, A., additional, Dossus, L., additional, Boutron-Ruault, M.-C., additional, Severi, G., additional, Kuhn, T., additional, Katzke, V., additional, de la Torre, R. A., additional, Gonzalez, C. A., additional, Sanchez, M.-J., additional, Dorronsoro, M., additional, Santiuste, C., additional, Barricarte, A., additional, Khaw, K.-T., additional, Wareham, N., additional, Travis, R. C., additional, Trichopoulou, A., additional, Giotaki, M., additional, Trichopoulos, D., additional, Palli, D., additional, Krogh, V., additional, Tumino, R., additional, Vineis, P., additional, Panico, S., additional, Tjonneland, A., additional, Olsen, A., additional, Bueno-de-Mesquita, H. B., additional, Peeters, P. H., additional, Ljungberg, B., additional, Wennberg, M., additional, Weiderpass, E., additional, Murphy, N., additional, Riboli, E., additional, Ueland, P. M., additional, Boeing, H., additional, Brennan, P., additional, and Johansson, M., additional
- Published
- 2014
- Full Text
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6. Imputation and subset-based association analysis across different cancer types identifies multiple independent risk loci in the TERT-CLPTM1L region on chromosome 5p15.33
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Wang, Z., primary, Zhu, B., additional, Zhang, M., additional, Parikh, H., additional, Jia, J., additional, Chung, C. C., additional, Sampson, J. N., additional, Hoskins, J. W., additional, Hutchinson, A., additional, Burdette, L., additional, Ibrahim, A., additional, Hautman, C., additional, Raj, P. S., additional, Abnet, C. C., additional, Adjei, A. A., additional, Ahlbom, A., additional, Albanes, D., additional, Allen, N. E., additional, Ambrosone, C. B., additional, Aldrich, M., additional, Amiano, P., additional, Amos, C., additional, Andersson, U., additional, Andriole, G., additional, Andrulis, I. L., additional, Arici, C., additional, Arslan, A. A., additional, Austin, M. A., additional, Baris, D., additional, Barkauskas, D. A., additional, Bassig, B. A., additional, Beane Freeman, L. E., additional, Berg, C. D., additional, Berndt, S. I., additional, Bertazzi, P. A., additional, Biritwum, R. B., additional, Black, A., additional, Blot, W., additional, Boeing, H., additional, Boffetta, P., additional, Bolton, K., additional, Boutron-Ruault, M.-C., additional, Bracci, P. M., additional, Brennan, P., additional, Brinton, L. A., additional, Brotzman, M., additional, Bueno-de-Mesquita, H. B., additional, Buring, J. E., additional, Butler, M. A., additional, Cai, Q., additional, Cancel-Tassin, G., additional, Canzian, F., additional, Cao, G., additional, Caporaso, N. E., additional, Carrato, A., additional, Carreon, T., additional, Carta, A., additional, Chang, G.-C., additional, Chang, I.-S., additional, Chang-Claude, J., additional, Che, X., additional, Chen, C.-J., additional, Chen, C.-Y., additional, Chen, C.-H., additional, Chen, C., additional, Chen, K.-Y., additional, Chen, Y.-M., additional, Chokkalingam, A. P., additional, Chu, L. W., additional, Clavel-Chapelon, F., additional, Colditz, G. A., additional, Colt, J. S., additional, Conti, D., additional, Cook, M. B., additional, Cortessis, V. K., additional, Crawford, E. D., additional, Cussenot, O., additional, Davis, F. G., additional, De Vivo, I., additional, Deng, X., additional, Ding, T., additional, Dinney, C. P., additional, Di Stefano, A. L., additional, Diver, W. R., additional, Duell, E. J., additional, Elena, J. W., additional, Fan, J.-H., additional, Feigelson, H. S., additional, Feychting, M., additional, Figueroa, J. D., additional, Flanagan, A. M., additional, Fraumeni, J. F., additional, Freedman, N. D., additional, Fridley, B. L., additional, Fuchs, C. S., additional, Gago-Dominguez, M., additional, Gallinger, S., additional, Gao, Y.-T., additional, Gapstur, S. M., additional, Garcia-Closas, M., additional, Garcia-Closas, R., additional, Gastier-Foster, J. M., additional, Gaziano, J. M., additional, Gerhard, D. S., additional, Giffen, C. A., additional, Giles, G. G., additional, Gillanders, E. M., additional, Giovannucci, E. L., additional, Goggins, M., additional, Gokgoz, N., additional, Goldstein, A. M., additional, Gonzalez, C., additional, Gorlick, R., additional, Greene, M. H., additional, Gross, M., additional, Grossman, H. B., additional, Grubb, R., additional, Gu, J., additional, Guan, P., additional, Haiman, C. A., additional, Hallmans, G., additional, Hankinson, S. E., additional, Harris, C. C., additional, Hartge, P., additional, Hattinger, C., additional, Hayes, R. B., additional, He, Q., additional, Helman, L., additional, Henderson, B. E., additional, Henriksson, R., additional, Hoffman-Bolton, J., additional, Hohensee, C., additional, Holly, E. A., additional, Hong, Y.-C., additional, Hoover, R. N., additional, Hosgood, H. D., additional, Hsiao, C.-F., additional, Hsing, A. W., additional, Hsiung, C. A., additional, Hu, N., additional, Hu, W., additional, Hu, Z., additional, Huang, M.-S., additional, Hunter, D. J., additional, Inskip, P. D., additional, Ito, H., additional, Jacobs, E. J., additional, Jacobs, K. B., additional, Jenab, M., additional, Ji, B.-T., additional, Johansen, C., additional, Johansson, M., additional, Johnson, A., additional, Kaaks, R., additional, Kamat, A. M., additional, Kamineni, A., additional, Karagas, M., additional, Khanna, C., additional, Khaw, K.-T., additional, Kim, C., additional, Kim, I.-S., additional, Kim, J. H., additional, Kim, Y. H., additional, Kim, Y.-C., additional, Kim, Y. T., additional, Kang, C. H., additional, Jung, Y. J., additional, Kitahara, C. M., additional, Klein, A. P., additional, Klein, R., additional, Kogevinas, M., additional, Koh, W.-P., additional, Kohno, T., additional, Kolonel, L. N., additional, Kooperberg, C., additional, Kratz, C. P., additional, Krogh, V., additional, Kunitoh, H., additional, Kurtz, R. C., additional, Kurucu, N., additional, Lan, Q., additional, Lathrop, M., additional, Lau, C. C., additional, Lecanda, F., additional, Lee, K.-M., additional, Lee, M. P., additional, Le Marchand, L., additional, Lerner, S. P., additional, Li, D., additional, Liao, L. M., additional, Lim, W.-Y., additional, Lin, D., additional, Lin, J., additional, Lindstrom, S., additional, Linet, M. S., additional, Lissowska, J., additional, Liu, J., additional, Ljungberg, B., additional, Lloreta, J., additional, Lu, D., additional, Ma, J., additional, Malats, N., additional, Mannisto, S., additional, Marina, N., additional, Mastrangelo, G., additional, Matsuo, K., additional, McGlynn, K. A., additional, McKean-Cowdin, R., additional, McNeill, L. H., additional, McWilliams, R. R., additional, Melin, B. S., additional, Meltzer, P. S., additional, Mensah, J. E., additional, Miao, X., additional, Michaud, D. S., additional, Mondul, A. M., additional, Moore, L. E., additional, Muir, K., additional, Niwa, S., additional, Olson, S. H., additional, Orr, N., additional, Panico, S., additional, Park, J. Y., additional, Patel, A. V., additional, Patino-Garcia, A., additional, Pavanello, S., additional, Peeters, P. H. M., additional, Peplonska, B., additional, Peters, U., additional, Petersen, G. M., additional, Picci, P., additional, Pike, M. C., additional, Porru, S., additional, Prescott, J., additional, Pu, X., additional, Purdue, M. P., additional, Qiao, Y.-L., additional, Rajaraman, P., additional, Riboli, E., additional, Risch, H. A., additional, Rodabough, R. J., additional, Rothman, N., additional, Ruder, A. M., additional, Ryu, J.-S., additional, Sanson, M., additional, Schned, A., additional, Schumacher, F. R., additional, Schwartz, A. G., additional, Schwartz, K. L., additional, Schwenn, M., additional, Scotlandi, K., additional, Seow, A., additional, Serra, C., additional, Serra, M., additional, Sesso, H. D., additional, Severi, G., additional, Shen, H., additional, Shen, M., additional, Shete, S., additional, Shiraishi, K., additional, Shu, X.-O., additional, Siddiq, A., additional, Sierrasesumaga, L., additional, Sierri, S., additional, Loon Sihoe, A. D., additional, Silverman, D. T., additional, Simon, M., additional, Southey, M. C., additional, Spector, L., additional, Spitz, M., additional, Stampfer, M., additional, Stattin, P., additional, Stern, M. C., additional, Stevens, V. L., additional, Stolzenberg-Solomon, R. Z., additional, Stram, D. O., additional, Strom, S. S., additional, Su, W.-C., additional, Sund, M., additional, Sung, S. W., additional, Swerdlow, A., additional, Tan, W., additional, Tanaka, H., additional, Tang, W., additional, Tang, Z.-Z., additional, Tardon, A., additional, Tay, E., additional, Taylor, P. R., additional, Tettey, Y., additional, Thomas, D. M., additional, Tirabosco, R., additional, Tjonneland, A., additional, Tobias, G. S., additional, Toro, J. R., additional, Travis, R. C., additional, Trichopoulos, D., additional, Troisi, R., additional, Truelove, A., additional, Tsai, Y.-H., additional, Tucker, M. A., additional, Tumino, R., additional, Van Den Berg, D., additional, Van Den Eeden, S. K., additional, Vermeulen, R., additional, Vineis, P., additional, Visvanathan, K., additional, Vogel, U., additional, Wang, C., additional, Wang, J., additional, Wang, S. S., additional, Weiderpass, E., additional, Weinstein, S. J., additional, Wentzensen, N., additional, Wheeler, W., additional, White, E., additional, Wiencke, J. K., additional, Wolk, A., additional, Wolpin, B. M., additional, Wong, M. P., additional, Wrensch, M., additional, Wu, C., additional, Wu, T., additional, Wu, X., additional, Wu, Y.-L., additional, Wunder, J. S., additional, Xiang, Y.-B., additional, Xu, J., additional, Yang, H. P., additional, Yang, P.-C., additional, Yatabe, Y., additional, Ye, Y., additional, Yeboah, E. D., additional, Yin, Z., additional, Ying, C., additional, Yu, C.-J., additional, Yu, K., additional, Yuan, J.-M., additional, Zanetti, K. A., additional, Zeleniuch-Jacquotte, A., additional, Zheng, W., additional, Zhou, B., additional, Mirabello, L., additional, Savage, S. A., additional, Kraft, P., additional, Chanock, S. J., additional, Yeager, M., additional, Landi, M. T., additional, Shi, J., additional, Chatterjee, N., additional, and Amundadottir, L. T., additional
- Published
- 2014
- Full Text
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7. Genome-wide interaction study of smoking and bladder cancer risk
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Figueroa, J. D., primary, Han, S. S., additional, Garcia-Closas, M., additional, Baris, D., additional, Jacobs, E. J., additional, Kogevinas, M., additional, Schwenn, M., additional, Malats, N., additional, Johnson, A., additional, Purdue, M. P., additional, Caporaso, N., additional, Landi, M. T., additional, Prokunina-Olsson, L., additional, Wang, Z., additional, Hutchinson, A., additional, Burdette, L., additional, Wheeler, W., additional, Vineis, P., additional, Siddiq, A., additional, Cortessis, V. K., additional, Kooperberg, C., additional, Cussenot, O., additional, Benhamou, S., additional, Prescott, J., additional, Porru, S., additional, Bueno-de-Mesquita, H. B., additional, Trichopoulos, D., additional, Ljungberg, B., additional, Clavel-Chapelon, F., additional, Weiderpass, E., additional, Krogh, V., additional, Dorronsoro, M., additional, Travis, R., additional, Tjonneland, A., additional, Brenan, P., additional, Chang-Claude, J., additional, Riboli, E., additional, Conti, D., additional, Gago-Dominguez, M., additional, Stern, M. C., additional, Pike, M. C., additional, Van Den Berg, D., additional, Yuan, J.-M., additional, Hohensee, C., additional, Rodabough, R., additional, Cancel-Tassin, G., additional, Roupret, M., additional, Comperat, E., additional, Chen, C., additional, De Vivo, I., additional, Giovannucci, E., additional, Hunter, D. J., additional, Kraft, P., additional, Lindstrom, S., additional, Carta, A., additional, Pavanello, S., additional, Arici, C., additional, Mastrangelo, G., additional, Karagas, M. R., additional, Schned, A., additional, Armenti, K. R., additional, Hosain, G. M. M., additional, Haiman, C. A., additional, Fraumeni, J. F., additional, Chanock, S. J., additional, Chatterjee, N., additional, Rothman, N., additional, and Silverman, D. T., additional
