1. Diethylstilbestrol exposure during pregnancy with primary clear cell carcinoma of the cervix in an 8-year-old granddaughter: a multigenerational effect of endocrine disruptors?
- Author
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Samir Hamamah, Arnauld Verschuur, Nathalie Cassel-Knipping, Laura Gaspari, Charles Sultan, Xavier Carcopino-Tusoli, Marie-Odile Soyer-Gobillard, Françoise Paris, Julia Villeret, and Nicolas Kalfa
- Subjects
medicine.medical_specialty ,Diethylstilbestrol ,Cervix Uteri ,Endocrine Disruptors ,Cervical Clear Cell Adenocarcinoma ,03 medical and health sciences ,0302 clinical medicine ,Pregnancy ,medicine ,Humans ,Vaginal bleeding ,Clear-cell adenocarcinoma ,Child ,Cervix ,030304 developmental biology ,0303 health sciences ,Obstetrics ,business.industry ,Rehabilitation ,Obstetrics and Gynecology ,medicine.disease ,medicine.anatomical_structure ,Reproductive Medicine ,Prenatal Exposure Delayed Effects ,030220 oncology & carcinogenesis ,Clear cell carcinoma ,Vagina ,Female ,Neoplasm Recurrence, Local ,medicine.symptom ,business ,Adenocarcinoma, Clear Cell ,medicine.drug - Abstract
To date, vaginal/cervical clear cell adenocarcinoma (CCAC) has not been reported in the granddaughters of women treated with diethylstilbestrol (DES) during pregnancy. We present an 8-year-old girl with a history of severe vaginal bleeding who was diagnosed with cervical CCAC. She underwent fertility-sparing surgery and radiotherapy. No sign of recurrence was detected throughout a 10-year follow-up. Her grandmother had received DES therapy during pregnancy with the patient’s mother. Although no direct causal link is demonstrated, this case raises for the first time, the hypothesis of multigenerational effects of DES in girls and strongly suggests the need to follow the granddaughters of DES-treated women.
- Published
- 2020