1. Age-Associated Alteration in Innate Immune Response in Captive Baboons
- Author
-
Dianne McFarlane, Roman F. Wolf, Gary L. White, and Kristen A. McDaniel
- Subjects
Lipopolysaccharides ,Male ,Aging ,medicine.medical_specialty ,medicine.medical_treatment ,In Vitro Techniques ,Peripheral blood mononuclear cell ,Immune system ,Species Specificity ,Transforming Growth Factor beta ,Internal medicine ,biology.animal ,Journal of Gerontology: BIOLOGICAL SCIENCES ,medicine ,Animals ,Humans ,Interleukin 6 ,Whole blood ,Innate immune system ,biology ,Dehydroepiandrosterone Sulfate ,Interleukin-6 ,Tumor Necrosis Factor-alpha ,Immunity, Innate ,Interleukin-10 ,Interleukin 10 ,C-Reactive Protein ,Cytokine ,Endocrinology ,Models, Animal ,Immunology ,Leukocytes, Mononuclear ,biology.protein ,Female ,Papio hamadryas ,Geriatrics and Gerontology ,Baboon - Abstract
Baboons are an ideal model for studies of human inflammatory response due to their physiological and immunological similarities to people; however; little is known about how age affects immune function in the baboon. We sought to determine if baboons show age-related innate immune changes similar to that described in people. Age was correlated with increased serum C-reactive protein and interleukin-6 or, however, no change in interleukin-10 concentration was observed (n = 120 baboons). Cytokine release from unstimulated peripheral blood mononuclear cells as well as following immune (lipopolysaccharide) stimulation increased with age. When whole blood was assayed, both lipopolysaccharide stimulated and unstimulated samples showed an age-related increase in interleukin-6 response, although the unstimulated cytokine response was reduced compared with that observed in peripheral blood mononuclear cells. Tumor necrosis factor-α response was not related to age. Cytokine response in lipopolysaccharide-stimulated whole blood was negatively correlated with serum DHEA-S concentration and positively correlated with TGF-β concentration.
- Published
- 2011