- Published
- 2014
- Full Text
- View/download PDF
8. Estimation and selection of complex covariate effects in pooled nested case-control studies with heterogeneity
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Liu, M., primary, Lu, W., additional, Krogh, V., additional, Hallmans, G., additional, Clendenen, T. V., additional, and Zeleniuch-Jacquotte, A., additional
- Published
- 2013
- Full Text
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9. Association of Type 2 Diabetes Susceptibility Variants With Advanced Prostate Cancer Risk in the Breast and Prostate Cancer Cohort Consortium
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Machiela, M. J., primary, Lindstrom, S., additional, Allen, N. E., additional, Haiman, C. A., additional, Albanes, D., additional, Barricarte, A., additional, Berndt, S. I., additional, Bueno-de-Mesquita, H. B., additional, Chanock, S., additional, Gaziano, J. M., additional, Gapstur, S. M., additional, Giovannucci, E., additional, Henderson, B. E., additional, Jacobs, E. J., additional, Kolonel, L. N., additional, Krogh, V., additional, Ma, J., additional, Stampfer, M. J., additional, Stevens, V. L., additional, Stram, D. O., additional, Tjonneland, A., additional, Travis, R., additional, Willett, W. C., additional, Hunter, D. J., additional, Le Marchand, L., additional, and Kraft, P., additional
- Published
- 2012
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10. Genetic variation in alcohol dehydrogenase (ADH1A, ADH1B, ADH1C, ADH7) and aldehyde dehydrogenase (ALDH2), alcohol consumption and gastric cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort
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Duell, E. J., primary, Sala, N., additional, Travier, N., additional, Munoz, X., additional, Boutron-Ruault, M. C., additional, Clavel-Chapelon, F., additional, Barricarte, A., additional, Arriola, L., additional, Navarro, C., additional, Sanchez-Cantalejo, E., additional, Quiros, J. R., additional, Krogh, V., additional, Vineis, P., additional, Mattiello, A., additional, Tumino, R., additional, Khaw, K.-T., additional, Wareham, N., additional, Allen, N. E., additional, Peeters, P. H., additional, Numans, M. E., additional, Bueno-de-Mesquita, H. B., additional, van Oijen, M. G. H., additional, Bamia, C., additional, Benetou, V., additional, Trichopoulos, D., additional, Canzian, F., additional, Kaaks, R., additional, Boeing, H., additional, Bergmann, M. M., additional, Lund, E., additional, Ehrnstrom, R., additional, Johansen, D., additional, Hallmans, G., additional, Stenling, R., additional, Tjonneland, A., additional, Overvad, K., additional, Ostergaard, J. N., additional, Ferrari, P., additional, Fedirko, V., additional, Jenab, M., additional, Nesi, G., additional, Riboli, E., additional, and Gonzalez, C. A., additional
- Published
- 2011
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11. Menopausal Hormone Therapy and Risk of Endometrial Carcinoma Among Postmenopausal Women in the European Prospective Investigation into Cancer and Nutrition
- Author
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Allen, N. E., primary, Tsilidis, K. K., additional, Key, T. J., additional, Dossus, L., additional, Kaaks, R., additional, Lund, E., additional, Bakken, K., additional, Gavrilyuk, O., additional, Overvad, K., additional, Tjonneland, A., additional, Olsen, A., additional, Fournier, A., additional, Fabre, A., additional, Clavel-Chapelon, F., additional, Chabbert-Buffet, N., additional, Sacerdote, C., additional, Krogh, V., additional, Bendinelli, B., additional, Tumino, R., additional, Panico, S., additional, Bergmann, M., additional, Schuetze, M., additional, van Duijnhoven, F. J. B., additional, Bas Bueno-de-Mesquita, H., additional, Charlotte Onland-Moret, N., additional, van Gils, C. H., additional, Amiano, P., additional, Barricarte, A., additional, Chirlaque, M.-D., additional, Molina-Montes, M.-E., additional, Redondo, M.-L., additional, Duell, E. J., additional, Khaw, K.-T., additional, Wareham, N., additional, Rinaldi, S., additional, Fedirko, V., additional, Mouw, T., additional, Michaud, D. S., additional, and Riboli, E., additional
- Published
- 2010
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12. Circulating C-Reactive Protein Concentrations and Risks of Colon and Rectal Cancer: A Nested Case-Control Study Within the European Prospective Investigation into Cancer and Nutrition
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Aleksandrova, K., primary, Jenab, M., additional, Boeing, H., additional, Jansen, E., additional, Bueno-de-Mesquita, H. B., additional, Rinaldi, S., additional, Riboli, E., additional, Overvad, K., additional, Dahm, C. C., additional, Olsen, A., additional, Tjonneland, A., additional, Boutron-Ruault, M.-C., additional, Clavel-Chapelon, F., additional, Morois, S., additional, Palli, D., additional, Krogh, V., additional, Tumino, R., additional, Vineis, P., additional, Panico, S., additional, Kaaks, R., additional, Rohrmann, S., additional, Trichopoulou, A., additional, Lagiou, P., additional, Trichopoulos, D., additional, van Duijnhoven, F. J. B., additional, Leufkens, A. M., additional, Peeters, P. H., additional, Rodriguez, L., additional, Bonet, C., additional, Sanchez, M.-J., additional, Dorronsoro, M., additional, Navarro, C., additional, Barricarte, A., additional, Palmqvist, R., additional, Hallmans, G., additional, Khaw, K.-T., additional, Wareham, N., additional, Allen, N. E., additional, Spencer, E., additional, Romaguera, D., additional, Norat, T., additional, and Pischon, T., additional
- Published
- 2010
- Full Text
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13. The Role of Smoking and Diet in Explaining Educational Inequalities in Lung Cancer Incidence
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Menvielle, G., primary, Boshuizen, H., additional, Kunst, A. E., additional, Dalton, S. O., additional, Vineis, P., additional, Bergmann, M. M., additional, Hermann, S., additional, Ferrari, P., additional, Raaschou-Nielsen, O., additional, Tjonneland, A., additional, Kaaks, R., additional, Linseisen, J., additional, Kosti, M., additional, Trichopoulou, A., additional, Dilis, V., additional, Palli, D., additional, Krogh, V., additional, Panico, S., additional, Tumino, R., additional, Buchner, F. L., additional, van Gils, C. H., additional, Peeters, P. H. M., additional, Braaten, T., additional, Gram, I. T., additional, Lund, E., additional, Rodriguez, L., additional, Agudo, A., additional, Sanchez, M.-J., additional, Tormo, M.-J., additional, Ardanaz, E., additional, Manjer, J., additional, Wirfalt, E., additional, Hallmans, G., additional, Rasmuson, T., additional, Bingham, S., additional, Khaw, K.-T., additional, Allen, N., additional, Key, T., additional, Boffetta, P., additional, Duell, E. J., additional, Slimani, N., additional, Gallo, V., additional, Riboli, E., additional, and Bueno-de-Mesquita, H. B., additional
- Published
- 2009
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14. Urinary 6-Sulfatoxymelatonin Levels and Risk of Breast Cancer in Postmenopausal Women
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Schernhammer, E. S., primary, Berrino, F., additional, Krogh, V., additional, Secreto, G., additional, Micheli, A., additional, Venturelli, E., additional, Sieri, S., additional, Sempos, C. T., additional, Cavalleri, A., additional, Schunemann, H. J., additional, Strano, S., additional, and Muti, P., additional
- Published
- 2008
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15. Polymorphisms of genes coding for ghrelin and its receptor in relation to anthropometry, circulating levels of IGF-I and IGFBP-3, and breast cancer risk: a case-control study nested within the European Prospective Investigation into Cancer and Nutrition (EPIC)
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Dossus, L., primary, McKay, J. D., additional, Canzian, F., additional, Wilkening, S., additional, Rinaldi, S., additional, Biessy, C., additional, Olsen, A., additional, Tjonneland, A., additional, Jakobsen, M. U., additional, Overvad, K., additional, Clavel-Chapelon, F., additional, Boutron-Ruault, M.-C., additional, Fournier, A., additional, Linseisen, J., additional, Lukanova, A., additional, Boeing, H., additional, Fisher, E., additional, Trichopoulou, A., additional, Georgila, C., additional, Trichopoulos, D., additional, Palli, D., additional, Krogh, V., additional, Tumino, R., additional, Vineis, P., additional, Quiros, J. R., additional, Sala, N., additional, Martinez-Garcia, C., additional, Dorronsoro, M., additional, Chirlaque, M.-D., additional, Barricarte, A., additional, van Duijnhoven, F. J.B., additional, Bueno-de-Mesquita, H.B., additional, van Gils, C. H., additional, Peeters, P. H.M., additional, Hallmans, G., additional, Lenner, P., additional, Bingham, S., additional, Khaw, K. T., additional, Key, T. J., additional, Travis, R. C., additional, Ferrari, P., additional, Jenab, M., additional, Riboli, E., additional, and Kaaks, R., additional
- Published
- 2008
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16. Fruits, Vegetables, and Colon Cancer Risk in a Pooled Analysis of 14 Cohort Studies
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Koushik, A., primary, Hunter, D. J., additional, Spiegelman, D., additional, Beeson, W. L., additional, van den Brandt, P. A., additional, Buring, J. E., additional, Calle, E. E., additional, Cho, E., additional, Fraser, G. E., additional, Freudenheim, J. L., additional, Fuchs, C. S., additional, Giovannucci, E. L., additional, Goldbohm, R. A., additional, Harnack, L., additional, Jacobs, D. R., additional, Kato, I., additional, Krogh, V., additional, Larsson, S. C., additional, Leitzmann, M. F., additional, Marshall, J. R., additional, McCullough, M. L., additional, Miller, A. B., additional, Pietinen, P., additional, Rohan, T. E., additional, Schatzkin, A., additional, Sieri, S., additional, Virtanen, M. J., additional, Wolk, A., additional, Zeleniuch-Jacquotte, A., additional, Zhang, S. M., additional, and Smith-Warner, S. A., additional
- Published
- 2007
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17. Lactase Persistence and Bitter Taste Response: Instrumental Variables and Mendelian Randomization in Epidemiologic Studies of Dietary Factors and Cancer Risk
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Sacerdote, C., primary, Guarrera, S., additional, Smith, G. D., additional, Grioni, S., additional, Krogh, V., additional, Masala, G., additional, Mattiello, A., additional, Palli, D., additional, Panico, S., additional, Tumino, R., additional, Veglia, F., additional, Matullo, G., additional, and Vineis, P., additional
- Published
- 2007
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18. Re: Endogenous Steroid Hormone Concentrations and Risk of Breast Cancer Among Premenopausal Women
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Micheli, A., primary, Secreto, G., additional, Meneghini, E., additional, Krogh, V., additional, Muti, P., additional, Venturelli, E., additional, and Berrino, F., additional
- Published
- 2007
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19. −344C/T Variant in the Promoter of the Aldosterone Synthase Gene (CYP11B2) Is Associated With Metabolic Syndrome in Men
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RUSSO, P, primary, LAURIA, F, additional, LOGUERCIO, M, additional, BARBA, G, additional, ARNOUT, J, additional, CAPPUCCIO, F, additional, DELORGERIL, M, additional, DONATI, M, additional, IACOVIELLO, L, additional, and KROGH, V, additional
- Published
- 2007
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20. Is ghrelin a signal of decreased fat-free mass in elderly subjects?
