1. Increased Burden of Illness Associated with Antimicrobial‐ResistantSalmonella entericaSerotype Typhimurium Infections
- Author
-
Dean Middleton, Rafiq Ahmed, Kathryn Doré, Franklin Pollari, Scott A. McEwen, Leah J. Martin, Bonnie Henry, Frances Jamieson, Bruce Ciebin, Murray Fyfe, and Jane A. Buxton
- Subjects
Adult ,Male ,Salmonella typhimurium ,Serotype ,Canada ,medicine.medical_specialty ,Adolescent ,animal diseases ,Drug resistance ,Biology ,Cost of Illness ,Risk Factors ,Internal medicine ,Ampicillin ,Drug Resistance, Bacterial ,Odds Ratio ,medicine ,Humans ,Immunology and Allergy ,Child ,Sulfamethoxazole ,Infant ,Kanamycin ,Odds ratio ,Middle Aged ,biochemical phenomena, metabolism, and nutrition ,bacterial infections and mycoses ,biology.organism_classification ,Anti-Bacterial Agents ,Hospitalization ,Logistic Models ,Infectious Diseases ,Streptomycin ,Salmonella enterica ,Child, Preschool ,Salmonella Infections ,Immunology ,Female ,Salmonella Phages ,medicine.drug - Abstract
This study investigated the burden of illness associated with 440 cases of Salmonella enterica serotype Typhimurium infection identified in Canada between December 1999 and November 2000. We categorized case subjects' infections by definitive phage type 104 (DT104) and antimicrobial-resistance patterns. These variables were then investigated as risk factors for hospitalization. Hospitalization was more likely to occur among case subjects whose infections were resistant to at least ampicillin, chloramphenicol and/or kanamycin, streptomycin, sulphamethoxazole, and tetracycline (R-type AK/CSSuT; odds ratio [OR], 2.3; P=.003), compared with case subjects with AK/CSSuT-susceptible infections, and among case subjects with non-DT104 R-type AKSSuT infections (OR, 3.6; P=.005), compared with case subjects with non-DT104 AKSSuT-susceptible infections. In contrast, hospitalization rates did not differ between case subjects with DT104 infections and case subjects with non-DT104 infections or between case subjects with DT104 R-type ACSSuT infections and case subjects with DT104 ACSSuT-susceptible infections. We estimated that 57% of the hospitalizations among AK/CSSuT case subjects and 72% of the hospitalizations among non-DT104 AKSSuT case subjects were attributable to the resistance patterns of the infections.
- Published
- 2004
- Full Text
- View/download PDF