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Start Over Author "Kouichi Hirai" Publisher oxford university press (oup)
2 results on '"Kouichi Hirai"'

2. Blood pressure-lowering effect of extract from Lactobacillus casei in spontaneously hypertensive rats(SHR)

Author

Hiroshi Sansawa, Masayoshi Furushiro, Mahoko Motoike, Seizaburo Kobayashi, Kouichi Hirai, Masaaki Watanuki, Teruo Yokokura, and Haruji Sawada

Subjects
chemistry.chemical_classification, medicine.medical_specialty, Lactobacillus casei, biology, Chemistry, A protein, biology.organism_classification, Polysaccharide, General Biochemistry, Genetics and Molecular Biology, Endocrinology, Blood pressure, Distilled water, Oral administration, Internal medicine, Immunology, medicine, cardiovascular diseases, Blood pressure lowering, General Agricultural and Biological Sciences, circulatory and respiratory physiology
Abstract

The effects of oral administration of hot water extract from autologous lysate of Lactobacillus casei (LEx) on the systolic blood pressure (SBP) were studied in spontaneously hypertensive rats (SHR). Oral doses of 10 mg/kg of LEx produced a significant decrease of the SBP of SHR, but LEx had no effect in normotensive rats. The long-term administration of LEx (1 or 10 mg/kg/day) to SHR from 5 to 17 weeks after birth suppressed the development of hypertension. LEx dialysed against distilled water was separated into a polysaccharide fraction (SG-1), a protein fraction (PR-1), and a nucleic acid fraction (NA-1), and SBP-lowering effects of these materials were investigated in SHR at the same dose (10mg/kg). The most effective material of these three was SG-1.

Published
1990
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