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Bertoli, S, primary, Magni, P, additional, Krogh, V, additional, Ruscica, M, additional, Dozio, E, additional, Testolin, G, additional, and Battezzati, A, additional
- Published
- 2006
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21. Multi-factor dimensionality reduction applied to a large prospective investigation on gene-gene and gene-environment interactions
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Manuguerra, M., primary, Matullo, G., additional, Veglia, F., additional, Autrup, H., additional, Dunning, A.M., additional, Garte, S., additional, Gormally, E., additional, Malaveille, C., additional, Guarrera, S., additional, Polidoro, S., additional, Saletta, F., additional, Peluso, M., additional, Airoldi, L., additional, Overvad, K., additional, Raaschou-Nielsen, O., additional, Clavel-Chapelon, F., additional, Linseisen, J., additional, Boeing, H., additional, Trichopoulos, D., additional, Kalandidi, A., additional, Palli, D., additional, Krogh, V., additional, Tumino, R., additional, Panico, S., additional, Bueno-De-Mesquita, H.B., additional, Peeters, P.H., additional, Lund, E., additional, Pera, G., additional, Martinez, C., additional, Amiano, P., additional, Barricarte, A., additional, Tormo, M.J., additional, Quiros, J.R., additional, Berglund, G., additional, Janzon, L., additional, Jarvholm, B., additional, Day, N.E., additional, Allen, N.E., additional, Saracci, R., additional, Kaaks, R., additional, Ferrari, P., additional, Riboli, E., additional, and Vineis, P., additional
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- 2006
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22. Plasma and dietary vitamin C levels and risk of gastric cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC-EURGAST)
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Jenab, M., primary, Riboli, E., additional, Ferrari, P., additional, Sabate, J., additional, Slimani, N., additional, Norat, T., additional, Friesen, M., additional, Tjonneland, A., additional, Olsen, A., additional, Overvad, K., additional, Boutron-Ruault, M.-C., additional, Clavel-Chapelon, F., additional, Touvier, M., additional, Boeing, H., additional, Schulz, M., additional, Linseisen, J., additional, Nagel, G., additional, Trichopoulou, A., additional, Naska, A., additional, Oikonomou, E., additional, Krogh, V., additional, Panico, S., additional, Masala, G., additional, Sacerdote, C., additional, Tumino, R., additional, Peeters, P. H., additional, Numans, M. E., additional, Bueno-de-Mesquita, H. B., additional, Buchner, F. L., additional, Lund, E., additional, Pera, G., additional, Sanchez, C. N., additional, Sanchez, M.-J., additional, Arriola, L., additional, Barricarte, A., additional, Quiros, J. R., additional, Hallmans, G., additional, Stenling, R., additional, Berglund, G., additional, Bingham, S., additional, Khaw, K.-T., additional, Key, T., additional, Allen, N., additional, Carneiro, F., additional, Mahlke, U., additional, Giudice, G. D., additional, Palli, D., additional, Kaaks, R., additional, and Gonzalez, C. A., additional
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- 2006
- Full Text
- View/download PDF
23. DNA repair polymorphisms and cancer risk in non-smokers in a cohort study
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Matullo, G., primary, Dunning, A.M., additional, Guarrera, S., additional, Baynes, C., additional, Polidoro, S., additional, Garte, S., additional, Autrup, H., additional, Malaveille, C., additional, Peluso, M., additional, Airoldi, L., additional, Veglia, F., additional, Gormally, E., additional, Hoek, G., additional, Krzyzanowski, M., additional, Overvad, K., additional, Raaschou-Nielsen, O., additional, Clavel-Chapelon, F., additional, Linseisen, J., additional, Boeing, H., additional, Trichopoulou, A., additional, Palli, D., additional, Krogh, V., additional, Tumino, R., additional, Panico, S., additional, Bueno-De-Mesquita, H.B., additional, Peeters, P.H., additional, Lund, E., additional, Pera, G., additional, Martinez, C., additional, Dorronsoro, M., additional, Barricarte, A., additional, Tormo, M.J., additional, Quiros, J.R., additional, Day, N.E., additional, Key, T.J., additional, Saracci, R., additional, Kaaks, R., additional, Riboli, E., additional, and Vineis, P., additional
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- 2005
- Full Text
- View/download PDF
24. Body mass index, circulating levels of sex-steroid hormones, IGF-I and IGF-binding protein-3: a cross-sectional study in healthy women
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Lukanova, A, primary, Lundin, E, additional, Zeleniuch-Jacquotte, A, additional, Muti, P, additional, Mure, A, additional, Rinaldi, S, additional, Dossus, L, additional, Micheli, A, additional, Arslan, A, additional, Lenner, P, additional, Shore, RE, additional, Krogh, V, additional, Koenig, KL, additional, Riboli, E, additional, Berrino, F, additional, Hallmans, G, additional, Stattin, P, additional, Toniolo, P, additional, and Kaaks, R, additional
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- 2004
- Full Text
- View/download PDF
25. Erythrocyte Membrane Fatty Acids and Subsequent Breast Cancer: a Prospective Italian Study
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Pala, V., primary, Krogh, V., additional, Muti, P., additional, Chajes, V., additional, Riboli, E., additional, Micheli, A., additional, Saadatian, M., additional, Sieri, S., additional, and Berrino, F., additional
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- 2001
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26. Long Term Relations between Earthquake Experiences and Coronary Heart Disease Risk Factors
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Bland, S. H., primary, Farinaro, E., additional, Krogh, V., additional, Jossa, F., additional, Scottoni, A., additional, and Trevisan, M., additional
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- 2000
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- View/download PDF
27. Serum Sex Hormone Levels After Menopause and Subsequent Breast Cancer
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Berrino, F., primary, Muti, P., additional, Micheli, A., additional, Bolelli, G., additional, Krogh, V., additional, Sciajno, R., additional, Pisani, P., additional, Panico, S., additional, and Secreto, G., additional
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- 1996
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28. Imputation and subset-based association analysis across different cancer types identifies multiple independent risk loci in the TERT-CLPTM1L region on chromosome 5p15.33
