1. A Unique Metabolite of Nimesulide*†
- Author
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Pratibha Sarkar, Randy K. Leavitt, Heather Gouthro, and John M. McIntosh
- Subjects
Male ,Drug ,Magnetic Resonance Spectroscopy ,Health, Toxicology and Mutagenesis ,media_common.quotation_subject ,Metabolite ,Administration, Oral ,Urine ,Toxicology ,Race track ,Analytical Chemistry ,chemistry.chemical_compound ,Oral administration ,Spectroscopy, Fourier Transform Infrared ,medicine ,Animals ,Environmental Chemistry ,Anilides ,Horses ,media_common ,Doping in Sports ,Sulfonamides ,Chemical Health and Safety ,Chromatography ,Chemistry ,Anti-Inflammatory Agents, Non-Steroidal ,Reproducibility of Results ,Hydrogen-Ion Concentration ,Thin-layer chromatography ,Nitro ,Chromatography, Thin Layer ,Oxidation-Reduction ,Nimesulide ,medicine.drug - Abstract
Nimesulide is a nonsteroidal anti-inflammatory drug recently detected in equine blood and urine samples taken at the race track. The detection of the drug in a blood sample led to the identification of an unknown thin-layer chromatographic (TLC) spot in track urine samples as a metabolite of nimesulide. Characterization of the unknown TLC spot and comparison with the synthesized compound shows that the unknown TLC spot is a previously unreported equine metabolite of nimesulide. The metabolite was identified as resulting from the reduction of the nitro group on nimesulide to an amino group. This reduced nitro metabolite (4-amino-2-phenoxy-methanesulfonanilide) is a major metabolite of nimesulide in the equine.
- Published
- 1997
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