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Hidemi Ito, Stephen K. Van Den Eeden, Abdisamad M. Ibrahim, Ching C. Lau, Preetha Rajaraman, Gloria M. Petersen, Judith Hoffman-Bolton, Colin P.N. Dinney, Chang Hyun Kang, Melinda C. Aldrich, Mark P. Purdue, Xiao-Ou Shu, William J. Blot, Sanjay Shete, Alpa V. Patel, Charles Kooperberg, Paolo Vineis, David Van Den Berg, Chao A. Hsiung, Anthony J. Swerdlow, Qing Lan, Wu Chou Su, Afshan Siddiq, Ulrike Peters, Katia Scotlandi, Sara H. Olson, Kendra Schwartz, Kelly L. Bolton, Chancellor Hohensee, Josep Lloreta, Kevin B. Jacobs, Debra T. Silverman, Rudolf Kaaks, Wei Zheng, Steven Gallinger, Junwen Wang, Angela Carta, Massimo Serra, Petra H.M. Peeters, Victoria L. Stevens, Yasushi Yatabe, Geraldine Cancel-Tassin, Joshua N. Sampson, Young Tae Kim, Graham A. Colditz, Pan-Chyr Yang, Baosen Zhou, Fredrick R. Schumacher, Nicolas Wentzensen, Evelyn Tay, Claudia Maria Hattinger, Chen Wu, Pilar Amiano, Mattias Johansson, Maxwell P. Lee, Christian P. Kratz, Michael B. Cook, Mingfeng Zhang, Kay-Tee Khaw, Jian-Min Yuan, Anne Zeleniuch-Jacquotte, Jinping Jia, Roberto Tirabosco, Jing Ma, Neil E. Caporaso, Christopher A. Haiman, Bu Tian Ji, Adrienne M. Flanagan, Neyssa Marina, Eric J. Jacobs, Sophia S. Wang, Chong-Jen Yu, Edward Giovannucci, Margaret Wrensch, Robert L. Grubb, Bin Zhu, Daniel O. Stram, Manolis Kogevinas, Margaret R. Karagas, Mazda Jenab, Alison M. Mondul, Jun Xu, Preethi S. Raj, Anders Ahlbom, Christine D. Berg, Shelley Niwa, Kala Visvanathan, Loic Le Marchand, Jorge R. Toro, Robert N. Hoover, Heather Spencer Feigelson, Michelle Brotzman, Laurence N. Kolonel, Krista A. Zanetti, Chengfeng Wang, Mary Ann Butler, Ann Truelove, Irene L. Andrulis, Hongbing Shen, H. Dean Hosgood, Ming Shyan Huang, Gee-Chen Chang, Jianjun Liu, John K. Wiencke, Stephanie J. Weinstein, Beatrice Melin, Kouya Shiraishi, Zhihua Yin, Lee E. Moore, Börje Ljungberg, Jolanta Lissowska, Elizabeth M. Gillanders, M. T. Landi, Cari M. Kitahara, Maria Feychting, Kuan-Yu Chen, Matthias Simon, Brian M. Wolpin, Hemang Parikh, Hannah P. Yang, Graham G. Giles, Alison Johnson, Demetrius Albanes, Carlos González, Brian E. Henderson, Xifeng Wu, Harvey A. Risch, Amy Hutchinson, Christopher Hautman, Constance Chen, Zhibin Hu, Donghui Li, Elio Riboli, Julie E. Buring, Curtis C. Harris, Xu Che, Núria Malats, Roger Henriksson, Rosario Tumino, Joanne S. Colt, Alfredo Carrato, Paolo Boffetta, Maria Pik Wong, Hideo Tanaka, Federico Canzian, Alan D. L. Sihoe, Chien-Jen Chen, Kenneth Muir, Chen Ying, Qincheng He, Melissa C. Southey, Marc Sanson, Victoria K. Cortessis, Sharon A. Savage, Wei Hu, Yao Tettey, Daniela S. Gerhard, Sofia Pavanello, Guangwen Cao, H. Barton Grossman, Michael Goggins, Hideo Kunitoh, Peter D. Inskip, Seth P. Lerner, Peter Kraft, David Thomas, Peng Guan, Chung Hsing Chen, I. Shou Chang, Christoffer Johansen, Roberta McKean-Cowdin, Lee J. Helman, Yuh Min Chen, Ana Patiño-García, Pär Stattin, Xiaoping Miao, Tangchun Wu, Jay S. Wunder, Ann W. Hsing, Yu-Tang Gao, Brooke L. Fridley, Tania Carreón, Charles C. Chung, Nan Hu, Yoo Jin Jung, Richard B. Biritwum, Eric J. Duell, Philip R. Taylor, Satu Männistö, Kai Yu, Meredith Yeager, Xia Pu, Vittorio Krogh, Anand P. Chokkalingam, Susan M. Gapstur, W. Ryan Diver, Yuanqing Ye, Keitaro Matsuo, Cecilia Arici, You-Lin Qiao, Alan R. Schned, Dominique S. Michaud, Joanne W. Elena, Christopher Kim, Dongxin Lin, Yun-Chul Hong, Daru Lu, Reina García-Closas, Jonine D. Figueroa, Linda M. Liao, Yi-Long Wu, Heiner Boeing, Mark Lathrop, Göran Hallmans, Elizabeth A. Holly, Carol Giffen, Andrew A. Adjei, Consol Serra, Anne Tjønneland, Joseph F. Fraumeni, Alisa M. Goldstein, Ruth C. Travis, Rebecca Troisi, Dalsu Baris, Nalan Gokgoz, Olivier Cussenot, Xiang Deng, Yeul Hong Kim, Malin Sund, Sonja I. Berndt, E. David Crawford, Edward D. Yeboah, Sook Whan Sung, Françoise Clavel-Chapelon, Woon-Puay Koh, Nilgun Kurucu, Richard B. Hayes, Ashish M. Kamat, Beata Peplonska, Laurie Burdette, Ze Zhang Tang, Alan A. Arslan, Malcolm C. Pike, Sabina Sierri, J. Michael Gaziano, Lorna H. McNeil, Katherine A. McGlynn, Ulla Vogel, Logan G. Spector, H. Bas Bueno-de-Mesquita, Stephen J. Chanock, Jae Yong Park, Jennifer Prescott, Fernando Lecanda, Margaret A. Tucker, Ti Ding, Christian C. Abnet, Jenny Chang-Claude, Dimitrios Trichopoulos, Wei-Yen Lim, Wen Tan, Nick Orr, Jin Hee Kim, Stefano Porru, Chand Khanna, Robert R. McWilliams, Zhaoming Wang, Jeong Seon Ryu, David V. Conti, Alison P. Klein, Adonina Tardón, Robert J. Klein, Rebecca J. Rodabough, Mark H. Greene, Aruna Kamineni, Jie Lin, Rachael Z. Stolzenberg-Solomon, Patricia Hartge, Susan E. Hankinson, Young-Chul Kim, In Sam Kim, Luis Sierrasesúmaga, Roel Vermeulen, Paige M. Bracci, Mariana C. Stern, Louise A. Brinton, Myron D. Gross, Yong-Bing Xiang, Chih Yi Chen, G. A. Gerald Andriole, Paul S. Meltzer, Ying-Huang Tsai, Faith G. Davis, Ulrika Andersson, Paul Brennan, Sara Lindström, Chaoyu Wang, Giuseppe Mastrangelo, Laufey T. Amundadottir, Immaculata De Vivo, Bryan A. Bassig, Elisabete Weiderpass, Takashi Kohno, Nilanjan Chatterjee, Margaret R. Spitz, Pier Alberto Bertazzi, William Wheeler, David J. Hunter, Wei Tang, Qiuyin Cai, Naomi E. Allen, Molly Schwenn, Emily White, Min Shen, Adeline Seow, Laura E. Beane Freeman, James E. Mensah, Howard D. Sesso, Anna Luisa Di Stefano, Amanda Black, Manuela Gago-Dominguez, Christine B. Ambrosone, Avima M. Ruder, Martha S. Linet, Meir J. Stampfer, Robert C. Kurtz, Donald A. Barkauskas, Lisa W. Chu, Montserrat Garcia-Closas, Jason W. Hoskins, Melissa A. Austin, Kyoung Mu Lee, Jianxin Shi, Charles S. Fuchs, Nathaniel Rothman, Richard Gorlick, Piero Picci, Gianluca Severi, Ann G. Schwartz, Jian Gu, Christopher I. Amos, Marie-Christine Boutron-Ruault, Salvatore Panico, Alicja Wolk, Sara S. Strom, Lisa Mirabello, Jin-Hu Fan, Chin-Fu Hsiao, Neal D. Freedman, Geoffrey S. Tobias, Julie M. Gastier-Foster, Wang, Z, Zhu, B, Zhang, M, Parikh, H, Jia, J, Chung, Cc, Sampson, Jn, Hoskins, Jw, Hutchinson, A, Burdette, L, Ibrahim, A, Hautman, C, Raj, P, Abnet, Cc, Adjei, Aa, Ahlbom, A, Albanes, D, Allen, Ne, Ambrosone, Cb, Aldrich, M, Amiano, P, Amos, C, Andersson, U, Andriole G., Jr, Andrulis, Il, Arici, C, Arslan, Aa, Austin, Ma, Baris, D, Barkauskas, Da, Bassig, Ba, Beane Freeman, Le, Berg, Cd, Berndt, Si, Bertazzi, Pa, Biritwum, Rb, Black, A, Blot, W, Boeing, H, Boffetta, P, Bolton, K, Boutron Ruault, Mc, Bracci, Pm, Brennan, P, Brinton, La, Brotzman, M, Bueno de Mesquita, Hb, Buring, Je, Butler, Ma, Cai, Q, Cancel Tassin, G, Canzian, F, Cao, G, Caporaso, Ne, Carrato, A, Carreon, T, Carta, A, Chang, Gc, Chang, I, Chang Claude, J, Che, X, Chen, Cj, Chen, Cy, Chen, Ch, Chen, C, Chen, Ky, Chen, Ym, Chokkalingam, Ap, Chu, Lw, Clavel Chapelon, F, Colditz, Ga, Colt, J, Conti, D, Cook, Mb, Cortessis, Vk, Crawford, Ed, Cussenot, O, Davis, Fg, De Vivo, I, Deng, X, Ding, T, Dinney, Cp, Di Stefano, Al, Diver, Wr, Duell, Ej, Elena, Jw, Fan, Jh, Feigelson, H, Feychting, M, Figueroa, Jd, Flanagan, Am, Fraumeni JF, Jr, Freedman, Nd, Fridley, Bl, Fuchs, C, Gago Dominguez, M, Gallinger, S, Gao, Yt, Gapstur, Sm, Garcia Closas, M, Garcia Closas, R, Gastier Foster, Jm, Gaziano, Jm, Gerhard, D, Giffen, Ca, Giles, Gg, Gillanders, Em, Giovannucci, El, Goggins, M, Gokgoz, N, Goldstein, Am, Gonzalez, C, Gorlick, R, Greene, Mh, Gross, M, Grossman, Hb, Grubb R., 3rd, Gu, J, Guan, P, Haiman, Ca, Hallmans, G, Hankinson, Se, Harris, Cc, Hartge, P, Hattinger, C, Hayes, Rb, He, Q, Helman, L, Henderson, Be, Henriksson, R, Hoffman Bolton, J, Hohensee, C, Holly, Ea, Hong, Yc, Hoover, Rn, Hosgood HD, 3rd, Hsiao, Cf, Hsing, Aw, Hsiung, Ca, Hu, N, Hu, W, Hu, Z, Huang, M, Hunter, Dj, Inskip, Pd, Ito, H, Jacobs, Ej, Jacobs, Kb, Jenab, M, Ji, Bt, Johansen, C, Johansson, M, Johnson, A, Kaaks, R, Kamat, Am, Kamineni, A, Karagas, M, Khanna, C, Khaw, Kt, Kim, C, Kim, I, Kim, Yh, Kim, Yc, Kim, Yt, Kang, Ch, Jung, Yj, Kitahara, Cm, Klein, Ap, Klein, R, Kogevinas, M, Koh, Wp, Kohno, T, Kolonel, Ln, Kooperberg, C, Kratz, Cp, Krogh, V, Kunitoh, H, Kurtz, Rc, Kurucu, N, Lan, Q, Lathrop, M, Lau, Cc, Lecanda, F, Lee, Km, Lee, Mp, Le Marchand, L, Lerner, Sp, Li, D, Liao, Lm, Lim, Wy, Lin, D, Lin, J, Lindstrom, S, Linet, M, Lissowska, J, Liu, J, Ljungberg, B, Lloreta, J, Lu, D, Ma, J, Malats, N, Mannisto, S, Marina, N, Mastrangelo, G, Matsuo, K, Mcglynn, Ka, McKean Cowdin, R, Mcneill, Lh, Mcwilliams, Rr, Melin, B, Meltzer, P, Mensah, Je, Miao, X, Michaud, D, Mondul, Am, Moore, Le, Muir, K, Niwa, S, Olson, Sh, Orr, N, Panico, Salvatore, Park, Jy, Patel, Av, Patino Garcia, A, Pavanello, S, Peeters, Ph, Peplonska, B, Peters, U, Petersen, Gm, Picci, P, Pike, Mc, Porru, S, Prescott, J, Pu, X, Purdue, Mp, Qiao, Yl, Rajaraman, P, Riboli, E, Risch, Ha, Rodabough, Rj, Rothman, N, Ruder, Am, Ryu, J, Sanson, M, Schned, A, Schumacher, Fr, Schwartz, Ag, Schwartz, Kl, Schwenn, M, Scotlandi, K, Seow, A, Serra, C, Serra, M, Sesso, Hd, Severi, G, Shen, H, Shen, M, Shete, S, Shiraishi, K, Shu, Xo, Siddiq, A, Sierrasesumaga, L, Sierri, S, Loon Sihoe, Ad, Silverman, Dt, Simon, M, Southey, Mc, Spector, L, Spitz, M, Stampfer, M, Stattin, P, Stern, Mc, Stevens, Vl, Stolzenberg Solomon, Rz, Stram, Do, Strom, S, Su, Wc, Sund, M, Sung, Sw, Swerdlow, A, Tan, W, Tanaka, H, Tang, W, Tang, Zz, Tardon, A, Tay, E, Taylor, Pr, Tettey, Y, Thomas, Dm, Tirabosco, R, Tjonneland, A, Tobias, G, Toro, Jr, Travis, Rc, Trichopoulos, D, Troisi, R, Truelove, A, Tsai, Yh, Tucker, Ma, Tumino, R, Van Den Berg, D, Van Den Eeden, Sk, Vermeulen, R, Vineis, P, Visvanathan, K, Vogel, U, Wang, C, Wang, J, Wang, S, Weiderpass, E, Weinstein, Sj, Wentzensen, N, Wheeler, W, White, E, Wiencke, Jk, Wolk, A, Wolpin, Bm, Wong, Mp, Wrensch, M, Wu, C, Wu, T, Wu, X, Wu, Yl, Wunder, J, Xiang, Yb, Xu, J, Yang, Hp, Yang, Pc, Yatabe, Y, Ye, Y, Yeboah, Ed, Yin, Z, Ying, C, Yu, Cj, Yu, K, Yuan, Jm, Zanetti, Ka, Zeleniuch Jacquotte, A, Zheng, W, Zhou, B, Mirabello, L, Savage, Sa, Kraft, P, Chanock, Sj, Yeager, M, Landi, Mt, Shi, J, Chatterjee, N, Amundadottir, Lt, Wang, Z., Zhu, B., Zhang, M., Parikh, H., Jia, J., Chung, C.C., Sampson, J.N., Hoskins, J.W., Hutchinson, A., Burdette, L., Ibrahim, A., Hautman, C., Raj, P.S., Abnet, C.C., Adjei, A.A., Ahlbom, A., Albanes, D., Allen, N.E., Ambrosone, C.B., Aldrich, M., Amiano, P., Amos, C., Andersson, U., Gerald Andriole, G.A., Jr., Andrulis, I.L., Arici, C., Arslan, A.A., Austin, M.A., Baris, D., Barkauskas, D.A., Bassig, B.A., Freeman, L.E.B., Berg, C.D., Berndt, S.I., Bertazzi, P.A., Biritwum, R.B., Black, A., Blot, W., Boeing, H., Boffetta, P., Bolton, K., Boutron-Ruault, M.-C., Bracci, P.M., Brennan, P., Brinton, L.A., Brotzman, M., Bueno-de-Mesquita, H.B., Buring, J.E., Butler, M.A., Cai, Q., Cancel-Tassin, G., Canzian, F., Cao, G., Caporaso, N.E., Carrato, A., Carreon, T., Carta, A., Chang, G.-C., Chang, I.-S., Chang-Claude, J., Che, X., Chen, C.-J., Chen, C.-Y., Chen, C.-H., Chen, C., Chen, K.-Y., Chen, Y.-M., Chokkalingam, A.P., Chu, L.W., Clavel-Chapelon, F., Colditz, G.A., Colt, J.S., Conti, D., Cook, M.B., Cortessis, V.K., Crawford, E.D., Cussenot, O., Davis, F.G., De Vivo, I., Deng, X., Ding, T., Dinney, C.P., Di Stefano, A.L., Diver, W.R., Duell, E.J., Elena, J.W., Fan, J.-H., Feigelson, H.S., Feychting, M., Figueroa, J.D., Flanagan, A.M., Fraumeni, J.F., Jr., Freedman, N.D., Fridley, B.L., Fuchs, C.S., Gago-Dominguez, M., Gallinger, S., Gao, Y.-T., Gapstur, S.M., Garcia-Closas, M., Garcia-Closas, R., Gastier-Foster, J.M., Gaziano, J.M., Gerhard, D.S., Giffen, C.A., Giles, G.G., Gillanders, E.M., Giovannucci, E.L., Goggins, M., Gokgoz, N., Goldstein, A.M., Gonzalez, C., Gorlick, R., Greene, M.H., Gross, M., Grossman, H.B., Grubb, R., III and Gu, J., Guan, P., Haiman, C.A., Hallmans, G., Hankinson, S.E., Harris, C.C., Hartge, P., Hattinger, C., Hayes, R.B., He, Q., Helman, L., Henderson, B.E., Henriksson, R., Hoffman-Bolton, J., Hohensee, C., Holly, E.A., Hong, Y.-C., Hoover, R.N., Dean Hosgood, H., Hsiao, C.-F., Hsing, A.W., Hsiung, C.A., Hu, N., Hu, W., Hu, Z., Huang, M.-S., Hunter, D.J., Inskip, P.D., Ito, H., Jacobs, E.J., Jacobs, K.B., Jenab, M., Ji, B.-T., Johansen, C., Johansson, M., Johnson, A., Kaaks, R., Kamat, A.M., Kamineni, A., Karagas, M., Khanna, C., Khaw, K.-T., Kim, C., Kim, I.-S., Kim, J.H., Kim, Y.H., Kim, Y.-C., Kim, Y.T., Kang, C.H., Jung, Y.J., Kitahara, C.M., Klein, A.P., Klein, R., Kogevinas, M., Koh, W.-P., Kohno, T., Kolonel, L.N., Kooperberg, C., Kratz, C.P., Krogh, V., Kunitoh, H., Kurtz, R.C., Kurucu, N., Lan, Q., Lathrop, M., Lau, C.C., Lecanda, F., Lee, K.-M., Lee, M.P., Marchand, L.L., Lerner, S.P., Li, D., Liao, L.M., Lim, W.-Y., Lin, D., Lin, J., Lindstrom, S., Linet, M.S., Lissowska, J., Liu, J., Ljungberg, B., Lloreta, J., Lu, D., Ma, J., Malats, N., Mannisto, S., Marina, N., Mastrangelo, G., Matsuo, K., McGlynn, K.A., McKean-Cowdin, R., McNeil, L.H., McWilliams, R.R., Melin, B.S., Meltzer, P.S., Mensah, J.E., Miao, X., Michaud, D.S., Mondul, A.M., Moore, L.E., Muir, K., Niwa, S., Olson, S.H., Orr, N., Panico, S., Park, J.Y., Patel, A.V., Patino-Garcia, A., Pavanello, S., Peeters, P.H.M., Peplonska, B., Peters, U., Petersen, G.M., Picci, P., Pike, M.C., Porru, S., Prescott, J., Pu, X., Purdue, M.P., Qiao, Y.-L., Rajaraman, P., Riboli, E., Risch, H.A., Rodabough, R.J., Rothman, N., Ruder, A.M., Ryu, J.-S., Sanson, M., Schned, A., Schumacher, F.R., Schwartz, A.G., Schwartz, K.L., Schwenn, M., Scotlandi, K., Seow, A., Serra, C., Serra, M., Sesso, H.D., Severi, G., Shen, H., Shen, M., Shete, S., Shiraishi, K., Shu, X.-O., Siddiq, A., Sierrasesumaga, L., Sierri, S., Sihoe, A.D.L., Silverman, D.T., Simon, M., Southey, M.C., Spector, L., Spitz, M., Stampfer, M., Stattin, P., Stern, M.C., Stevens, V.L., Stolzenberg-Solomon, R.Z., Stram, D.O., Strom, S.S., Su, W.-C., Sund, M., Sung, S.W., Swerdlow, A., Tan, W., Tanaka, H., Tang, W., Tang, Z.-Z., Tardon, A., Tay, E., Taylor, P.R., Tettey, Y., Thomas, D.M., Tirabosco, R., Tjonneland, A., Tobias, G.S., Toro, J.R., Travis, R.C., Trichopoulos, D., Troisi, R., Truelove, A., Tsai, Y.-H., Tucker, M.A., Tumino, R., Van Den Berg, D., Van Den Eeden, S.K., Vermeulen, R., Vineis, P., Visvanathan, K., Vogel, U., Wang, C., Wang, J., Wang, S.S., Weiderpass, E., Weinstein, S.J., Wentzensen, N., Wheeler, W., White, E., Wiencke, J.K., Wolk, A., Wolpin, B.M., Wong, M.P., Wrensch, M., Wu, C., Wu, T., Wu, X., Wu, Y.-L., Wunder, J.S., Xiang, Y.-B., Xu, J., Yang, H.P., Yang, P.-C., Yatabe, Y., Ye, Y., Yeboah, E.D., Yin, Z., Ying, C., Yu, C.-J., Yu, K., Yuan, J.-M., Zanetti, K.A., Zeleniuch-Jacquotte, A., Zheng, W., Zhou, B., Mirabello, L., Savage, S.A., Kraft, P., Chanock, S.J., Yeager, M., Landi, M.T., Shi, J., Chatterjee, N., and Amundadottir, L.T.
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Male ,SINGLE-NUCLEOTIDE POLYMORPHISM ,Genome-wide association study ,Epigenesis, Genetic ,Gene Frequency ,Molecular Biology ,Genetics ,Genetics (clinical) ,Neoplasms ,Odds Ratio ,Genome-wide association studies (GWAS) ,Telomerase ,DNA METHYLATION Author Information ,Association Studies Articles ,General Medicine ,PANCREATIC-CANCER ,PROSTATE-CANCER ,Neoplasm Proteins ,POSTMENOPAUSAL BREAST-CANCER ,TERT PROMOTER MUTATIONS ,Gene Expression Regulation, Neoplastic ,2 SUSCEPTIBILITY LOCI ,DNA methylation ,Chromosomes, Human, Pair 5 ,Female ,Risk ,Locus (genetics) ,Single-nucleotide polymorphism ,TERT and CLPTM1L gene ,Biology ,Polymorphism, Single Nucleotide ,LUNG-CANCER ,Humans ,Genetic Predisposition to Disease ,GENOME-WIDE ASSOCIATION ,Allele ,Gene ,Allele frequency ,Alleles ,Genetic association ,chromosome 5p15.33 ,Computational Biology ,Membrane Proteins ,DNA Methylation ,Genetic Loci ,TELOMERE LENGTH ,Genome-Wide Association Study - Abstract
Genome-wide association studies (GWAS) have mapped risk alleles for at least 10 distinct cancers to a small region of 63 000 bp on chromosome 5p15.33. This region harbors the TERT and CLPTM1L genes; the former encodes the catalytic subunit of telomerase reverse transcriptase and the latter may play a role in apoptosis. To investigate further the genetic architecture of common susceptibility alleles in this region, we conducted an agnostic subset-based meta-analysis (association analysis based on subsets) across six distinct cancers in 34 248 cases and 45 036 controls. Based on sequential conditional analysis, we identified as many as six independent risk loci marked by common single-nucleotide polymorphisms: five in the TERT gene (Region 1: rs7726159, P = 2.10 x 10(-39); Region 3: rs2853677, P = 3.30 x 10(-36) and PConditional = 2.36 x 10(-8); Region 4: rs2736098, P = 3.87 x 10(-12) and PConditional = 5.19 x 10(-6), Region 5: rs13172201, P = 0.041 and PConditional = 2.04 x 10(-6); and Region 6: rs10069690, P = 7.49 x 10(-15) and PConditional = 5.35 x 10(-7)) and one in the neighboring CLPTM1L gene (Region 2: rs451360; P = 1.90 x 10(-18) and PConditional = 7.06 x 10(-16)). Between three and five cancers mapped to each independent locus with both risk-enhancing and protective effects. Allele-specific effects on DNA methylation were seen for a subset of risk loci, indicating that methylation and subsequent effects on gene expression may contribute to the biology of risk variants on 5p15.33. Our results provide strong support for extensive pleiotropy across this region of 5p15.33, to an extent not previously observed in other cancer susceptibility loci.
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- 2014
29. Reducing socio-economic inequalities in all-cause mortality: a counterfactual mediation approach
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Marcel Goldberg, Graham G. Giles, Jessica E. Laine, Cyrille Delpierre, Salvatore Panico, Henrique Barros, Martina Gandini, Pierre Antoine Dugué, Gianluca Severi, Marie Zins, Paolo Vineis, Roger L. Milne, Silvia Stringhini, Allison M. Hodge, Carlotta Sacerdote, Valéria Troncoso Baltar, Marc Chadeau-Hyam, Rosario Tumino, Mika Kivimäki, Vittorio Krogh, Vittorio Perduca, LIFEPATH Consortium, Alenius, H., Avendano, M., Baltar, V., Bartley, M., Barros, H., Bochud, M., Carmeli, C., Carra, L., Castagné, R., Chadeau-Hyam, M., Clavel-Chapelon, F.O., Costa, G., Courtin, E., Delpierre, C., Donkin, A., D'Errico, A., Dugué, P.A., Elliott, P., Fiorito, G., Fraga, S., Garès, V., Gandini, M., Giles, G., Goldberg, M., Greco, D., Hodge, A., Karimi, M., Kelly-Irving, M., Karisola, P., Kivimaki, M., Krogh, V., Laine, J., Lang, T., Layte, R., Lepage, B., Mackenbach, J., Marmot, M., de Mestral, C., McCrory, C., Milne, R., Muennig, P., Nusselder, W., Panico, S., Petrovic, D., Polidoro, S., Preisig, M., Raitakari, O., Ribeiro, A.I., Ricceri, F., Reinhard, E., Robinson, O., Valverde, J.R., Sacerdote, C., Satolli, R., Severi, G., Shipley, M.J., Stringhini, S., Tumino, R., Tieulent, J., Vaccarella, S., Vergnaud, A.C., Vineis, P., Vollenweider, P., Zins, M., Medical Research Council (MRC), and Commission of the European Communities
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LIFEPATH Consortium ,Adult ,Male ,Mediation (statistics) ,medicine.medical_specialty ,Socio-economic inequalities ,Social Determinants of Health ,Epidemiology ,030209 endocrinology & metabolism ,1117 Public Health and Health Services ,health behaviours ,Cohort Studies ,03 medical and health sciences ,0302 clinical medicine ,Cause of Death ,all-cause mortality ,causal inference ,intervention ,mediation ,multiple mediators ,Humans ,Medicine ,030212 general & internal medicine ,Mortality ,ddc:613 ,Cause of death ,business.industry ,0104 Statistics ,Hazard ratio ,Health Status Disparities ,General Medicine ,Middle Aged ,Mortality/trends ,Confidence interval ,Editorial Commentary ,Socioeconomic Factors ,Female ,Observational study ,business ,Body mass index ,Demography ,Cohort study - Abstract
Background Socio-economic inequalities in mortality are well established, yet the contribution of intermediate risk factors that may underlie these relationships remains unclear. We evaluated the role of multiple modifiable intermediate risk factors underlying socio-economic-associated mortality and quantified the potential impact of reducing early all-cause mortality by hypothetically altering socio-economic risk factors. Methods Data were from seven cohort studies participating in the LIFEPATH Consortium (total n = 179 090). Using both socio-economic position (SEP) (based on occupation) and education, we estimated the natural direct effect on all-cause mortality and the natural indirect effect via the joint mediating role of smoking, alcohol intake, dietary patterns, physical activity, body mass index, hypertension, diabetes and coronary artery disease. Hazard ratios (HRs) were estimated, using counterfactual natural effect models under different hypothetical actions of either lower or higher SEP or education. Results Lower SEP and education were associated with an increase in all-cause mortality within an average follow-up time of 17.5 years. Mortality was reduced via modelled hypothetical actions of increasing SEP or education. Through higher education, the HR was 0.85 [95% confidence interval (CI) 0.84, 0.86] for women and 0.71 (95% CI 0.70, 0.74) for men, compared with lower education. In addition, 34% and 38% of the effect was jointly mediated for women and men, respectively. The benefits from altering SEP were slightly more modest. Conclusions These observational findings support policies to reduce mortality both through improving socio-economic circumstances and increasing education, and by altering intermediaries, such as lifestyle behaviours and morbidities.
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- 2019
30. Menopausal Hormone Therapy and Risk of Endometrial Carcinoma Among Postmenopausal Women in the European Prospective Investigation into Cancer and Nutrition
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Kim Overvad, Konstantinos K. Tsilidis, Eiliv Lund, Timothy J. Key, N. Charlotte Onland-Moret, Benedetta Bendinelli, H. Bas Bueno-de-Mesquita, Agnès Fournier, Kay-Tee Khaw, Salvatore Panico, Eric J. Duell, Alban Fabre, Anja Olsen, Aurelio Barricarte, Maria-Dolores Chirlaque, Rudolf Kaaks, Madlen Schuetze, Pilar Amiano, Vittorio Krogh, Carla H. van Gils, Françoise Clavel-Chapelon, Nathalie Chabbert-Buffet, Veronika Fedirko, Kjersti Bakken, Manuela M. Bergmann, Maria-Esther Molina-Montes, Anne Tjønneland, Elio Riboli, Laure Dossus, Naomi E. Allen, Dominique S. Michaud, Nicholas J. Wareham, María-Luisa Redondo, Traci Mouw, Fränzel J. B. van Duijnhoven, Carlotta Sacerdote, Rosario Tumino, Oxana Gavrilyuk, Sabina Rinaldi, Allen, Ne, Tsilidis, Kk, Key, Tj, Dossus, L, Kaaks, R, Lund, E, Bakken, K, Gavrilyuk, O, Overvad, K, Tjønneland, A, Olsen, A, Fournier, A, Fabre, A, Clavel Chapelon, F, Chabbert Buffet, N, Sacerdote, C, Krogh, V, Bendinelli, B, Tumino, R, Panico, Salvatore, Bergmann, M, Schuetze, M, van Duijnhoven, Fj, Bueno de Mesquita, Hb, Onland Moret, Nc, van Gils, Ch, Amiano, P, Barricarte, A, Chirlaque, Md, Molina Montes, Me, Redondo, Ml, Duell, Ej, Khaw, Kt, Wareham, N, Rinaldi, S, Fedirko, V, Mouw, T, Michaud, D, and Riboli, E.
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Oncology ,medicine.medical_specialty ,Norpregnenes ,Epidemiology ,medicine.drug_class ,medicine.medical_treatment ,Tibolone ,Body Mass Index ,Cohort Studies ,03 medical and health sciences ,0302 clinical medicine ,Estrogen Receptor Modulators ,Risk Factors ,Internal medicine ,medicine ,Humans ,Risk factor ,Aged ,Proportional Hazards Models ,Retrospective Studies ,Gynecology ,030219 obstetrics & reproductive medicine ,business.industry ,Incidence ,Endometrial cancer ,Estrogen Replacement Therapy ,Age Factors ,Cancer ,Middle Aged ,medicine.disease ,Endometrial Neoplasms ,3. Good health ,European Prospective Investigation into Cancer and Nutrition ,Europe ,Postmenopause ,Menopause ,030220 oncology & carcinogenesis ,Female ,Hormone therapy ,business ,Progestin ,medicine.drug - Abstract
Udgivelsesdato: 2010-Oct-20 Estrogen-only menopausal hormone therapy (HT) increases the risk of endometrial cancer, but less is known about the association with other types of HT. Using Cox proportional hazards regression, the authors examined the association of various types of HT with the risk of endometrial cancer among 115,474 postmenopausal women recruited into the European Prospective Investigation into Cancer and Nutrition between 1992 and 2000. After a mean follow-up period of 9 years, 601 incident cases of endometrial cancer were identified. In comparison with never users of HT, risk of endometrial cancer was increased among current users of estrogen-only HT (hazard ratio (HR) = 2.52, 95% confidence interval (CI): 1.77, 3.57), tibolone (HR = 2.96, 95% CI: 1.67, 5.26), and, to a lesser extent, estrogen-plus-progestin HT (HR = 1.41, 95% CI: 1.08, 1.83), although risks differed according to regimen and type of progestin constituent. The association of HT use with risk was stronger among women who were older, leaner, or had ever smoked cigarettes. The finding of a strong increased risk of endometrial cancer with estrogen-only HT and a weaker association with combined HT supports the hypothesis that progestins have an attenuating effect on endometrial cancer risk. The increased risk associated with tibolone use requires further investigation.
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- 2010
31. Analysis of Heritability and Shared Heritability Based on Genome-Wide Association Studies for Thirteen Cancer Types
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Yeul Hong Kim, Sonja I. Berndt, José María Huerta, Morgan Rouprêt, Reury Perng Perng, Yi Young Choi, Lindsay M. Morton, Roberto Tirabosco, H. Bas Bueno-de-Mesquita, Wendy Cozen, Neil E. Caporaso, Stephen J. Chanock, Zhenhong Zhao, Dina Halai, Neyssa Marina, Ann L. Oberg, Stephen M. Ansell, Zhibin Hu, Donghui Li, Anne J. Novak, Jenny Turner, Wen Tan, Julie E. Buring, Stefano Porru, Qincheng He, Tania Carreón, Guoping Wu, Graham G. Giles, Claire M. Vajdic, Rudolf Kaaks, Ulrika Andersson, Susan L. Slager, Jen Yu Hung, Luis Sierrasesúmaga, Roel Vermeulen, Louise A. Brinton, Myron D. Gross, Jennifer Prescott, E. Lund, Chih Yi Chen, Jin Eun Choi, Chaoyu Wang, George J. Weiner, H. Dean Hosgood, Haixin Li, Carrie A. Thompson, Núria Malats, James McKay, Stephanie J. Weinstein, Young Tae Kim, Emily White, Pan-Chyr Yang, Orestis A. Panagiotou, Robert J. Klein, Joseph Vijai, Josep Lloreta, Immaculata De Vivo, Sofia Pavanello, Thomas E. Witzig, Montserrat Garcia-Closas, Roger Henriksson, Bryan A. Bassig, Tait D. Shanafelt, Rachel S. Kelly, Joseph M. Connors, Marco Rais, Wu Chou Su, Alex Smith, John J. Spinelli, Julie M. Gastier-Foster, Anne Kricker, In Kyu Park, Marc J. Gunter, Chancellor Hohensee, Simon Crouch, Jarmo Virtamo, M. G. Ennas, Lucia Conde, Lotte Maxild Mortensen, Lenka Foretova, Eric J. Duell, Anthony Staines, Hongyan Chen, Baosen Zhou, Brian M. Wolpin, Simone Benhamou, Zhaoming Wang, Françoise Clavel-Chapelon, Charles C. Chung, Nan Hu, Domenico Palli, Rebecca Montalvan, Thomas M. Habermann, Debra T. Silverman, Preetha Rajaraman, Christian C. Abnet, Wei-Yen Lim, Yuh Min Chen, Michelle Cotterchio, Lucia Miligi, Claudia Maria Hattinger, Eve Roman, Christopher Kim, Federico Canzian, Alan D. L. Sihoe, Sharon A. Savage, Mark P. Purdue, Maria Teresa Landi, Susan M. Gapstur, M Zucca, Yuanqing Ye, Jian Su, Chong-Jen Yu, Edward Giovannucci, Alain Monnereau, Afshan Siddiq, Ralph L. Erickson, Katherine A. McGlynn, Petra H.M. Peeters, W. Ryan Diver, David Van Den Berg, Gloria M. Petersen, Judith Hoffman-Bolton, Xiao-Ou Shu, Ying Chen, Eric J. Jacobs, Heiner Boeing, Sophia S. Wang, Hans-Olov Adami, Yuqing Li, Jacqueline Clavel, Ellen T. Chang, Tongzhang Zheng, William Pao, Hideo Kunitoh, Ulrike Peters, Jenny Chang-Claude, Alexandra Nieters, Silvia de Sanjosé, Chen Wu, Anders Ahlbom, Jun Suk Kim, Fredrick R. Schumacher, Roberta McKean-Cowdin, Laurence N. Kolonel, Herbert Yu, Li Liu, Vittorio Krogh, Tangchun Wu, Ho Il Yoon, Joseph F. Fraumeni, Olivier Cussenot, Jae Sook Sung, Kari E. North, Andrew D. Zelenetz, Ana Patiño-García, Anne Zeleniuch-Jacquotte, Christopher A. Haiman, Biyun Qian, Giovanni Maria Ferri, Rebecca Rodabough, Xifeng Wu, Maria Feychting, Kuan-Yu Chen, Laure Dossus, Jianjun Liu, Jean Wactawski-Wende, Constance Chen, Robert L. Grubb, Paolo Vineis, Mads Melbye, Chien Chung Lin, Malin Sund, Wei Zheng, Jun Xu, Yi Song Chen, Kay-Tee Khaw, Richard K. Severson, Kun-Chieh Chen, Jian-Min Yuan, Bu Tian Ji, Simonetta Di Lollo, Ping Xu, Howard D. Sesso, Yoo Jin Jung, Margaret R. Karagas, Piero Picci, Gianluca Severi, Margaret A. Tucker, Ti Ding, Gee-Chen Chang, Li Hsin Chien, She-Juan An, Maria Pik Wong, Chien-Jen Chen, Jonine D. Figueroa, Sun-Seog Kweon, Katia Scotlandi, Sara H. Olson, Kendra Schwartz, Chang Hyun Kang, Marta Crous-Bou, Yawei Zhang, Ludmila Prokunina-Olsson, Yolanda Benavente, Christine D. Berg, Kala Visvanathan, Loic Le Marchand, Takashi Kohno, Nilanjan Chatterjee, Tracy Lightfoot, Zhihua Yin, Lee E. Moore, Joanne S. Colt, Laurie Burdett, Tetsuya Mitsudomi, Harvey A. Risch, Alfredo Carrato, Hyo Sung Jeon, Victoria L. Stevens, Richard Gorlick, Danylo J. Villano, Alison P. Klein, Angela Brooks-Wilson, Joshua N. Sampson, Chu Chen, You-Lin Qiao, Kouya Shiraishi, Alan R. Schned, Dominique S. Michaud, Peng Guan, Philip R. Taylor, Gerald L. Andriole, John K.C. Chan, Eva Comperat, Randy D. Gascoyne, Marc Maynadie, Kyong Hwa Park, Amanda Black, Charles Kooperberg, Andrea La Croix, Kenneth Offit, Peter Kraft, David Thomas, Manuela Gago-Dominguez, Manolis Kogevinas, Theodore R. Holford, Pamela L. Horn-Ross, Xingzhou He, Massimo Serra, Satu Männistö, Christoffer Johansen, Meredith Yeager, Robert N. Hoover, Mary Ann Butler, William Wheeler, Jian Gu, Wei Wu, Ying Hsiang Chen, Leslie Bernstein, Yao Jen Li, David J. Hunter, In-Jae Oh, Jay S. Wunder, Meng Zhu, Henrik Hjalgrim, Martyn T. Smith, Alisa M. Goldstein, Linda M. Liao, Chao Agnes Hsiung, Ruth C. Travis, Jiucun Wang, Marie-Christine Boutron-Ruault, Daru Lu, Reina García-Closas, Avima M. Ruder, Martha S. Linet, Wei Tang, Geraldine Cancel-Tassin, Brian K. Link, Rebecca D. Jackson, J. Michael Gaziano, Malcolm C. Pike, Yu-Tang Gao, Lisa Mirabello, Alan A. Arslan, Hong Zheng, Nicolas Wentzensen, Chung Hsing Chen, I. Shou Chang, Meir J. Stampfer, Brenda M. Birmann, Alison Johnson, Wong-Ho Chow, Chin-Fu Hsiao, Neal D. Freedman, Robert C. Kurtz, Donald A. Barkauskas, Steven Gallinger, Junwen Wang, Simina M. Boca, Irene L. Andrulis, Hongbing Shen, Adrienne M. Flanagan, Cosmeri Rizzato, Marianna C. Stern, Angela Carta, Melissa C. Southey, Corrado Magnani, Sook Whan Sung, Lesley F. Tinker, M. Dorronsoro, Guangfu Jin, Giovanna Masala, Yi-Long Wu, Min-Ho Shin, Ming Shyan Huang, Göran Hallmans, Xueying Zhao, Jacques Riby, Beatrice Melin, Adonina Tardón, Börje Ljungberg, Mark Liebow, Elizabeth A. Holly, Carol Giffen, Paolo Boffetta, Maria Fernanda Amary, Jihua Li, Mazda Jenab, Keitaro Matsuo, Nalan Gokgoz, Karin E. Smedby, Cari M. Kitahara, Mia M. Gaudet, Cecilia Arici, Brian E. Henderson, Amy Hutchinson, Elio Riboli, Patricia Hartge, Victoria K. Cortessis, Kexin Chen, Dalsu Baris, Michael Goggins, Young-Chul Kim, Tsung-Ying Yang, Fusheng Wei, Peter D. Inskip, Demetrius Albanes, Fang Yu Tsai, Qing Lan, Li Jin, Charles E. Lawrence, Nikolaus Becker, Rachael S. Stolzenberg-Solomon, Bengt Glimelius, Wei Hu, Maria Dolores Chirlaque, Kimberly A. Bertrand, Bruce K. Armstrong, Veronica Wendy Setiawan, Kathy J. Helzlsouer, Manal M. Hassan, Jun Yokota, David V. Conti, Kai Yu, Chenwei Liu, Christine F. Skibola, Jae Yong Park, Fernando Lecanda, Dimitrios Trichopoulos, Eleanor Kane, Dongxin Lin, Yun-Chul Hong, Consol Serra, Anne Tjønneland, Melissa A. Austin, X. Zhang, Charles S. Fuchs, Nathaniel Rothman, Paul Brennan, Chih-Liang Wang, Wei Shen, Ying-Huang Tsai, Hee Nam Kim, Ghislaine Scelo, Faith G. Davis, Sara Lindström, Molly Schwenn, Giuseppe Mastrangelo, Adeline Seow, Laufey T. Amundadottir, Laura E. Beane Freeman, Huan Guo, Victor Ho-Fun Lee, Aruna Kamineni, Pierluigi Cocco, Jiang Chang, Emanuele Angelucci, Paige M. Bracci, Yong-Bing Xiang, G. M. Monawar Hosain, Elisabete Weiderpass, James R. Cerhan, Junjie Wu, Lauren R. Teras, Jin Hee Kim, Qiuyin Cai, Sampson, J.N., Wheeler, W.A., Yeager, M., Panagiotou, O., Wang, Z., Berndt, S.I., Lan, Q., Abnet, C.C., Amundadottir, L.T., Figueroa, J.D., Landi, M.T., Mirabello, L., Savage, S.A., Taylor, P.R., De Vivo, I., McGlynn, K.A., Purdue, M.P., Rajaraman, P., Adami, H.-O., Ahlbom, A., Albanes, D., Amary, M.F., An, S.-J., Andersson, U., Andriole, G., Jr., Andrulis, I.L., Angelucci, E., Ansell, S.M., Arici, C., Armstrong, B.K., Arslan, A.A., Austin, M.A., Baris, D., Barkauskas, D.A., Bassig, B.A., Becker, N., Benavente, Y., Benhamou, S., Berg, C., Van Den Berg, D., Bernstein, L., Bertrand, K.A., Birmann, B.M., Black, A., Boeing, H., Boffetta, P., Boutron-Ruault, M.-C., Bracci, P.M., Brinton, L., Brooks-Wilson, A.R., Bueno-De-Mesquita, H.B., Burdett, L., Buring, J., Butler, M.A., Cai, Q., Cancel-Tassin, G., Canzian, F., Carrato, A., Carreon, T., Carta, A., Chan, J.K.C., Chang, E.T., Chang, G.-C., Chang, I.S., Chang, J., Chang-Claude, J., Chen, C.-J., Chen, C.-Y., Chen, C., Chen, C.-H., Chen, H., Chen, K., Chen, K.-Y., Chen, K.-C., Chen, Y., Chen, Y.-H., Chen, Y.-S., Chen, Y.-M., Chien, L.-H., Chirlaque, M.-D., Choi, J.E., Choi, Y.Y., Chow, W.-H., Chung, C.C., Clavel, J., Clavel-Chapelon, F., Cocco, P., Colt, J.S., Comperat, E., Conde, L., Connors, J.M., Conti, D., Cortessis, V.K., Cotterchio, M., Cozen, W., Crouch, S., Crous-Bou, M., Cussenot, O., Davis, F.G., Ding, T., Diver, W.R., Dorronsoro, M., Dossus, L., Duell, E.J., Ennas, M.G., Erickson, R.L., Feychting, M., Flanagan, A.M., Foretova, L., Fraumeni, J.F., Jr., Freedman, N.D., Freeman, L.E.B., Fuchs, C., Gago-Dominguez, M., Gallinger, S., Gao, Y.-T., Gapstur, S.M., Garcia-Closas, M., García-Closas, R., Gascoyne, R.D., Gastier-Foster, J., Gaudet, M.M., Gaziano, J.M., Giffen, C., Giles, G.G., Giovannucci, E., Glimelius, B., Goggins, M., Gokgoz, N., Goldstein, A.M., Gorlick, R., Gross, M., Grubb, R., III and Gu, J., Guan, P., Gunter, M., Guo, H., Habermann, T.M., Haiman, C.A., Halai, D., Hallmans, G., Hassan, M., Hattinger, C., He, Q., He, X., Helzlsouer, K., Henderson, B., Henriksson, R., Hjalgrim, H., Hoffman-Bolton, J., Hohensee, C., Holford, T.R., Holly, E.A., Hong, Y.-C., Hoover, R.N., Horn-Ross, P.L., Hosain, G.M.M., Hosgood, H.D., III and Hsiao, C.-F., Hu, N., Hu, W., Hu, Z., Huang, M.-S., Huerta, J.-M., Hung, J.-Y., Hutchinson, A., Inskip, P.D., Jackson, R.D., Jacobs, E.J., Jenab, M., Jeon, H.-S., Ji, B.-T., Jin, G., Jin, L., Johansen, C., Johnson, A., Jung, Y.J., Kaaks, R., Kamineni, A., Kane, E., Kang, C.H., Karagas, M.R., Kelly, R.S., Khaw, K.-T., Kim, C., Kim, H.N., Kim, J.H., Kim, J.S., Kim, Y.H., Kim, Y.T., Kim, Y.-C., Kitahara, C.M., Klein, A.P., Klein, R.J., Kogevinas, M., Kohno, T., Kolonel, L.N., Kooperberg, C., Kricker, A., Krogh, V., Kunitoh, H., Kurtz, R.C., Kweon, S.-S., La Croix, A., Lawrence, C., Lecanda, F., Lee, V.H.F., Li, D., Li, H., Li, J., Li, Y.-J., Li, Y., Liao, L.M., Liebow, M., Lightfoot, T., Lim, W.-Y., Lin, C.-C., Lin, D., Lindstrom, S., Linet, M.S., Link, B.K., Liu, C., Liu, J., Liu, L., Ljungberg, B., Lloreta, J., Di Lollo, S., Lu, D., Lund, E., Malats, N., Mannisto, S., Marchand, L.L., Marina, N., Masala, G., Mastrangelo, G., Matsuo, K., Maynadie, M., McKay, J., McKean-Cowdin, R., Melbye, M., Melin, B.S., Michaud, D.S., Mitsudomi, T., Monnereau, A., Montalvan, R., Moore, L.E., Mortensen, L.M., Nieters, A., North, K.E., Novak, A.J., Oberg, A.L., Offit, K., Oh, I.-J., Olson, S.H., Palli, D., Pao, W., Park, I.K., Park, J.Y., Park, K.H., Patiño-Garcia, A., Pavanello, S., Peeters, P.H.M., Perng, R.-P., Peters, U., Petersen, G.M., Picci, P., Pike, M.C., Porru, S., Prescott, J., Prokunina-Olsson, L., Qian, B., Qiao, Y.-L., Rais, M., Riboli, E., Riby, J., Risch, H.A., Rizzato, C., Rodabough, R., Roman, E., Roupret, M., Ruder, A.M., De Sanjose, S., Scelo, G., Schned, A., Schumacher, F., Schwartz, K., Schwenn, M., Scotlandi, K., Seow, A., Serra, C., Serra, M., Sesso, H.D., Setiawan, V.W., Severi, G., Severson, R.K., Shanafelt, T.D., Shen, H., Shen, W., Shin, M.-H., Shiraishi, K., Shu, X.-O., Siddiq, A., Sierrasesúmaga, L., Sihoe, A.D.L., Skibola, C.F., Smith, A., Smith, M.T., Southey, M.C., Spinelli, J.J., Staines, A., Stampfer, M., Stern, M.C., Stevens, V.L., Stolzenberg-Solomon, R.S., Su, J., Su, W.-C., Sund, M., Sung, J.S., Sung, S.W., Tan, W., Tang, W., Tardón, A., Thomas, D., Thompson, C.A., Tinker, L.F., Tirabosco, R., Tjønneland, A., Travis, R.C., Trichopoulos, D., Tsai, F.-Y., Tsai, Y.-H., Tucker, M., Turner, J., Vajdic, C.M., Vermeulen, R.C.H., Villano, D.J., Vineis, P., Virtamo, J., Visvanathan, K., Wactawski-Wende, J., Wang, C., Wang, C.-L., Wang, J.-C., Wang, J., Wei, F., Weiderpass, E., Weiner, G.J., Weinstein, S., Wentzensen, N., White, E., Witzig, T.E., Wolpin, B.M., Wong, M.P., Wu, C., Wu, G., Wu, J., Wu, T., Wu, W., Wu, X., Wu, Y.-L., Wunder, J.S., Xiang, Y.-B., Xu, J., Xu, P., Yang, P.-C., Yang, T.-Y., Ye, Y., Yin, Z., Yokota, J., Yoon, H.-I., Yu, C.-J., Yu, H., Yu, K., Yuan, 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- Subjects
Male ,Cancer Research ,Lung Neoplasms ,Lymphoma ,Genome-wide association study ,Polymorphism (computer science) ,Neoplasms ,Medicine ,Chronic ,Genetics ,Osteosarcoma ,Oncology And Carcinogenesis ,Leukemia ,Smoking ,Family aggregation ,Single Nucleotide ,Middle Aged ,Familial risk ,Diffuse ,Kidney Neoplasms ,Lymphocytic ,Oncology ,Adult ,Aged ,Asian Continental Ancestry Group ,Bone Neoplasms ,European Continental Ancestry Group ,Female ,Humans ,Leukemia, Lymphocytic, Chronic, B-Cell ,Lymphoma, Large B-Cell, Diffuse ,Polymorphism, Single Nucleotide ,Testicular Neoplasms ,Tissue Array Analysis ,Urinary Bladder Neoplasms ,Genetic Predisposition to Disease ,Genome-Wide Association Study ,Genetic correlation ,Large B-Cell ,Oncology & Carcinogenesis ,Polymorphism ,business.industry ,Extramural ,B-Cell ,Cancer ,Heritability ,Genome-wide association studies for thirteen cancer types ,medicine.disease ,business - Abstract
BACKGROUND: Studies of related individuals have consistently demonstrated notable familial aggregation of cancer. We aim to estimate the heritability and genetic correlation attributable to the additive effects of common single-nucleotide polymorphisms (SNPs) for cancer at 13 anatomical sites.METHODS: Between 2007 and 2014, the US National Cancer Institute has generated data from genome-wide association studies (GWAS) for 49 492 cancer case patients and 34 131 control patients. We apply novel mixed model methodology (GCTA) to this GWAS data to estimate the heritability of individual cancers, as well as the proportion of heritability attributable to cigarette smoking in smoking-related cancers, and the genetic correlation between pairs of cancers.RESULTS: GWAS heritability was statistically significant at nearly all sites, with the estimates of array-based heritability, hl (2), on the liability threshold (LT) scale ranging from 0.05 to 0.38. Estimating the combined heritability of multiple smoking characteristics, we calculate that at least 24% (95% confidence interval [CI] = 14% to 37%) and 7% (95% CI = 4% to 11%) of the heritability for lung and bladder cancer, respectively, can be attributed to genetic determinants of smoking. Most pairs of cancers studied did not show evidence of strong genetic correlation. We found only four pairs of cancers with marginally statistically significant correlations, specifically kidney and testes (ρ = 0.73, SE = 0.28), diffuse large B-cell lymphoma (DLBCL) and pediatric osteosarcoma (ρ = 0.53, SE = 0.21), DLBCL and chronic lymphocytic leukemia (CLL) (ρ = 0.51, SE =0.18), and bladder and lung (ρ = 0.35, SE = 0.14). Correlation analysis also indicates that the genetic architecture of lung cancer differs between a smoking population of European ancestry and a nonsmoking Asian population, allowing for the possibility that the genetic etiology for the same disease can vary by population and environmental exposures.CONCLUSION: Our results provide important insights into the genetic architecture of cancers and suggest new avenues for investigation.
- Published
- 2015
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